1P2JI

Structural consequences of accommodation of four non-cognate amino-acid residues in the s1 pocket of bovine trypsin and chymotrypsin
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
56
structure length
56
Chain Sequence
DFCLEPPYTGPCLARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCLRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural consequences of accommodation of four non-cognate amino acid residues in the S1 pocket of bovine trypsin and chymotrypsin.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Bos taurus
molecule keywords Trypsinogen, cationic
total genus 11
structure length 56
sequence length 56
ec nomenclature
pdb deposition date 2003-04-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 1p2jI00
5JB6A 3FP7J 2KNTA 2W8XA 2RA3C 1BPIA 4U30W 1SHPA 1OA55 2ODYE 1JV8A 2DDIA 4BD9B 4DG4C 2TPII 3AUEA 1BRBI 1UUBA 2FI5I 1D0DA 2ZVXA 7PTIA 1FANA 1P2MB 3BTHI 3L3TE 1BUNB 4U32X 1DEMA 3BTQI 1PITA 1BZXI 1TFXC 1BIKA 1NAGA 5C67C 4ISOB 1T8NB 3AUDA 2KCRA 1KNTA 3LDIA 3GYMI 1MTND 2FI4I 4PTIA 3TPII 2UUYB 1TOCR 1YC0I 3BTDI 1QLQA 3TGII 2FTMB 1DTKA 1BTIA 2DDJA 1K6UA 1Y62A 9PTIA 1LD5A 4WWYC 2M99A 1P2OB 4ISLB 1T8LB 3AUBA 5JB7A 1F7ZI 3OTJI 3AUCA 2M01A 4TPII 1ADZA 1F5RI 1JV9A 3AUHA 3TGJI 1BPTA 1AALA 3BYBA 2J6DA 3TGKI 1FAKI 4Y0YI 2IJOI 1TAWB 3LDMA 3LDJA 1FY8I 1BHCA 1JC6A 1P2KI 3T62D 1T8OB 4Y0ZI 3BTGI 3BTWI 6PTIA 3CI7A 1P2JI 3BTTI 5PTIA 3UIRC 1UUAA 3BTFI 3BTMI 2FTLI 1CA0D 2LFLA 1TAPA 1P2II 2JOTA 2CA7A 3L33E 1P2NB 2ZJXA 4BNRI 4NTXB 2FI3I 1BRCI 2KAII 1AAPA 1CO7I 1ZJDB 1KTHA 3P92E 4WXVC 1P2QB 1CBWD 1T8MB 3BTEI 3P95E 3WNYA 1BZ5A 5JB5A 2LFKA 3FP8I 4Y10I 5JB4A 3BTKI 1YKTB 1EAWB 1EJMB 1G6XA 1TPAI 3OFWA 4NTYB 1D0DB 3UOUB 1OA65 3M7QB 1ZR0B 2TGPI 4ISNB 1LD6A 2R9PE 2PTCI 1DENA 1TCPA 1BF0A 2UUXA 1T7CB 1DTXA 1YLDB 3AUGA 1IRHA 1BTHP 1KIGI 3FP6I 2HEXA 4BQDA 1B0CA 4DTGK 3U1JE 4Y11I 3D65I 1KUNA 4NTWB 3AUIA 1YLCB 8PTIA
chains in the Genus database with same CATH superfamily
5JB6A 3FP7J 2KNTA 2W8XA 2RA3C 1BPIA 4U30W 1SHPA 1OA55 2ODYE 1JV8A 2DDIA 4BD9B 4DG4C 2TPII 3AUEA 1BRBI 1UUBA 2FI5I 1D0DA 2ZVXA 7PTIA 1FANA 1P2MB 3BTHI 3L3TE 1BUNB 4U32X 1DEMA 3BTQI 1PITA 1BZXI 1TFXC 1BIKA 1NAGA 5C67C 4ISOB 1T8NB 3AUDA 2KCRA 1KNTA 3LDIA 3GYMI 1MTND 2FI4I 4PTIA 3TPII 2UUYB 1TOCR 1YC0I 3BTDI 1QLQA 3TGII 2FTMB 1DTKA 1BTIA 2DDJA 1K6UA 1Y62A 9PTIA 1LD5A 4WWYC 2M99A 1P2OB 4ISLB 1T8LB 3AUBA 5JB7A 1F7ZI 3OTJI 3AUCA 2M01A 