1TWFE

Rna polymerase ii complexed with utp at 2.3 a resolution
Total Genus 67
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
67
sequence length
215
structure length
215
Chain Sequence
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSAMKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center.
pubmed doi rcsb
molecule tags Transcription
molecule keywords DNA-directed RNA polymerase II largest subunit
total genus 67
structure length 215
sequence length 215
ec nomenclature
pdb deposition date 2004-06-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01191 RNA_pol_Rpb5_C RNA polymerase Rpb5, C-terminal domain
E PF03871 RNA_pol_Rpb5_N RNA polymerase Rpb5, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1340.10 Alpha Beta 3-Layer(aba) Sandwich Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1 RNA polymerase, Rpb5, N-terminal domain 1twfE01
3.90.940.20 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit RPB5-like RNA polymerase subunit 1twfE02
3H0GE 3GTOE 3GTJE 5M5XE 3S1QE 5C4XE 3S15E 4X6AE 1TWFE 1I6HE 3I4NE 3HOXE 4C2ME 3FKIE 3GTPE 4A93E 3S1NE 2JA7E 4BBSE 1SFOE 3RZDE 2JA5E 2NVXE 3S2DE 2JA6E 2E2HE 4Y52E 5IYDE 4A3EE 3HOWE 4A3KE 3GTLE 3I4ME 1R9TE 5M3FE 3H3VF 2WAQH 1I3QE 1Y1WE 2NVQE 4A3BE 5IP7E 5IP9E 5IYCE 2YU9E 4Y7NE 2PMZH 4A3JE 1I50E 3HOVE 4A3CE 1K83E 2E2JE 2E2IE 3S17E 5M5YE 5C3EE 4BY1E 5M3ME 1TWGE 2R93E 4AYBH 3GTKE 3M3YE 4A3LE 4BXXE 3HOUE 3S1RE 5FJ8E 2R92E 4C3IE 3RZOE 2B63E 4A3IE 1Y1VE 4A3DE 1TWCE 1DZFA 5FLME 3S2HE 1TWAE 1EIKA 4A3FE 4QIWH 5C4JE 4BY7E 3HKZH 3PO3E 2NVYE 4C3HE 4BBRE 2Y0SH 2R7ZE 3GTGE 3GTME 2NVTE 2WB1H 3K7AE 2VUME 3HOZE 1TWHE 5C44E 3CQZE 3PO2E 3GTQE 4A3GE 2JA8E 3S14E 5M5WE 3S16E 4A3ME 5IYBE 3HOYE 3M4OE 4C3JE 3S1ME 1WCME
chains in the Genus database with same CATH superfamily
4YFKE 2PPBE 1IW7E 2O5JE 3H0GE 3GTOE 2KRXA 4Q5SE 3S1QF 5C44F 3CQZF 3PO2F 4X6AF 3GTJE 2O5IE 4Q4ZE 3GTQF 4A3GF 1I6HF 5M5XE 3S1QE 5C4XE 3S15E 4X6AE 3WODE 3S14F 5IPLE 1TWFE 5M5WF 1I6HE 3FKIF 3I4NE 3GTPF 5TMFE 4A3MF 4OIPE 3HOXE 4C2ME 3FKIE 3GTPE 4A93E 3S1NE 4KMUE 3H3VG 2A68E 2JA7E 4BBSE 4C3JF 2NVXF 3S2DF 2E2HF 1WCMF 1SFOE 3HOZF 3RZDE 2JA5E 2NVXE 3S2DE 3H0GF 3GTOF 2JA6E 2E2HE 4Y52E 2WAQK 4LK0E 4OIQE 4OINE 5IYDE 4MEYE 5M3FF 3DXJE 3GTJF 5E17E 4A3EE 3HOWE 4A3KE 3GTLE 3I4ME 1HQME 4KN7E 5M5XF 2NVQF 4A3BF 3S15F 1R9TE 5M3FE 3H3VF 2PMZK 1TWFF 4Y7NF 2WAQH 4G7HE 1I3QE 1Y1WE 2NVQE 4A3BE 