1CA0D

Bovine chymotrypsin complexed to appi
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
54
structure length
54
Chain Sequence
EVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
pubmed rcsb
molecule tags Complex (serine protease/inhibitor)
source organism Bos taurus
molecule keywords BOVINE CHYMOTRYPSIN
total genus 9
structure length 54
sequence length 54
chains with identical sequence I
ec nomenclature
pdb deposition date 1997-01-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
D PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 1ca0D00
1Y62A 1ZR0B 2FI5I 4NTWB 1G6XA 1KTHA 1BZ5A 1TPAI 2FTLI 3BTFI 1NAGA 1SHPA 2J6DA 1ADZA 6PTIA 1YKTB 1LD5A 4Y0YI 1TOCR 3BTDI 1OA65 2M01A 4PTIA 3AUBA 3FP7J 1UUAA 1JV9A 1BTHP 5JB6A 1AALA 1P2OB 1CBWD 1YLDB 2HEXA 4WXVC 1P2MB 5JB7A 1P2JI 3BTTI 1CO7I 2LFLA 9PTIA 1KNTA 3WNYA 2M99A 1P2II 1FY8I 1YC0I 2FTMB 2FI4I 2TGPI 1EJMB 3LDIA 4WWYC 3AUHA 1K6UA 1UUBA 1BHCA 3P92E 2DDIA 4U32X 1TAWB 1BPIA 2RA3C 3L33E 1T8LB 1KUNA 1CA0D 1QLQA 1B0CA 4NTYB 1DTXA 1FANA 5PTIA 5JB5A 3AUEA 4DTGK 4Y10I 3BTQI 1BF0A 4Y0ZI 3TGII 1ZJDB 2PTCI 2DDJA 2UUYB 3BTHI 1AAPA 1DEMA 4Y11I 1BIKA 1BZXI 7PTIA 1T8NB 1T8MB 2TPII 3BTMI 4NTXB 2R9PE 2LFKA 1DTKA 2JOTA 3T62D 1T8OB 3GYMI 1BRCI 3OTJI 1LD6A 3OFWA 2KNTA 3LDJA 1BPTA 1F7ZI 3BTWI 1P2KI 1MTND 1TCPA 3UIRC 4BQDA 1DENA 1F5RI 5JB4A 3AUGA 2ZJXA 3AUIA 3UOUB 1BTIA 4ISLB 1JC6A 1D0DA 1P2QB 3TPII 1BUNB 2UUXA 3BTEI 1OA55 3CI7A 3FP6I 5C67C 1BRBI 3P95E 2CA7A 1JV8A 1EAWB 1P2NB 3L3TE 2IJOI 2KCRA 4ISOB 2FI3I 1PITA 3AUDA 3BTGI 1KIGI 2ZVXA 3U1JE 3FP8I 3LDMA 3TGJI 1IRHA 3D65I 1TFXC 2ODYE 4ISNB 3BTKI 4BNRI 3TGKI 4TPII 2W8XA 1D0DB 1T7CB 4BD9B 4DG4C 3BYBA 2KAII 3AUCA 1FAKI 1YLCB 1TAPA 4U30W 8PTIA 3M7QB
chains in the Genus database with same CATH superfamily
1Y62A 1ZR0B 2FI5I 4NTWB 1G6XA 1KTHA 1BZ5A 1TPAI 2FTLI 3BTFI 1NAGA 1SHPA 2J6DA 1ADZA 6PTIA 1YKTB 1LD5A 4Y0YI 1TOCR 3BTDI 1OA65 2M01A 4PTIA 3AUBA 3FP7J 1UUAA 1JV9A 1BTHP 5JB6A 1AALA 1P2OB 1CBWD 1YLDB 2HEXA 4WXVC 1P2MB 5JB7A 1P2JI 3BTTI 1CO7I 2LFLA 9PTIA 1KNTA 3WNYA 2M99A 1P2II 1FY8I 1YC0I 2FTMB 2FI4I 2TGPI 1EJMB 3LDIA 4WWYC 3AUHA 1K6UA 1UUBA 1BHCA 3P92E 2DDIA 4U32X 1TAWB 1BPIA 2RA3C 3L33E 1T8LB 1KUNA 1CA0D 1QLQA 1B0CA 4NTYB 1DTXA 1FANA 5PTIA 5JB5A 3AUEA 4DTGK 4Y10I 3BTQI 1BF0A 4Y0ZI 3TGII 1ZJDB 2PTCI 2DDJA 2UUYB 3BTHI 1AAPA 1DEMA 4Y11I 1BIKA 1BZXI 7PTIA 1T8NB 