1IRHA

The solution structure of the third kunitz domain of tissue factor pathway inhibitor
Total Genus 2
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
2
sequence length
61
structure length
61
Chain Sequence
EFHGPSWCLTPADRGLCRANENRFYYNSVIGKCRPFKYSGCGGNENNFTSKQECLRACKKG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural mechanism for heparin-binding of the third Kunitz domain of human tissue factor pathway inhibitor.
pubmed doi rcsb
molecule tags Protein binding
source organism Homo sapiens
molecule keywords tissue factor pathway inhibitor
total genus 2
structure length 61
sequence length 61
ec nomenclature
pdb deposition date 2001-10-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 1irhA00
1KIGI 1D0DB 1Y62A 4BQDA 1DENA 3GYMI 3BTHI 3FP6I 1BF0A 2ZVXA 1FANA 2M01A 1QLQA 3P92E 1ZJDB 1JV8A 5JB7A 1YLCB 2RA3C 1JV9A 1DEMA 2W8XA 1EAWB 4ISNB 1T8MB 4NTYB 2FI3I 5C67C 1UUBA 4U30W 4PTIA 2KAII 1P2OB 3TGII 1ADZA 3AUGA 3AUIA 4Y0YI 1IRHA 1BTHP 3WNYA 2TPII 3FP7J 2LFLA 4ISOB 1JC6A 2FTMB 3AUEA 1SHPA 1ZR0B 9PTIA 8PTIA 1TFXC 1CA0D 2R9PE 3BTFI 1LD6A 3L3TE 2UUXA 4NTWB 3TGJI 1P2II 4BNRI 1MTND 1KUNA 1F7ZI 1YLDB 4DTGK 1TAWB 2KCRA 3OTJI 2FI4I 3AUDA 3U1JE 1BZ5A 1T8NB 1TCPA 3BTEI 1BPTA 2DDJA 1NAGA 1BIKA 2TGPI 3TGKI 1D0DA 2PTCI 2ZJXA 4DG4C 4Y0ZI 4TPII 1KNTA 5JB4A 1LD5A 1DTXA 3M7QB 4Y10I 4BD9B 2ODYE 2CA7A 3BTMI 3BTGI 1G6XA 4ISLB 4WXVC 1UUAA 2IJOI 3BYBA 6PTIA 5JB6A 3LDIA 3AUBA 3T62D 3BTKI 1P2NB 3BTDI 1T7CB 1OA55 3BTWI 1K6UA 1FY8I 3P95E 5JB5A 1TPAI 1KTHA 3TPII 1CBWD 3BTQI 2FTLI 1BTIA 1BZXI 3LDMA 1BHCA 4WWYC 2J6DA 2JOTA 5PTIA 3D65I 1P2MB 1BRCI 1OA65 2DDIA 2UUYB 3AUCA 1B0CA 1P2JI 1P2KI 4Y11I 2FI5I 3L33E 1DTKA 1AAPA 1BPIA 1T8OB 3CI7A 1CO7I 3BTTI 4NTXB 7PTIA 1BUNB 1BRBI 1T8LB 2KNTA 3AUHA 3OFWA 1PITA 1F5RI 1P2QB 1FAKI 1TOCR 3UOUB 1TAPA 1AALA 4U32X 2HEXA 1EJMB 2LFKA 1YKTB 3FP8I 2M99A 3LDJA 3UIRC 1YC0I
chains in the Genus database with same CATH superfamily
1KIGI 1D0DB 1Y62A 4BQDA 1DENA 3GYMI 3BTHI 3FP6I 1BF0A 2ZVXA 1FANA 2M01A 1QLQA 3P92E 1ZJDB 1JV8A 5JB7A 1YLCB 2RA3C 1JV9A 1DEMA 2W8XA 1EAWB 4ISNB 1T8MB 4NTYB 2FI3I 5C67C 1UUBA 4U30W 4PTIA 2KAII 1P2OB 3TGII 1ADZA 3AUGA 3AUIA 4Y0YI 1IRHA 1BTHP 3WNYA 2TPII 3FP7J 2LFLA 4ISOB 1JC6A 2FTMB 3AUEA 1SHPA 1ZR0B 9PTIA 8PTIA 1TFXC 1CA0D 2R9PE 3BTFI 1LD6A 3L3TE 2UUXA 4NTWB 3TGJI 1P2II 4BNRI 1MTND 1KUNA 1F7ZI 1YLDB 4DTGK 1TAWB 2KCRA 3OTJI 2FI4I 3AUDA 3U1JE 1BZ5A 1T8NB 