1EAWB

Crystal structure of the mtsp1 (matriptase)-bpti (aprotinin) complex
Total Genus 10
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
10
sequence length
56
structure length
56
Chain Sequence
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/inhibitor
source organism Homo sapiens
publication title Catalytic Domain Structures of Mt-Sp1/Matriptase, a Matrix-Degrading Transmembrane Serine Proteinase.
pubmed doi rcsb
molecule keywords SUPPRESSOR OF TUMORIGENICITY 14
total genus 10
structure length 56
sequence length 56
chains with identical sequence D
ec nomenclature
pdb deposition date 2001-07-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 1eawB00
1KIGI 2M99A 1G6XA 4Y0ZI 1JV8A 3LDIA 1IRHA 1P2II 2CA7A 2FTLI 5JB4A 1EAWB 2HEXA 1FY8I 3BYBA 2ZVXA 1BRCI 1BUNB 1B0CA 1DTKA 1ZR0B 4U30W 1TFXC 1JV9A 1TPAI 2ZJXA 1BRBI 1BTIA 1P2KI 4ISOB 1BHCA 3BTFI 1NAGA 4WWYC 1ZJDB 2UUYB 3WNYA 3AUHA 2DDIA 1Y62A 2IJOI 1CO7I 3OFWA 4Y0YI 1P2OB 1AAPA 3TGJI 5C67C 6PTIA 1CA0D 3P92E 1DTXA 1DENA 7PTIA 8PTIA 2W8XA 2UUXA 1BF0A 9PTIA 1F5RI 1LD6A 1CBWD 1TOCR 1BZ5A 1K6UA 3GYMI 3D65I 1KNTA 3AUBA 1BPTA 1AALA 2J6DA 3BTDI 1BIKA 2ODYE 3BTEI 2DDJA 3M7QB 2M01A 1EJMB 1BPIA 1UUBA 1MTND 4NTXB 2FI5I 3AUGA 3LDJA 2LFLA 4TPII 1PITA 5JB6A 2FTMB 4NTWB 3CI7A 2FI4I 4BNRI 4DTGK 3LDMA 4DG4C 1BTHP 3TGII 3UIRC 2R9PE 1P2QB 1P2NB 2PTCI 1T8LB 1FANA 3TGKI 1KUNA 3AUEA 5JB7A 1YLCB 1T8MB 1T8OB 2KAII 1KTHA 1OA65 3T62D 1T8NB 3L33E 2LFKA 3FP8I 3FP7J 1T7CB 4NTYB 2KNTA 3UOUB 3U1JE 1ADZA 4U32X 3BTKI 4PTIA 2FI3I 3FP6I 3OTJI 3BTQI 3BTWI 1UUAA 1YC0I 4ISNB 3BTTI 1JC6A 1YLDB 3P95E 1YKTB 1TCPA 2RA3C 4Y10I 1F7ZI 4BQDA 1P2MB 1TAPA 1DEMA 3AUCA 4WXVC 4Y11I 1SHPA 4BD9B 1OA55 1P2JI 3BTMI 3L3TE 1QLQA 5JB5A 1FAKI 3TPII 3AUDA 2TPII 5PTIA 2TGPI 1LD5A 1TAWB 3BTGI 2KCRA 2JOTA 4ISLB 3BTHI 1D0DA 1D0DB 3AUIA 1BZXI
chains in the Genus database with same CATH superfamily
1KIGI 2M99A 1G6XA 4Y0ZI 1JV8A 3LDIA 1IRHA 1P2II 2CA7A 2FTLI 5JB4A 1EAWB 2HEXA 1FY8I 3BYBA 2ZVXA 1BRCI 1BUNB 1B0CA 1DTKA 1ZR0B 4U30W 1TFXC 1JV9A 1TPAI 2ZJXA 1BRBI 1BTIA 1P2KI 4ISOB 1BHCA 3BTFI 1NAGA 4WWYC 1ZJDB 2UUYB 3WNYA 3AUHA 2DDIA 1Y62A 2IJOI 1CO7I 3OFWA 4Y0YI 1P2OB 1AAPA 3TGJI 5C67C 6PTIA 1CA0D 3P92E 1DTXA 1DENA 7PTIA 8PTIA 2W8XA 2UUXA 1BF0A 9PTIA 1F5RI 1LD6A 1CBWD 1TOCR 1BZ5A 1K6UA 3GYMI 3D65I 1KNTA 3AUBA 1BPTA 1AALA 2J6DA 3BTDI 1BIKA 2ODYE 3BTEI 2DDJA 3M7QB 2M01A 1EJMB 1BPIA 