4TPII 1ADZA 1F5RI 1JV9A 3AUHA 3TGJI 1BPTA 1AALA 3BYBA 2J6DA 3TGKI 1FAKI 4Y0YI 2IJOI 1TAWB 3LDMA 3LDJA 1FY8I 1BHCA 1JC6A 1P2KI 3T62D 1T8OB 4Y0ZI 3BTGI 3BTWI 6PTIA 3CI7A 1P2JI 3BTTI 5PTIA 3UIRC 1UUAA 3BTFI 3BTMI 2FTLI 1CA0D 2LFLA 1TAPA 1P2II 2JOTA 2CA7A 3L33E 1P2NB 2ZJXA 4BNRI 4NTXB 2FI3I 1BRCI 2KAII 1AAPA 1CO7I 1ZJDB 1KTHA 3P92E 4WXVC 1P2QB 1CBWD 1T8MB 3BTEI 3P95E 3WNYA 1BZ5A 5JB5A 2LFKA 3FP8I 4Y10I 5JB4A 3BTKI 1YKTB 1EAWB 1EJMB 1G6XA 1TPAI 3OFWA 4NTYB 1D0DB 3UOUB 1OA65 3M7QB 1ZR0B 2TGPI 4ISNB 1LD6A 2R9PE 2PTCI 1DENA 1TCPA 1BF0A 2UUXA 1T7CB 1DTXA 1YLDB 3AUGA 1IRHA 1BTHP 1KIGI 3FP6I 2HEXA 4BQDA 1B0CA 4DTGK 3U1JE 4Y11I 3D65I 1KUNA 4NTWB 3AUIA 1YLCB 8PTIA
chains in the Genus database with same CATH topology
5JB6A 3FP7J 2KNTA 2W8XA 2RA3C 1BPIA 4U30W 1SHPA 1OA55 2ODYE 1JV8A 2DDIA 4BD9B 4DG4C 2TPII 3AUEA 1BRBI 1UUBA 2FI5I 1D0DA 2ZVXA 7PTIA 1FANA 1P2MB 3BTHI 3L3TE 1BUNB 4U32X 1DEMA 3BTQI 1PITA 1BZXI 1TFXC 1BIKA 1NAGA 5C67C 4ISOB 1T8NB 3AUDA 2KCRA 1KNTA 3LDIA 3GYMI 1MTND 2FI4I 4PTIA 3TPII 2UUYB 1TOCR 1YC0I 3BTDI 1QLQA 3TGII 2FTMB 1DTKA 1BTIA 2DDJA 1K6UA 1Y62A 9PTIA 1LD5A 4WWYC 2M99A 1P2OB 4ISLB 1T8LB 3AUBA 5JB7A 1F7ZI 3OTJI 3AUCA 2M01A 4TPII 1ADZA 1F5RI 1JV9A 3AUHA 3TGJI 1BPTA 1AALA 3BYBA 2J6DA 3TGKI 1FAKI 4Y0YI 2IJOI 1TAWB 3LDMA 3LDJA 1FY8I 1BHCA 1JC6A 1P2KI 3T62D 1T8OB 4Y0ZI 3BTGI 3BTWI 6PTIA 3CI7A 1P2JI 3BTTI 5PTIA 3UIRC 1UUAA 3BTFI 3BTMI 2FTLI 1CA0D 2LFLA 1TAPA 1P2II 2JOTA 2CA7A 3L33E 1P2NB 2ZJXA 4BNRI 4NTXB 2FI3I 1BRCI 2KAII 1AAPA 1CO7I 1ZJDB 1KTHA 3P92E 4WXVC 1P2QB 1CBWD 1T8MB 3BTEI 3P95E 3WNYA 1BZ5A 5JB5A 2LFKA 3FP8I 4Y10I 5JB4A 3BTKI 1YKTB 1EAWB 1EJMB 1G6XA 1TPAI 3OFWA 4NTYB 1D0DB 3UOUB 1OA65 3M7QB 1ZR0B 2TGPI 4ISNB 1LD6A 2R9PE 2PTCI 1DENA 1TCPA 1BF0A 2UUXA 1T7CB 1DTXA 1YLDB 3AUGA 1IRHA 1BTHP 1KIGI 3FP6I 2HEXA 4BQDA 1B0CA 4DTGK 3U1JE 4Y11I 3D65I 1KUNA 4NTWB 3AUIA 1YLCB 8PTIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5JB6 A;  3FP7 J;  2KNT A;  2W8X A;  2RA3 C;  1BPI A;  4U30 W;  1SHP A;  1OA5 5;  2ODY E;  1JV8 A;  2DDI A;  4BD9 B;  4DG4 C;  2TPI I;  3AUE A;  1BRB I;  1UUB A;  2FI5 I;  1D0D A;  2ZVX A;  7PTI A;  1FAN A;  1P2M B;  3BTH I;  3L3T E;  1BUN B;  4U32 X;  1DEM A;  3BTQ I;  1PIT A;  1BZX I;  1TFX C;  1BIK A;  1NAG A;  5C67 C;  4ISO B;  1T8N B;  3AUD A;  2KCR A;  1KNT A;  3LDI A;  3GYM I;  1MTN D;  2FI4 I;  4PTI A;  3TPI I;  2UUY B;  1TOC R;  1YC0 I;  3BTD I;  1QLQ A;  3TGI