1BTHP

Structure of thrombin complexed with bovine pancreatic trypsin inhibitor
Total Genus 9
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin.
pubmed doi rcsb
molecule tags Complex (serine protease/inhibitor)
source organism Bos taurus
molecule keywords THROMBIN
total genus 9
structure length 58
sequence length 58
chains with identical sequence Q
ec nomenclature
pdb deposition date 1996-12-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
P PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 1bthP00
2ZJXA 1KUNA 2TPII 1MTND 2J6DA 5JB4A 1IRHA 1BIKA 1DTXA 3AUHA 3OFWA 3BTDI 1Y62A 2KCRA 3BTHI 1BPTA 1P2MB 3BTWI 1TFXC 1DEMA 3BTEI 3M7QB 1FAKI 2HEXA 1T7CB 2W8XA 4U30W 2LFLA 3BTQI 1BTHP 4ISLB 3TGJI 3UIRC 3BTTI 2ZVXA 4Y10I 1OA55 1BZXI 2KNTA 3AUCA 1AAPA 1BRBI 2CA7A 3BYBA 4NTWB 3LDIA 3U1JE 2LFKA 3TGKI 1DENA 1DTKA 3UOUB 1LD6A 1KNTA 1YLDB 1CA0D 2RA3C 7PTIA 4ISNB 5JB6A 1CO7I 3GYMI 2M99A 1JV8A 1YKTB 4NTYB 1P2II 3BTFI 5JB7A 1TAWB 1KIGI 1D0DB 3WNYA 1YC0I 4PTIA 1P2NB 3FP7J 3P92E 3FP6I 2ODYE 1NAGA 2PTCI 1ADZA 6PTIA 1BRCI 1LD5A 2FTLI 3AUBA 1TAPA 1FANA 1CBWD 1T8LB 1P2JI 2DDJA 2UUYB 3AUIA 1B0CA 1TPAI 1P2KI 2FI3I 1ZJDB 4NTXB 4U32X 3L3TE 1AALA 1UUBA 1EJMB 1PITA 9PTIA 1BPIA 4Y0YI 2M01A 4WXVC 8PTIA 2FI5I 1T8MB 1T8OB 4Y0ZI 2DDIA 3TGII 4TPII 5JB5A 1BZ5A 4BD9B 1JC6A 1ZR0B 3AUDA 2IJOI 3AUEA 1SHPA 1BTIA 1EAWB 2JOTA 4Y11I 1P2OB 4DG4C 2R9PE 1BF0A 1BUNB 1TOCR 2FI4I 3FP8I 3BTGI 1YLCB 4ISOB 1F5RI 1G6XA 3CI7A 4BQDA 3BTMI 3LDMA 4DTGK 3AUGA 1T8NB 3L33E 3T62D 2UUXA 1F7ZI 2TGPI 1BHCA 3BTKI 1OA65 1QLQA 1UUAA 2KAII 3D65I 3LDJA 3TPII 5C67C 1FY8I 4WWYC 4BNRI 1K6UA 1P2QB 3OTJI 1D0DA 2FTMB 1JV9A 1TCPA 5PTIA 1KTHA 3P95E
chains in the Genus database with same CATH superfamily
2ZJXA 1KUNA 2TPII 1MTND 2J6DA 5JB4A 1IRHA 1BIKA 1DTXA 3AUHA 3OFWA 3BTDI 1Y62A 2KCRA 3BTHI 1BPTA 1P2MB 3BTWI 1TFXC 1DEMA 3BTEI 3M7QB 1FAKI 2HEXA 1T7CB 2W8XA 4U30W 2LFLA 3BTQI 1BTHP 4ISLB 3TGJI 3UIRC 3BTTI 2ZVXA 4Y10I 1OA55 1BZXI 2KNTA 3AUCA 1AAPA 1BRBI 2CA7A 3BYBA 4NTWB 3LDIA 3U1JE 2LFKA 3TGKI 1DENA 1DTKA 3UOUB 1LD6A 1KNTA 1YLDB 1CA0D 2RA3C 7PTIA 4ISNB 5JB6A 1CO7I 3GYMI 2M99A 1JV8A 1YKTB 4NTYB 1P2II 3BTFI 5JB7A 1TAWB 1KIGI 1D0DB 3WNYA 1YC0I 4PTIA 1P2NB 3FP7J 3P92E 3FP6I 2ODYE 1NAGA 2PTCI 1ADZA 6PTIA 1BRCI 1LD5A 2FTLI 3AUBA 1TAPA 1FANA 1CBWD 1T8LB 1P2JI 2DDJA 2UUYB 3AUIA 1B0CA 1TPAI 