5E18E 5IP7E 3I4NF 5IP9E 5IYCE 4YG2E 3HOXF 4A3JF 3HOVF 4C2MF 2YU9E 4G7ZE 4Y7NE 5D4DE 4A93F 4XLPE 2PMZH 3S1NF 4A3JE 1I50E 3HOVE 4AYBK 4A3CE 1K83E 2E2JE 4ZH4E 2E2IE 3S17E 5M5YE 2JA7F 4BBSF 5C3EE 4MQ9E 4BY1E 4XSZE 5M3ME 1SFOF 1TWGE 2R93E 3RZDF 4AYBH 2JA5F 4A3LF 2JA6F 1I6VE 1ZYRE 4Y52F 4OIOE 5C4XF 3GTKE 3M3YE 4A3LE 4BXXE 5IYDF 3HOUE 3S1RE 2R92F 4A3EF 3HOWF 5FJ8E 4A3KF 3GTLF 3I4MF 4A3CF 4GZYE 1R9TF 2R92E 4C3IE 3RZOE 2B63E 4A3IE 1I3QF 1Y1WF 5IP7F 5IP9F 5IYCF 1Y1VE 1TWAF 4LK1E 2YU9F 4A3DE 1TWCE 4YFXE 1DZFA 5FLME 3S2HE 1I50F 2Y0SI 2A69E 3HKZK 1TWAE 1K83F 2WB1I 5BYHE 2E2JF 2E2IF 4A3FF 2A6HE 5M5YF 3S17F 5C3EF 4BY1F 1EIKA 5M3MF 4A3FE 4QIWH 1TWGF 5C4JE 5D4CE 4BY7E 3HKZH 2R93F 3PO3E 5D4EE 2R7ZF 3GTMF 4MEXE 2NVYE 4C3HE 4G7OE 4BBRE 2Y0SH 3GTKF 3M3YF 4BXXF 2R7ZE 3GTGE 3GTME 3S1RF 2NVTE 2WB1H 5FJ8F 3HOUF 1SMYE 3K7AE 5TMCE 4YFNE 2VUMF 1TWHF 4C3IF 3RZOF 2B63F 2VUME 4A3IF 4JK1E 3HOZE 4XSXE 1Y1VF 1TWHE 1QKLA 5C44E 2JA8F 3CQZE 3PO2E 2A6EE 4A3DF 3GTQE 4A3GE 1TWCF 3S16F 5FLMF 3S2HF 2BE5E 2JA8E 3S14E 1YNJK 4XLNE 5M5WE 3S16E 4QIWK 4A3ME 5IYBF 4KN4E 5C4JF 3HOYF 4BY7F 3M4OF 3PO3F 1YNNK 2NVYF 5IYBE 4C3HF 3S1MF 4BBRF 3EQLE 3HOYE 3M4OE 3GTGF 4LLGE 4LJZE 4OIRE 4C3JE 3S1ME 2NVTF 3K7AF 2CW0E 1WCME
chains in the Genus database with same CATH topology
3H0GE 3GTOE 3GTJE 5M5XE 3S1QE 5C4XE 3S15E 4X6AE 1TWFE 1I6HE 3I4NE 3HOXE 4C2ME 3FKIE 3GTPE 4A93E 3S1NE 2JA7E 4BBSE 1SFOE 3RZDE 2JA5E 2NVXE 3S2DE 2JA6E 2E2HE 4Y52E 5IYDE 4A3EE 3HOWE 4A3KE 3GTLE 3I4ME 1R9TE 5M3FE 3H3VF 2WAQH 1I3QE 1Y1WE 2NVQE 4A3BE 5IP7E 5IP9E 5IYCE 2YU9E 4Y7NE 2PMZH 4A3JE 1I50E 3HOVE 4A3CE 1K83E 2E2JE 2E2IE 3S17E 5M5YE 5C3EE 4BY1E 5M3ME 1TWGE 2R93E 4AYBH 3GTKE 3M3YE 4A3LE 4BXXE 3HOUE 3S1RE 5FJ8E 2R92E 4C3IE 3RZOE 2B63E 4A3IE 1Y1VE 4A3DE 1TWCE 1DZFA 5FLME 3S2HE 1TWAE 1EIKA 4A3FE 4QIWH 5C4JE 4BY7E 3HKZH 3PO3E 2NVYE 4C3HE 4BBRE 2Y0SH 2R7ZE 3GTGE 3GTME 2NVTE 2WB1H 3K7AE 2VUME 3HOZE 1TWHE 5C44E 3CQZE 3PO2E 3GTQE 4A3GE 2JA8E 3S14E 5M5WE 3S16E 4A3ME 5IYBE 3HOYE 3M4OE 4C3JE 3S1ME 1WCME
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3H0G E;  3GTO E;  3GTJ E;  5M5X E;  3S1Q E;  5C4X E;  3S15 E;  4X6A E;  1TWF E;  1I6H E;  3I4N E;  3HOX E;  4C2M E;  3FKI E;  3GTP E;  4A93 E;  3S1N E;  2JA7 E;  4BBS E;  1SFO E;  3RZD E;  2JA5 E;  2NVX E;  3S2D E;  2JA6 E;  2E2H E;  4Y52 E;  5IYD E;  4A3E E;  3HOW E;  4A3K E;  3GTL E;  3I4M E;  1R9T E;  5M3F E;  3H3V F;  