1TWCE

Rna polymerase ii complexed with gtp
Total Genus 63
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
63
sequence length
215
structure length
215
Chain Sequence
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSAMKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center.
pubmed doi rcsb
molecule tags Transcription
molecule keywords DNA-directed RNA polymerase II largest subunit
total genus 63
structure length 215
sequence length 215
ec nomenclature
pdb deposition date 2004-06-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01191 RNA_pol_Rpb5_C RNA polymerase Rpb5, C-terminal domain
E PF03871 RNA_pol_Rpb5_N RNA polymerase Rpb5, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1340.10 Alpha Beta 3-Layer(aba) Sandwich Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1 RNA polymerase, Rpb5, N-terminal domain 1twcE01
3.90.940.20 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit RPB5-like RNA polymerase subunit 1twcE02
3HOXE 3GTQE 5C4XE 4C2ME 2NVXE 4A3DE 5C3EE 5FLME 3CQZE 1TWGE 3GTOE 1Y1WE 5IYDE 2JA5E 2R93E 4C3JE 3S16E 3GTME 4A3CE 4C3HE 1TWHE 3S1ME 4A3BE 2JA7E 3S2HE 5C44E 3GTGE 4A3FE 3GTKE 1TWCE 2R92E 3PO3E 3RZOE 3HOZE 5C4JE 3HOUE 1DZFA 3HKZH 2NVQE 3S1QE 4BY1E 5IP7E 2WAQH 3S2DE 3H3VF 3S1NE 2YU9E 5M3FE 2PMZH 3I4ME 4AYBH 1R9TE 3GTPE 1I3QE 2NVYE 4X6AE 3S1RE 1Y1VE 4A3JE 5M3ME 2JA8E 4BBSE 2WB1H 4A3EE 1K83E 4A3KE 3PO2E 3H0GE 1WCME 4A3LE 2NVTE 4BY7E 1SFOE 1EIKA 2JA6E 2Y0SH 1I50E 1I6HE 4A93E 5IYBE 4A3IE 3M3YE 2E2IE 3GTLE 4Y7NE 5IYCE 4QIWH 3K7AE 4C3IE 3M4OE 5IP9E 2B63E 3I4NE 4BBRE 4Y52E 2E2JE 1TWAE 3HOVE 1TWFE 2E2HE 3S17E 3S15E 3S14E 3HOWE 5M5YE 4A3ME 3HOYE 5FJ8E 3RZDE 2R7ZE 3GTJE 4A3GE 5M5WE 3FKIE 2VUME 5M5XE 4BXXE
chains in the Genus database with same CATH superfamily
3HOXE 3GTQE 5C4XE 2A6EE 4LJZE 4C2ME 2NVXE 4A3DE 5C3EE 5FLME 3CQZE 4ZH4E 1TWGE 3GTOE 3S1QF 1Y1WE 2JA6F 3EQLE 4LLGE 4BY1F 4XLNE 5IP7F 4OIOE 5E17E 4OINE 3S2DF 5IYDE 3S1NF 2YU9F 2JA5E 5M3FF 3I4MF 1I6HF 3GTPF 2R93E 4A93F 2NVYF 5IYBF 4MEXE 4LK0E 4C3JE 3S1RF 1Y1VF 4A3JF 5M3MF 3M3YF 2BE5E 4XLPE 3GTLF 3K7AF 4A3EF 3S16E 1K83F 3WODE 3GTME 2CW0E 1SMYE 1IW7E 4A3CE 3M4OF 3PO2F 4C3HE 1TWHE 2O5JE 3S1ME 2B63F 1WCMF 4A3BE 4BBRF 3I4NF 2JA7E 3S2HE 5C44E 3GTGE 4A3FE 3GTKE 4A3LF 1TWCE 4BY7F 4G7OE 2R92E 3PO3E 3RZOE 4Q4ZE 3H3VG 3GTQF 5D4EE 4G7ZE 3S17F 3HOZE 1SFOF 4OIQE 3HOWF 5C4JE 3HOUE 5M5YF 1DZFA 5IPLE 