1TCPA 3BTEI 1BPTA 2DDJA 1NAGA 1BIKA 2TGPI 3TGKI 1D0DA 2PTCI 2ZJXA 4DG4C 4Y0ZI 4TPII 1KNTA 5JB4A 1LD5A 1DTXA 3M7QB 4Y10I 4BD9B 2ODYE 2CA7A 3BTMI 3BTGI 1G6XA 4ISLB 4WXVC 1UUAA 2IJOI 3BYBA 6PTIA 5JB6A 3LDIA 3AUBA 3T62D 3BTKI 1P2NB 3BTDI 1T7CB 1OA55 3BTWI 1K6UA 1FY8I 3P95E 5JB5A 1TPAI 1KTHA 3TPII 1CBWD 3BTQI 2FTLI 1BTIA 1BZXI 3LDMA 1BHCA 4WWYC 2J6DA 2JOTA 5PTIA 3D65I 1P2MB 1BRCI 1OA65 2DDIA 2UUYB 3AUCA 1B0CA 1P2JI 1P2KI 4Y11I 2FI5I 3L33E 1DTKA 1AAPA 1BPIA 1T8OB 3CI7A 1CO7I 3BTTI 4NTXB 7PTIA 1BUNB 1BRBI 1T8LB 2KNTA 3AUHA 3OFWA 1PITA 1F5RI 1P2QB 1FAKI 1TOCR 3UOUB 1TAPA 1AALA 4U32X 2HEXA 1EJMB 2LFKA 1YKTB 3FP8I 2M99A 3LDJA 3UIRC 1YC0I
chains in the Genus database with same CATH topology
1KIGI 1D0DB 1Y62A 4BQDA 1DENA 3GYMI 3BTHI 3FP6I 1BF0A 2ZVXA 1FANA 2M01A 1QLQA 3P92E 1ZJDB 1JV8A 5JB7A 1YLCB 2RA3C 1JV9A 1DEMA 2W8XA 1EAWB 4ISNB 1T8MB 4NTYB 2FI3I 5C67C 1UUBA 4U30W 4PTIA 2KAII 1P2OB 3TGII 1ADZA 3AUGA 3AUIA 4Y0YI 1IRHA 1BTHP 3WNYA 2TPII 3FP7J 2LFLA 4ISOB 1JC6A 2FTMB 3AUEA 1SHPA 1ZR0B 9PTIA 8PTIA 1TFXC 1CA0D 2R9PE 3BTFI 1LD6A 3L3TE 2UUXA 4NTWB 3TGJI 1P2II 4BNRI 1MTND 1KUNA 1F7ZI 1YLDB 4DTGK 1TAWB 2KCRA 3OTJI 2FI4I 3AUDA 3U1JE 1BZ5A 1T8NB 1TCPA 3BTEI 1BPTA 2DDJA 1NAGA 1BIKA 2TGPI 3TGKI 1D0DA 2PTCI 2ZJXA 4DG4C 4Y0ZI 4TPII 1KNTA 5JB4A 1LD5A 1DTXA 3M7QB 4Y10I 4BD9B 2ODYE 2CA7A 3BTMI 3BTGI 1G6XA 4ISLB 4WXVC 1UUAA 2IJOI 3BYBA 6PTIA 5JB6A 3LDIA 3AUBA 3T62D 3BTKI 1P2NB 3BTDI 1T7CB 1OA55 3BTWI 1K6UA 1FY8I 3P95E 5JB5A 1TPAI 1KTHA 3TPII 1CBWD 3BTQI 2FTLI 1BTIA 1BZXI 3LDMA 1BHCA 4WWYC 2J6DA 2JOTA 5PTIA 3D65I 1P2MB 1BRCI 1OA65 2DDIA 2UUYB 3AUCA 1B0CA 1P2JI 1P2KI 4Y11I 2FI5I 3L33E 1DTKA 1AAPA 1BPIA 1T8OB 3CI7A 1CO7I 3BTTI 4NTXB 7PTIA 1BUNB 1BRBI 1T8LB 2KNTA 3AUHA 3OFWA 1PITA 1F5RI 1P2QB 1FAKI 1TOCR 3UOUB 1TAPA 1AALA 4U32X 2HEXA 1EJMB 2LFKA 1YKTB 3FP8I 2M99A 3LDJA 3UIRC 1YC0I
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1KIG I;  1D0D B;  1Y62 A;  4BQD A;  1DEN A;  3GYM I;  3BTH I;  3FP6 I;  1BF0 A;  2ZVX A;  1FAN A;  2M01 A;  1QLQ A;  3P92 E;  1ZJD B;  1JV8 A;  5JB7 A;  1YLC B;  2RA3 C;  1JV9 A;  1DEM A;  2W8X A;  1EAW B;  4ISN B;  1T8M B;  4NTY B;  2FI3 I;  5C67 C;  1UUB A;  4U30 W;  4PTI A;  2KAI I;  1P2O B;  3TGI I;  1ADZ A;  3AUG A;  3AUI A;  4Y0Y I;  1IRH A;  1BTH P;  3WNY A;  2TPI I;  3FP7 J;  2LFL A;  4ISO B;  1JC6 A;  2FTM B;  3AUE A;  1SHP A;  1ZR0 B;  9PTI A;  8PTI A;  1TFX C;  1CA0 D;  