1TPAI

The geometry of the reactive site and of the peptide groups in trypsin, trypsinogen and its complexes with inhibitors
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and its Complexes with Inhibitors
pubmed rcsb
molecule tags Complex (proteinase/inhibitor)
source organism Bos taurus
molecule keywords ANHYDRO-TRYPSIN
total genus 11
structure length 58
sequence length 58
ec nomenclature
pdb deposition date 1982-09-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 1tpaI00
3AUDA 3TPII 4DTGK 1P2NB 3CI7A 2M99A 3FP8I 4WXVC 1IRHA 2JOTA 1TAPA 2LFKA 4U32X 1BTIA 1D0DA 1PITA 4BD9B 2ODYE 1NAGA 1CBWD 1B0CA 1P2JI 1DTKA 1BRBI 3TGII 4BNRI 1BZXI 3P92E 9PTIA 3BTWI 1LD5A 3LDMA 2UUYB 1P2KI 1T8OB 2FTMB 2CA7A 2R9PE 3U1JE 1DTXA 1KNTA 4Y0YI 3BTTI 3D65I 3AUGA 2M01A 1YLDB 2HEXA 1TAWB 2J6DA 2UUXA 3BYBA 1BTHP 1OA65 3AUEA 1P2II 1BZ5A 3UIRC 1JV8A 5JB5A 3GYMI 1ZJDB 3BTMI 1T8LB 1FY8I 1BUNB 2W8XA 1YKTB 3L3TE 3P95E 1K6UA 5JB4A 1ADZA 3BTFI 6PTIA 1YLCB 1F7ZI 1BPTA 4ISNB 1ZR0B 2ZJXA 1G6XA 1FAKI 2TPII 1P2OB 7PTIA 4NTYB 3AUCA 5JB7A 1DENA 3L33E 5C67C 4U30W 1QLQA 4BQDA 1TPAI 3AUIA 1EAWB 2FTLI 1KIGI 2TGPI 3OTJI 3TGJI 1T7CB 4NTWB 1BPIA 1T8MB 3LDJA 1TCPA 2FI5I 1BRCI 1BIKA 3BTQI 3T62D 3BTKI 5PTIA 4ISLB 2KCRA 1AALA 3M7QB 1UUAA 1TFXC 4DG4C 1KTHA 2IJOI 2ZVXA 3BTGI 1CO7I 4Y10I 5JB6A 1CA0D 1JV9A 4PTIA 3WNYA 1D0DB 3UOUB 3TGKI 4Y0ZI 1Y62A 2LFLA 1T8NB 3OFWA 4ISOB 1P2MB 4NTXB 1SHPA 8PTIA 1OA55 1FANA 3FP7J 3FP6I 2PTCI 1JC6A 1YC0I 3AUHA 1BF0A 1BHCA 1F5RI 2KNTA 2DDJA 2FI3I 2RA3C 2KAII 3BTDI 1LD6A 1EJMB 1P2QB 3BTEI 1TOCR 1KUNA 3BTHI 3LDIA 1AAPA 3AUBA 4Y11I 1DEMA 2FI4I 4WWYC 1UUBA 2DDIA 4TPII 1MTND
chains in the Genus database with same CATH superfamily
3AUDA 3TPII 4DTGK 1P2NB 3CI7A 2M99A 3FP8I 4WXVC 1IRHA 2JOTA 1TAPA 2LFKA 4U32X 1BTIA 1D0DA 1PITA 4BD9B 2ODYE 1NAGA 1CBWD 1B0CA 1P2JI 1DTKA 1BRBI 3TGII 4BNRI 1BZXI 3P92E 9PTIA 3BTWI 1LD5A 3LDMA 2UUYB 1P2KI 1T8OB 2FTMB 2CA7A 2R9PE 3U1JE 1DTXA 1KNTA 4Y0YI 3BTTI 3D65I 3AUGA 2M01A 1YLDB 2HEXA 1TAWB 2J6DA 2UUXA 3BYBA 1BTHP 1OA65 3AUEA 1P2II 1BZ5A 3UIRC 1JV8A 5JB5A 3GYMI 1ZJDB 3BTMI 1T8LB 1FY8I 1BUNB 2W8XA 1YKTB 3L3TE 3P95E 1K6UA 5JB4A 1ADZA 3BTFI 6PTIA 1YLCB 1F7ZI 1BPTA 4ISNB 1ZR0B 2ZJXA 1G6XA 1FAKI 2TPII 1P2OB 7PTIA 4NTYB 3AUCA 5JB7A 1DENA 3L33E 5C67C 4U30W 1QLQA 4BQDA 1TPAI 3AUIA 1EAWB 2FTLI 1KIGI 2TGPI 3OTJI 3TGJI 1T7CB 