I;  2FTM B;  1DTK A;  1BTI A;  2DDJ A;  1K6U A;  1Y62 A;  9PTI A;  1LD5 A;  4WWY C;  2M99 A;  1P2O B;  4ISL B;  1T8L B;  3AUB A;  5JB7 A;  1F7Z I;  3OTJ I;  3AUC A;  2M01 A;  4TPI I;  1ADZ A;  1F5R I;  1JV9 A;  3AUH A;  3TGJ I;  1BPT A;  1AAL A;  3BYB A;  2J6D A;  3TGK I;  1FAK I;  4Y0Y I;  2IJO I;  1TAW B;  3LDM A;  3LDJ A;  1FY8 I;  1BHC A;  1JC6 A;  1P2K I;  3T62 D;  1T8O B;  4Y0Z I;  3BTG I;  3BTW I;  6PTI A;  3CI7 A;  1P2J I;  3BTT I;  5PTI A;  3UIR C;  1UUA A;  3BTF I;  3BTM I;  2FTL I;  1CA0 D;  2LFL A;  1TAP A;  1P2I I;  2JOT A;  2CA7 A;  3L33 E;  1P2N B;  2ZJX A;  4BNR I;  4NTX B;  2FI3 I;  1BRC I;  2KAI I;  1AAP A;  1CO7 I;  1ZJD B;  1KTH A;  3P92 E;  4WXV C;  1P2Q B;  1CBW D;  1T8M B;  3BTE I;  3P95 E;  3WNY A;  1BZ5 A;  5JB5 A;  2LFK A;  3FP8 I;  4Y10 I;  5JB4 A;  3BTK I;  1YKT B;  1EAW B;  1EJM B;  1G6X A;  1TPA I;  3OFW A;  4NTY B;  1D0D B;  3UOU B;  1OA6 5;  3M7Q B;  1ZR0 B;  2TGP I;  4ISN B;  1LD6 A;  2R9P E;  2PTC I;  1DEN A;  1TCP A;  1BF0 A;  2UUX A;  1T7C B;  1DTX A;  1YLD B;  3AUG A;  1IRH A;  1BTH P;  1KIG I;  3FP6 I;  2HEX A;  4BQD A;  1B0C A;  4DTG K;  3U1J E;  4Y11 I;  3D65 I;  1KUN A;  4NTW B;  3AUI A;  1YLC B;  8PTI A; 
#chains in the Genus database with same CATH topology
 5JB6 A;  3FP7 J;  2KNT A;  2W8X A;  2RA3 C;  1BPI A;  4U30 W;  1SHP A;  1OA5 5;  2ODY E;  1JV8 A;  2DDI A;  4BD9 B;  4DG4 C;  2TPI I;  3AUE A;  1BRB I;  1UUB A;  2FI5 I;  1D0D A;  2ZVX A;  7PTI A;  1FAN A;  1P2M B;  3BTH I;  3L3T E;  1BUN B;  4U32 X;  1DEM A;  3BTQ I;  1PIT A;  1BZX I;  1TFX C;  1BIK A;  1NAG A;  5C67 C;  4ISO B;  1T8N B;  3AUD A;  2KCR A;  1KNT A;  3LDI A;  3GYM I;  1MTN D;  2FI4 I;  4PTI A;  3TPI I;  2UUY B;  1TOC R;  1YC0 I;  3BTD I;  1QLQ A;  3TGI I;  2FTM B;  1DTK A;  1BTI A;  2DDJ A;  1K6U A;  1Y62 A;  9PTI A;  1LD5 A;  4WWY C;  2M99 A;  1P2O B;  4ISL B;  1T8L B;  3AUB A;  5JB7 A;  1F7Z I;  3OTJ I;  3AUC A;  2M01 A;  4TPI I;  1ADZ A;  1F5R I;  1JV9 A;  3AUH A;  3TGJ I;  1BPT A;  1AAL A;  3BYB A;  2J6D A;  3TGK I;  1FAK I;  4Y0Y I;  2IJO I;  1TAW B;  3LDM A;  3LDJ A;  1FY8 I;  1BHC A;  1JC6 A;  1P2K I;  3T62 D;  1T8O B;  4Y0Z I;  3BTG I;  3BTW I;  6PTI A;  3CI7 A;  1P2J I;  3BTT I;  5PTI A;  3UIR C;  1UUA A;  3BTF I;  3BTM I;  2FTL I;  1CA0 D;  2LFL A;  1TAP A;  1P2I I;  2JOT A;  2CA7 A;  3L33 E;  1P2N B;  2ZJX A;  4BNR I;  4NTX B;  2FI3 I;  1BRC I;  2KAI I;  1AAP