2R9P E;  3BTF I;  1LD6 A;  3L3T E;  2UUX A;  4NTW B;  3TGJ I;  1P2I I;  4BNR I;  1MTN D;  1KUN A;  1F7Z I;  1YLD B;  4DTG K;  1TAW B;  2KCR A;  3OTJ I;  2FI4 I;  3AUD A;  3U1J E;  1BZ5 A;  1T8N B;  1TCP A;  3BTE I;  1BPT A;  2DDJ A;  1NAG A;  1BIK A;  2TGP I;  3TGK I;  1D0D A;  2PTC I;  2ZJX A;  4DG4 C;  4Y0Z I;  4TPI I;  1KNT A;  5JB4 A;  1LD5 A;  1DTX A;  3M7Q B;  4Y10 I;  4BD9 B;  2ODY E;  2CA7 A;  3BTM I;  3BTG I;  1G6X A;  4ISL B;  4WXV C;  1UUA A;  2IJO I;  3BYB A;  6PTI A;  5JB6 A;  3LDI A;  3AUB A;  3T62 D;  3BTK I;  1P2N B;  3BTD I;  1T7C B;  1OA5 5;  3BTW I;  1K6U A;  1FY8 I;  3P95 E;  5JB5 A;  1TPA I;  1KTH A;  3TPI I;  1CBW D;  3BTQ I;  2FTL I;  1BTI A;  1BZX I;  3LDM A;  1BHC A;  4WWY C;  2J6D A;  2JOT A;  5PTI A;  3D65 I;  1P2M B;  1BRC I;  1OA6 5;  2DDI A;  2UUY B;  3AUC A;  1B0C A;  1P2J I;  1P2K I;  4Y11 I;  2FI5 I;  3L33 E;  1DTK A;  1AAP A;  1BPI A;  1T8O B;  3CI7 A;  1CO7 I;  3BTT I;  4NTX B;  7PTI A;  1BUN B;  1BRB I;  1T8L B;  2KNT A;  3AUH A;  3OFW A;  1PIT A;  1F5R I;  1P2Q B;  1FAK I;  1TOC R;  3UOU B;  1TAP A;  1AAL A;  4U32 X;  2HEX A;  1EJM B;  2LFK A;  1YKT B;  3FP8 I;  2M99 A;  3LDJ A;  3UIR C;  1YC0 I; 
#chains in the Genus database with same CATH topology
 1KIG I;  1D0D B;  1Y62 A;  4BQD A;  1DEN A;  3GYM I;  3BTH I;  3FP6 I;  1BF0 A;  2ZVX A;  1FAN A;  2M01 A;  1QLQ A;  3P92 E;  1ZJD B;  1JV8 A;  5JB7 A;  1YLC B;  2RA3 C;  1JV9 A;  1DEM A;  2W8X A;  1EAW B;  4ISN B;  1T8M B;  4NTY B;  2FI3 I;  5C67 C;  1UUB A;  4U30 W;  4PTI A;  2KAI I;  1P2O B;  3TGI I;  1ADZ A;  3AUG A;  3AUI A;  4Y0Y I;  1IRH A;  1BTH P;  3WNY A;  2TPI I;  3FP7 J;  2LFL A;  4ISO B;  1JC6 A;  2FTM B;  3AUE A;  1SHP A;  1ZR0 B;  9PTI A;  8PTI A;  1TFX C;  1CA0 D;  2R9P E;  3BTF I;  1LD6 A;  3L3T E;  2UUX A;  4NTW B;  3TGJ I;  1P2I I;  4BNR I;  1MTN D;  1KUN A;  1F7Z I;  1YLD B;  4DTG K;  1TAW B;  2KCR A;  3OTJ I;  2FI4 I;  3AUD A;  3U1J E;  1BZ5 A;  1T8N B;  1TCP A;  3BTE I;  1BPT A;  2DDJ A;  1NAG A;  1BIK A;  2TGP I;  3TGK I;  1D0D A;  2PTC I;  2ZJX A;  4DG4 C;  4Y0Z I;  4TPI I;  1KNT A;  5JB4 A;  1LD5 A;  1DTX A;  3M7Q B;  4Y10 I;  4BD9 B;  2ODY E;  2CA7 A;  3BTM I;  3BTG I;  1G6X A;  4ISL B;  4WXV C;  1UUA A;  2IJO I;  3BYB A;  6PTI A;  5JB6 A;  3LDI A;  3AUB A;  3T62 D;  3BTK I;  1P2N B;  3BTD I;  1T7C B;  1OA5 5;  3BTW I;  1K6U A;  1FY8 I;  3P95 E;  5JB5 A;  1TPA I;  1KTH