4NTWB 1BPIA 1T8MB 3LDJA 1TCPA 2FI5I 1BRCI 1BIKA 3BTQI 3T62D 3BTKI 5PTIA 4ISLB 2KCRA 1AALA 3M7QB 1UUAA 1TFXC 4DG4C 1KTHA 2IJOI 2ZVXA 3BTGI 1CO7I 4Y10I 5JB6A 1CA0D 1JV9A 4PTIA 3WNYA 1D0DB 3UOUB 3TGKI 4Y0ZI 1Y62A 2LFLA 1T8NB 3OFWA 4ISOB 1P2MB 4NTXB 1SHPA 8PTIA 1OA55 1FANA 3FP7J 3FP6I 2PTCI 1JC6A 1YC0I 3AUHA 1BF0A 1BHCA 1F5RI 2KNTA 2DDJA 2FI3I 2RA3C 2KAII 3BTDI 1LD6A 1EJMB 1P2QB 3BTEI 1TOCR 1KUNA 3BTHI 3LDIA 1AAPA 3AUBA 4Y11I 1DEMA 2FI4I 4WWYC 1UUBA 2DDIA 4TPII 1MTND
chains in the Genus database with same CATH topology
3AUDA 3TPII 4DTGK 1P2NB 3CI7A 2M99A 3FP8I 4WXVC 1IRHA 2JOTA 1TAPA 2LFKA 4U32X 1BTIA 1D0DA 1PITA 4BD9B 2ODYE 1NAGA 1CBWD 1B0CA 1P2JI 1DTKA 1BRBI 3TGII 4BNRI 1BZXI 3P92E 9PTIA 3BTWI 1LD5A 3LDMA 2UUYB 1P2KI 1T8OB 2FTMB 2CA7A 2R9PE 3U1JE 1DTXA 1KNTA 4Y0YI 3BTTI 3D65I 3AUGA 2M01A 1YLDB 2HEXA 1TAWB 2J6DA 2UUXA 3BYBA 1BTHP 1OA65 3AUEA 1P2II 1BZ5A 3UIRC 1JV8A 5JB5A 3GYMI 1ZJDB 3BTMI 1T8LB 1FY8I 1BUNB 2W8XA 1YKTB 3L3TE 3P95E 1K6UA 5JB4A 1ADZA 3BTFI 6PTIA 1YLCB 1F7ZI 1BPTA 4ISNB 1ZR0B 2ZJXA 1G6XA 1FAKI 2TPII 1P2OB 7PTIA 4NTYB 3AUCA 5JB7A 1DENA 3L33E 5C67C 4U30W 1QLQA 4BQDA 1TPAI 3AUIA 1EAWB 2FTLI 1KIGI 2TGPI 3OTJI 3TGJI 1T7CB 4NTWB 1BPIA 1T8MB 3LDJA 1TCPA 2FI5I 1BRCI 1BIKA 3BTQI 3T62D 3BTKI 5PTIA 4ISLB 2KCRA 1AALA 3M7QB 1UUAA 1TFXC 4DG4C 1KTHA 2IJOI 2ZVXA 3BTGI 1CO7I 4Y10I 5JB6A 1CA0D 1JV9A 4PTIA 3WNYA 1D0DB 3UOUB 3TGKI 4Y0ZI 1Y62A 2LFLA 1T8NB 3OFWA 4ISOB 1P2MB 4NTXB 1SHPA 8PTIA 1OA55 1FANA 3FP7J 3FP6I 2PTCI 1JC6A 1YC0I 3AUHA 1BF0A 1BHCA 1F5RI 2KNTA 2DDJA 2FI3I 2RA3C 2KAII 3BTDI 1LD6A 1EJMB 1P2QB 3BTEI 1TOCR 1KUNA 3BTHI 3LDIA 1AAPA 3AUBA 4Y11I 1DEMA 2FI4I 4WWYC 1UUBA 2DDIA 4TPII 1MTND
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3AUD A;  3TPI I;  4DTG K;  1P2N B;  3CI7 A;  2M99 A;  3FP8 I;  4WXV C;  1IRH A;  2JOT A;  1TAP A;  2LFK A;  4U32 X;  1BTI A;  1D0D A;  1PIT A;  4BD9 B;  2ODY E;  1NAG A;  1CBW D;  1B0C A;  1P2J I;  1DTK A;  1BRB I;  3TGI I;  4BNR I;  1BZX I;  3P92 E;  9PTI A;  3BTW I;  1LD5 A;  3LDM A;  2UUY B;  1P2K I;  1T8O B;  2FTM B;  2CA7 A;  2R9P E;  3U1J E;  1DTX A;  1KNT A;  4Y0Y I;  3BTT I;  3D65 I;  3AUG A;  2M01 A;  1YLD B;  2HEX A;  1TAW B;  2J6D A;  2UUX A;  3BYB A;  1BTH P;  1OA6 5;  3AUE A;  1P2I I;  1BZ5 A;  3UIR C;  1JV8 A;  5JB5 A;  3GYM I;  1ZJD B;  3BTM I;  1T8L B;  1FY8 I;  1BUN B;  2W8X