2R7ZF 4GZYE 3GTJF 4A3GF 3HKZH 2NVQE 3S1QE 1I50F 4BY1E 2E2IF 5IP7E 2WAQH 5M5XF 3S2DE 3H3VF 2A6HE 4MQ9E 4A3IF 3S1NE 3HKZK 4Y7NF 2YU9E 3HOXF 5M3FE 2PMZH 3DXJE 4Q5SE 5IYCF 2NVXF 3I4ME 4AYBH 1R9TE 3GTPE 1I3QE 5FLMF 2NVYE 2WAQK 4YG2E 4YFNE 4X6AE 3GTOF 4C3IF 1YNNK 3S1RE 1Y1VE 4A3JE 5M3ME 2JA8E 4BBSE 1HQME 2PMZK 2WB1H 4KN7E 4XSZE 5IP9F 4AYBK 4A3EE 1K83E 4Y52F 4A3KE 5TMCE 1TWAF 2E2JF 2JA5F 3PO2E 3HOVF 3H0GE 1TWFF 1WCME 4A3LE 2E2HF 2NVTE 4BY7E 3S15F 3S14F 5BYHE 4A3MF 3HOYF 1QKLA 5FJ8F 3RZDF 4OIRE 1YNJK 4C3HF 1SFOE 1EIKA 5M5WF 2JA6E 4A3BF 2Y0SH 2KRXA 3FKIF 2JA7F 2VUMF 4A3FF 3GTGF 4KN4E 3S2HF 4BXXF 4C2MF 1I6VE 1I50E 4YFKE 1I6HE 5C3EF 2PPBE 4A93E 2O5IE 5IYBE 3CQZF 4A3DF 5D4DE 1TWGF 4A3IE 5TMFE 2NVTF 3M3YE 1Y1WF 2E2IE 3GTLE 4Y7NE 2Y0SI 5C4JF 3HOUF 5IYCE 4QIWH 3K7AE 5IYDF 1ZYRE 5E18E 2NVQF 4C3IE 3M4OE 2A69E 4JK1E 2R93F 4QIWK 5IP9E 2B63E 3I4NE 4BBRE 4MEYE 2WB1I 4C3JF 4Y52E 2E2JE 1TWAE 3HOVE 1R9TF 1TWFE 1I3QF 5D4CE 3GTKF 3GTMF 3HOZF 3S16F 4X6AF 4A3CF 2JA8F 2E2HE 3S17E 1TWHF 4XSXE 4BBSF 3S15E 3S14E 3HOWE 3S1MF 5M5YE 4OIPE 4A3ME 3HOYE 4KMUE 5C44F 5FJ8E 3RZDE 2R7ZE 1TWCF 4A3KF 3GTJE 4A3GE 4YFXE 2A68E 4G7HE 3H0GF 2R92F 5M5WE 3PO3F 5C4XF 3RZOF 3FKIE 2VUME 5M5XE 4LK1E 4BXXE
chains in the Genus database with same CATH topology
3HOXE 3GTQE 5C4XE 4C2ME 2NVXE 4A3DE 5C3EE 5FLME 3CQZE 1TWGE 3GTOE 1Y1WE 5IYDE 2JA5E 2R93E 4C3JE 3S16E 3GTME 4A3CE 4C3HE 1TWHE 3S1ME 4A3BE 2JA7E 3S2HE 5C44E 3GTGE 4A3FE 3GTKE 1TWCE 2R92E 3PO3E 3RZOE 3HOZE 5C4JE 3HOUE 1DZFA 3HKZH 2NVQE 3S1QE 4BY1E 5IP7E 2WAQH 3S2DE 3H3VF 3S1NE 2YU9E 5M3FE 2PMZH 3I4ME 4AYBH 1R9TE 3GTPE 1I3QE 2NVYE 4X6AE 3S1RE 1Y1VE 4A3JE 5M3ME 2JA8E 4BBSE 2WB1H 4A3EE 1K83E 4A3KE 3PO2E 3H0GE 1WCME 4A3LE 2NVTE 4BY7E 1SFOE 1EIKA 2JA6E 2Y0SH 1I50E 1I6HE 4A93E 5IYBE 4A3IE 3M3YE 2E2IE 3GTLE 4Y7NE 5IYCE 4QIWH 3K7AE 4C3IE 3M4OE 5IP9E 2B63E 3I4NE 4BBRE 4Y52E 2E2JE 1TWAE 3HOVE 1TWFE 2E2HE 3S17E 3S15E 3S14E 3HOWE 5M5YE 4A3ME 3HOYE 5FJ8E 3RZDE 2R7ZE 3GTJE 4A3GE 5M5WE 3FKIE 2VUME 5M5XE 4BXXE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3HOX E;  3GTQ E;  5C4X E;  4C2M E;  2NVX E;  4A3D E;  5C3E E;  5FLM E;  3CQZ E;  1TWG E;  3GTO E;  1Y1W E;  5IYD E;  2JA5 E;  2R93 E;  4C3J E;  3S16 E;  3GTM E;  4A3C E;  4C3H E;  1TWH E;  3S1M E;  4A3B E;  2JA7 E;  3S2H E;  5C44 E;  3GTG E;  4A3F E;  3GTK E;  1TWC E;  2R92 E;  3PO3 E;  3RZO E;  3HOZ E;  5C4J E;  3HOU E;  1DZF A;  