1FY8I

Crystal structure of the deltaile16val17 rat anionic trypsinogen-bpti complex
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
56
structure length
56
Chain Sequence
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The energetic cost of induced fit catalysis: Crystal structures of trypsinogen mutants with enhanced activity and inhibitor affinity.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Rattus rattus
molecule keywords TRYPSIN II, ANIONIC
total genus 9
structure length 56
sequence length 56
ec nomenclature
pdb deposition date 2000-09-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 1fy8I00
1KNTA 2W8XA 3BTDI 2CA7A 2DDJA 1F5RI 5JB4A 2RA3C 1OA55 2PTCI 1CA0D 3BTEI 1G6XA 2FTLI 1CBWD 4WWYC 1D0DB 3FP6I 1EAWB 4Y10I 2UUYB 3OFWA 1B0CA 1CO7I 1P2MB 1P2NB 2KNTA 3AUGA 1BPTA 4PTIA 3BTWI 2FTMB 3AUIA 1FANA 3BYBA 1JV8A 1ZR0B 3OTJI 3FP7J 1T8LB 3BTKI 1P2QB 1K6UA 3AUEA 4Y11I 2ZVXA 3L33E 1TFXC 1T7CB 1BRCI 3L3TE 2IJOI 1F7ZI 1LD5A 1T8MB 7PTIA 2DDIA 2LFLA 1BIKA 1BZ5A 2KCRA 4TPII 4NTYB 1KIGI 1IRHA 3AUHA 1BF0A 1AAPA 5JB7A 3T62D 3FP8I 2KAII 3LDJA 3P95E 1T8NB 3BTHI 1TAWB 3GYMI 4U30W 1QLQA 1BTHP 2FI5I 4Y0ZI 1OA65 2M01A 3M7QB 1DENA 3BTQI 4NTWB 1BHCA 5JB5A 3D65I 1ZJDB 3AUDA 4NTXB 2ZJXA 3AUCA 2ODYE 1P2KI 2FI4I 3UIRC 2R9PE 2TPII 5C67C 1YC0I 1UUBA 3LDMA 1JV9A 1D0DA 2UUXA 3TGKI 2HEXA 1TAPA 3P92E 5JB6A 3TGII 2JOTA 1ADZA 3CI7A 3TPII 1TCPA 3LDIA 1DTXA 2LFKA 4BQDA 1FY8I 3AUBA 1LD6A 2FI3I 3BTMI 1P2JI 4ISNB 4ISOB 1FAKI 4DG4C 4WXVC 1KUNA 9PTIA 1Y62A 3BTFI 4U32X 1BPIA 6PTIA 1EJMB 2J6DA 1PITA 3WNYA 1NAGA 4ISLB 1YLDB 1KTHA 1UUAA 3UOUB 1DTKA 3BTTI 1YLCB 5PTIA 2M99A 1P2OB 8PTIA 1TPAI 3BTGI 1DEMA 3TGJI 4BNRI 2TGPI 4Y0YI 4BD9B 1BUNB 1MTND 4DTGK 1P2II 1JC6A 1BZXI 1YKTB 1BTIA 1SHPA 1AALA 1BRBI 1T8OB 3U1JE 1TOCR
chains in the Genus database with same CATH superfamily
1KNTA 2W8XA 3BTDI 2CA7A 2DDJA 1F5RI 5JB4A 2RA3C 1OA55 2PTCI 1CA0D 3BTEI 1G6XA 2FTLI 1CBWD 4WWYC 1D0DB 3FP6I 1EAWB 4Y10I 2UUYB 3OFWA 1B0CA 1CO7I 1P2MB 1P2NB 2KNTA 3AUGA 1BPTA 4PTIA 3BTWI 2FTMB 3AUIA 1FANA 3BYBA 1JV8A 1ZR0B 3OTJI 3FP7J 1T8LB 3BTKI 1P2QB 1K6UA 3AUEA 4Y11I 2ZVXA 3L33E 1TFXC 1T7CB 1BRCI 3L3TE 2IJOI 1F7ZI 1LD5A 1T8MB 7PTIA 2DDIA 2LFLA 1BIKA 1BZ5A 2KCRA 4TPII 4NTYB 1KIGI 1IRHA 3AUHA 1BF0A 1AAPA 5JB7A 3T62D 3FP8I 2KAII 3LDJA 3P95E 1T8NB 3BTHI 1TAWB 3GYMI 4U30W 1QLQA 1BTHP 2FI5I 4Y0ZI 1OA65 2M01A 3M7QB 1DENA 