1YC0I

Short form hgfa with first kunitz domain from hai-1
Total Genus 13
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
13
sequence length
66
structure length
66
Chain Sequence
QHQHQMHQTEDYCLASNKVGRCRGSFPRWYYDPTEQICKSFVYGGCLGNKNNYLREEECILACRGV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B.
pubmed doi rcsb
molecule tags Hydrolase/inhibitor
source organism Homo sapiens
molecule keywords Hepatocyte growth factor activator
total genus 13
structure length 66
sequence length 66
ec nomenclature
pdb deposition date 2004-12-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 1yc0I00
3BTEI 2ZVXA 4WWYC 3AUBA 3OTJI 3AUEA 1FANA 1P2II 3L33E 5JB4A 1AAPA 3BTWI 4NTWB 1YLCB 1KIGI 1F5RI 1TOCR 1T8OB 2LFKA 1P2NB 1PITA 2HEXA 3TGII 3P92E 8PTIA 1KNTA 1NAGA 1P2OB 2RA3C 4Y0ZI 1T8LB 2FI3I 3LDJA 3AUGA 3TGJI 3FP7J 1TFXC 3FP6I 3UOUB 1BRCI 1BZXI 1FAKI 3AUCA 3BTDI 1TPAI 5JB7A 1EAWB 1BRBI 3UIRC 3P95E 1B0CA 1TCPA 1BTHP 3CI7A 6PTIA 1FY8I 9PTIA 2J6DA 1T7CB 3OFWA 4DG4C 1BF0A 1G6XA 1KUNA 1BUNB 1DTXA 1T8MB 2M99A 5JB5A 1QLQA 1IRHA 1BIKA 3U1JE 1EJMB 4WXVC 1CBWD 3BTQI 2ODYE 1AALA 3T62D 1ZJDB 1OA65 1ZR0B 2LFLA 1K6UA 1F7ZI 2UUYB 3M7QB 1SHPA 1TAPA 1MTND 1YLDB 2CA7A 1JV8A 2UUXA 1T8NB 1BHCA 4ISLB 4Y10I 2DDJA 4NTYB 3L3TE 2FI5I 1DTKA 1UUBA 3BTMI 4U32X 1JV9A 2FTMB 1P2JI 1ADZA 4ISNB 2ZJXA 1TAWB 5PTIA 3TPII 2TPII 1P2KI 4TPII 4Y11I 2R9PE 2W8XA 3D65I 3LDIA 4ISOB 3BTTI 1JC6A 3AUIA 3BTFI 2FTLI 1BPTA 2TGPI 4BD9B 1CO7I 1YC0I 1YKTB 1DENA 1D0DA 1DEMA 1LD6A 3WNYA 4Y0YI 2IJOI 3GYMI 1P2MB 3BTGI 4BQDA 1D0DB 2JOTA 5JB6A 2DDIA 3BYBA 3BTKI 7PTIA 1OA55 1Y62A 3LDMA 5C67C 3AUHA 1BZ5A 2KCRA 1BTIA 3FP8I 4U30W 4DTGK 2FI4I 4NTXB 1CA0D 3TGKI 1LD5A 1P2QB 1UUAA 2KNTA 2PTCI 2M01A 4BNRI 1KTHA 2KAII 1BPIA 3AUDA 4PTIA 3BTHI
chains in the Genus database with same CATH superfamily
3BTEI 2ZVXA 4WWYC 3AUBA 3OTJI 3AUEA 1FANA 1P2II 3L33E 5JB4A 1AAPA 3BTWI 4NTWB 1YLCB 1KIGI 1F5RI 1TOCR 1T8OB 2LFKA 1P2NB 1PITA 2HEXA 3TGII 3P92E 8PTIA 1KNTA 1NAGA 1P2OB 2RA3C 4Y0ZI 1T8LB 2FI3I 3LDJA 3AUGA 3TGJI 3FP7J 1TFXC 3FP6I 3UOUB 1BRCI 1BZXI 1FAKI 3AUCA 3BTDI 1TPAI 5JB7A 1EAWB 1BRBI 3UIRC 3P95E 1B0CA 1TCPA 1BTHP 3CI7A 6PTIA 1FY8I 9PTIA 2J6DA 1T7CB 3OFWA 4DG4C 1BF0A 1G6XA 1KUNA 1BUNB 1DTXA 1T8MB 2M99A 5JB5A 1QLQA 1IRHA 1BIKA 3U1JE 1EJMB 4WXVC 1CBWD 3BTQI 2ODYE 1AALA 3T62D 1ZJDB 1OA65 1ZR0B 2LFLA 1K6UA 1F7ZI 2UUYB 3M7QB 1SHPA 1TAPA 1MTND 