1TWGE

Rna polymerase ii complexed with ctp
Total Genus 60
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
60
sequence length
215
structure length
215
Chain Sequence
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSAMKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center.
pubmed doi rcsb
molecule tags Transcription
molecule keywords DNA-directed RNA polymerase II largest subunit
total genus 60
structure length 215
sequence length 215
ec nomenclature
pdb deposition date 2004-06-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01191 RNA_pol_Rpb5_C RNA polymerase Rpb5, C-terminal domain
E PF03871 RNA_pol_Rpb5_N RNA polymerase Rpb5, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1340.10 Alpha Beta 3-Layer(aba) Sandwich Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1 RNA polymerase, Rpb5, N-terminal domain 1twgE01
3.90.940.20 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit RPB5-like RNA polymerase subunit 1twgE02
2WAQH 1TWAE 3GTJE 4C3JE 5IP7E 3K7AE 2WB1H 5IYCE 3M4OE 3I4NE 3GTME 3HOVE 3GTPE 3PO3E 3GTQE 2PMZH 3PO2E 4A3DE 2E2JE 4C2ME 3S15E 4A3EE 3HOZE 4A3LE 3GTLE 5M5XE 4C3HE 2JA8E 5M3ME 3S2DE 1DZFA 2R93E 1TWGE 3S1NE 1TWHE 5IYBE 3S1QE 3M3YE 5M3FE 3HOWE 1R9TE 1TWCE 3H0GE 3HOYE 2E2HE 4C3IE 1TWFE 4AYBH 5M5YE 4X6AE 4A93E 3HKZH 4A3FE 4BY7E 3S14E 2VUME 4A3JE 1Y1VE 4A3CE 1I3QE 4A3GE 1WCME 2E2IE 2JA7E 4BXXE 3H3VF 3S1RE 3S17E 2NVYE 4BY1E 4A3BE 1K83E 3S2HE 2YU9E 3CQZE 1Y1WE 3HOUE 5IYDE 3GTKE 3HOXE 2Y0SH 3S1ME 5C3EE 3S16E 4A3IE 2JA6E 5FJ8E 3RZOE 3RZDE 1EIKA 1I6HE 3GTGE 5FLME 2JA5E 2NVQE 2NVXE 4QIWH 5C4JE 3I4ME 4BBRE 5M5WE 4Y7NE 1SFOE 4BBSE 2B63E 5IP9E 5C4XE 1I50E 2NVTE 3GTOE 4Y52E 2R7ZE 5C44E 4A3ME 3FKIE 2R92E 4A3KE
chains in the Genus database with same CATH superfamily
2WAQH 2JA8F 5M3MF 1TWAE 3GTJE 4KN4E 2R93F 4C3JE 1TWGF 5IP7E 3K7AE 2A68E 3S1NF 1TWHF 5IYBF 2WB1H 5IYCF 5IYCE 5TMFE 1ZYRE 3M4OE 3M4OF 3I4NE 3S1QF 3M3YF 3GTME 4XLPE 5M3FF 1R9TF 3HOWF 1YNJK 3HOVE 3GTPE 3PO3E 1SMYE 1TWCF 5IPLE 3H0GF 3HOYF 2E2HF 2PMZK 4YG2E 4AYBK 4C3IF 3GTQE 1TWFF 2PMZH 5M5YF 4A3DF 3PO2E 4A3DE 