A;  1YKT B;  3L3T E;  3P95 E;  1K6U A;  5JB4 A;  1ADZ A;  3BTF I;  6PTI A;  1YLC B;  1F7Z I;  1BPT A;  4ISN B;  1ZR0 B;  2ZJX A;  1G6X A;  1FAK I;  2TPI I;  1P2O B;  7PTI A;  4NTY B;  3AUC A;  5JB7 A;  1DEN A;  3L33 E;  5C67 C;  4U30 W;  1QLQ A;  4BQD A;  1TPA I;  3AUI A;  1EAW B;  2FTL I;  1KIG I;  2TGP I;  3OTJ I;  3TGJ I;  1T7C B;  4NTW B;  1BPI A;  1T8M B;  3LDJ A;  1TCP A;  2FI5 I;  1BRC I;  1BIK A;  3BTQ I;  3T62 D;  3BTK I;  5PTI A;  4ISL B;  2KCR A;  1AAL A;  3M7Q B;  1UUA A;  1TFX C;  4DG4 C;  1KTH A;  2IJO I;  2ZVX A;  3BTG I;  1CO7 I;  4Y10 I;  5JB6 A;  1CA0 D;  1JV9 A;  4PTI A;  3WNY A;  1D0D B;  3UOU B;  3TGK I;  4Y0Z I;  1Y62 A;  2LFL A;  1T8N B;  3OFW A;  4ISO B;  1P2M B;  4NTX B;  1SHP A;  8PTI A;  1OA5 5;  1FAN A;  3FP7 J;  3FP6 I;  2PTC I;  1JC6 A;  1YC0 I;  3AUH A;  1BF0 A;  1BHC A;  1F5R I;  2KNT A;  2DDJ A;  2FI3 I;  2RA3 C;  2KAI I;  3BTD I;  1LD6 A;  1EJM B;  1P2Q B;  3BTE I;  1TOC R;  1KUN A;  3BTH I;  3LDI A;  1AAP A;  3AUB A;  4Y11 I;  1DEM A;  2FI4 I;  4WWY C;  1UUB A;  2DDI A;  4TPI I;  1MTN D; 
#chains in the Genus database with same CATH topology
 3AUD A;  3TPI I;  4DTG K;  1P2N B;  3CI7 A;  2M99 A;  3FP8 I;  4WXV C;  1IRH A;  2JOT A;  1TAP A;  2LFK A;  4U32 X;  1BTI A;  1D0D A;  1PIT A;  4BD9 B;  2ODY E;  1NAG A;  1CBW D;  1B0C A;  1P2J I;  1DTK A;  1BRB I;  3TGI I;  4BNR I;  1BZX I;  3P92 E;  9PTI A;  3BTW I;  1LD5 A;  3LDM A;  2UUY B;  1P2K I;  1T8O B;  2FTM B;  2CA7 A;  2R9P E;  3U1J E;  1DTX A;  1KNT A;  4Y0Y I;  3BTT I;  3D65 I;  3AUG A;  2M01 A;  1YLD B;  2HEX A;  1TAW B;  2J6D A;  2UUX A;  3BYB A;  1BTH P;  1OA6 5;  3AUE A;  1P2I I;  1BZ5 A;  3UIR C;  1JV8 A;  5JB5 A;  3GYM I;  1ZJD B;  3BTM I;  1T8L B;  1FY8 I;  1BUN B;  2W8X A;  1YKT B;  3L3T E;  3P95 E;  1K6U A;  5JB4 A;  1ADZ A;  3BTF I;  6PTI A;  1YLC B;  1F7Z I;  1BPT A;  4ISN B;  1ZR0 B;  2ZJX A;  1G6X A;  1FAK I;  2TPI I;  1P2O B;  7PTI A;  4NTY B;  3AUC A;  5JB7 A;  1DEN A;  3L33 E;  5C67 C;  4U30 W;  1QLQ A;  4BQD A;  1TPA I;  3AUI A;  1EAW B;  2FTL I;  1KIG I;  2TGP I;  3OTJ I;  3TGJ I;  1T7C B;  4NTW B;  1BPI A;  1T8M B;  3LDJ A;  1TCP A;  2FI5 I;  1BRC I;  1BIK A;  3BTQ I;  3T62 D;  3BTK I;  5PTI A;  4ISL B;  2KCR A;  1AAL A;  3M7Q B;  1UUA A;  1TFX C;  4DG4 C;  1KTH A;  2IJO I;  2ZVX A;  3BTG I;  1CO7 I;  4Y10 I;  5JB6 A;  