1ADZA

The solution structure of the second kunitz domain of tissue factor pathway inhibitor, nmr, 30 structures
Total Genus 7
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
7
sequence length
71
structure length
71
Chain Sequence
DYKDDDDKLKPDFCFLEEDPGICRGYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICEDGPNGF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The second Kunitz domain of human tissue factor pathway inhibitor: cloning, structure determination and interaction with factor Xa.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords TISSUE FACTOR PATHWAY INHIBITOR
total genus 7
structure length 71
sequence length 71
ec nomenclature
pdb deposition date 1997-02-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 1adzA00
1UUBA 4Y10I 3T62D 3UOUB 3TGJI 2KCRA 1TFXC 3FP7J 1UUAA 1OA65 1QLQA 3LDIA 1DENA 1BRBI 4NTXB 3GYMI 1EAWB 1KNTA 1T7CB 3P95E 3AUEA 1OA55 7PTIA 4U30W 1F5RI 1TAPA 1DTKA 3BTHI 3BTTI 8PTIA 5JB6A 1T8NB 6PTIA 2ZJXA 1YLDB 1F7ZI 1BPTA 1CO7I 1P2KI 1KUNA 3TPII 1JV8A 3FP8I 4TPII 1D0DB 3AUIA 1TAWB 1LD5A 1BTHP 1BZXI 1G6XA 1B0CA 3L3TE 5C67C 4ISOB 2TGPI 3BTMI 4ISLB 1ZR0B 1EJMB 1TOCR 1T8OB 2KAII 1BRCI 2ZVXA 2FI5I 2FI4I 2FI3I 3U1JE 1JV9A 5JB7A 1TPAI 2FTLI 2W8XA 2M99A 1BPIA 4Y0ZI 1IRHA 1P2II 3UIRC 1T8LB 3AUGA 4DTGK 2IJOI 4WWYC 1BUNB 4Y0YI 3AUCA 4U32X 2JOTA 1PITA 2TPII 9PTIA 1ADZA 1JC6A 4PTIA 3BTDI 1FAKI 1P2NB 2PTCI 1NAGA 3BTKI 3OFWA 2DDJA 3LDJA 1Y62A 1P2MB 1SHPA 3TGII 3AUDA 1FANA 2UUXA 1MTND 1P2QB 4DG4C 2J6DA 1BIKA 3L33E 3WNYA 1AAPA 1BTIA 1K6UA 4BNRI 1P2OB 3BTEI 3BYBA 4NTYB 3BTQI 4ISNB 2UUYB 1AALA 1CA0D 1FY8I 3BTGI 1BF0A 2M01A 4BQDA 4NTWB 1KIGI 3D65I 1CBWD 2LFLA 3FP6I 1P2JI 3P92E 4WXVC 2HEXA 1ZJDB 3TGKI 4BD9B 1BHCA 2FTMB 1LD6A 3AUHA 3CI7A 5JB4A 1DEMA 1KTHA 5JB5A 1YLCB 3M7QB 2LFKA 5PTIA 1DTXA 2R9PE 2RA3C 2CA7A 3AUBA 3LDMA 4Y11I 2DDIA 1YC0I 2ODYE 1YKTB 1T8MB 3BTWI 2KNTA 3OTJI 1TCPA 3BTFI 1BZ5A 1D0DA
chains in the Genus database with same CATH superfamily
1UUBA 4Y10I 3T62D 3UOUB 3TGJI 2KCRA 1TFXC 3FP7J 1UUAA 1OA65 1QLQA 3LDIA 1DENA 1BRBI 4NTXB 3GYMI 1EAWB 1KNTA 1T7CB 3P95E 3AUEA 1OA55 7PTIA 4U30W 1F5RI 1TAPA 1DTKA 3BTHI 3BTTI 8PTIA 5JB6A 1T8NB 6PTIA 2ZJXA 1YLDB 1F7ZI 1BPTA 1CO7I 1P2KI 1KUNA 3TPII 1JV8A 3FP8I 4TPII 1D0DB 3AUIA 1TAWB 1LD5A 1BTHP 1BZXI 1G6XA 1B0CA 3L3TE 5C67C 4ISOB 2TGPI 3BTMI 4ISLB 1ZR0B 1EJMB 1TOCR 1T8OB 2KAII 1BRCI 2ZVXA 2FI5I 2FI4I 2FI3I 3U1JE 1JV9A 5JB7A 