2WAQ H;  1I3Q E;  1Y1W E;  2NVQ E;  4A3B E;  5IP7 E;  5IP9 E;  5IYC E;  2YU9 E;  4Y7N E;  2PMZ H;  4A3J E;  1I50 E;  3HOV E;  4A3C E;  1K83 E;  2E2J E;  2E2I E;  3S17 E;  5M5Y E;  5C3E E;  4BY1 E;  5M3M E;  1TWG E;  2R93 E;  4AYB H;  3GTK E;  3M3Y E;  4A3L E;  4BXX E;  3HOU E;  3S1R E;  5FJ8 E;  2R92 E;  4C3I E;  3RZO E;  2B63 E;  4A3I E;  1Y1V E;  4A3D E;  1TWC E;  1DZF A;  5FLM E;  3S2H E;  1TWA E;  1EIK A;  4A3F E;  4QIW H;  5C4J E;  4BY7 E;  3HKZ H;  3PO3 E;  2NVY E;  4C3H E;  4BBR E;  2Y0S H;  2R7Z E;  3GTG E;  3GTM E;  2NVT E;  2WB1 H;  3K7A E;  2VUM E;  3HOZ E;  1TWH E;  5C44 E;  3CQZ E;  3PO2 E;  3GTQ E;  4A3G E;  2JA8 E;  3S14 E;  5M5W E;  3S16 E;  4A3M E;  5IYB E;  3HOY E;  3M4O E;  4C3J E;  3S1M E;  1WCM E; 
#chains in the Genus database with same CATH topology
 4YFK E;  2PPB E;  1IW7 E;  2O5J E;  3H0G E;  3GTO E;  2KRX A;  4Q5S E;  3S1Q F;  5C44 F;  3CQZ F;  3PO2 F;  4X6A F;  3GTJ E;  2O5I E;  4Q4Z E;  3GTQ F;  4A3G F;  1I6H F;  5M5X E;  3S1Q E;  5C4X E;  3S15 E;  4X6A E;  3WOD E;  3S14 F;  5IPL E;  1TWF E;  5M5W F;  1I6H E;  3FKI F;  3I4N E;  3GTP F;  5TMF E;  4A3M F;  4OIP E;  3HOX E;  4C2M E;  3FKI E;  3GTP E;  4A93 E;  3S1N E;  4KMU E;  3H3V G;  2A68 E;  2JA7 E;  4BBS E;  4C3J F;  2NVX F;  3S2D F;  2E2H F;  1WCM F;  1SFO E;  3HOZ F;  3RZD E;  2JA5 E;  2NVX E;  3S2D E;  3H0G F;  3GTO F;  2JA6 E;  2E2H E;  4Y52 E;  2WAQ K;  4LK0 E;  4OIQ E;  4OIN E;  5IYD E;  4MEY E;  5M3F F;  3DXJ E;  3GTJ F;  5E17 E;  4A3E E;  3HOW E;  4A3K E;  3GTL E;  3I4M E;  1HQM E;  4KN7 E;  5M5X F;  2NVQ F;  4A3B F;  3S15 F;  1R9T E;  5M3F E;  3H3V F;  2PMZ K;  1TWF F;  4Y7N F;  2WAQ H;  4G7H E;  1I3Q E;  1Y1W E;  2NVQ E;  4A3B E;  5E18 E;  5IP7 E;  3I4N F;  5IP9 E;  5IYC E;  4YG2 E;  3HOX F;  4A3J F;  3HOV F;  4C2M F;  2YU9 E;  4G7Z E;  4Y7N E;  5D4D E;  4A93 F;  4XLP E;  2PMZ H;  3S1N F;  4A3J E;  1I50 E;  3HOV E;  4AYB K;  4A3C E;  1K83 E;  2E2J E;  4ZH4 E;  2E2I E;  3S17 E;  5M5Y E;  2JA7 F;  4BBS F;  5C3E E;  4MQ9 E;  4BY1 E;  4XSZ E;  5M3M E;  1SFO F;  1TWG E;  2R93 E;  3RZD F;  4AYB H;  2JA5 F;  4A3L F;  2JA6 F;  1I6V E;  1ZYR E;  4Y52 F;  4OIO E;  5C4X F;  3GTK E;  3M3Y E;  4A3L E;  4BXX E;  5IYD F;  3HOU E;  3S1R E;  2R92 F;  4A3E F;  3HOW F;  5FJ8 E;  4A3K F;  3GTL F;  3I4M F;  4A3C F;  4GZY E;  1R9T F;  2R92 E;  4C3I E;  3RZO E;  2B63 E;  4A3I E;  1I3Q F;  1Y1W F;  5IP7 F;  