1P2KI 2FI3I 1ZJDB 4NTXB 4U32X 3L3TE 1AALA 1UUBA 1EJMB 1PITA 9PTIA 1BPIA 4Y0YI 2M01A 4WXVC 8PTIA 2FI5I 1T8MB 1T8OB 4Y0ZI 2DDIA 3TGII 4TPII 5JB5A 1BZ5A 4BD9B 1JC6A 1ZR0B 3AUDA 2IJOI 3AUEA 1SHPA 1BTIA 1EAWB 2JOTA 4Y11I 1P2OB 4DG4C 2R9PE 1BF0A 1BUNB 1TOCR 2FI4I 3FP8I 3BTGI 1YLCB 4ISOB 1F5RI 1G6XA 3CI7A 4BQDA 3BTMI 3LDMA 4DTGK 3AUGA 1T8NB 3L33E 3T62D 2UUXA 1F7ZI 2TGPI 1BHCA 3BTKI 1OA65 1QLQA 1UUAA 2KAII 3D65I 3LDJA 3TPII 5C67C 1FY8I 4WWYC 4BNRI 1K6UA 1P2QB 3OTJI 1D0DA 2FTMB 1JV9A 1TCPA 5PTIA 1KTHA 3P95E
chains in the Genus database with same CATH topology
2ZJXA 1KUNA 2TPII 1MTND 2J6DA 5JB4A 1IRHA 1BIKA 1DTXA 3AUHA 3OFWA 3BTDI 1Y62A 2KCRA 3BTHI 1BPTA 1P2MB 3BTWI 1TFXC 1DEMA 3BTEI 3M7QB 1FAKI 2HEXA 1T7CB 2W8XA 4U30W 2LFLA 3BTQI 1BTHP 4ISLB 3TGJI 3UIRC 3BTTI 2ZVXA 4Y10I 1OA55 1BZXI 2KNTA 3AUCA 1AAPA 1BRBI 2CA7A 3BYBA 4NTWB 3LDIA 3U1JE 2LFKA 3TGKI 1DENA 1DTKA 3UOUB 1LD6A 1KNTA 1YLDB 1CA0D 2RA3C 7PTIA 4ISNB 5JB6A 1CO7I 3GYMI 2M99A 1JV8A 1YKTB 4NTYB 1P2II 3BTFI 5JB7A 1TAWB 1KIGI 1D0DB 3WNYA 1YC0I 4PTIA 1P2NB 3FP7J 3P92E 3FP6I 2ODYE 1NAGA 2PTCI 1ADZA 6PTIA 1BRCI 1LD5A 2FTLI 3AUBA 1TAPA 1FANA 1CBWD 1T8LB 1P2JI 2DDJA 2UUYB 3AUIA 1B0CA 1TPAI 1P2KI 2FI3I 1ZJDB 4NTXB 4U32X 3L3TE 1AALA 1UUBA 1EJMB 1PITA 9PTIA 1BPIA 4Y0YI 2M01A 4WXVC 8PTIA 2FI5I 1T8MB 1T8OB 4Y0ZI 2DDIA 3TGII 4TPII 5JB5A 1BZ5A 4BD9B 1JC6A 1ZR0B 3AUDA 2IJOI 3AUEA 1SHPA 1BTIA 1EAWB 2JOTA 4Y11I 1P2OB 4DG4C 2R9PE 1BF0A 1BUNB 1TOCR 2FI4I 3FP8I 3BTGI 1YLCB 4ISOB 1F5RI 1G6XA 3CI7A 4BQDA 3BTMI 3LDMA 4DTGK 3AUGA 1T8NB 3L33E 3T62D 2UUXA 1F7ZI 2TGPI 1BHCA 3BTKI 1OA65 1QLQA 1UUAA 2KAII 3D65I 3LDJA 3TPII 5C67C 1FY8I 4WWYC 4BNRI 1K6UA 1P2QB 3OTJI 1D0DA 2FTMB 1JV9A 1TCPA 5PTIA 1KTHA 3P95E
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ZJX A;  1KUN A;  2TPI I;  1MTN D;  2J6D A;  5JB4 A;  1IRH A;  1BIK A;  1DTX A;  3AUH A;  3OFW A;  3BTD I;  1Y62 A;  2KCR A;  3BTH I;  1BPT A;  1P2M B;  3BTW I;  1TFX C;  1DEM A;  3BTE I;  3M7Q B;  1FAK I;  2HEX A;  1T7C B;  2W8X A;  4U30 W;  2LFL A;  3BTQ I;  1BTH P;  4ISL B;  3TGJ I;  3UIR C;  3BTT I;  2ZVX A;  4Y10 I;  1OA5 5;  1BZX I;  2KNT A;  3AUC A;  1AAP A;  1BRB I;  2CA7 A;  3BYB A;  4NTW B;  3LDI A;  3U1J E;  2LFK A;  3TGK I;  1DEN A;  1DTK A;  3UOU B;  1LD6 A;  1KNT A;  1YLD B;  1CA0 D;  2RA3 C;  7PTI A;  4ISN B;  5JB6 A;  1CO7 I;  3GYM I;  