1T8MB 2TPII 3BTMI 4NTXB 2R9PE 2LFKA 1DTKA 2JOTA 3T62D 1T8OB 3GYMI 1BRCI 3OTJI 1LD6A 3OFWA 2KNTA 3LDJA 1BPTA 1F7ZI 3BTWI 1P2KI 1MTND 1TCPA 3UIRC 4BQDA 1DENA 1F5RI 5JB4A 3AUGA 2ZJXA 3AUIA 3UOUB 1BTIA 4ISLB 1JC6A 1D0DA 1P2QB 3TPII 1BUNB 2UUXA 3BTEI 1OA55 3CI7A 3FP6I 5C67C 1BRBI 3P95E 2CA7A 1JV8A 1EAWB 1P2NB 3L3TE 2IJOI 2KCRA 4ISOB 2FI3I 1PITA 3AUDA 3BTGI 1KIGI 2ZVXA 3U1JE 3FP8I 3LDMA 3TGJI 1IRHA 3D65I 1TFXC 2ODYE 4ISNB 3BTKI 4BNRI 3TGKI 4TPII 2W8XA 1D0DB 1T7CB 4BD9B 4DG4C 3BYBA 2KAII 3AUCA 1FAKI 1YLCB 1TAPA 4U30W 8PTIA 3M7QB
chains in the Genus database with same CATH topology
1Y62A 1ZR0B 2FI5I 4NTWB 1G6XA 1KTHA 1BZ5A 1TPAI 2FTLI 3BTFI 1NAGA 1SHPA 2J6DA 1ADZA 6PTIA 1YKTB 1LD5A 4Y0YI 1TOCR 3BTDI 1OA65 2M01A 4PTIA 3AUBA 3FP7J 1UUAA 1JV9A 1BTHP 5JB6A 1AALA 1P2OB 1CBWD 1YLDB 2HEXA 4WXVC 1P2MB 5JB7A 1P2JI 3BTTI 1CO7I 2LFLA 9PTIA 1KNTA 3WNYA 2M99A 1P2II 1FY8I 1YC0I 2FTMB 2FI4I 2TGPI 1EJMB 3LDIA 4WWYC 3AUHA 1K6UA 1UUBA 1BHCA 3P92E 2DDIA 4U32X 1TAWB 1BPIA 2RA3C 3L33E 1T8LB 1KUNA 1CA0D 1QLQA 1B0CA 4NTYB 1DTXA 1FANA 5PTIA 5JB5A 3AUEA 4DTGK 4Y10I 3BTQI 1BF0A 4Y0ZI 3TGII 1ZJDB 2PTCI 2DDJA 2UUYB 3BTHI 1AAPA 1DEMA 4Y11I 1BIKA 1BZXI 7PTIA 1T8NB 1T8MB 2TPII 3BTMI 4NTXB 2R9PE 2LFKA 1DTKA 2JOTA 3T62D 1T8OB 3GYMI 1BRCI 3OTJI 1LD6A 3OFWA 2KNTA 3LDJA 1BPTA 1F7ZI 3BTWI 1P2KI 1MTND 1TCPA 3UIRC 4BQDA 1DENA 1F5RI 5JB4A 3AUGA 2ZJXA 3AUIA 3UOUB 1BTIA 4ISLB 1JC6A 1D0DA 1P2QB 3TPII 1BUNB 2UUXA 3BTEI 1OA55 3CI7A 3FP6I 5C67C 1BRBI 3P95E 2CA7A 1JV8A 1EAWB 1P2NB 3L3TE 2IJOI 2KCRA 4ISOB 2FI3I 1PITA 3AUDA 3BTGI 1KIGI 2ZVXA 3U1JE 3FP8I 3LDMA 3TGJI 1IRHA 3D65I 1TFXC 2ODYE 4ISNB 3BTKI 4BNRI 3TGKI 4TPII 2W8XA 1D0DB 1T7CB 4BD9B 4DG4C 3BYBA 2KAII 3AUCA 1FAKI 1YLCB 1TAPA 4U30W 8PTIA 3M7QB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1Y62 A;  1ZR0 B;  2FI5 I;  4NTW B;  1G6X A;  1KTH A;  1BZ5 A;  1TPA I;  2FTL I;  3BTF I;  1NAG A;  1SHP A;  2J6D A;  1ADZ A;  6PTI A;  1YKT B;  1LD5 A;  4Y0Y I;  1TOC R;  3BTD I;  1OA6 5;  2M01 A;  4PTI A;  3AUB A;  3FP7 J;  1UUA A;  1JV9 A;  1BTH P;  5JB6 A;  1AAL A;  1P2O B;  1CBW D;  1YLD B;  2HEX A;  4WXV C;  1P2M B;  5JB7 A;  1P2J I;  3BTT I;  1CO7 I;  2LFL A;  9PTI A;  1KNT A;  3WNY A;  2M99 A;  1P2I I;  1FY8 I;  1YC0 I;  2FTM B;  2FI4 I;  2TGP I;  1EJM B;  3LDI A;  4WWY C;  3AUH A;  1K6U A;  1UUB A;  1BHC A;  3P92 E;  2DDI A;  4U32 X;  1TAW B;  