3BTQI 4NTWB 1BHCA 5JB5A 3D65I 1ZJDB 3AUDA 4NTXB 2ZJXA 3AUCA 2ODYE 1P2KI 2FI4I 3UIRC 2R9PE 2TPII 5C67C 1YC0I 1UUBA 3LDMA 1JV9A 1D0DA 2UUXA 3TGKI 2HEXA 1TAPA 3P92E 5JB6A 3TGII 2JOTA 1ADZA 3CI7A 3TPII 1TCPA 3LDIA 1DTXA 2LFKA 4BQDA 1FY8I 3AUBA 1LD6A 2FI3I 3BTMI 1P2JI 4ISNB 4ISOB 1FAKI 4DG4C 4WXVC 1KUNA 9PTIA 1Y62A 3BTFI 4U32X 1BPIA 6PTIA 1EJMB 2J6DA 1PITA 3WNYA 1NAGA 4ISLB 1YLDB 1KTHA 1UUAA 3UOUB 1DTKA 3BTTI 1YLCB 5PTIA 2M99A 1P2OB 8PTIA 1TPAI 3BTGI 1DEMA 3TGJI 4BNRI 2TGPI 4Y0YI 4BD9B 1BUNB 1MTND 4DTGK 1P2II 1JC6A 1BZXI 1YKTB 1BTIA 1SHPA 1AALA 1BRBI 1T8OB 3U1JE 1TOCR
chains in the Genus database with same CATH topology
1KNTA 2W8XA 3BTDI 2CA7A 2DDJA 1F5RI 5JB4A 2RA3C 1OA55 2PTCI 1CA0D 3BTEI 1G6XA 2FTLI 1CBWD 4WWYC 1D0DB 3FP6I 1EAWB 4Y10I 2UUYB 3OFWA 1B0CA 1CO7I 1P2MB 1P2NB 2KNTA 3AUGA 1BPTA 4PTIA 3BTWI 2FTMB 3AUIA 1FANA 3BYBA 1JV8A 1ZR0B 3OTJI 3FP7J 1T8LB 3BTKI 1P2QB 1K6UA 3AUEA 4Y11I 2ZVXA 3L33E 1TFXC 1T7CB 1BRCI 3L3TE 2IJOI 1F7ZI 1LD5A 1T8MB 7PTIA 2DDIA 2LFLA 1BIKA 1BZ5A 2KCRA 4TPII 4NTYB 1KIGI 1IRHA 3AUHA 1BF0A 1AAPA 5JB7A 3T62D 3FP8I 2KAII 3LDJA 3P95E 1T8NB 3BTHI 1TAWB 3GYMI 4U30W 1QLQA 1BTHP 2FI5I 4Y0ZI 1OA65 2M01A 3M7QB 1DENA 3BTQI 4NTWB 1BHCA 5JB5A 3D65I 1ZJDB 3AUDA 4NTXB 2ZJXA 3AUCA 2ODYE 1P2KI 2FI4I 3UIRC 2R9PE 2TPII 5C67C 1YC0I 1UUBA 3LDMA 1JV9A 1D0DA 2UUXA 3TGKI 2HEXA 1TAPA 3P92E 5JB6A 3TGII 2JOTA 1ADZA 3CI7A 3TPII 1TCPA 3LDIA 1DTXA 2LFKA 4BQDA 1FY8I 3AUBA 1LD6A 2FI3I 3BTMI 1P2JI 4ISNB 4ISOB 1FAKI 4DG4C 4WXVC 1KUNA 9PTIA 1Y62A 3BTFI 4U32X 1BPIA 6PTIA 1EJMB 2J6DA 1PITA 3WNYA 1NAGA 4ISLB 1YLDB 1KTHA 1UUAA 3UOUB 1DTKA 3BTTI 1YLCB 5PTIA 2M99A 1P2OB 8PTIA 1TPAI 3BTGI 1DEMA 3TGJI 4BNRI 2TGPI 4Y0YI 4BD9B 1BUNB 1MTND 4DTGK 1P2II 1JC6A 1BZXI 1YKTB 1BTIA 1SHPA 1AALA 1BRBI 1T8OB 3U1JE 1TOCR
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KNT A;  2W8X A;  3BTD I;  2CA7 A;  2DDJ A;  1F5R I;  5JB4 A;  2RA3 C;  1OA5 5;  2PTC I;  1CA0 D;  3BTE I;  1G6X A;  2FTL I;  1CBW D;  4WWY C;  1D0D B;  3FP6 I;  1EAW B;  4Y10 I;  2UUY B;  3OFW A;  1B0C A;  1CO7 I;  1P2M B;  1P2N B;  2KNT A;  3AUG A;  1BPT A;  4PTI A;  3BTW I;  2FTM B;  3AUI A;  1FAN A;  3BYB A;  1JV8 A;  1ZR0 B;  3OTJ I;  3FP7 J;  1T8L B;  3BTK I;  1P2Q B;  1K6U A;  3AUE A;  4Y11 I;  2ZVX A;  3L33 E;  1TFX C;  1T7C B;  1BRC I;  3L3T E;  2IJO I;  1F7Z I;  1LD5 A;  1T8M B;  7PTI A;  2DDI A;  2LFL A;  1BIK A;  