1SMYE

Structural basis for transcription regulation by alarmone ppgpp
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
95
structure length
95
Chain Sequence
AEPGIDKLFGMVDSKYRLTVVVAKRAQQLLRHGFKNTVLEPEERPKMQTLEGLFDDPNAETWAMKELLTGRLVFGENLVPEDRLQKEMERIYPGE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for transcription regulation by alarmone ppGpp
pubmed doi rcsb
molecule tags Transferase
molecule keywords DNA-directed RNA polymerase alpha chain
total genus 18
structure length 95
sequence length 95
chains with identical sequence O
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2004-03-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 1smyE00
3S2DF 3S1RF 4AYBK 2B63F 2R7ZF 2E2HF 4XLPE 3DXJE 3HOZF 5E17E 1SFOF 4OIQE 4G7OE 2O5IE 4C3JF 3GTLF 4LK1E 4A3BF 4XLNE 4LLGE 4YFNE 4A3JF 5C4XF 4BXXF 4A3GF 2NVXF 1K83F 4BBSF 2WAQK 4OIRE 3H3VG 2CW0E 4A3KF 1ZYRE 4YFXE 5TMFE 4G7HE 2NVYF 3PO3F 3S1QF 4A93F 2A68E 4OIPE 4YG2E 2VUMF 4A3DF 4C2MF 3GTGF 4KN7E 4BBRF 5C3EF 2NVQF 3I4NF 2A6EE 2O5JE 4MEXE 5E18E 1IW7E 1WCMF 4A3MF 3EQLE 2R93F 3HOVF 4KN4E 4BY1F 1I6VE 4XSXE 1SMYE 4MEYE 4XSZE 4YFKE 5BYHE 1TWHF 3K7AF 5M5WF 3HOYF 2R92F 3S15F 5C4JF 4GZYE 3CQZF 4X6AF 5IYCF 2PPBE 3M4OF 4Q5SE 2JA8F 1TWAF 5IP7F 3HOXF 1TWCF 3H0GF 3GTOF 4Y7NF 3S1NF 1YNNK 3GTQF 2A69E 4KMUE 5FJ8F 3RZDF 4A3FF 1I3QF 1TWFF 3GTKF 3S2HF 4ZH4E 3PO2F 3FKIF 1Y1VF 1YNJK 3HOUF 1I50F 2WB1I 3S14F 4LK0E 3WODE 2E2JF 5M5YF 1R9TF 4A3IF 2YU9F 5IYBF 5D4CE 2A6HE 1I6HF 4BY7F 5D4DE 3GTMF 5M5XF 2JA6F 2Y0SI 5FLMF 4A3LF 3HKZK 3RZOF 2PMZK 5M3MF 5D4EE 1QKLA 4JK1E 4Q4ZE 3S16F 3S1MF 4MQ9E 4A3EF 3HOWF 4Y52F 4A3CF 5IYDF 1Y1WF 2E2IF 2JA7F 3I4MF 4OIOE 4C3IF 4OINE 4C3HF 1TWGF 5TMCE 4G7ZE 2NVTF 2BE5E 2JA5F 4LJZE 5M3FF 3GTPF 5IP9F 3S17F 3M3YF 3GTJF 1HQME 5C44F 5IPLE
chains in the Genus database with same CATH superfamily
3S2DF 3S1RF 4AYBK 2B63F 2R7ZF 3S17E 4A3DE 4C2ME 3HKZH 2PMZH 2KRXA 3DXJE 4XLPE 2E2HF 3HOZF 5C3EE 4BBRE 1SFOF 4OIQE 2B63E 2NVQE 4G7OE 1I6HE 2O5IE 4C3JF 3I4NE 3GTLF 4LK1E 4A3BF 4XLNE 4LLGE 1WCME 4C3JE 4YFNE 4A3JF 4A3ME 5C4XF 3GTLE 4BXXF 4A3GF 4BY1E 2NVXF 1K83F 4BBSF 2WAQK 4A3JE 4OIRE 3H3VG 2CW0E 4A3KF 1ZYRE 4YFXE 1K83E 5TMFE 4G7HE 2NVYF 3PO3F 1TWHE 3K7AE 5M5WE 3S1QF 4A93F 