1TPAI 2FTLI 2W8XA 2M99A 1BPIA 4Y0ZI 1IRHA 1P2II 3UIRC 1T8LB 3AUGA 4DTGK 2IJOI 4WWYC 1BUNB 4Y0YI 3AUCA 4U32X 2JOTA 1PITA 2TPII 9PTIA 1ADZA 1JC6A 4PTIA 3BTDI 1FAKI 1P2NB 2PTCI 1NAGA 3BTKI 3OFWA 2DDJA 3LDJA 1Y62A 1P2MB 1SHPA 3TGII 3AUDA 1FANA 2UUXA 1MTND 1P2QB 4DG4C 2J6DA 1BIKA 3L33E 3WNYA 1AAPA 1BTIA 1K6UA 4BNRI 1P2OB 3BTEI 3BYBA 4NTYB 3BTQI 4ISNB 2UUYB 1AALA 1CA0D 1FY8I 3BTGI 1BF0A 2M01A 4BQDA 4NTWB 1KIGI 3D65I 1CBWD 2LFLA 3FP6I 1P2JI 3P92E 4WXVC 2HEXA 1ZJDB 3TGKI 4BD9B 1BHCA 2FTMB 1LD6A 3AUHA 3CI7A 5JB4A 1DEMA 1KTHA 5JB5A 1YLCB 3M7QB 2LFKA 5PTIA 1DTXA 2R9PE 2RA3C 2CA7A 3AUBA 3LDMA 4Y11I 2DDIA 1YC0I 2ODYE 1YKTB 1T8MB 3BTWI 2KNTA 3OTJI 1TCPA 3BTFI 1BZ5A 1D0DA
chains in the Genus database with same CATH topology
1UUBA 4Y10I 3T62D 3UOUB 3TGJI 2KCRA 1TFXC 3FP7J 1UUAA 1OA65 1QLQA 3LDIA 1DENA 1BRBI 4NTXB 3GYMI 1EAWB 1KNTA 1T7CB 3P95E 3AUEA 1OA55 7PTIA 4U30W 1F5RI 1TAPA 1DTKA 3BTHI 3BTTI 8PTIA 5JB6A 1T8NB 6PTIA 2ZJXA 1YLDB 1F7ZI 1BPTA 1CO7I 1P2KI 1KUNA 3TPII 1JV8A 3FP8I 4TPII 1D0DB 3AUIA 1TAWB 1LD5A 1BTHP 1BZXI 1G6XA 1B0CA 3L3TE 5C67C 4ISOB 2TGPI 3BTMI 4ISLB 1ZR0B 1EJMB 1TOCR 1T8OB 2KAII 1BRCI 2ZVXA 2FI5I 2FI4I 2FI3I 3U1JE 1JV9A 5JB7A 1TPAI 2FTLI 2W8XA 2M99A 1BPIA 4Y0ZI 1IRHA 1P2II 3UIRC 1T8LB 3AUGA 4DTGK 2IJOI 4WWYC 1BUNB 4Y0YI 3AUCA 4U32X 2JOTA 1PITA 2TPII 9PTIA 1ADZA 1JC6A 4PTIA 3BTDI 1FAKI 1P2NB 2PTCI 1NAGA 3BTKI 3OFWA 2DDJA 3LDJA 1Y62A 1P2MB 1SHPA 3TGII 3AUDA 1FANA 2UUXA 1MTND 1P2QB 4DG4C 2J6DA 1BIKA 3L33E 3WNYA 1AAPA 1BTIA 1K6UA 4BNRI 1P2OB 3BTEI 3BYBA 4NTYB 3BTQI 4ISNB 2UUYB 1AALA 1CA0D 1FY8I 3BTGI 1BF0A 2M01A 4BQDA 4NTWB 1KIGI 3D65I 1CBWD 2LFLA 3FP6I 1P2JI 3P92E 4WXVC 2HEXA 1ZJDB 3TGKI 4BD9B 1BHCA 2FTMB 1LD6A 3AUHA 3CI7A 5JB4A 1DEMA 1KTHA 5JB5A 1YLCB 3M7QB 2LFKA 5PTIA 1DTXA 2R9PE 2RA3C 2CA7A 3AUBA 3LDMA 4Y11I 2DDIA 1YC0I 2ODYE 1YKTB 1T8MB 3BTWI 2KNTA 3OTJI 1TCPA 3BTFI 1BZ5A 1D0DA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1UUB A;  4Y10 I;  3T62 D;  3UOU B;  3TGJ I;  2KCR A;  1TFX C;  3FP7 J;  1UUA A;  1OA6 5;  1QLQ A;  3LDI A;  1DEN A;  1BRB I;  4NTX B;  3GYM I;  1EAW B;  1KNT A;  1T7C B;  3P95 E;  3AUE A;  1OA5 5;  7PTI A;  4U30 W;  1F5R I;  1TAP A;  1DTK A;  3BTH I;  3BTT I;  8PTI A;  5JB6 A;  1T8N B;  6PTI A;  2ZJX A;  1YLD B;  1F7Z I;  1BPT A;  1CO7 I;  1P2K I;  1KUN A;  3TPI I;  1JV8 A;  3FP8 I;  4TPI I;  1D0D B;  3AUI A;  1TAW B;  1LD5 A;  1BTH P;  1BZX I;  1G6X A;  1B0C