5D4EE 2E2JE 4C2ME 3S15E 4X6AF 4A93F 4A3EE 3HOZE 4A3LE 4A3FF 1IW7E 3GTLE 4BY7F 5M5XE 5M5XF 3S14F 2VUMF 4A3JF 1Y1VF 4G7HE 4A3CF 5E17E 4XSXE 4C3HE 1I3QF 4A3GF 2JA8E 1WCMF 2E2IF 5M3ME 2JA7F 4BXXF 3S2DF 3S2DE 1DZFA 2R93E 1TWGE 3S1RF 3S17F 2NVYF 3S1NE 4BY1F 4YFKE 4OIOE 1K83F 4A3BF 1TWHE 5IYBE 4XSZE 4Q5SE 3S1QE 5D4DE 3CQZF 2YU9F 3M3YE 4OIQE 1Y1WF 5M3FE 3HOWE 1R9TE 2O5JE 3HOUF 5IYDF 2CW0E 1TWCE 4LK1E 3WODE 3H0GE 3HOYE 2KRXA 3GTKF 2E2HE 4GZYE 3HOXF 4C3IE 2A6EE 2A69E 3S1MF 1TWFE 5C3EF 4AYBH 3S16F 5M5YE 1HQME 4A3IF 2JA6F 4X6AE 3HKZK 4A93E 3HKZH 4A3FE 4MEYE 4BY7E 5BYHE 3S14E 2VUME 5FJ8F 3RZOF 4A3JE 1Y1VE 4A3CE 3RZDF 1I3QE 4A3GE 2BE5E 2PPBE 1WCME 2E2IE 2JA7E 4BXXE 3H3VF 1I6HF 2O5IE 3GTGF 5FLMF 4LK0E 2JA5F 2NVXF 1YNNK 3S1RE 3S17E 2NVYE 4BY1E 4A3BE 4YFXE 5C4JF 1K83E 5TMCE 3I4MF 2Y0SI 4KMUE 4BBRF 4Y7NF 5M5WF 1SFOF 1QKLA 3S2HF 3S2HE 2B63F 2YU9E 4BBSF 3CQZE 5IP9F 5D4CE 1I6VE 5C4XF 1Y1WE 2NVQF 1I50F 4Y52F 3HOUE 2NVTF 5IYDE 3GTOF 2R7ZF 5C44F 4A3MF 3FKIF 3GTKE 3HOXE 2Y0SH 4A3KF 2R92F 3S1ME 4KN7E 4ZH4E 4LJZE 5C3EE 3S16E 2WAQK 4A3IE 2JA6E 4XLNE 1TWAF 3GTJF 4MEXE 4C3JF 4OIPE 5IP7F 5FJ8E 3K7AF 3RZOE 4YFNE 3RZDE 1EIKA 1I6HE 4Q4ZE 3I4NF 2A6HE 4QIWK 4MQ9E 3GTGE 5FLME 2JA5E 2NVQE 2NVXE 4QIWH 3GTMF 3HOVF 5C4JE 3I4ME 3GTPF 3PO3F 4BBRE 5M5WE 4Y7NE 1SFOE 4OINE 4LLGE 4BBSE 4G7ZE 2B63E 5IP9E 5C4XE 3GTQF 4JK1E 1I50E 2NVTE 3GTOE 4Y52E 3EQLE 3PO2F 2E2JF 2R7ZE 4C2MF 5C44E 4A3ME 4A3EF 4OIRE 3FKIE 3H3VG 3HOZF 3S15F 4A3LF 4G7OE 3GTLF 2R92E 4A3KE 2WB1I 3DXJE 5E18E 4C3HF
chains in the Genus database with same CATH topology
2WAQH 1TWAE 3GTJE 4C3JE 5IP7E 3K7AE 2WB1H 5IYCE 3M4OE 3I4NE 3GTME 3HOVE 3GTPE 3PO3E 3GTQE 2PMZH 3PO2E 4A3DE 2E2JE 4C2ME 3S15E 4A3EE 3HOZE 4A3LE 3GTLE 5M5XE 4C3HE 2JA8E 5M3ME 3S2DE 1DZFA 2R93E 1TWGE 3S1NE 1TWHE 5IYBE 3S1QE 3M3YE 5M3FE 3HOWE 1R9TE 1TWCE 3H0GE 3HOYE 2E2HE 4C3IE 1TWFE 4AYBH 5M5YE 4X6AE 4A93E 3HKZH 4A3FE 4BY7E 3S14E 2VUME 4A3JE 1Y1VE 4A3CE 1I3QE 4A3GE 1WCME 2E2IE 2JA7E 4BXXE 3H3VF 3S1RE 3S17E 2NVYE 4BY1E 4A3BE 1K83E 3S2HE 2YU9E 3CQZE 1Y1WE 3HOUE 5IYDE 3GTKE 3HOXE 2Y0SH 3S1ME 5C3EE 3S16E 4A3IE 2JA6E 5FJ8E 