2A68E 4OIPE 4YG2E 4A3KE 3HOYE 3S15E 2VUMF 3PO3E 4X6AE 5IYCE 4A93E 4A3DF 3H3VF 3M4OE 4C2MF 3GTGF 4AYBH 4KN7E 4BBRF 5C3EF 2NVQF 3HOXE 1TWCE 3GTGE 3H0GE 3GTOE 3I4NF 4Y7NE 2A6EE 3S1NE 2O5JE 4MEXE 5E18E 1IW7E 1WCMF 4A3MF 3GTQE 3EQLE 2R93F 5FJ8E 3HOVF 4KN4E 4BY1F 3RZDE 1I6VE 4A3FE 1I3QE 4XSXE 1SMYE 4MEYE 4XSZE 4YFKE 2VUME 3HOVE 3S2HE 2R93E 3PO2E 2WAQH 2WB1H 3FKIE 5BYHE 1Y1VE 1TWHF 3K7AF 5M5WF 1I50E 3HOYF 3S14E 2R92F 3S15F 5C4JF 4GZYE 3CQZF 2E2JE 4X6AF 5IYCF 2YU9E 2R92E 5C4JE 2PPBE 3M4OF 3CQZE 4Q5SE 2JA8F 2Y0SH 1TWAF 5IP7F 3HOXF 1TWCF 3GTME 4QIWK 1EIKA 3H0GF 2JA8E 3GTOF 4Y7NF 1TWAE 5FLME 5IP7E 3S1NF 1YNNK 5M3ME 3GTQF 2A69E 4KMUE 5FJ8F 3RZDF 1DZFA 1I3QF 1TWFF 4A3FF 3GTKF 3S2HF 3S16E 4ZH4E 3S1ME 3PO2F 3FKIF 4A3EE 3HOWE 1TWFE 3GTKE 1Y1VF 1YNJK 4A3CE 3HOUF 4Y52E 1I50F 1Y1WE 2E2IE 2WB1I 3S14F 4LK0E 3WODE 2E2JF 5M5YF 4C3IE 3I4ME 1TWGE 4C3HE 1R9TF 3HOUE 4A3IF 2YU9F 5IYBF 2NVTE 5M5YE 1R9TE 5D4CE 4A3IE 2A6HE 5IYBE 1I6HF 5M3FE 4BY7F 5D4DE 5IP9E 3GTMF 3GTPE 5M5XF 2JA6F 3GTJE 3M3YE 2Y0SI 5C44E 5FLMF 4QIWH 4A3LF 3S2DE 3HKZK 3S1RE 3RZOF 2PMZK 5M3MF 5M5XE 2JA6E 5D4EE 2R7ZE 4BY7E 2E2HE 4A3LE 3HOZE 3RZOE 1QKLA 4JK1E 1SFOE 4Q4ZE 3S16F 3S1MF 4MQ9E 4A3EF 3HOWF 4A3BE 4Y52F 4A3CF 5IYDF 1Y1WF 2E2IF 5C4XE 2JA7F 4BXXE 4A3GE 2NVXE 3I4MF 4OIOE 4C3IF 4OINE 1TWGF 4C3HF 5TMCE 4BBSE 5IYDE 4G7ZE 2JA7E 2NVTF 5E17E 2BE5E 2NVYE 4LJZE 2JA5F 3S1QE 2JA5E 5M3FF 3GTPF 5IP9F 3S17F 3M3YF 3GTJF 1HQME 5C44F 5IPLE
chains in the Genus database with same CATH topology
3S2DF 3S1RF 4AYBK 2B63F 2R7ZF 2E2HF 2KRXA 3DXJE 4XLPE 3HOZF 5E17E 1SFOF 4OIQE 4G7OE 2O5IE 4C3JF 3GTLF 4LK1E 4A3BF 4XLNE 4LLGE 4YFNE 4A3JF 5C4XF 4BXXF 4A3GF 2NVXF 1K83F 4BBSF 2WAQK 4OIRE 3H3VG 2CW0E 4A3KF 1ZYRE 4YFXE 5TMFE 4G7HE 2NVYF 3PO3F 3S1QF 4A93F 2A68E 4OIPE 4YG2E 2VUMF 4A3DF 4C2MF 3GTGF 4KN7E 4BBRF 5C3EF 2NVQF 3I4NF 2A6EE 2O5JE 4MEXE 5E18E 1IW7E 1WCMF 4A3MF 3EQLE 2R93F 3HOVF 4KN4E 4BY1F 1I6VE 4XSXE 1SMYE 4MEYE 4XSZE 4YFKE 5BYHE 1TWHF 3K7AF 5M5WF 3HOYF 2R92F 3S15F 5C4JF 4GZYE 3CQZF 4X6AF 5IYCF 2PPBE 3M4OF 4Q5SE 2JA8F 1TWAF 5IP7F 3HOXF 1TWCF 4QIWK 3H0GF 3GTOF 4Y7NF 3S1NF 1YNNK 3GTQF 2A69E 4KMUE 5FJ8F 3RZDF 4A3FF 1I3QF 1TWFF 3GTKF 3S2HF 4ZH4E 3PO2F 3FKIF 1Y1VF 1YNJK 3HOUF 1I50F 2WB1I 