1IW7E

Crystal structure of the rna polymerase holoenzyme from thermus thermophilus at 2.6a resolution
Total Genus 19
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
19
sequence length
95
structure length
95
Chain Sequence
AEPGIDKLFGMVDSKYRLTVVVAKRAQQLLRHGFKNTVLEPEERPKMQTLEGLFDDPNAETWAMKELLTGRLVFGENLVPEDRLQKEMERIYPGE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal structure of a bacterial RNA polymerase holoenzyme at 2.6 A resolution
pubmed doi rcsb
molecule tags Transferase
molecule keywords RNA polymerase alpha subunit
total genus 19
structure length 95
sequence length 95
chains with identical sequence O
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2002-04-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 1iw7E00
3I4NF 2NVTF 4A3DF 4A3CF 5M3FF 2E2JF 2JA7F 3S15F 2R7ZF 4A3FF 3WODE 5IP9F 3I4MF 3GTQF 1I6HF 2NVXF 2R93F 3H0GF 4AYBK 3HOWF 4BXXF 4LK1E 4C3IF 5IYBF 2PMZK 4G7OE 2E2IF 1TWGF 5E17E 3HKZK 1I3QF 4LK0E 3GTPF 1Y1VF 4XLNE 3PO2F 4YFNE 5C4XF 3GTOF 2BE5E 5E18E 2A6EE 4YG2E 4X6AF 3H3VG 4KMUE 1I50F 1TWHF 1I6VE 5C44F 3PO3F 2O5JE 4A3KF 4OINE 5C3EF 1K83F 3CQZF 3S1MF 4A3GF 3S16F 2NVYF 4YFXE 1HQME 5IP7F 5IYDF 4YFKE 3S14F 5D4EE 3DXJE 2WB1I 3RZOF 2A68E 3M4OF 3S17F 4KN7E 5D4DE 5IYCF 3S1RF 3S2HF 4MEYE 1YNNK 4Q5SE 4Y7NF 1ZYRE 3HOZF 4BBSF 5M5WF 5M5XF 2B63F 4C3JF 4C3HF 3HOVF 2PPBE 2CW0E 1SFOF 2JA5F 4BY1F 5FLMF 2E2HF 4OIQE 4OIPE 3S2DF 3FKIF 4LJZE 5FJ8F 4BY7F 4C2MF 1YNJK 5C4JF 4KN4E 5D4CE 3GTKF 1TWCF 1SMYE 4Q4ZE 4XLPE 4Y52F 2WAQK 3GTJF 1R9TF 4MQ9E 2JA6F 2Y0SI 1WCMF 2A6HE 5TMFE 3EQLE 1QKLA 2O5IE 5M5YF 1Y1WF 2VUMF 3S1NF 2R92F 2JA8F 4A3MF 4GZYE 4LLGE 4G7ZE 3M3YF 4A3BF 4A3LF 3K7AF 3GTLF 1IW7E 4XSZE 4A93F 5IPLE 4MEXE 3S1QF 4OIRE 3GTGF 2A69E 4ZH4E 4A3IF 4XSXE 4JK1E 4G7HE 5M3MF 5BYHE 2NVQF 5TMCE 3HOXF 4A3EF 3GTMF 4OIOE 1TWAF 4A3JF 3HOUF 3HOYF 3RZDF 2YU9F 1TWFF 4BBRF
chains in the Genus database with same CATH superfamily