1YLDB 2CA7A 1JV8A 2UUXA 1T8NB 1BHCA 4ISLB 4Y10I 2DDJA 4NTYB 3L3TE 2FI5I 1DTKA 1UUBA 3BTMI 4U32X 1JV9A 2FTMB 1P2JI 1ADZA 4ISNB 2ZJXA 1TAWB 5PTIA 3TPII 2TPII 1P2KI 4TPII 4Y11I 2R9PE 2W8XA 3D65I 3LDIA 4ISOB 3BTTI 1JC6A 3AUIA 3BTFI 2FTLI 1BPTA 2TGPI 4BD9B 1CO7I 1YC0I 1YKTB 1DENA 1D0DA 1DEMA 1LD6A 3WNYA 4Y0YI 2IJOI 3GYMI 1P2MB 3BTGI 4BQDA 1D0DB 2JOTA 5JB6A 2DDIA 3BYBA 3BTKI 7PTIA 1OA55 1Y62A 3LDMA 5C67C 3AUHA 1BZ5A 2KCRA 1BTIA 3FP8I 4U30W 4DTGK 2FI4I 4NTXB 1CA0D 3TGKI 1LD5A 1P2QB 1UUAA 2KNTA 2PTCI 2M01A 4BNRI 1KTHA 2KAII 1BPIA 3AUDA 4PTIA 3BTHI
chains in the Genus database with same CATH topology
3BTEI 2ZVXA 4WWYC 3AUBA 3OTJI 3AUEA 1FANA 1P2II 3L33E 5JB4A 1AAPA 3BTWI 4NTWB 1YLCB 1KIGI 1F5RI 1TOCR 1T8OB 2LFKA 1P2NB 1PITA 2HEXA 3TGII 3P92E 8PTIA 1KNTA 1NAGA 1P2OB 2RA3C 4Y0ZI 1T8LB 2FI3I 3LDJA 3AUGA 3TGJI 3FP7J 1TFXC 3FP6I 3UOUB 1BRCI 1BZXI 1FAKI 3AUCA 3BTDI 1TPAI 5JB7A 1EAWB 1BRBI 3UIRC 3P95E 1B0CA 1TCPA 1BTHP 3CI7A 6PTIA 1FY8I 9PTIA 2J6DA 1T7CB 3OFWA 4DG4C 1BF0A 1G6XA 1KUNA 1BUNB 1DTXA 1T8MB 2M99A 5JB5A 1QLQA 1IRHA 1BIKA 3U1JE 1EJMB 4WXVC 1CBWD 3BTQI 2ODYE 1AALA 3T62D 1ZJDB 1OA65 1ZR0B 2LFLA 1K6UA 1F7ZI 2UUYB 3M7QB 1SHPA 1TAPA 1MTND 1YLDB 2CA7A 1JV8A 2UUXA 1T8NB 1BHCA 4ISLB 4Y10I 2DDJA 4NTYB 3L3TE 2FI5I 1DTKA 1UUBA 3BTMI 4U32X 1JV9A 2FTMB 1P2JI 1ADZA 4ISNB 2ZJXA 1TAWB 5PTIA 3TPII 2TPII 1P2KI 4TPII 4Y11I 2R9PE 2W8XA 3D65I 3LDIA 4ISOB 3BTTI 1JC6A 3AUIA 3BTFI 2FTLI 1BPTA 2TGPI 4BD9B 1CO7I 1YC0I 1YKTB 1DENA 1D0DA 1DEMA 1LD6A 3WNYA 4Y0YI 2IJOI 3GYMI 1P2MB 3BTGI 4BQDA 1D0DB 2JOTA 5JB6A 2DDIA 3BYBA 3BTKI 7PTIA 1OA55 1Y62A 3LDMA 5C67C 3AUHA 1BZ5A 2KCRA 1BTIA 3FP8I 4U30W 4DTGK 2FI4I 4NTXB 1CA0D 3TGKI 1LD5A 1P2QB 1UUAA 2KNTA 2PTCI 2M01A 4BNRI 1KTHA 2KAII 1BPIA 3AUDA 4PTIA 3BTHI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BTE I;  2ZVX A;  4WWY C;  3AUB A;  3OTJ I;  3AUE A;  1FAN A;  1P2I I;  3L33 E;  5JB4 A;  1AAP A;  3BTW I;  4NTW B;  1YLC B;  1KIG I;  1F5R I;  1TOC R;  1T8O B;  2LFK A;  1P2N B;  1PIT A;  2HEX A;  3TGI I;  3P92 E;  8PTI A;  1KNT A;  1NAG A;  1P2O B;  2RA3 C;  4Y0Z I;  1T8L B;  2FI3 I;  3LDJ A;  3AUG A;  3TGJ I;  3FP7 J;  1TFX C;  3FP6 I;  3UOU B;  1BRC I;  1BZX I;  1FAK I;  3AUC A;  3BTD I;  1TPA I;  5JB7 A;  1EAW B;  1BRB I;  3UIR C;  3P95 E;  1B0C A;  1TCP A;  1BTH P;  3CI7 A;  6PTI A;  1FY8 I;  9PTI A;  2J6D A;  1T7C B;  3OFW A;  4DG4 