2M99 A;  1JV8 A;  1YKT B;  4NTY B;  1P2I I;  3BTF I;  5JB7 A;  1TAW B;  1KIG I;  1D0D B;  3WNY A;  1YC0 I;  4PTI A;  1P2N B;  3FP7 J;  3P92 E;  3FP6 I;  2ODY E;  1NAG A;  2PTC I;  1ADZ A;  6PTI A;  1BRC I;  1LD5 A;  2FTL I;  3AUB A;  1TAP A;  1FAN A;  1CBW D;  1T8L B;  1P2J I;  2DDJ A;  2UUY B;  3AUI A;  1B0C A;  1TPA I;  1P2K I;  2FI3 I;  1ZJD B;  4NTX B;  4U32 X;  3L3T E;  1AAL A;  1UUB A;  1EJM B;  1PIT A;  9PTI A;  1BPI A;  4Y0Y I;  2M01 A;  4WXV C;  8PTI A;  2FI5 I;  1T8M B;  1T8O B;  4Y0Z I;  2DDI A;  3TGI I;  4TPI I;  5JB5 A;  1BZ5 A;  4BD9 B;  1JC6 A;  1ZR0 B;  3AUD A;  2IJO I;  3AUE A;  1SHP A;  1BTI A;  1EAW B;  2JOT A;  4Y11 I;  1P2O B;  4DG4 C;  2R9P E;  1BF0 A;  1BUN B;  1TOC R;  2FI4 I;  3FP8 I;  3BTG I;  1YLC B;  4ISO B;  1F5R I;  1G6X A;  3CI7 A;  4BQD A;  3BTM I;  3LDM A;  4DTG K;  3AUG A;  1T8N B;  3L33 E;  3T62 D;  2UUX A;  1F7Z I;  2TGP I;  1BHC A;  3BTK I;  1OA6 5;  1QLQ A;  1UUA A;  2KAI I;  3D65 I;  3LDJ A;  3TPI I;  5C67 C;  1FY8 I;  4WWY C;  4BNR I;  1K6U A;  1P2Q B;  3OTJ I;  1D0D A;  2FTM B;  1JV9 A;  1TCP A;  5PTI A;  1KTH A;  3P95 E; 
#chains in the Genus database with same CATH topology
 2ZJX A;  1KUN A;  2TPI I;  1MTN D;  2J6D A;  5JB4 A;  1IRH A;  1BIK A;  1DTX A;  3AUH A;  3OFW A;  3BTD I;  1Y62 A;  2KCR A;  3BTH I;  1BPT A;  1P2M B;  3BTW I;  1TFX C;  1DEM A;  3BTE I;  3M7Q B;  1FAK I;  2HEX A;  1T7C B;  2W8X A;  4U30 W;  2LFL A;  3BTQ I;  1BTH P;  4ISL B;  3TGJ I;  3UIR C;  3BTT I;  2ZVX A;  4Y10 I;  1OA5 5;  1BZX I;  2KNT A;  3AUC A;  1AAP A;  1BRB I;  2CA7 A;  3BYB A;  4NTW B;  3LDI A;  3U1J E;  2LFK A;  3TGK I;  1DEN A;  1DTK A;  3UOU B;  1LD6 A;  1KNT A;  1YLD B;  1CA0 D;  2RA3 C;  7PTI A;  4ISN B;  5JB6 A;  1CO7 I;  3GYM I;  2M99 A;  1JV8 A;  1YKT B;  4NTY B;  1P2I I;  3BTF I;  5JB7 A;  1TAW B;  1KIG I;  1D0D B;  3WNY A;  1YC0 I;  4PTI A;  1P2N B;  3FP7 J;  3P92 E;  3FP6 I;  2ODY E;  1NAG A;  2PTC I;  1ADZ A;  6PTI A;  1BRC I;  1LD5 A;  2FTL I;  3AUB A;  1TAP A;  1FAN A;  1CBW D;  1T8L B;  1P2J I;  2DDJ A;  2UUY B;  3AUI A;  1B0C A;  1TPA I;  1P2K I;  2FI3 I;  1ZJD B;  4NTX B;  4U32 X;  3L3T E;  1AAL A;  1UUB A;  1EJM B;  1PIT A;  9PTI A;  1BPI A;  4Y0Y I;  2M01 A;  4WXV C;  8PTI A;  2FI5 I;  1T8M B;  1T8O B;  4Y0Z I;  2DDI A;  3TGI I;  4TPI I;  5JB5 A;  1BZ5 A;  4BD9 B;  1JC6 A;  