A;  3TPI I;  1CBW D;  3BTQ I;  2FTL I;  1BTI A;  1BZX I;  3LDM A;  1BHC A;  4WWY C;  2J6D A;  2JOT A;  5PTI A;  3D65 I;  1P2M B;  1BRC I;  1OA6 5;  2DDI A;  2UUY B;  3AUC A;  1B0C A;  1P2J I;  1P2K I;  4Y11 I;  2FI5 I;  3L33 E;  1DTK A;  1AAP A;  1BPI A;  1T8O B;  3CI7 A;  1CO7 I;  3BTT I;  4NTX B;  7PTI A;  1BUN B;  1BRB I;  1T8L B;  2KNT A;  3AUH A;  3OFW A;  1PIT A;  1F5R I;  1P2Q B;  1FAK I;  1TOC R;  3UOU B;  1TAP A;  1AAL A;  4U32 X;  2HEX A;  1EJM B;  2LFK A;  1YKT B;  3FP8 I;  2M99 A;  3LDJ A;  3UIR C;  1YC0 I; 
#chains in the Genus database with same CATH homology
 1KIG I;  1D0D B;  1Y62 A;  4BQD A;  1DEN A;  3GYM I;  3BTH I;  3FP6 I;  1BF0 A;  2ZVX A;  1FAN A;  2M01 A;  1QLQ A;  3P92 E;  1ZJD B;  1JV8 A;  5JB7 A;  1YLC B;  2RA3 C;  1JV9 A;  1DEM A;  2W8X A;  1EAW B;  4ISN B;  1T8M B;  4NTY B;  2FI3 I;  5C67 C;  1UUB A;  4U30 W;  4PTI A;  2KAI I;  1P2O B;  3TGI I;  1ADZ A;  3AUG A;  3AUI A;  4Y0Y I;  1IRH A;  1BTH P;  3WNY A;  2TPI I;  3FP7 J;  2LFL A;  4ISO B;  1JC6 A;  2FTM B;  3AUE A;  1SHP A;  1ZR0 B;  9PTI A;  8PTI A;  1TFX C;  1CA0 D;  2R9P E;  3BTF I;  1LD6 A;  3L3T E;  2UUX A;  4NTW B;  3TGJ I;  1P2I I;  4BNR I;  1MTN D;  1KUN A;  1F7Z I;  1YLD B;  4DTG K;  1TAW B;  2KCR A;  3OTJ I;  2FI4 I;  3AUD A;  3U1J E;  1BZ5 A;  1T8N B;  1TCP A;  3BTE I;  1BPT A;  2DDJ A;  1NAG A;  1BIK A;  2TGP I;  3TGK I;  1D0D A;  2PTC I;  2ZJX A;  4DG4 C;  4Y0Z I;  4TPI I;  1KNT A;  5JB4 A;  1LD5 A;  1DTX A;  3M7Q B;  4Y10 I;  4BD9 B;  2ODY E;  2CA7 A;  3BTM I;  3BTG I;  1G6X A;  4ISL B;  4WXV C;  1UUA A;  2IJO I;  3BYB A;  6PTI A;  5JB6 A;  3LDI A;  3AUB A;  3T62 D;  3BTK I;  1P2N B;  3BTD I;  1T7C B;  1OA5 5;  3BTW I;  1K6U A;  1FY8 I;  3P95 E;  5JB5 A;  1TPA I;  1KTH A;  3TPI I;  1CBW D;  3BTQ I;  2FTL I;  1BTI A;  1BZX I;  3LDM A;  1BHC A;  4WWY C;  2J6D A;  2JOT A;  5PTI A;  3D65 I;  1P2M B;  1BRC I;  1OA6 5;  2DDI A;  2UUY B;  3AUC A;  1B0C A;  1P2J I;  1P2K I;  4Y11 I;  2FI5 I;  3L33 E;  1DTK A;  1AAP A;  1BPI A;  1T8O B;  3CI7 A;  1CO7 I;  3BTT I;  4NTX B;  7PTI A;  1BUN B;  1BRB I;  1T8L B;  2KNT A;  3AUH A;  3OFW A;  1PIT A;  1F5R I;  1P2Q B;  1FAK I;  1TOC R;  3UOU B;  1TAP A;  1AAL A;  4U32 X;  2HEX A;  1EJM B;  2LFK A;  1YKT B;  3FP8 I;  2M99 A;  3LDJ A;  3UIR C;  1YC0 I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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