1BPI A;  2RA3 C;  3L33 E;  1T8L B;  1KUN A;  1CA0 D;  1QLQ A;  1B0C A;  4NTY B;  1DTX A;  1FAN A;  5PTI A;  5JB5 A;  3AUE A;  4DTG K;  4Y10 I;  3BTQ I;  1BF0 A;  4Y0Z I;  3TGI I;  1ZJD B;  2PTC I;  2DDJ A;  2UUY B;  3BTH I;  1AAP A;  1DEM A;  4Y11 I;  1BIK A;  1BZX I;  7PTI A;  1T8N B;  1T8M B;  2TPI I;  3BTM I;  4NTX B;  2R9P E;  2LFK A;  1DTK A;  2JOT A;  3T62 D;  1T8O B;  3GYM I;  1BRC I;  3OTJ I;  1LD6 A;  3OFW A;  2KNT A;  3LDJ A;  1BPT A;  1F7Z I;  3BTW I;  1P2K I;  1MTN D;  1TCP A;  3UIR C;  4BQD A;  1DEN A;  1F5R I;  5JB4 A;  3AUG A;  2ZJX A;  3AUI A;  3UOU B;  1BTI A;  4ISL B;  1JC6 A;  1D0D A;  1P2Q B;  3TPI I;  1BUN B;  2UUX A;  3BTE I;  1OA5 5;  3CI7 A;  3FP6 I;  5C67 C;  1BRB I;  3P95 E;  2CA7 A;  1JV8 A;  1EAW B;  1P2N B;  3L3T E;  2IJO I;  2KCR A;  4ISO B;  2FI3 I;  1PIT A;  3AUD A;  3BTG I;  1KIG I;  2ZVX A;  3U1J E;  3FP8 I;  3LDM A;  3TGJ I;  1IRH A;  3D65 I;  1TFX C;  2ODY E;  4ISN B;  3BTK I;  4BNR I;  3TGK I;  4TPI I;  2W8X A;  1D0D B;  1T7C B;  4BD9 B;  4DG4 C;  3BYB A;  2KAI I;  3AUC A;  1FAK I;  1YLC B;  1TAP A;  4U30 W;  8PTI A;  3M7Q B; 
#chains in the Genus database with same CATH topology
 1Y62 A;  1ZR0 B;  2FI5 I;  4NTW B;  1G6X A;  1KTH A;  1BZ5 A;  1TPA I;  2FTL I;  3BTF I;  1NAG A;  1SHP A;  2J6D A;  1ADZ A;  6PTI A;  1YKT B;  1LD5 A;  4Y0Y I;  1TOC R;  3BTD I;  1OA6 5;  2M01 A;  4PTI A;  3AUB A;  3FP7 J;  1UUA A;  1JV9 A;  1BTH P;  5JB6 A;  1AAL A;  1P2O B;  1CBW D;  1YLD B;  2HEX A;  4WXV C;  1P2M B;  5JB7 A;  1P2J I;  3BTT I;  1CO7 I;  2LFL A;  9PTI A;  1KNT A;  3WNY A;  2M99 A;  1P2I I;  1FY8 I;  1YC0 I;  2FTM B;  2FI4 I;  2TGP I;  1EJM B;  3LDI A;  4WWY C;  3AUH A;  1K6U A;  1UUB A;  1BHC A;  3P92 E;  2DDI A;  4U32 X;  1TAW B;  1BPI A;  2RA3 C;  3L33 E;  1T8L B;  1KUN A;  1CA0 D;  1QLQ A;  1B0C A;  4NTY B;  1DTX A;  1FAN A;  5PTI A;  5JB5 A;  3AUE A;  4DTG K;  4Y10 I;  3BTQ I;  1BF0 A;  4Y0Z I;  3TGI I;  1ZJD B;  2PTC I;  2DDJ A;  2UUY B;  3BTH I;  1AAP A;  1DEM A;  4Y11 I;  1BIK A;  1BZX I;  7PTI A;  1T8N B;  1T8M B;  2TPI I;  3BTM I;  4NTX B;  2R9P E;  2LFK A;  1DTK A;  2JOT A;  3T62 D;  1T8O B;  3GYM I;  1BRC I;  3OTJ I;  1LD6 A;  3OFW A;  2KNT A;  3LDJ A;  1BPT A;  1F7Z I;  3BTW I;  1P2K I;  1MTN D;  1TCP A;  3UIR C;  4BQD A;  1DEN A;  1F5R I;  5JB4 A;  3AUG A;  2ZJX A;  3AUI A;  3UOU B;  1BTI A;  4ISL B;  