C;  1BF0 A;  1G6X A;  1KUN A;  1BUN B;  1DTX A;  1T8M B;  2M99 A;  5JB5 A;  1QLQ A;  1IRH A;  1BIK A;  3U1J E;  1EJM B;  4WXV C;  1CBW D;  3BTQ I;  2ODY E;  1AAL A;  3T62 D;  1ZJD B;  1OA6 5;  1ZR0 B;  2LFL A;  1K6U A;  1F7Z I;  2UUY B;  3M7Q B;  1SHP A;  1TAP A;  1MTN D;  1YLD B;  2CA7 A;  1JV8 A;  2UUX A;  1T8N B;  1BHC A;  4ISL B;  4Y10 I;  2DDJ A;  4NTY B;  3L3T E;  2FI5 I;  1DTK A;  1UUB A;  3BTM I;  4U32 X;  1JV9 A;  2FTM B;  1P2J I;  1ADZ A;  4ISN B;  2ZJX A;  1TAW B;  5PTI A;  3TPI I;  2TPI I;  1P2K I;  4TPI I;  4Y11 I;  2R9P E;  2W8X A;  3D65 I;  3LDI A;  4ISO B;  3BTT I;  1JC6 A;  3AUI A;  3BTF I;  2FTL I;  1BPT A;  2TGP I;  4BD9 B;  1CO7 I;  1YC0 I;  1YKT B;  1DEN A;  1D0D A;  1DEM A;  1LD6 A;  3WNY A;  4Y0Y I;  2IJO I;  3GYM I;  1P2M B;  3BTG I;  4BQD A;  1D0D B;  2JOT A;  5JB6 A;  2DDI A;  3BYB A;  3BTK I;  7PTI A;  1OA5 5;  1Y62 A;  3LDM A;  5C67 C;  3AUH A;  1BZ5 A;  2KCR A;  1BTI A;  3FP8 I;  4U30 W;  4DTG K;  2FI4 I;  4NTX B;  1CA0 D;  3TGK I;  1LD5 A;  1P2Q B;  1UUA A;  2KNT A;  2PTC I;  2M01 A;  4BNR I;  1KTH A;  2KAI I;  1BPI A;  3AUD A;  4PTI A;  3BTH I; 
#chains in the Genus database with same CATH topology
 3BTE I;  2ZVX A;  4WWY C;  3AUB A;  3OTJ I;  3AUE A;  1FAN A;  1P2I I;  3L33 E;  5JB4 A;  1AAP A;  3BTW I;  4NTW B;  1YLC B;  1KIG I;  1F5R I;  1TOC R;  1T8O B;  2LFK A;  1P2N B;  1PIT A;  2HEX A;  3TGI I;  3P92 E;  8PTI A;  1KNT A;  1NAG A;  1P2O B;  2RA3 C;  4Y0Z I;  1T8L B;  2FI3 I;  3LDJ A;  3AUG A;  3TGJ I;  3FP7 J;  1TFX C;  3FP6 I;  3UOU B;  1BRC I;  1BZX I;  1FAK I;  3AUC A;  3BTD I;  1TPA I;  5JB7 A;  1EAW B;  1BRB I;  3UIR C;  3P95 E;  1B0C A;  1TCP A;  1BTH P;  3CI7 A;  6PTI A;  1FY8 I;  9PTI A;  2J6D A;  1T7C B;  3OFW A;  4DG4 C;  1BF0 A;  1G6X A;  1KUN A;  1BUN B;  1DTX A;  1T8M B;  2M99 A;  5JB5 A;  1QLQ A;  1IRH A;  1BIK A;  3U1J E;  1EJM B;  4WXV C;  1CBW D;  3BTQ I;  2ODY E;  1AAL A;  3T62 D;  1ZJD B;  1OA6 5;  1ZR0 B;  2LFL A;  1K6U A;  1F7Z I;  2UUY B;  3M7Q B;  1SHP A;  1TAP A;  1MTN D;  1YLD B;  2CA7 A;  1JV8 A;  2UUX A;  1T8N B;  1BHC A;  4ISL B;  4Y10 I;  2DDJ A;  4NTY B;  3L3T E;  2FI5 I;  1DTK A;  1UUB A;  3BTM I;  4U32 X;  1JV9 A;  2FTM B;  1P2J I;  1ADZ A;  4ISN B;  2ZJX A;  1TAW B;  5PTI A;  3TPI I;  2TPI I;  1P2K I;  4TPI I;  4Y11 I;  2R9P E;  2W8X A;  3D65 I;  3LDI A;  4ISO B;  3BTT I;  1JC6 A;  