3I4NF 2Y0SH 2NVTE 2NVTF 2KRXA 4A3CE 4A3CF 2JA8E 4A3DF 5M3FE 5M3FF 2E2JF 2JA7F 2JA7E 3S15E 3S15F 3M3YE 2R7ZF 4A3FF 3WODE 5IP9E 5IP9F 3I4MF 4A93E 3GTQF 1I6HE 1I6HF 2WAQH 3S1QE 2NVXE 2NVXF 2R93F 4AYBK 3HOWE 3HOWF 4BXXE 4BXXF 1DZFA 4LK1E 4A3IE 4C3IF 5IYBF 2PMZK 5IYBE 4G7OE 2E2IF 2NVQE 1TWGF 5E17E 3HKZK 4LK0E 1I3QF 3HOXE 3GTPF 3GTPE 1Y1VF 4XLNE 3PO2F 4YFNE 5C4XE 5C4XF 3GTOE 3GTOF 2BE5E 5E18E 2A6EE 4YG2E 4X6AE 4X6AF 3H3VG 4KMUE 1I50F 1TWHF 3RZDE 1I6VE 5C44F 2YU9E 3PO3E 3PO3F 2O5JE 1TWFE 3H0GE 4BBRE 4A3KF 4OINE 5C3EE 5C3EF 1K83E 1K83F 3CQZF 3CQZE 3I4NE 3S1MF 4A3DE 4A3GE 4A3GF 3S16E 3S16F 2NVYF 2E2JE 4YFXE 1HQME 5IP7F 5IYDE 5IYDF 4YFKE 2R7ZE 4A3FE 3S14F 3I4ME 5D4EE 3GTQE 3DXJE 2WB1I 3RZOE 3M4OE 2A68E 3M4OF 3RZOF 2R93E 3S17F 4KN7E 5D4DE 5IYCE 5IYCF 3S1RF 4C3IE 3S2HE 3S2HF 4MEYE 1YNNK 4Q5SE 4Y7NE 4Y7NF 1TWGE 2E2IE 1ZYRE 3HOZF 1I3QE 1Y1VE 5M5WE 5M5WF 5M5XF 2B63F 3PO2E 4BBSF 4C3JF 4BBSE 4C3HF 1I50E 1TWHE 5C44E 3HOVF 3HOVE 2PPBE 1SFOE 2CW0E 4A3KE 1SFOF 2JA5E 2JA5F 5FLME 4BY1F 5FLMF 4BY1E 3S1ME 2E2HE 2E2HF 4QIWK 2NVYE 4OIQE 5IP7E 4OIPE 3S2DF 3FKIE 3FKIF 4LJZE 5FJ8F 4BY7E 4BY7F 4C2ME 4C2MF 3S14E 1YNJK 5C4JE 5C4JF 4KN4E 5D4CE 3GTKF 3HKZH 1TWCF 1SMYE 4Q4ZE 4XLPE 3S17E 4Y52F 2WAQK 3GTJE 3GTJF 3S1RE 1R9TF 4MQ9E 2JA6F 2Y0SI 1WCMF 2A6HE 5TMFE 2WB1H 3HOZE 3EQLE 1QKLA 2O5IE 2B63E 5M5XE 5M5YE 4C3JE 5M5YF 1Y1WF 1Y1WE 2VUME 2VUMF 3S1NF 3S1NE 4C3HE 2R92E 2R92F 2JA8F 4A3ME 4A3MF 4GZYE 4LLGE 4G7ZE 3M3YF 4A3BE 4A3BF 3K7AE 3K7AF 3GTLF 3GTLE 4A3LE 4A3LF 1EIKA 4AYBH 1IW7E 4XSZE 3S2DE 4A93F 5IPLE 4MEXE 3S1QF 5FJ8E 4OIRE 3GTGE 2PMZH 3GTGF 2A69E 4ZH4E 3GTKE 4A3IF 4XSXE 4JK1E 4G7HE 1TWCE 5M3ME 5M3MF 5BYHE 2NVQF 5TMCE 4Y52E 4A3EE 4BBRF 3HOXF 4A3EF 3GTME 1R9TE 3GTMF 2JA6E 1TWAE 1TWAF 4OIOE 1WCME 4A3JF 4A3JE 3H3VF 3HOUE 3HOUF 3HOYE 3HOYF 3RZDF 2YU9F 4QIWH 1TWFF 3H0GF
chains in the Genus database with same CATH topology
3I4NF 2NVTF 2KRXA 4A3CF 4A3DF 5M3FF 2E2JF 2JA7F 3S15F 2R7ZF 4A3FF 3WODE 5IP9F 3I4MF 3GTQF 1I6HF 2NVXF 2R93F 3H0GF 4AYBK 3HOWF 4BXXF 4LK1E 4C3IF 5IYBF 2PMZK 4G7OE 2E2IF 1TWGF 5E17E 3HKZK 1I3QF 4LK0E 3GTPF 1Y1VF 4XLNE 3PO2F 4YFNE 5C4XF 3GTOF 2BE5E 5E18E 2A6EE 4YG2E 4X6AF 3H3VG 4KMUE 1I50F 1TWHF 1I6VE 5C44F 3PO3F 2O5JE 4A3KF 4OINE 5C3EF 1K83F 3CQZF 3S1MF 4A3GF 3S16F 2NVYF 4YFXE 1HQME 5IP7F 5IYDF 4YFKE 3S14F 5D4EE 3DXJE 2WB1I 3RZOF 2A68E 3M4OF 3S17F 4KN7E 5D4DE 5IYCF 3S1RF 3S2HF 4MEYE 1YNNK 4Q5SE 4Y7NF 1ZYRE 3HOZF 4BBSF 5M5WF 5M5XF 2B63F 4C3JF 4C3HF 3HOVF 2PPBE 2CW0E 1SFOF 2JA5F 4BY1F 5FLMF 2E2HF 4QIWK 4OIQE 4OIPE 3S2DF 3FKIF 4LJZE 5FJ8F 4BY7F 