3S14F 4LK0E 3WODE 2E2JF 5M5YF 1R9TF 4A3IF 2YU9F 5IYBF 5D4CE 2A6HE 1I6HF 4BY7F 5D4DE 3GTMF 5M5XF 2JA6F 2Y0SI 5FLMF 4A3LF 3HKZK 3RZOF 2PMZK 5M3MF 5D4EE 1QKLA 4JK1E 4Q4ZE 3S16F 3S1MF 4MQ9E 4A3EF 3HOWF 4Y52F 4A3CF 5IYDF 1Y1WF 2E2IF 2JA7F 3I4MF 4OIOE 4C3IF 4OINE 4C3HF 1TWGF 5TMCE 4G7ZE 2NVTF 2BE5E 2JA5F 4LJZE 5M3FF 3GTPF 5IP9F 3S17F 3M3YF 3GTJF 1HQME 5C44F 5IPLE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3S2D F;  3S1R F;  4AYB K;  2B63 F;  2R7Z F;  2E2H F;  4XLP E;  3DXJ E;  3HOZ F;  5E17 E;  1SFO F;  4OIQ E;  4G7O E;  2O5I E;  4C3J F;  3GTL F;  4LK1 E;  4A3B F;  4XLN E;  4LLG E;  4YFN E;  4A3J F;  5C4X F;  4BXX F;  4A3G F;  2NVX F;  1K83 F;  4BBS F;  2WAQ K;  4OIR E;  3H3V G;  2CW0 E;  4A3K F;  1ZYR E;  4YFX E;  5TMF E;  4G7H E;  2NVY F;  3PO3 F;  3S1Q F;  4A93 F;  2A68 E;  4OIP E;  4YG2 E;  2VUM F;  4A3D F;  4C2M F;  3GTG F;  4KN7 E;  4BBR F;  5C3E F;  2NVQ F;  3I4N F;  2A6E E;  2O5J E;  4MEX E;  5E18 E;  1IW7 E;  1WCM F;  4A3M F;  3EQL E;  2R93 F;  3HOV F;  4KN4 E;  4BY1 F;  1I6V E;  4XSX E;  1SMY E;  4MEY E;  4XSZ E;  4YFK E;  5BYH E;  1TWH F;  3K7A F;  5M5W F;  3HOY F;  2R92 F;  3S15 F;  5C4J F;  4GZY E;  3CQZ F;  4X6A F;  5IYC F;  2PPB E;  3M4O F;  4Q5S E;  2JA8 F;  1TWA F;  5IP7 F;  3HOX F;  1TWC F;  3H0G F;  3GTO F;  4Y7N F;  3S1N F;  1YNN K;  3GTQ F;  2A69 E;  4KMU E;  5FJ8 F;  3RZD F;  4A3F F;  1I3Q F;  1TWF F;  3GTK F;  3S2H F;  4ZH4 E;  3PO2 F;  3FKI F;  1Y1V F;  1YNJ K;  3HOU F;  1I50 F;  2WB1 I;  3S14 F;  4LK0 E;  3WOD E;  2E2J F;  5M5Y F;  1R9T F;  4A3I F;  2YU9 F;  5IYB F;  5D4C E;  2A6H E;  1I6H F;  4BY7 F;  5D4D E;  3GTM F;  5M5X F;  2JA6 F;  2Y0S I;  5FLM F;  4A3L F;  3HKZ K;  3RZO F;  2PMZ K;  5M3M F;  5D4E E;  1QKL A;  4JK1 E;  4Q4Z E;  3S16 F;  3S1M F;  4MQ9 E;  4A3E F;  3HOW F;  4Y52 F;  4A3C F;  5IYD F;  1Y1W F;  2E2I F;  2JA7 F;  3I4M F;  4OIO E;  4C3I F;  4OIN E;  4C3H F;  1TWG F;  5TMC E;  4G7Z E;  2NVT F;  2BE5 E;  2JA5 F;  4LJZ E;  5M3F F;  3GTP F;  5IP9 F;  3S17 F;  3M3Y F;  3GTJ F;  1HQM E;  5C44 F;  5IPL E; 
#chains in the Genus database with same CATH topology