3HKZ H;  2NVQ E;  3S1Q E;  4BY1 E;  5IP7 E;  2WAQ H;  3S2D E;  3H3V F;  3S1N E;  2YU9 E;  5M3F E;  2PMZ H;  3I4M E;  4AYB H;  1R9T E;  3GTP E;  1I3Q E;  2NVY E;  4X6A E;  3S1R E;  1Y1V E;  4A3J E;  5M3M E;  2JA8 E;  4BBS E;  2WB1 H;  4A3E E;  1K83 E;  4A3K E;  3PO2 E;  3H0G E;  1WCM E;  4A3L E;  2NVT E;  4BY7 E;  1SFO E;  1EIK A;  2JA6 E;  2Y0S H;  1I50 E;  1I6H E;  4A93 E;  5IYB E;  4A3I E;  3M3Y E;  2E2I E;  3GTL E;  4Y7N E;  5IYC E;  4QIW H;  3K7A E;  4C3I E;  3M4O E;  5IP9 E;  2B63 E;  3I4N E;  4BBR E;  4Y52 E;  2E2J E;  1TWA E;  3HOV E;  1TWF E;  2E2H E;  3S17 E;  3S15 E;  3S14 E;  3HOW E;  5M5Y E;  4A3M E;  3HOY E;  5FJ8 E;  3RZD E;  2R7Z E;  3GTJ E;  4A3G E;  5M5W E;  3FKI E;  2VUM E;  5M5X E;  4BXX E; 
#chains in the Genus database with same CATH topology
 3HOX E;  3GTQ E;  5C4X E;  2A6E E;  4LJZ E;  4C2M E;  2NVX E;  4A3D E;  5C3E E;  5FLM E;  3CQZ E;  4ZH4 E;  1TWG E;  3GTO E;  3S1Q F;  1Y1W E;  2JA6 F;  3EQL E;  4LLG E;  4BY1 F;  4XLN E;  5IP7 F;  4OIO E;  5E17 E;  4OIN E;  3S2D F;  5IYD E;  3S1N F;  2YU9 F;  2JA5 E;  5M3F F;  3I4M F;  1I6H F;  3GTP F;  2R93 E;  4A93 F;  2NVY F;  5IYB F;  4MEX E;  4LK0 E;  4C3J E;  3S1R F;  1Y1V F;  4A3J F;  5M3M F;  3M3Y F;  2BE5 E;  4XLP E;  3GTL F;  3K7A F;  4A3E F;  3S16 E;  1K83 F;  3WOD E;  3GTM E;  2CW0 E;  1SMY E;  1IW7 E;  4A3C E;  3M4O F;  3PO2 F;  4C3H E;  1TWH E;  2O5J E;  3S1M E;  2B63 F;  1WCM F;  4A3B E;  4BBR F;  3I4N F;  2JA7 E;  3S2H E;  5C44 E;  3GTG E;  4A3F E;  3GTK E;  4A3L F;  1TWC E;  4BY7 F;  4G7O E;  2R92 E;  3PO3 E;  3RZO E;  4Q4Z E;  3H3V G;  3GTQ F;  5D4E E;  4G7Z E;  3S17 F;  3HOZ E;  1SFO F;  4OIQ E;  3HOW F;  5C4J E;  3HOU E;  5M5Y F;  1DZF A;  5IPL E;  2R7Z F;  4GZY E;  3GTJ F;  4A3G F;  3HKZ H;  2NVQ E;  3S1Q E;  1I50 F;  4BY1 E;  2E2I F;  5IP7 E;  2WAQ H;  5M5X F;  3S2D E;  3H3V F;  2A6H E;  4MQ9 E;  4A3I F;  3S1N E;  3HKZ K;  4Y7N F;  2YU9 E;  3HOX F;  5M3F E;  2PMZ H;  3DXJ E;  4Q5S E;  5IYC F;  2NVX F;  3I4M E;  4AYB H;  1R9T E;  3GTP E;  1I3Q E;  5FLM F;  2NVY E;  2WAQ K;  4YG2 E;  4YFN E;  4X6A E;  3GTO F;  4C3I F;  1YNN K;  3S1R E;  1Y1V E;  4A3J E;  5M3M E;  2JA8 E;  4BBS E;  1HQM E;  2PMZ K;  2WB1 H;  4KN7 E;  4XSZ E;  5IP9 F;  4AYB K;  4A3E E;  1K83 E;  4Y52 F;  4A3K E;  5TMC E;  1TWA F;  2E2J F;  2JA5 F;  3PO2 E;  3HOV F;  3H0G E;  1TWF F;  1WCM E;  4A3L E;  2E2H F;  2NVT E;  4BY7 E;  