A;  3L3T E;  5C67 C;  4ISO B;  2TGP I;  3BTM I;  4ISL B;  1ZR0 B;  1EJM B;  1TOC R;  1T8O B;  2KAI I;  1BRC I;  2ZVX A;  2FI5 I;  2FI4 I;  2FI3 I;  3U1J E;  1JV9 A;  5JB7 A;  1TPA I;  2FTL I;  2W8X A;  2M99 A;  1BPI A;  4Y0Z I;  1IRH A;  1P2I I;  3UIR C;  1T8L B;  3AUG A;  4DTG K;  2IJO I;  4WWY C;  1BUN B;  4Y0Y I;  3AUC A;  4U32 X;  2JOT A;  1PIT A;  2TPI I;  9PTI A;  1ADZ A;  1JC6 A;  4PTI A;  3BTD I;  1FAK I;  1P2N B;  2PTC I;  1NAG A;  3BTK I;  3OFW A;  2DDJ A;  3LDJ A;  1Y62 A;  1P2M B;  1SHP A;  3TGI I;  3AUD A;  1FAN A;  2UUX A;  1MTN D;  1P2Q B;  4DG4 C;  2J6D A;  1BIK A;  3L33 E;  3WNY A;  1AAP A;  1BTI A;  1K6U A;  4BNR I;  1P2O B;  3BTE I;  3BYB A;  4NTY B;  3BTQ I;  4ISN B;  2UUY B;  1AAL A;  1CA0 D;  1FY8 I;  3BTG I;  1BF0 A;  2M01 A;  4BQD A;  4NTW B;  1KIG I;  3D65 I;  1CBW D;  2LFL A;  3FP6 I;  1P2J I;  3P92 E;  4WXV C;  2HEX A;  1ZJD B;  3TGK I;  4BD9 B;  1BHC A;  2FTM B;  1LD6 A;  3AUH A;  3CI7 A;  5JB4 A;  1DEM A;  1KTH A;  5JB5 A;  1YLC B;  3M7Q B;  2LFK A;  5PTI A;  1DTX A;  2R9P E;  2RA3 C;  2CA7 A;  3AUB A;  3LDM A;  4Y11 I;  2DDI A;  1YC0 I;  2ODY E;  1YKT B;  1T8M B;  3BTW I;  2KNT A;  3OTJ I;  1TCP A;  3BTF I;  1BZ5 A;  1D0D A; 
#chains in the Genus database with same CATH topology
 1UUB A;  4Y10 I;  3T62 D;  3UOU B;  3TGJ I;  2KCR A;  1TFX C;  3FP7 J;  1UUA A;  1OA6 5;  1QLQ A;  3LDI A;  1DEN A;  1BRB I;  4NTX B;  3GYM I;  1EAW B;  1KNT A;  1T7C B;  3P95 E;  3AUE A;  1OA5 5;  7PTI A;  4U30 W;  1F5R I;  1TAP A;  1DTK A;  3BTH I;  3BTT I;  8PTI A;  5JB6 A;  1T8N B;  6PTI A;  2ZJX A;  1YLD B;  1F7Z I;  1BPT A;  1CO7 I;  1P2K I;  1KUN A;  3TPI I;  1JV8 A;  3FP8 I;  4TPI I;  1D0D B;  3AUI A;  1TAW B;  1LD5 A;  1BTH P;  1BZX I;  1G6X A;  1B0C A;  3L3T E;  5C67 C;  4ISO B;  2TGP I;  3BTM I;  4ISL B;  1ZR0 B;  1EJM B;  1TOC R;  1T8O B;  2KAI I;  1BRC I;  2ZVX A;  2FI5 I;  2FI4 I;  2FI3 I;  3U1J E;  1JV9 A;  5JB7 A;  1TPA I;  2FTL I;  2W8X A;  2M99 A;  1BPI A;  4Y0Z I;  1IRH A;  1P2I I;  3UIR C;  1T8L B;  3AUG A;  4DTG K;  2IJO I;  4WWY C;  1BUN B;  4Y0Y I;  3AUC A;  4U32 X;  2JOT A;  1PIT A;  2TPI I;  9PTI A;  1ADZ A;  1JC6 A;  4PTI A;  3BTD I;  1FAK I;  1P2N B;  2PTC I;  1NAG A;  3BTK I;  3OFW A;  2DDJ A;  3LDJ A;  1Y62 A;  1P2M B;  1SHP A;  3TGI I;  3AUD A;  1FAN A;  2UUX A;  1MTN D;  1P2Q B;  4DG4 C;  2J6D A;  1BIK A;  3L33 E;  3WNY A;  1AAP A;  1BTI A;  1K6U A;  4BNR