 3S2D F;  3S1R F;  4AYB K;  2B63 F;  2R7Z F;  3S17 E;  4A3D E;  4C2M E;  3HKZ H;  2PMZ H;  2KRX A;  3DXJ E;  4XLP E;  2E2H F;  3HOZ F;  5C3E E;  4BBR E;  1SFO F;  4OIQ E;  2B63 E;  2NVQ E;  4G7O E;  1I6H E;  2O5I E;  4C3J F;  3I4N E;  3GTL F;  4LK1 E;  4A3B F;  4XLN E;  4LLG E;  1WCM E;  4C3J E;  4YFN E;  4A3J F;  4A3M E;  5C4X F;  3GTL E;  4BXX F;  4A3G F;  4BY1 E;  2NVX F;  1K83 F;  4BBS F;  2WAQ K;  4A3J E;  4OIR E;  3H3V G;  2CW0 E;  4A3K F;  1ZYR E;  4YFX E;  1K83 E;  5TMF E;  4G7H E;  2NVY F;  3PO3 F;  1TWH E;  3K7A E;  5M5W E;  3S1Q F;  4A93 F;  2A68 E;  4OIP E;  4YG2 E;  4A3K E;  3HOY E;  3S15 E;  2VUM F;  3PO3 E;  4X6A E;  5IYC E;  4A93 E;  4A3D F;  3H3V F;  3M4O E;  4C2M F;  3GTG F;  4AYB H;  4KN7 E;  4BBR F;  5C3E F;  2NVQ F;  3HOX E;  1TWC E;  3GTG E;  3H0G E;  3GTO E;  3I4N F;  4Y7N E;  2A6E E;  3S1N E;  2O5J E;  4MEX E;  5E18 E;  1IW7 E;  1WCM F;  4A3M F;  3GTQ E;  3EQL E;  2R93 F;  5FJ8 E;  3HOV F;  4KN4 E;  4BY1 F;  3RZD E;  1I6V E;  4A3F E;  1I3Q E;  4XSX E;  1SMY E;  4MEY E;  4XSZ E;  4YFK E;  2VUM E;  3HOV E;  3S2H E;  2R93 E;  3PO2 E;  2WAQ H;  2WB1 H;  3FKI E;  5BYH E;  1Y1V E;  1TWH F;  3K7A F;  5M5W F;  1I50 E;  3HOY F;  3S14 E;  2R92 F;  3S15 F;  5C4J F;  4GZY E;  3CQZ F;  2E2J E;  4X6A F;  5IYC F;  2YU9 E;  2R92 E;  5C4J E;  2PPB E;  3M4O F;  3CQZ E;  4Q5S E;  2JA8 F;  2Y0S H;  1TWA F;  5IP7 F;  3HOX F;  1TWC F;  3GTM E;  4QIW K;  1EIK A;  3H0G F;  2JA8 E;  3GTO F;  4Y7N F;  1TWA E;  5FLM E;  5IP7 E;  3S1N F;  1YNN K;  5M3M E;  3GTQ F;  2A69 E;  4KMU E;  5FJ8 F;  3RZD F;  1DZF A;  1I3Q F;  1TWF F;  4A3F F;  3GTK F;  3S2H F;  3S16 E;  4ZH4 E;  3S1M E;  3PO2 F;  3FKI F;  4A3E E;  3HOW E;  1TWF E;  3GTK E;  1Y1V F;  1YNJ K;  4A3C E;  3HOU F;  4Y52 E;  1I50 F;  1Y1W E;  2E2I E;  2WB1 I;  3S14 F;  4LK0 E;  3WOD E;  2E2J F;  5M5Y F;  4C3I E;  3I4M E;  1TWG E;  4C3H E;  1R9T F;  3HOU E;  4A3I F;  2YU9 F;  5IYB F;  2NVT E;  5M5Y E;  1R9T E;  5D4C E;  4A3I E;  2A6H E;  5IYB E;  1I6H F;  5M3F E;  4BY7 F;  5D4D E;  5IP9 E;  3GTM F;  3GTP E;  5M5X F;  2JA6 F;  3GTJ E;  3M3Y E;  2Y0S I;  5C44 E;  5FLM F;  4QIW H;  4A3L F;  3S2D E;  3HKZ K;  3S1R E;  3RZO F;  2PMZ K;  5M3M F;  5M5X E;  2JA6 E;  5D4E E;  2R7Z E;  4BY7 E;  2E2H E;  4A3L E;  3HOZ E;  3RZO E;  1QKL A;  4JK1 E;  1SFO E;  4Q4Z E;  