3S15 F;  3S14 F;  5BYH E;  4A3M F;  3HOY F;  1QKL A;  5FJ8 F;  3RZD F;  4OIR E;  1YNJ K;  4C3H F;  1SFO E;  1EIK A;  5M5W F;  2JA6 E;  4A3B F;  2Y0S H;  2KRX A;  3FKI F;  2JA7 F;  2VUM F;  4A3F F;  3GTG F;  4KN4 E;  3S2H F;  4BXX F;  4C2M F;  1I6V E;  1I50 E;  4YFK E;  1I6H E;  5C3E F;  2PPB E;  4A93 E;  2O5I E;  5IYB E;  3CQZ F;  4A3D F;  5D4D E;  1TWG F;  4A3I E;  5TMF E;  2NVT F;  3M3Y E;  1Y1W F;  2E2I E;  3GTL E;  4Y7N E;  2Y0S I;  5C4J F;  3HOU F;  5IYC E;  4QIW H;  3K7A E;  5IYD F;  1ZYR E;  5E18 E;  2NVQ F;  4C3I E;  3M4O E;  2A69 E;  4JK1 E;  2R93 F;  4QIW K;  5IP9 E;  2B63 E;  3I4N E;  4BBR E;  4MEY E;  2WB1 I;  4C3J F;  4Y52 E;  2E2J E;  1TWA E;  3HOV E;  1R9T F;  1TWF E;  1I3Q F;  5D4C E;  3GTK F;  3GTM F;  3HOZ F;  3S16 F;  4X6A F;  4A3C F;  2JA8 F;  2E2H E;  3S17 E;  1TWH F;  4XSX E;  4BBS F;  3S15 E;  3S14 E;  3HOW E;  3S1M F;  5M5Y E;  4OIP E;  4A3M E;  3HOY E;  4KMU E;  5C44 F;  5FJ8 E;  3RZD E;  2R7Z E;  1TWC F;  4A3K F;  3GTJ E;  4A3G E;  4YFX E;  2A68 E;  4G7H E;  3H0G F;  2R92 F;  5M5W E;  3PO3 F;  5C4X F;  3RZO F;  3FKI E;  2VUM E;  5M5X E;  4LK1 E;  4BXX E; 
#chains in the Genus database with same CATH homology
 3HOX E;  3GTQ E;  5C4X E;  4C2M E;  2NVX E;  4A3D E;  5C3E E;  5FLM E;  3CQZ E;  1TWG E;  3GTO E;  1Y1W E;  5IYD E;  2JA5 E;  2R93 E;  4C3J E;  3S16 E;  3GTM E;  4A3C E;  4C3H E;  1TWH E;  3S1M E;  4A3B E;  2JA7 E;  3S2H E;  5C44 E;  3GTG E;  4A3F E;  3GTK E;  1TWC E;  2R92 E;  3PO3 E;  3RZO E;  3HOZ E;  5C4J E;  3HOU E;  1DZF A;  3HKZ H;  2NVQ E;  3S1Q E;  4BY1 E;  5IP7 E;  2WAQ H;  3S2D E;  3H3V F;  3S1N E;  2YU9 E;  5M3F E;  2PMZ H;  3I4M E;  4AYB H;  1R9T E;  3GTP E;  1I3Q E;  2NVY E;  4X6A E;  3S1R E;  1Y1V E;  4A3J E;  5M3M E;  2JA8 E;  4BBS E;  2WB1 H;  4A3E E;  1K83 E;  4A3K E;  3PO2 E;  3H0G E;  1WCM E;  4A3L E;  2NVT E;  4BY7 E;  1SFO E;  1EIK A;  2JA6 E;  2Y0S H;  1I50 E;  1I6H E;  4A93 E;  5IYB E;  4A3I E;  3M3Y E;  2E2I E;  3GTL E;  4Y7N E;  5IYC E;  4QIW H;  3K7A E;  4C3I E;  3M4O E;  5IP9 E;  2B63 E;  3I4N E;  4BBR E;  4Y52 E;  2E2J E;  1TWA E;  3HOV E;  1TWF E;  2E2H E;  3S17 E;  3S15 E;  3S14 E;  3HOW E;  5M5Y E;  4A3M E;  3HOY E;  5FJ8 E;  3RZD E;  2R7Z E;  3GTJ E;  4A3G E;  5M5W E;  3FKI E;  2VUM E;  5M5X E;  4BXX E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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