1ZR0 B;  3AUD A;  2IJO I;  3AUE A;  1SHP A;  1BTI A;  1EAW B;  2JOT A;  4Y11 I;  1P2O B;  4DG4 C;  2R9P E;  1BF0 A;  1BUN B;  1TOC R;  2FI4 I;  3FP8 I;  3BTG I;  1YLC B;  4ISO B;  1F5R I;  1G6X A;  3CI7 A;  4BQD A;  3BTM I;  3LDM A;  4DTG K;  3AUG A;  1T8N B;  3L33 E;  3T62 D;  2UUX A;  1F7Z I;  2TGP I;  1BHC A;  3BTK I;  1OA6 5;  1QLQ A;  1UUA A;  2KAI I;  3D65 I;  3LDJ A;  3TPI I;  5C67 C;  1FY8 I;  4WWY C;  4BNR I;  1K6U A;  1P2Q B;  3OTJ I;  1D0D A;  2FTM B;  1JV9 A;  1TCP A;  5PTI A;  1KTH A;  3P95 E; 
#chains in the Genus database with same CATH homology
 2ZJX A;  1KUN A;  2TPI I;  1MTN D;  2J6D A;  5JB4 A;  1IRH A;  1BIK A;  1DTX A;  3AUH A;  3OFW A;  3BTD I;  1Y62 A;  2KCR A;  3BTH I;  1BPT A;  1P2M B;  3BTW I;  1TFX C;  1DEM A;  3BTE I;  3M7Q B;  1FAK I;  2HEX A;  1T7C B;  2W8X A;  4U30 W;  2LFL A;  3BTQ I;  1BTH P;  4ISL B;  3TGJ I;  3UIR C;  3BTT I;  2ZVX A;  4Y10 I;  1OA5 5;  1BZX I;  2KNT A;  3AUC A;  1AAP A;  1BRB I;  2CA7 A;  3BYB A;  4NTW B;  3LDI A;  3U1J E;  2LFK A;  3TGK I;  1DEN A;  1DTK A;  3UOU B;  1LD6 A;  1KNT A;  1YLD B;  1CA0 D;  2RA3 C;  7PTI A;  4ISN B;  5JB6 A;  1CO7 I;  3GYM I;  2M99 A;  1JV8 A;  1YKT B;  4NTY B;  1P2I I;  3BTF I;  5JB7 A;  1TAW B;  1KIG I;  1D0D B;  3WNY A;  1YC0 I;  4PTI A;  1P2N B;  3FP7 J;  3P92 E;  3FP6 I;  2ODY E;  1NAG A;  2PTC I;  1ADZ A;  6PTI A;  1BRC I;  1LD5 A;  2FTL I;  3AUB A;  1TAP A;  1FAN A;  1CBW D;  1T8L B;  1P2J I;  2DDJ A;  2UUY B;  3AUI A;  1B0C A;  1TPA I;  1P2K I;  2FI3 I;  1ZJD B;  4NTX B;  4U32 X;  3L3T E;  1AAL A;  1UUB A;  1EJM B;  1PIT A;  9PTI A;  1BPI A;  4Y0Y I;  2M01 A;  4WXV C;  8PTI A;  2FI5 I;  1T8M B;  1T8O B;  4Y0Z I;  2DDI A;  3TGI I;  4TPI I;  5JB5 A;  1BZ5 A;  4BD9 B;  1JC6 A;  1ZR0 B;  3AUD A;  2IJO I;  3AUE A;  1SHP A;  1BTI A;  1EAW B;  2JOT A;  4Y11 I;  1P2O B;  4DG4 C;  2R9P E;  1BF0 A;  1BUN B;  1TOC R;  2FI4 I;  3FP8 I;  3BTG I;  1YLC B;  4ISO B;  1F5R I;  1G6X A;  3CI7 A;  4BQD A;  3BTM I;  3LDM A;  4DTG K;  3AUG A;  1T8N B;  3L33 E;  3T62 D;  2UUX A;  1F7Z I;  2TGP I;  1BHC A;  3BTK I;  1OA6 5;  1QLQ A;  1UUA A;  2KAI I;  3D65 I;  3LDJ A;  3TPI I;  5C67 C;  1FY8 I;  4WWY C;  4BNR I;  1K6U A;  1P2Q B;  3OTJ I;  1D0D A;  2FTM B;  1JV9 A;  1TCP A;  5PTI A;  1KTH A;  3P95 E; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...