A;  1CO7 I;  1ZJD B;  1KTH A;  3P92 E;  4WXV C;  1P2Q B;  1CBW D;  1T8M B;  3BTE I;  3P95 E;  3WNY A;  1BZ5 A;  5JB5 A;  2LFK A;  3FP8 I;  4Y10 I;  5JB4 A;  3BTK I;  1YKT B;  1EAW B;  1EJM B;  1G6X A;  1TPA I;  3OFW A;  4NTY B;  1D0D B;  3UOU B;  1OA6 5;  3M7Q B;  1ZR0 B;  2TGP I;  4ISN B;  1LD6 A;  2R9P E;  2PTC I;  1DEN A;  1TCP A;  1BF0 A;  2UUX A;  1T7C B;  1DTX A;  1YLD B;  3AUG A;  1IRH A;  1BTH P;  1KIG I;  3FP6 I;  2HEX A;  4BQD A;  1B0C A;  4DTG K;  3U1J E;  4Y11 I;  3D65 I;  1KUN A;  4NTW B;  3AUI A;  1YLC B;  8PTI A; 
#chains in the Genus database with same CATH homology
 5JB6 A;  3FP7 J;  2KNT A;  2W8X A;  2RA3 C;  1BPI A;  4U30 W;  1SHP A;  1OA5 5;  2ODY E;  1JV8 A;  2DDI A;  4BD9 B;  4DG4 C;  2TPI I;  3AUE A;  1BRB I;  1UUB A;  2FI5 I;  1D0D A;  2ZVX A;  7PTI A;  1FAN A;  1P2M B;  3BTH I;  3L3T E;  1BUN B;  4U32 X;  1DEM A;  3BTQ I;  1PIT A;  1BZX I;  1TFX C;  1BIK A;  1NAG A;  5C67 C;  4ISO B;  1T8N B;  3AUD A;  2KCR A;  1KNT A;  3LDI A;  3GYM I;  1MTN D;  2FI4 I;  4PTI A;  3TPI I;  2UUY B;  1TOC R;  1YC0 I;  3BTD I;  1QLQ A;  3TGI I;  2FTM B;  1DTK A;  1BTI A;  2DDJ A;  1K6U A;  1Y62 A;  9PTI A;  1LD5 A;  4WWY C;  2M99 A;  1P2O B;  4ISL B;  1T8L B;  3AUB A;  5JB7 A;  1F7Z I;  3OTJ I;  3AUC A;  2M01 A;  4TPI I;  1ADZ A;  1F5R I;  1JV9 A;  3AUH A;  3TGJ I;  1BPT A;  1AAL A;  3BYB A;  2J6D A;  3TGK I;  1FAK I;  4Y0Y I;  2IJO I;  1TAW B;  3LDM A;  3LDJ A;  1FY8 I;  1BHC A;  1JC6 A;  1P2K I;  3T62 D;  1T8O B;  4Y0Z I;  3BTG I;  3BTW I;  6PTI A;  3CI7 A;  1P2J I;  3BTT I;  5PTI A;  3UIR C;  1UUA A;  3BTF I;  3BTM I;  2FTL I;  1CA0 D;  2LFL A;  1TAP A;  1P2I I;  2JOT A;  2CA7 A;  3L33 E;  1P2N B;  2ZJX A;  4BNR I;  4NTX B;  2FI3 I;  1BRC I;  2KAI I;  1AAP A;  1CO7 I;  1ZJD B;  1KTH A;  3P92 E;  4WXV C;  1P2Q B;  1CBW D;  1T8M B;  3BTE I;  3P95 E;  3WNY A;  1BZ5 A;  5JB5 A;  2LFK A;  3FP8 I;  4Y10 I;  5JB4 A;  3BTK I;  1YKT B;  1EAW B;  1EJM B;  1G6X A;  1TPA I;  3OFW A;  4NTY B;  1D0D B;  3UOU B;  1OA6 5;  3M7Q B;  1ZR0 B;  2TGP I;  4ISN B;  1LD6 A;  2R9P E;  2PTC I;  1DEN A;  1TCP A;  1BF0 A;  2UUX A;  1T7C B;  1DTX A;  1YLD B;  3AUG A;  1IRH A;  1BTH P;  1KIG I;  3FP6 I;  2HEX A;  4BQD A;  1B0C A;  4DTG K;  3U1J E;  4Y11 I;  3D65 I;  1KUN A;  4NTW B;  3AUI A;  1YLC B;  8PTI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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