1CA0 D;  1JV9 A;  4PTI A;  3WNY A;  1D0D B;  3UOU B;  3TGK I;  4Y0Z I;  1Y62 A;  2LFL A;  1T8N B;  3OFW A;  4ISO B;  1P2M B;  4NTX B;  1SHP A;  8PTI A;  1OA5 5;  1FAN A;  3FP7 J;  3FP6 I;  2PTC I;  1JC6 A;  1YC0 I;  3AUH A;  1BF0 A;  1BHC A;  1F5R I;  2KNT A;  2DDJ A;  2FI3 I;  2RA3 C;  2KAI I;  3BTD I;  1LD6 A;  1EJM B;  1P2Q B;  3BTE I;  1TOC R;  1KUN A;  3BTH I;  3LDI A;  1AAP A;  3AUB A;  4Y11 I;  1DEM A;  2FI4 I;  4WWY C;  1UUB A;  2DDI A;  4TPI I;  1MTN D; 
#chains in the Genus database with same CATH homology
 3AUD A;  3TPI I;  4DTG K;  1P2N B;  3CI7 A;  2M99 A;  3FP8 I;  4WXV C;  1IRH A;  2JOT A;  1TAP A;  2LFK A;  4U32 X;  1BTI A;  1D0D A;  1PIT A;  4BD9 B;  2ODY E;  1NAG A;  1CBW D;  1B0C A;  1P2J I;  1DTK A;  1BRB I;  3TGI I;  4BNR I;  1BZX I;  3P92 E;  9PTI A;  3BTW I;  1LD5 A;  3LDM A;  2UUY B;  1P2K I;  1T8O B;  2FTM B;  2CA7 A;  2R9P E;  3U1J E;  1DTX A;  1KNT A;  4Y0Y I;  3BTT I;  3D65 I;  3AUG A;  2M01 A;  1YLD B;  2HEX A;  1TAW B;  2J6D A;  2UUX A;  3BYB A;  1BTH P;  1OA6 5;  3AUE A;  1P2I I;  1BZ5 A;  3UIR C;  1JV8 A;  5JB5 A;  3GYM I;  1ZJD B;  3BTM I;  1T8L B;  1FY8 I;  1BUN B;  2W8X A;  1YKT B;  3L3T E;  3P95 E;  1K6U A;  5JB4 A;  1ADZ A;  3BTF I;  6PTI A;  1YLC B;  1F7Z I;  1BPT A;  4ISN B;  1ZR0 B;  2ZJX A;  1G6X A;  1FAK I;  2TPI I;  1P2O B;  7PTI A;  4NTY B;  3AUC A;  5JB7 A;  1DEN A;  3L33 E;  5C67 C;  4U30 W;  1QLQ A;  4BQD A;  1TPA I;  3AUI A;  1EAW B;  2FTL I;  1KIG I;  2TGP I;  3OTJ I;  3TGJ I;  1T7C B;  4NTW B;  1BPI A;  1T8M B;  3LDJ A;  1TCP A;  2FI5 I;  1BRC I;  1BIK A;  3BTQ I;  3T62 D;  3BTK I;  5PTI A;  4ISL B;  2KCR A;  1AAL A;  3M7Q B;  1UUA A;  1TFX C;  4DG4 C;  1KTH A;  2IJO I;  2ZVX A;  3BTG I;  1CO7 I;  4Y10 I;  5JB6 A;  1CA0 D;  1JV9 A;  4PTI A;  3WNY A;  1D0D B;  3UOU B;  3TGK I;  4Y0Z I;  1Y62 A;  2LFL A;  1T8N B;  3OFW A;  4ISO B;  1P2M B;  4NTX B;  1SHP A;  8PTI A;  1OA5 5;  1FAN A;  3FP7 J;  3FP6 I;  2PTC I;  1JC6 A;  1YC0 I;  3AUH A;  1BF0 A;  1BHC A;  1F5R I;  2KNT A;  2DDJ A;  2FI3 I;  2RA3 C;  2KAI I;  3BTD I;  1LD6 A;  1EJM B;  1P2Q B;  3BTE I;  1TOC R;  1KUN A;  3BTH I;  3LDI A;  1AAP A;  3AUB A;  4Y11 I;  1DEM A;  2FI4 I;  4WWY C;  1UUB A;  2DDI A;  4TPI I;  1MTN D; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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