5IP9 F;  5IYC F;  1Y1V E;  1TWA F;  4LK1 E;  2YU9 F;  4A3D E;  1TWC E;  4YFX E;  1DZF A;  5FLM E;  3S2H E;  1I50 F;  2Y0S I;  2A69 E;  3HKZ K;  1TWA E;  1K83 F;  2WB1 I;  5BYH E;  2E2J F;  2E2I F;  4A3F F;  2A6H E;  5M5Y F;  3S17 F;  5C3E F;  4BY1 F;  1EIK A;  5M3M F;  4A3F E;  4QIW H;  1TWG F;  5C4J E;  5D4C E;  4BY7 E;  3HKZ H;  2R93 F;  3PO3 E;  5D4E E;  2R7Z F;  3GTM F;  4MEX E;  2NVY E;  4C3H E;  4G7O E;  4BBR E;  2Y0S H;  3GTK F;  3M3Y F;  4BXX F;  2R7Z E;  3GTG E;  3GTM E;  3S1R F;  2NVT E;  2WB1 H;  5FJ8 F;  3HOU F;  1SMY E;  3K7A E;  5TMC E;  4YFN E;  2VUM F;  1TWH F;  4C3I F;  3RZO F;  2B63 F;  2VUM E;  4A3I F;  4JK1 E;  3HOZ E;  4XSX E;  1Y1V F;  1TWH E;  1QKL A;  5C44 E;  2JA8 F;  3CQZ E;  3PO2 E;  2A6E E;  4A3D F;  3GTQ E;  4A3G E;  1TWC F;  3S16 F;  5FLM F;  3S2H F;  2BE5 E;  2JA8 E;  3S14 E;  1YNJ K;  4XLN E;  5M5W E;  3S16 E;  4QIW K;  4A3M E;  5IYB F;  4KN4 E;  5C4J F;  3HOY F;  4BY7 F;  3M4O F;  3PO3 F;  1YNN K;  2NVY F;  5IYB E;  4C3H F;  3S1M F;  4BBR F;  3EQL E;  3HOY E;  3M4O E;  3GTG F;  4LLG E;  4LJZ E;  4OIR E;  4C3J E;  3S1M E;  2NVT F;  3K7A F;  2CW0 E;  1WCM E; 
#chains in the Genus database with same CATH homology
 3H0G E;  3GTO E;  3GTJ E;  5M5X E;  3S1Q E;  5C4X E;  3S15 E;  4X6A E;  1TWF E;  1I6H E;  3I4N E;  3HOX E;  4C2M E;  3FKI E;  3GTP E;  4A93 E;  3S1N E;  2JA7 E;  4BBS E;  1SFO E;  3RZD E;  2JA5 E;  2NVX E;  3S2D E;  2JA6 E;  2E2H E;  4Y52 E;  5IYD E;  4A3E E;  3HOW E;  4A3K E;  3GTL E;  3I4M E;  1R9T E;  5M3F E;  3H3V F;  2WAQ H;  1I3Q E;  1Y1W E;  2NVQ E;  4A3B E;  5IP7 E;  5IP9 E;  5IYC E;  2YU9 E;  4Y7N E;  2PMZ H;  4A3J E;  1I50 E;  3HOV E;  4A3C E;  1K83 E;  2E2J E;  2E2I E;  3S17 E;  5M5Y E;  5C3E E;  4BY1 E;  5M3M E;  1TWG E;  2R93 E;  4AYB H;  3GTK E;  3M3Y E;  4A3L E;  4BXX E;  3HOU E;  3S1R E;  5FJ8 E;  2R92 E;  4C3I E;  3RZO E;  2B63 E;  4A3I E;  1Y1V E;  4A3D E;  1TWC E;  1DZF A;  5FLM E;  3S2H E;  1TWA E;  1EIK A;  4A3F E;  4QIW H;  5C4J E;  4BY7 E;  3HKZ H;  3PO3 E;  2NVY E;  4C3H E;  4BBR E;  2Y0S H;  2R7Z E;  3GTG E;  3GTM E;  2NVT E;  2WB1 H;  3K7A E;  2VUM E;  3HOZ E;  1TWH E;  5C44 E;  3CQZ E;  3PO2 E;  3GTQ E;  4A3G E;  2JA8 E;  3S14 E;  5M5W E;  3S16 E;  4A3M E;  5IYB E;  3HOY E;  3M4O E;  4C3J E;  3S1M E;  1WCM E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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