I;  1P2O B;  3BTE I;  3BYB A;  4NTY B;  3BTQ I;  4ISN B;  2UUY B;  1AAL A;  1CA0 D;  1FY8 I;  3BTG I;  1BF0 A;  2M01 A;  4BQD A;  4NTW B;  1KIG I;  3D65 I;  1CBW D;  2LFL A;  3FP6 I;  1P2J I;  3P92 E;  4WXV C;  2HEX A;  1ZJD B;  3TGK I;  4BD9 B;  1BHC A;  2FTM B;  1LD6 A;  3AUH A;  3CI7 A;  5JB4 A;  1DEM A;  1KTH A;  5JB5 A;  1YLC B;  3M7Q B;  2LFK A;  5PTI A;  1DTX A;  2R9P E;  2RA3 C;  2CA7 A;  3AUB A;  3LDM A;  4Y11 I;  2DDI A;  1YC0 I;  2ODY E;  1YKT B;  1T8M B;  3BTW I;  2KNT A;  3OTJ I;  1TCP A;  3BTF I;  1BZ5 A;  1D0D A; 
#chains in the Genus database with same CATH homology
 1UUB A;  4Y10 I;  3T62 D;  3UOU B;  3TGJ I;  2KCR A;  1TFX C;  3FP7 J;  1UUA A;  1OA6 5;  1QLQ A;  3LDI A;  1DEN A;  1BRB I;  4NTX B;  3GYM I;  1EAW B;  1KNT A;  1T7C B;  3P95 E;  3AUE A;  1OA5 5;  7PTI A;  4U30 W;  1F5R I;  1TAP A;  1DTK A;  3BTH I;  3BTT I;  8PTI A;  5JB6 A;  1T8N B;  6PTI A;  2ZJX A;  1YLD B;  1F7Z I;  1BPT A;  1CO7 I;  1P2K I;  1KUN A;  3TPI I;  1JV8 A;  3FP8 I;  4TPI I;  1D0D B;  3AUI A;  1TAW B;  1LD5 A;  1BTH P;  1BZX I;  1G6X A;  1B0C A;  3L3T E;  5C67 C;  4ISO B;  2TGP I;  3BTM I;  4ISL B;  1ZR0 B;  1EJM B;  1TOC R;  1T8O B;  2KAI I;  1BRC I;  2ZVX A;  2FI5 I;  2FI4 I;  2FI3 I;  3U1J E;  1JV9 A;  5JB7 A;  1TPA I;  2FTL I;  2W8X A;  2M99 A;  1BPI A;  4Y0Z I;  1IRH A;  1P2I I;  3UIR C;  1T8L B;  3AUG A;  4DTG K;  2IJO I;  4WWY C;  1BUN B;  4Y0Y I;  3AUC A;  4U32 X;  2JOT A;  1PIT A;  2TPI I;  9PTI A;  1ADZ A;  1JC6 A;  4PTI A;  3BTD I;  1FAK I;  1P2N B;  2PTC I;  1NAG A;  3BTK I;  3OFW A;  2DDJ A;  3LDJ A;  1Y62 A;  1P2M B;  1SHP A;  3TGI I;  3AUD A;  1FAN A;  2UUX A;  1MTN D;  1P2Q B;  4DG4 C;  2J6D A;  1BIK A;  3L33 E;  3WNY A;  1AAP A;  1BTI A;  1K6U A;  4BNR I;  1P2O B;  3BTE I;  3BYB A;  4NTY B;  3BTQ I;  4ISN B;  2UUY B;  1AAL A;  1CA0 D;  1FY8 I;  3BTG I;  1BF0 A;  2M01 A;  4BQD A;  4NTW B;  1KIG I;  3D65 I;  1CBW D;  2LFL A;  3FP6 I;  1P2J I;  3P92 E;  4WXV C;  2HEX A;  1ZJD B;  3TGK I;  4BD9 B;  1BHC A;  2FTM B;  1LD6 A;  3AUH A;  3CI7 A;  5JB4 A;  1DEM A;  1KTH A;  5JB5 A;  1YLC B;  3M7Q B;  2LFK A;  5PTI A;  1DTX A;  2R9P E;  2RA3 C;  2CA7 A;  3AUB A;  3LDM A;  4Y11 I;  2DDI A;  1YC0 I;  2ODY E;  1YKT B;  1T8M B;  3BTW I;  2KNT A;  3OTJ I;  1TCP A;  3BTF I;  1BZ5 A;  1D0D A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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