1JC6 A;  1D0D A;  1P2Q B;  3TPI I;  1BUN B;  2UUX A;  3BTE I;  1OA5 5;  3CI7 A;  3FP6 I;  5C67 C;  1BRB I;  3P95 E;  2CA7 A;  1JV8 A;  1EAW B;  1P2N B;  3L3T E;  2IJO I;  2KCR A;  4ISO B;  2FI3 I;  1PIT A;  3AUD A;  3BTG I;  1KIG I;  2ZVX A;  3U1J E;  3FP8 I;  3LDM A;  3TGJ I;  1IRH A;  3D65 I;  1TFX C;  2ODY E;  4ISN B;  3BTK I;  4BNR I;  3TGK I;  4TPI I;  2W8X A;  1D0D B;  1T7C B;  4BD9 B;  4DG4 C;  3BYB A;  2KAI I;  3AUC A;  1FAK I;  1YLC B;  1TAP A;  4U30 W;  8PTI A;  3M7Q B; 
#chains in the Genus database with same CATH homology
 1Y62 A;  1ZR0 B;  2FI5 I;  4NTW B;  1G6X A;  1KTH A;  1BZ5 A;  1TPA I;  2FTL I;  3BTF I;  1NAG A;  1SHP A;  2J6D A;  1ADZ A;  6PTI A;  1YKT B;  1LD5 A;  4Y0Y I;  1TOC R;  3BTD I;  1OA6 5;  2M01 A;  4PTI A;  3AUB A;  3FP7 J;  1UUA A;  1JV9 A;  1BTH P;  5JB6 A;  1AAL A;  1P2O B;  1CBW D;  1YLD B;  2HEX A;  4WXV C;  1P2M B;  5JB7 A;  1P2J I;  3BTT I;  1CO7 I;  2LFL A;  9PTI A;  1KNT A;  3WNY A;  2M99 A;  1P2I I;  1FY8 I;  1YC0 I;  2FTM B;  2FI4 I;  2TGP I;  1EJM B;  3LDI A;  4WWY C;  3AUH A;  1K6U A;  1UUB A;  1BHC A;  3P92 E;  2DDI A;  4U32 X;  1TAW B;  1BPI A;  2RA3 C;  3L33 E;  1T8L B;  1KUN A;  1CA0 D;  1QLQ A;  1B0C A;  4NTY B;  1DTX A;  1FAN A;  5PTI A;  5JB5 A;  3AUE A;  4DTG K;  4Y10 I;  3BTQ I;  1BF0 A;  4Y0Z I;  3TGI I;  1ZJD B;  2PTC I;  2DDJ A;  2UUY B;  3BTH I;  1AAP A;  1DEM A;  4Y11 I;  1BIK A;  1BZX I;  7PTI A;  1T8N B;  1T8M B;  2TPI I;  3BTM I;  4NTX B;  2R9P E;  2LFK A;  1DTK A;  2JOT A;  3T62 D;  1T8O B;  3GYM I;  1BRC I;  3OTJ I;  1LD6 A;  3OFW A;  2KNT A;  3LDJ A;  1BPT A;  1F7Z I;  3BTW I;  1P2K I;  1MTN D;  1TCP A;  3UIR C;  4BQD A;  1DEN A;  1F5R I;  5JB4 A;  3AUG A;  2ZJX A;  3AUI A;  3UOU B;  1BTI A;  4ISL B;  1JC6 A;  1D0D A;  1P2Q B;  3TPI I;  1BUN B;  2UUX A;  3BTE I;  1OA5 5;  3CI7 A;  3FP6 I;  5C67 C;  1BRB I;  3P95 E;  2CA7 A;  1JV8 A;  1EAW B;  1P2N B;  3L3T E;  2IJO I;  2KCR A;  4ISO B;  2FI3 I;  1PIT A;  3AUD A;  3BTG I;  1KIG I;  2ZVX A;  3U1J E;  3FP8 I;  3LDM A;  3TGJ I;  1IRH A;  3D65 I;  1TFX C;  2ODY E;  4ISN B;  3BTK I;  4BNR I;  3TGK I;  4TPI I;  2W8X A;  1D0D B;  1T7C B;  4BD9 B;  4DG4 C;  3BYB A;  2KAI I;  3AUC A;  1FAK I;  1YLC B;  1TAP A;  4U30 W;  8PTI A;  3M7Q B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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