1BZ5 A;  2KCR A;  4TPI I;  4NTY B;  1KIG I;  1IRH A;  3AUH A;  1BF0 A;  1AAP A;  5JB7 A;  3T62 D;  3FP8 I;  2KAI I;  3LDJ A;  3P95 E;  1T8N B;  3BTH I;  1TAW B;  3GYM I;  4U30 W;  1QLQ A;  1BTH P;  2FI5 I;  4Y0Z I;  1OA6 5;  2M01 A;  3M7Q B;  1DEN A;  3BTQ I;  4NTW B;  1BHC A;  5JB5 A;  3D65 I;  1ZJD B;  3AUD A;  4NTX B;  2ZJX A;  3AUC A;  2ODY E;  1P2K I;  2FI4 I;  3UIR C;  2R9P E;  2TPI I;  5C67 C;  1YC0 I;  1UUB A;  3LDM A;  1JV9 A;  1D0D A;  2UUX A;  3TGK I;  2HEX A;  1TAP A;  3P92 E;  5JB6 A;  3TGI I;  2JOT A;  1ADZ A;  3CI7 A;  3TPI I;  1TCP A;  3LDI A;  1DTX A;  2LFK A;  4BQD A;  1FY8 I;  3AUB A;  1LD6 A;  2FI3 I;  3BTM I;  1P2J I;  4ISN B;  4ISO B;  1FAK I;  4DG4 C;  4WXV C;  1KUN A;  9PTI A;  1Y62 A;  3BTF I;  4U32 X;  1BPI A;  6PTI A;  1EJM B;  2J6D A;  1PIT A;  3WNY A;  1NAG A;  4ISL B;  1YLD B;  1KTH A;  1UUA A;  3UOU B;  1DTK A;  3BTT I;  1YLC B;  5PTI A;  2M99 A;  1P2O B;  8PTI A;  1TPA I;  3BTG I;  1DEM A;  3TGJ I;  4BNR I;  2TGP I;  4Y0Y I;  4BD9 B;  1BUN B;  1MTN D;  4DTG K;  1P2I I;  1JC6 A;  1BZX I;  1YKT B;  1BTI A;  1SHP A;  1AAL A;  1BRB I;  1T8O B;  3U1J E;  1TOC R; 
#chains in the Genus database with same CATH topology
 1KNT A;  2W8X A;  3BTD I;  2CA7 A;  2DDJ A;  1F5R I;  5JB4 A;  2RA3 C;  1OA5 5;  2PTC I;  1CA0 D;  3BTE I;  1G6X A;  2FTL I;  1CBW D;  4WWY C;  1D0D B;  3FP6 I;  1EAW B;  4Y10 I;  2UUY B;  3OFW A;  1B0C A;  1CO7 I;  1P2M B;  1P2N B;  2KNT A;  3AUG A;  1BPT A;  4PTI A;  3BTW I;  2FTM B;  3AUI A;  1FAN A;  3BYB A;  1JV8 A;  1ZR0 B;  3OTJ I;  3FP7 J;  1T8L B;  3BTK I;  1P2Q B;  1K6U A;  3AUE A;  4Y11 I;  2ZVX A;  3L33 E;  1TFX C;  1T7C B;  1BRC I;  3L3T E;  2IJO I;  1F7Z I;  1LD5 A;  1T8M B;  7PTI A;  2DDI A;  2LFL A;  1BIK A;  1BZ5 A;  2KCR A;  4TPI I;  4NTY B;  1KIG I;  1IRH A;  3AUH A;  1BF0 A;  1AAP A;  5JB7 A;  3T62 D;  3FP8 I;  2KAI I;  3LDJ A;  3P95 E;  1T8N B;  3BTH I;  1TAW B;  3GYM I;  4U30 W;  1QLQ A;  1BTH P;  2FI5 I;  4Y0Z I;  1OA6 5;  2M01 A;  3M7Q B;  1DEN A;  3BTQ I;  4NTW B;  1BHC A;  5JB5 A;  3D65 I;  1ZJD B;  3AUD A;  4NTX B;  2ZJX A;  3AUC A;  2ODY E;  1P2K I;  2FI4 I;  3UIR C;  2R9P E;  2TPI I;  5C67 C;  1YC0 I;  1UUB A;  3LDM A;  1JV9 A;  1D0D A;  2UUX A;  3TGK I;  2HEX A;  1TAP A;  3P92 E;  5JB6 A;  3TGI I;  2JOT A;  1ADZ A;  3CI7 A;  3TPI I;  1TCP A;  3LDI A;  1DTX A;  2LFK A;  4BQD A;  1FY8 I;  3AUB