1UUBA 1MTND 4NTXB 2FI5I 3AUGA 3LDJA 2LFLA 4TPII 1PITA 5JB6A 2FTMB 4NTWB 3CI7A 2FI4I 4BNRI 4DTGK 3LDMA 4DG4C 1BTHP 3TGII 3UIRC 2R9PE 1P2QB 1P2NB 2PTCI 1T8LB 1FANA 3TGKI 1KUNA 3AUEA 5JB7A 1YLCB 1T8MB 1T8OB 2KAII 1KTHA 1OA65 3T62D 1T8NB 3L33E 2LFKA 3FP8I 3FP7J 1T7CB 4NTYB 2KNTA 3UOUB 3U1JE 1ADZA 4U32X 3BTKI 4PTIA 2FI3I 3FP6I 3OTJI 3BTQI 3BTWI 1UUAA 1YC0I 4ISNB 3BTTI 1JC6A 1YLDB 3P95E 1YKTB 1TCPA 2RA3C 4Y10I 1F7ZI 4BQDA 1P2MB 1TAPA 1DEMA 3AUCA 4WXVC 4Y11I 1SHPA 4BD9B 1OA55 1P2JI 3BTMI 3L3TE 1QLQA 5JB5A 1FAKI 3TPII 3AUDA 2TPII 5PTIA 2TGPI 1LD5A 1TAWB 3BTGI 2KCRA 2JOTA 4ISLB 3BTHI 1D0DA 1D0DB 3AUIA 1BZXI
chains in the Genus database with same CATH topology
1KIGI 2M99A 1G6XA 4Y0ZI 1JV8A 3LDIA 1IRHA 1P2II 2CA7A 2FTLI 5JB4A 1EAWB 2HEXA 1FY8I 3BYBA 2ZVXA 1BRCI 1BUNB 1B0CA 1DTKA 1ZR0B 4U30W 1TFXC 1JV9A 1TPAI 2ZJXA 1BRBI 1BTIA 1P2KI 4ISOB 1BHCA 3BTFI 1NAGA 4WWYC 1ZJDB 2UUYB 3WNYA 3AUHA 2DDIA 1Y62A 2IJOI 1CO7I 3OFWA 4Y0YI 1P2OB 1AAPA 3TGJI 5C67C 6PTIA 1CA0D 3P92E 1DTXA 1DENA 7PTIA 8PTIA 2W8XA 2UUXA 1BF0A 9PTIA 1F5RI 1LD6A 1CBWD 1TOCR 1BZ5A 1K6UA 3GYMI 3D65I 1KNTA 3AUBA 1BPTA 1AALA 2J6DA 3BTDI 1BIKA 2ODYE 3BTEI 2DDJA 3M7QB 2M01A 1EJMB 1BPIA 1UUBA 1MTND 4NTXB 2FI5I 3AUGA 3LDJA 2LFLA 4TPII 1PITA 5JB6A 2FTMB 4NTWB 3CI7A 2FI4I 4BNRI 4DTGK 3LDMA 4DG4C 1BTHP 3TGII 3UIRC 2R9PE 1P2QB 1P2NB 2PTCI 1T8LB 1FANA 3TGKI 1KUNA 3AUEA 5JB7A 1YLCB 1T8MB 1T8OB 2KAII 1KTHA 1OA65 3T62D 1T8NB 3L33E 2LFKA 3FP8I 3FP7J 1T7CB 4NTYB 2KNTA 3UOUB 3U1JE 1ADZA 4U32X 3BTKI 4PTIA 2FI3I 3FP6I 3OTJI 3BTQI 3BTWI 1UUAA 1YC0I 4ISNB 3BTTI 1JC6A 1YLDB 3P95E 1YKTB 1TCPA 2RA3C 4Y10I 1F7ZI 4BQDA 1P2MB 1TAPA 1DEMA 3AUCA 4WXVC 4Y11I 1SHPA 4BD9B 1OA55 1P2JI 3BTMI 3L3TE 1QLQA 5JB5A 1FAKI 3TPII 3AUDA 2TPII 5PTIA 2TGPI 1LD5A 1TAWB 3BTGI 2KCRA 2JOTA 4ISLB 3BTHI 1D0DA 1D0DB 3AUIA 1BZXI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KIG I;  2M99 A;  1G6X A;  4Y0Z I;  1JV8 A;  3LDI A;  1IRH A;  1P2I I;  2CA7 A;  2FTL I;  5JB4 A;  1EAW B;  2HEX A;  1FY8 I;  3BYB A;  2ZVX A;  1BRC I;  1BUN B;  1B0C A;  1DTK A;  1ZR0 B;  4U30 W;  1TFX C;  1JV9 A;  1TPA I;  2ZJX A;  1BRB I;  1BTI A;  1P2K I;  4ISO B;  1BHC A;  3BTF I;  1NAG A;  4WWY C;  1ZJD B;  2UUY B;  3WNY A;  3AUH A;  2DDI A;  1Y62 A;  2IJO I;  1CO7 I;  3OFW A;  4Y0Y I;  1P2O B;  1AAP A;  3TGJ I;  5C67 C;  6PTI A;  1CA0 D;  3P92 E;  1DTX A;  1DEN A;  7PTI A;  8PTI A;  2W8X A;  2UUX