4C2MF 1YNJK 5C4JF 4KN4E 5D4CE 3GTKF 1TWCF 1SMYE 4Q4ZE 4XLPE 4Y52F 2WAQK 3GTJF 1R9TF 4MQ9E 2JA6F 2Y0SI 1WCMF 2A6HE 5TMFE 3EQLE 1QKLA 2O5IE 5M5YF 1Y1WF 2VUMF 3S1NF 2R92F 2JA8F 4A3MF 4GZYE 4LLGE 4G7ZE 3M3YF 4A3BF 4A3LF 3K7AF 3GTLF 1IW7E 4XSZE 4A93F 5IPLE 4MEXE 3S1QF 4OIRE 3GTGF 2A69E 4ZH4E 4A3IF 4XSXE 4JK1E 4G7HE 5M3MF 5BYHE 2NVQF 5TMCE 3HOXF 4A3EF 3GTMF 4OIOE 1TWAF 4A3JF 3HOUF 3HOYF 3RZDF 2YU9F 1TWFF 4BBRF
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3I4N F;  2NVT F;  4A3D F;  4A3C F;  5M3F F;  2E2J F;  2JA7 F;  3S15 F;  2R7Z F;  4A3F F;  3WOD E;  5IP9 F;  3I4M F;  3GTQ F;  1I6H F;  2NVX F;  2R93 F;  3H0G F;  4AYB K;  3HOW F;  4BXX F;  4LK1 E;  4C3I F;  5IYB F;  2PMZ K;  4G7O E;  2E2I F;  1TWG F;  5E17 E;  3HKZ K;  1I3Q F;  4LK0 E;  3GTP F;  1Y1V F;  4XLN E;  3PO2 F;  4YFN E;  5C4X F;  3GTO F;  2BE5 E;  5E18 E;  2A6E E;  4YG2 E;  4X6A F;  3H3V G;  4KMU E;  1I50 F;  1TWH F;  1I6V E;  5C44 F;  3PO3 F;  2O5J E;  4A3K F;  4OIN E;  5C3E F;  1K83 F;  3CQZ F;  3S1M F;  4A3G F;  3S16 F;  2NVY F;  4YFX E;  1HQM E;  5IP7 F;  5IYD F;  4YFK E;  3S14 F;  5D4E E;  3DXJ E;  2WB1 I;  3RZO F;  2A68 E;  3M4O F;  3S17 F;  4KN7 E;  5D4D E;  5IYC F;  3S1R F;  3S2H F;  4MEY E;  1YNN K;  4Q5S E;  4Y7N F;  1ZYR E;  3HOZ F;  4BBS F;  5M5W F;  5M5X F;  2B63 F;  4C3J F;  4C3H F;  3HOV F;  2PPB E;  2CW0 E;  1SFO F;  2JA5 F;  4BY1 F;  5FLM F;  2E2H F;  4OIQ E;  4OIP E;  3S2D F;  3FKI F;  4LJZ E;  5FJ8 F;  4BY7 F;  4C2M F;  1YNJ K;  5C4J F;  4KN4 E;  5D4C E;  3GTK F;  1TWC F;  1SMY E;  4Q4Z E;  4XLP E;  4Y52 F;  2WAQ K;  3GTJ F;  1R9T F;  4MQ9 E;  2JA6 F;  2Y0S I;  1WCM F;  2A6H E;  5TMF E;  3EQL E;  1QKL A;  2O5I E;  5M5Y F;  1Y1W F;  2VUM F;  3S1N F;  2R92 F;  2JA8 F;  4A3M F;  4GZY E;  4LLG E;  4G7Z E;  3M3Y F;  4A3B F;  4A3L F;  3K7A F;  3GTL F;  1IW7 E;  4XSZ E;  4A93 F;  5IPL E;  4MEX E;  3S1Q F;  4OIR E;  3GTG F;  2A69 E;  4ZH4 E;  4A3I F;  4XSX E;  4JK1 E;  4G7H E;  5M3M F;  5BYH E;  2NVQ F;  5TMC E;  3HOX F;  4A3E F;  3GTM F;  4OIO E;  1TWA F;  4A3J F;  3HOU F;  3HOY F;  3RZD F;  2YU9 F;  1TWF F;  4BBR F; 
#chains in the Genus database with same CATH topology