3S16 F;  3S1M F;  4MQ9 E;  4A3E F;  3HOW F;  4A3B E;  4Y52 F;  4A3C F;  5IYD F;  1Y1W F;  2E2I F;  5C4X E;  2JA7 F;  4BXX E;  4A3G E;  2NVX E;  3I4M F;  4OIO E;  4C3I F;  4OIN E;  1TWG F;  4C3H F;  5TMC E;  4BBS E;  5IYD E;  4G7Z E;  2JA7 E;  2NVT F;  5E17 E;  2BE5 E;  2NVY E;  4LJZ E;  2JA5 F;  3S1Q E;  2JA5 E;  5M3F F;  3GTP F;  5IP9 F;  3S17 F;  3M3Y F;  3GTJ F;  1HQM E;  5C44 F;  5IPL E; 
#chains in the Genus database with same CATH homology
 3S2D F;  3S1R F;  4AYB K;  2B63 F;  2R7Z F;  2E2H F;  2KRX A;  3DXJ E;  4XLP E;  3HOZ F;  5E17 E;  1SFO F;  4OIQ E;  4G7O E;  2O5I E;  4C3J F;  3GTL F;  4LK1 E;  4A3B F;  4XLN E;  4LLG E;  4YFN E;  4A3J F;  5C4X F;  4BXX F;  4A3G F;  2NVX F;  1K83 F;  4BBS F;  2WAQ K;  4OIR E;  3H3V G;  2CW0 E;  4A3K F;  1ZYR E;  4YFX E;  5TMF E;  4G7H E;  2NVY F;  3PO3 F;  3S1Q F;  4A93 F;  2A68 E;  4OIP E;  4YG2 E;  2VUM F;  4A3D F;  4C2M F;  3GTG F;  4KN7 E;  4BBR F;  5C3E F;  2NVQ F;  3I4N F;  2A6E E;  2O5J E;  4MEX E;  5E18 E;  1IW7 E;  1WCM F;  4A3M F;  3EQL E;  2R93 F;  3HOV F;  4KN4 E;  4BY1 F;  1I6V E;  4XSX E;  1SMY E;  4MEY E;  4XSZ E;  4YFK E;  5BYH E;  1TWH F;  3K7A F;  5M5W F;  3HOY F;  2R92 F;  3S15 F;  5C4J F;  4GZY E;  3CQZ F;  4X6A F;  5IYC F;  2PPB E;  3M4O F;  4Q5S E;  2JA8 F;  1TWA F;  5IP7 F;  3HOX F;  1TWC F;  4QIW K;  3H0G F;  3GTO F;  4Y7N F;  3S1N F;  1YNN K;  3GTQ F;  2A69 E;  4KMU E;  5FJ8 F;  3RZD F;  4A3F F;  1I3Q F;  1TWF F;  3GTK F;  3S2H F;  4ZH4 E;  3PO2 F;  3FKI F;  1Y1V F;  1YNJ K;  3HOU F;  1I50 F;  2WB1 I;  3S14 F;  4LK0 E;  3WOD E;  2E2J F;  5M5Y F;  1R9T F;  4A3I F;  2YU9 F;  5IYB F;  5D4C E;  2A6H E;  1I6H F;  4BY7 F;  5D4D E;  3GTM F;  5M5X F;  2JA6 F;  2Y0S I;  5FLM F;  4A3L F;  3HKZ K;  3RZO F;  2PMZ K;  5M3M F;  5D4E E;  1QKL A;  4JK1 E;  4Q4Z E;  3S16 F;  3S1M F;  4MQ9 E;  4A3E F;  3HOW F;  4Y52 F;  4A3C F;  5IYD F;  1Y1W F;  2E2I F;  2JA7 F;  3I4M F;  4OIO E;  4C3I F;  4OIN E;  4C3H F;  1TWG F;  5TMC E;  4G7Z E;  2NVT F;  2BE5 E;  2JA5 F;  4LJZ E;  5M3F F;  3GTP F;  5IP9 F;  3S17 F;  3M3Y F;  3GTJ F;  1HQM E;  5C44 F;  5IPL E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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