3AUI A;  3BTF I;  2FTL I;  1BPT A;  2TGP I;  4BD9 B;  1CO7 I;  1YC0 I;  1YKT B;  1DEN A;  1D0D A;  1DEM A;  1LD6 A;  3WNY A;  4Y0Y I;  2IJO I;  3GYM I;  1P2M B;  3BTG I;  4BQD A;  1D0D B;  2JOT A;  5JB6 A;  2DDI A;  3BYB A;  3BTK I;  7PTI A;  1OA5 5;  1Y62 A;  3LDM A;  5C67 C;  3AUH A;  1BZ5 A;  2KCR A;  1BTI A;  3FP8 I;  4U30 W;  4DTG K;  2FI4 I;  4NTX B;  1CA0 D;  3TGK I;  1LD5 A;  1P2Q B;  1UUA A;  2KNT A;  2PTC I;  2M01 A;  4BNR I;  1KTH A;  2KAI I;  1BPI A;  3AUD A;  4PTI A;  3BTH I; 
#chains in the Genus database with same CATH homology
 3BTE I;  2ZVX A;  4WWY C;  3AUB A;  3OTJ I;  3AUE A;  1FAN A;  1P2I I;  3L33 E;  5JB4 A;  1AAP A;  3BTW I;  4NTW B;  1YLC B;  1KIG I;  1F5R I;  1TOC R;  1T8O B;  2LFK A;  1P2N B;  1PIT A;  2HEX A;  3TGI I;  3P92 E;  8PTI A;  1KNT A;  1NAG A;  1P2O B;  2RA3 C;  4Y0Z I;  1T8L B;  2FI3 I;  3LDJ A;  3AUG A;  3TGJ I;  3FP7 J;  1TFX C;  3FP6 I;  3UOU B;  1BRC I;  1BZX I;  1FAK I;  3AUC A;  3BTD I;  1TPA I;  5JB7 A;  1EAW B;  1BRB I;  3UIR C;  3P95 E;  1B0C A;  1TCP A;  1BTH P;  3CI7 A;  6PTI A;  1FY8 I;  9PTI A;  2J6D A;  1T7C B;  3OFW A;  4DG4 C;  1BF0 A;  1G6X A;  1KUN A;  1BUN B;  1DTX A;  1T8M B;  2M99 A;  5JB5 A;  1QLQ A;  1IRH A;  1BIK A;  3U1J E;  1EJM B;  4WXV C;  1CBW D;  3BTQ I;  2ODY E;  1AAL A;  3T62 D;  1ZJD B;  1OA6 5;  1ZR0 B;  2LFL A;  1K6U A;  1F7Z I;  2UUY B;  3M7Q B;  1SHP A;  1TAP A;  1MTN D;  1YLD B;  2CA7 A;  1JV8 A;  2UUX A;  1T8N B;  1BHC A;  4ISL B;  4Y10 I;  2DDJ A;  4NTY B;  3L3T E;  2FI5 I;  1DTK A;  1UUB A;  3BTM I;  4U32 X;  1JV9 A;  2FTM B;  1P2J I;  1ADZ A;  4ISN B;  2ZJX A;  1TAW B;  5PTI A;  3TPI I;  2TPI I;  1P2K I;  4TPI I;  4Y11 I;  2R9P E;  2W8X A;  3D65 I;  3LDI A;  4ISO B;  3BTT I;  1JC6 A;  3AUI A;  3BTF I;  2FTL I;  1BPT A;  2TGP I;  4BD9 B;  1CO7 I;  1YC0 I;  1YKT B;  1DEN A;  1D0D A;  1DEM A;  1LD6 A;  3WNY A;  4Y0Y I;  2IJO I;  3GYM I;  1P2M B;  3BTG I;  4BQD A;  1D0D B;  2JOT A;  5JB6 A;  2DDI A;  3BYB A;  3BTK I;  7PTI A;  1OA5 5;  1Y62 A;  3LDM A;  5C67 C;  3AUH A;  1BZ5 A;  2KCR A;  1BTI A;  3FP8 I;  4U30 W;  4DTG K;  2FI4 I;  4NTX B;  1CA0 D;  3TGK I;  1LD5 A;  1P2Q B;  1UUA A;  2KNT A;  2PTC I;  2M01 A;  4BNR I;  1KTH A;  2KAI I;  1BPI A;  3AUD A;  4PTI A;  3BTH I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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