 3I4N F;  2Y0S H;  2NVT E;  2NVT F;  2KRX A;  4A3C E;  4A3C F;  2JA8 E;  4A3D F;  5M3F E;  5M3F F;  2E2J F;  2JA7 F;  2JA7 E;  3S15 E;  3S15 F;  3M3Y E;  2R7Z F;  4A3F F;  3WOD E;  5IP9 E;  5IP9 F;  3I4M F;  4A93 E;  3GTQ F;  1I6H E;  1I6H F;  2WAQ H;  3S1Q E;  2NVX E;  2NVX F;  2R93 F;  4AYB K;  3HOW E;  3HOW F;  4BXX E;  4BXX F;  1DZF A;  4LK1 E;  4A3I E;  4C3I F;  5IYB F;  2PMZ K;  5IYB E;  4G7O E;  2E2I F;  2NVQ E;  1TWG F;  5E17 E;  3HKZ K;  4LK0 E;  1I3Q F;  3HOX E;  3GTP F;  3GTP E;  1Y1V F;  4XLN E;  3PO2 F;  4YFN E;  5C4X E;  5C4X F;  3GTO E;  3GTO F;  2BE5 E;  5E18 E;  2A6E E;  4YG2 E;  4X6A E;  4X6A F;  3H3V G;  4KMU E;  1I50 F;  1TWH F;  3RZD E;  1I6V E;  5C44 F;  2YU9 E;  3PO3 E;  3PO3 F;  2O5J E;  1TWF E;  3H0G E;  4BBR E;  4A3K F;  4OIN E;  5C3E E;  5C3E F;  1K83 E;  1K83 F;  3CQZ F;  3CQZ E;  3I4N E;  3S1M F;  4A3D E;  4A3G E;  4A3G F;  3S16 E;  3S16 F;  2NVY F;  2E2J E;  4YFX E;  1HQM E;  5IP7 F;  5IYD E;  5IYD F;  4YFK E;  2R7Z E;  4A3F E;  3S14 F;  3I4M E;  5D4E E;  3GTQ E;  3DXJ E;  2WB1 I;  3RZO E;  3M4O E;  2A68 E;  3M4O F;  3RZO F;  2R93 E;  3S17 F;  4KN7 E;  5D4D E;  5IYC E;  5IYC F;  3S1R F;  4C3I E;  3S2H E;  3S2H F;  4MEY E;  1YNN K;  4Q5S E;  4Y7N E;  4Y7N F;  1TWG E;  2E2I E;  1ZYR E;  3HOZ F;  1I3Q E;  1Y1V E;  5M5W E;  5M5W F;  5M5X F;  2B63 F;  3PO2 E;  4BBS F;  4C3J F;  4BBS E;  4C3H F;  1I50 E;  1TWH E;  5C44 E;  3HOV F;  3HOV E;  2PPB E;  1SFO E;  2CW0 E;  4A3K E;  1SFO F;  2JA5 E;  2JA5 F;  5FLM E;  4BY1 F;  5FLM F;  4BY1 E;  3S1M E;  2E2H E;  2E2H F;  4QIW K;  2NVY E;  4OIQ E;  5IP7 E;  4OIP E;  3S2D F;  3FKI E;  3FKI F;  4LJZ E;  5FJ8 F;  4BY7 E;  4BY7 F;  4C2M E;  4C2M F;  3S14 E;  1YNJ K;  5C4J E;  5C4J F;  4KN4 E;  5D4C E;  3GTK F;  3HKZ H;  1TWC F;  1SMY E;  4Q4Z E;  4XLP E;  3S17 E;  4Y52 F;  2WAQ K;  3GTJ E;  3GTJ F;  3S1R E;  1R9T F;  4MQ9 E;  2JA6 F;  2Y0S I;  1WCM F;  2A6H E;  5TMF E;  2WB1 H;  3HOZ E;  3EQL E;  1QKL A;  2O5I E;  2B63 E;  5M5X E;  5M5Y E;  4C3J E;  5M5Y F;  1Y1W F;  1Y1W E;  2VUM E;  2VUM F;  3S1N F;  3S1N E;  4C3H E;  2R92 E;  2R92 F;  2JA8 F;  4A3M E;  4A3M F;  4GZY E;  4LLG E;  4G7Z E;  3M3Y F;  4A3B E;  4A3B F;  3K7A E;  3K7A F;  3GTL F;  3GTL E;  4A3L E;  4A3L F;  1EIK A;  4AYB H;  1IW7 E;  4XSZ E;  3S2D E;  4A93 F;  5IPL