A;  1LD6 A;  2FI3 I;  3BTM I;  1P2J I;  4ISN B;  4ISO B;  1FAK I;  4DG4 C;  4WXV C;  1KUN A;  9PTI A;  1Y62 A;  3BTF I;  4U32 X;  1BPI A;  6PTI A;  1EJM B;  2J6D A;  1PIT A;  3WNY A;  1NAG A;  4ISL B;  1YLD B;  1KTH A;  1UUA A;  3UOU B;  1DTK A;  3BTT I;  1YLC B;  5PTI A;  2M99 A;  1P2O B;  8PTI A;  1TPA I;  3BTG I;  1DEM A;  3TGJ I;  4BNR I;  2TGP I;  4Y0Y I;  4BD9 B;  1BUN B;  1MTN D;  4DTG K;  1P2I I;  1JC6 A;  1BZX I;  1YKT B;  1BTI A;  1SHP A;  1AAL A;  1BRB I;  1T8O B;  3U1J E;  1TOC R; 
#chains in the Genus database with same CATH homology
 1KNT A;  2W8X A;  3BTD I;  2CA7 A;  2DDJ A;  1F5R I;  5JB4 A;  2RA3 C;  1OA5 5;  2PTC I;  1CA0 D;  3BTE I;  1G6X A;  2FTL I;  1CBW D;  4WWY C;  1D0D B;  3FP6 I;  1EAW B;  4Y10 I;  2UUY B;  3OFW A;  1B0C A;  1CO7 I;  1P2M B;  1P2N B;  2KNT A;  3AUG A;  1BPT A;  4PTI A;  3BTW I;  2FTM B;  3AUI A;  1FAN A;  3BYB A;  1JV8 A;  1ZR0 B;  3OTJ I;  3FP7 J;  1T8L B;  3BTK I;  1P2Q B;  1K6U A;  3AUE A;  4Y11 I;  2ZVX A;  3L33 E;  1TFX C;  1T7C B;  1BRC I;  3L3T E;  2IJO I;  1F7Z I;  1LD5 A;  1T8M B;  7PTI A;  2DDI A;  2LFL A;  1BIK A;  1BZ5 A;  2KCR A;  4TPI I;  4NTY B;  1KIG I;  1IRH A;  3AUH A;  1BF0 A;  1AAP A;  5JB7 A;  3T62 D;  3FP8 I;  2KAI I;  3LDJ A;  3P95 E;  1T8N B;  3BTH I;  1TAW B;  3GYM I;  4U30 W;  1QLQ A;  1BTH P;  2FI5 I;  4Y0Z I;  1OA6 5;  2M01 A;  3M7Q B;  1DEN A;  3BTQ I;  4NTW B;  1BHC A;  5JB5 A;  3D65 I;  1ZJD B;  3AUD A;  4NTX B;  2ZJX A;  3AUC A;  2ODY E;  1P2K I;  2FI4 I;  3UIR C;  2R9P E;  2TPI I;  5C67 C;  1YC0 I;  1UUB A;  3LDM A;  1JV9 A;  1D0D A;  2UUX A;  3TGK I;  2HEX A;  1TAP A;  3P92 E;  5JB6 A;  3TGI I;  2JOT A;  1ADZ A;  3CI7 A;  3TPI I;  1TCP A;  3LDI A;  1DTX A;  2LFK A;  4BQD A;  1FY8 I;  3AUB A;  1LD6 A;  2FI3 I;  3BTM I;  1P2J I;  4ISN B;  4ISO B;  1FAK I;  4DG4 C;  4WXV C;  1KUN A;  9PTI A;  1Y62 A;  3BTF I;  4U32 X;  1BPI A;  6PTI A;  1EJM B;  2J6D A;  1PIT A;  3WNY A;  1NAG A;  4ISL B;  1YLD B;  1KTH A;  1UUA A;  3UOU B;  1DTK A;  3BTT I;  1YLC B;  5PTI A;  2M99 A;  1P2O B;  8PTI A;  1TPA I;  3BTG I;  1DEM A;  3TGJ I;  4BNR I;  2TGP I;  4Y0Y I;  4BD9 B;  1BUN B;  1MTN D;  4DTG K;  1P2I I;  1JC6 A;  1BZX I;  1YKT B;  1BTI A;  1SHP A;  1AAL A;  1BRB I;  1T8O B;  3U1J E;  1TOC R; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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