A;  1BF0 A;  9PTI A;  1F5R I;  1LD6 A;  1CBW D;  1TOC R;  1BZ5 A;  1K6U A;  3GYM I;  3D65 I;  1KNT A;  3AUB A;  1BPT A;  1AAL A;  2J6D A;  3BTD I;  1BIK A;  2ODY E;  3BTE I;  2DDJ A;  3M7Q B;  2M01 A;  1EJM B;  1BPI A;  1UUB A;  1MTN D;  4NTX B;  2FI5 I;  3AUG A;  3LDJ A;  2LFL A;  4TPI I;  1PIT A;  5JB6 A;  2FTM B;  4NTW B;  3CI7 A;  2FI4 I;  4BNR I;  4DTG K;  3LDM A;  4DG4 C;  1BTH P;  3TGI I;  3UIR C;  2R9P E;  1P2Q B;  1P2N B;  2PTC I;  1T8L B;  1FAN A;  3TGK I;  1KUN A;  3AUE A;  5JB7 A;  1YLC B;  1T8M B;  1T8O B;  2KAI I;  1KTH A;  1OA6 5;  3T62 D;  1T8N B;  3L33 E;  2LFK A;  3FP8 I;  3FP7 J;  1T7C B;  4NTY B;  2KNT A;  3UOU B;  3U1J E;  1ADZ A;  4U32 X;  3BTK I;  4PTI A;  2FI3 I;  3FP6 I;  3OTJ I;  3BTQ I;  3BTW I;  1UUA A;  1YC0 I;  4ISN B;  3BTT I;  1JC6 A;  1YLD B;  3P95 E;  1YKT B;  1TCP A;  2RA3 C;  4Y10 I;  1F7Z I;  4BQD A;  1P2M B;  1TAP A;  1DEM A;  3AUC A;  4WXV C;  4Y11 I;  1SHP A;  4BD9 B;  1OA5 5;  1P2J I;  3BTM I;  3L3T E;  1QLQ A;  5JB5 A;  1FAK I;  3TPI I;  3AUD A;  2TPI I;  5PTI A;  2TGP I;  1LD5 A;  1TAW B;  3BTG I;  2KCR A;  2JOT A;  4ISL B;  3BTH I;  1D0D A;  1D0D B;  3AUI A;  1BZX I; 
#chains in the Genus database with same CATH topology
 1KIG I;  2M99 A;  1G6X A;  4Y0Z I;  1JV8 A;  3LDI A;  1IRH A;  1P2I I;  2CA7 A;  2FTL I;  5JB4 A;  1EAW B;  2HEX A;  1FY8 I;  3BYB A;  2ZVX A;  1BRC I;  1BUN B;  1B0C A;  1DTK A;  1ZR0 B;  4U30 W;  1TFX C;  1JV9 A;  1TPA I;  2ZJX A;  1BRB I;  1BTI A;  1P2K I;  4ISO B;  1BHC A;  3BTF I;  1NAG A;  4WWY C;  1ZJD B;  2UUY B;  3WNY A;  3AUH A;  2DDI A;  1Y62 A;  2IJO I;  1CO7 I;  3OFW A;  4Y0Y I;  1P2O B;  1AAP A;  3TGJ I;  5C67 C;  6PTI A;  1CA0 D;  3P92 E;  1DTX A;  1DEN A;  7PTI A;  8PTI A;  2W8X A;  2UUX A;  1BF0 A;  9PTI A;  1F5R I;  1LD6 A;  1CBW D;  1TOC R;  1BZ5 A;  1K6U A;  3GYM I;  3D65 I;  1KNT A;  3AUB A;  1BPT A;  1AAL A;  2J6D A;  3BTD I;  1BIK A;  2ODY E;  3BTE I;  2DDJ A;  3M7Q B;  2M01 A;  1EJM B;  1BPI A;  1UUB A;  1MTN D;  4NTX B;  2FI5 I;  3AUG A;  3LDJ A;  2LFL A;  4TPI I;  1PIT A;  5JB6 A;  2FTM B;  4NTW B;  3CI7 A;  2FI4 I;  4BNR I;  4DTG K;  3LDM A;  4DG4 C;  1BTH P;  3TGI I;  3UIR C;  2R9P E;  1P2Q B;  1P2N B;  2PTC I;  1T8L B;  1FAN A;  3TGK I;  1KUN A;  3AUE A;  5JB7 A;  1YLC B;  1T8M B;  1T8O B;  2KAI I;  1KTH A;  1OA6 5;  3T62 D;  1T8N B;  3L33 E;  2LFK A;  3FP8 I;  3FP7 J;  1T7C B;  