E;  4MEX E;  3S1Q F;  5FJ8 E;  4OIR E;  3GTG E;  2PMZ H;  3GTG F;  2A69 E;  4ZH4 E;  3GTK E;  4A3I F;  4XSX E;  4JK1 E;  4G7H E;  1TWC E;  5M3M E;  5M3M F;  5BYH E;  2NVQ F;  5TMC E;  4Y52 E;  4A3E E;  4BBR F;  3HOX F;  4A3E F;  3GTM E;  1R9T E;  3GTM F;  2JA6 E;  1TWA E;  1TWA F;  4OIO E;  1WCM E;  4A3J F;  4A3J E;  3H3V F;  3HOU E;  3HOU F;  3HOY E;  3HOY F;  3RZD F;  2YU9 F;  4QIW H;  1TWF F;  3H0G F; 
#chains in the Genus database with same CATH homology
 3I4N F;  2NVT F;  2KRX A;  4A3C F;  4A3D F;  5M3F F;  2E2J F;  2JA7 F;  3S15 F;  2R7Z F;  4A3F F;  3WOD E;  5IP9 F;  3I4M F;  3GTQ F;  1I6H F;  2NVX F;  2R93 F;  3H0G F;  4AYB K;  3HOW F;  4BXX F;  4LK1 E;  4C3I F;  5IYB F;  2PMZ K;  4G7O E;  2E2I F;  1TWG F;  5E17 E;  3HKZ K;  1I3Q F;  4LK0 E;  3GTP F;  1Y1V F;  4XLN E;  3PO2 F;  4YFN E;  5C4X F;  3GTO F;  2BE5 E;  5E18 E;  2A6E E;  4YG2 E;  4X6A F;  3H3V G;  4KMU E;  1I50 F;  1TWH F;  1I6V E;  5C44 F;  3PO3 F;  2O5J E;  4A3K F;  4OIN E;  5C3E F;  1K83 F;  3CQZ F;  3S1M F;  4A3G F;  3S16 F;  2NVY F;  4YFX E;  1HQM E;  5IP7 F;  5IYD F;  4YFK E;  3S14 F;  5D4E E;  3DXJ E;  2WB1 I;  3RZO F;  2A68 E;  3M4O F;  3S17 F;  4KN7 E;  5D4D E;  5IYC F;  3S1R F;  3S2H F;  4MEY E;  1YNN K;  4Q5S E;  4Y7N F;  1ZYR E;  3HOZ F;  4BBS F;  5M5W F;  5M5X F;  2B63 F;  4C3J F;  4C3H F;  3HOV F;  2PPB E;  2CW0 E;  1SFO F;  2JA5 F;  4BY1 F;  5FLM F;  2E2H F;  4QIW K;  4OIQ E;  4OIP E;  3S2D F;  3FKI F;  4LJZ E;  5FJ8 F;  4BY7 F;  4C2M F;  1YNJ K;  5C4J F;  4KN4 E;  5D4C E;  3GTK F;  1TWC F;  1SMY E;  4Q4Z E;  4XLP E;  4Y52 F;  2WAQ K;  3GTJ F;  1R9T F;  4MQ9 E;  2JA6 F;  2Y0S I;  1WCM F;  2A6H E;  5TMF E;  3EQL E;  1QKL A;  2O5I E;  5M5Y F;  1Y1W F;  2VUM F;  3S1N F;  2R92 F;  2JA8 F;  4A3M F;  4GZY E;  4LLG E;  4G7Z E;  3M3Y F;  4A3B F;  4A3L F;  3K7A F;  3GTL F;  1IW7 E;  4XSZ E;  4A93 F;  5IPL E;  4MEX E;  3S1Q F;  4OIR E;  3GTG F;  2A69 E;  4ZH4 E;  4A3I F;  4XSX E;  4JK1 E;  4G7H E;  5M3M F;  5BYH E;  2NVQ F;  5TMC E;  3HOX F;  4A3E F;  3GTM F;  4OIO E;  1TWA F;  4A3J F;  3HOU F;  3HOY F;  3RZD F;  2YU9 F;  1TWF F;  4BBR F; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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