4NTY B;  2KNT A;  3UOU B;  3U1J E;  1ADZ A;  4U32 X;  3BTK I;  4PTI A;  2FI3 I;  3FP6 I;  3OTJ I;  3BTQ I;  3BTW I;  1UUA A;  1YC0 I;  4ISN B;  3BTT I;  1JC6 A;  1YLD B;  3P95 E;  1YKT B;  1TCP A;  2RA3 C;  4Y10 I;  1F7Z I;  4BQD A;  1P2M B;  1TAP A;  1DEM A;  3AUC A;  4WXV C;  4Y11 I;  1SHP A;  4BD9 B;  1OA5 5;  1P2J I;  3BTM I;  3L3T E;  1QLQ A;  5JB5 A;  1FAK I;  3TPI I;  3AUD A;  2TPI I;  5PTI A;  2TGP I;  1LD5 A;  1TAW B;  3BTG I;  2KCR A;  2JOT A;  4ISL B;  3BTH I;  1D0D A;  1D0D B;  3AUI A;  1BZX I; 
#chains in the Genus database with same CATH homology
 1KIG I;  2M99 A;  1G6X A;  4Y0Z I;  1JV8 A;  3LDI A;  1IRH A;  1P2I I;  2CA7 A;  2FTL I;  5JB4 A;  1EAW B;  2HEX A;  1FY8 I;  3BYB A;  2ZVX A;  1BRC I;  1BUN B;  1B0C A;  1DTK A;  1ZR0 B;  4U30 W;  1TFX C;  1JV9 A;  1TPA I;  2ZJX A;  1BRB I;  1BTI A;  1P2K I;  4ISO B;  1BHC A;  3BTF I;  1NAG A;  4WWY C;  1ZJD B;  2UUY B;  3WNY A;  3AUH A;  2DDI A;  1Y62 A;  2IJO I;  1CO7 I;  3OFW A;  4Y0Y I;  1P2O B;  1AAP A;  3TGJ I;  5C67 C;  6PTI A;  1CA0 D;  3P92 E;  1DTX A;  1DEN A;  7PTI A;  8PTI A;  2W8X A;  2UUX A;  1BF0 A;  9PTI A;  1F5R I;  1LD6 A;  1CBW D;  1TOC R;  1BZ5 A;  1K6U A;  3GYM I;  3D65 I;  1KNT A;  3AUB A;  1BPT A;  1AAL A;  2J6D A;  3BTD I;  1BIK A;  2ODY E;  3BTE I;  2DDJ A;  3M7Q B;  2M01 A;  1EJM B;  1BPI A;  1UUB A;  1MTN D;  4NTX B;  2FI5 I;  3AUG A;  3LDJ A;  2LFL A;  4TPI I;  1PIT A;  5JB6 A;  2FTM B;  4NTW B;  3CI7 A;  2FI4 I;  4BNR I;  4DTG K;  3LDM A;  4DG4 C;  1BTH P;  3TGI I;  3UIR C;  2R9P E;  1P2Q B;  1P2N B;  2PTC I;  1T8L B;  1FAN A;  3TGK I;  1KUN A;  3AUE A;  5JB7 A;  1YLC B;  1T8M B;  1T8O B;  2KAI I;  1KTH A;  1OA6 5;  3T62 D;  1T8N B;  3L33 E;  2LFK A;  3FP8 I;  3FP7 J;  1T7C B;  4NTY B;  2KNT A;  3UOU B;  3U1J E;  1ADZ A;  4U32 X;  3BTK I;  4PTI A;  2FI3 I;  3FP6 I;  3OTJ I;  3BTQ I;  3BTW I;  1UUA A;  1YC0 I;  4ISN B;  3BTT I;  1JC6 A;  1YLD B;  3P95 E;  1YKT B;  1TCP A;  2RA3 C;  4Y10 I;  1F7Z I;  4BQD A;  1P2M B;  1TAP A;  1DEM A;  3AUC A;  4WXV C;  4Y11 I;  1SHP A;  4BD9 B;  1OA5 5;  1P2J I;  3BTM I;  3L3T E;  1QLQ A;  5JB5 A;  1FAK I;  3TPI I;  3AUD A;  2TPI I;  5PTI A;  2TGP I;  1LD5 A;  1TAW B;  3BTG I;  2KCR A;  2JOT A;  4ISL B;  3BTH I;  1D0D A;  1D0D B;  3AUI A;  1BZX I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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