3RZOE 3RZDE 1EIKA 1I6HE 3GTGE 5FLME 2JA5E 2NVQE 2NVXE 4QIWH 5C4JE 3I4ME 4BBRE 5M5WE 4Y7NE 1SFOE 4BBSE 2B63E 5IP9E 5C4XE 1I50E 2NVTE 3GTOE 4Y52E 2R7ZE 5C44E 4A3ME 3FKIE 2R92E 4A3KE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2WAQ H;  1TWA E;  3GTJ E;  4C3J E;  5IP7 E;  3K7A E;  2WB1 H;  5IYC E;  3M4O E;  3I4N E;  3GTM E;  3HOV E;  3GTP E;  3PO3 E;  3GTQ E;  2PMZ H;  3PO2 E;  4A3D E;  2E2J E;  4C2M E;  3S15 E;  4A3E E;  3HOZ E;  4A3L E;  3GTL E;  5M5X E;  4C3H E;  2JA8 E;  5M3M E;  3S2D E;  1DZF A;  2R93 E;  1TWG E;  3S1N E;  1TWH E;  5IYB E;  3S1Q E;  3M3Y E;  5M3F E;  3HOW E;  1R9T E;  1TWC E;  3H0G E;  3HOY E;  2E2H E;  4C3I E;  1TWF E;  4AYB H;  5M5Y E;  4X6A E;  4A93 E;  3HKZ H;  4A3F E;  4BY7 E;  3S14 E;  2VUM E;  4A3J E;  1Y1V E;  4A3C E;  1I3Q E;  4A3G E;  1WCM E;  2E2I E;  2JA7 E;  4BXX E;  3H3V F;  3S1R E;  3S17 E;  2NVY E;  4BY1 E;  4A3B E;  1K83 E;  3S2H E;  2YU9 E;  3CQZ E;  1Y1W E;  3HOU E;  5IYD E;  3GTK E;  3HOX E;  2Y0S H;  3S1M E;  5C3E E;  3S16 E;  4A3I E;  2JA6 E;  5FJ8 E;  3RZO E;  3RZD E;  1EIK A;  1I6H E;  3GTG E;  5FLM E;  2JA5 E;  2NVQ E;  2NVX E;  4QIW H;  5C4J E;  3I4M E;  4BBR E;  5M5W E;  4Y7N E;  1SFO E;  4BBS E;  2B63 E;  5IP9 E;  5C4X E;  1I50 E;  2NVT E;  3GTO E;  4Y52 E;  2R7Z E;  5C44 E;  4A3M E;  3FKI E;  2R92 E;  4A3K E; 
#chains in the Genus database with same CATH topology
 2WAQ H;  2JA8 F;  5M3M F;  1TWA E;  3GTJ E;  4KN4 E;  2R93 F;  4C3J E;  1TWG F;  5IP7 E;  3K7A E;  2A68 E;  3S1N F;  1TWH F;  5IYB F;  2WB1 H;  5IYC F;  5IYC E;  5TMF E;  1ZYR E;  3M4O E;  3M4O F;  3I4N E;  3S1Q F;  3M3Y F;  3GTM E;  4XLP E;  5M3F F;  1R9T F;  3HOW F;  1YNJ K;  3HOV E;  3GTP E;  3PO3 E;  1SMY E;  1TWC F;  5IPL E;  3H0G F;  3HOY F;  2E2H F;  2PMZ K;  4YG2 E;  4AYB K;  4C3I F;  3GTQ E;  1TWF F;  2PMZ H;  5M5Y F;  4A3D F;  3PO2 E;  4A3D E;  5D4E E;  2E2J E;  4C2M E;  3S15 E;  4X6A F;  4A93 F;  4A3E E;  3HOZ E;  4A3L E;  4A3F F;  1IW7 E;  3GTL E;  4BY7 F;  5M5X E;  5M5X F;  3S14 F;  2VUM F;  4A3J F;  1Y1V F;  4G7H E;  4A3C F;  5E17 E;  4XSX E;  4C3H E;  1I3Q F;  4A3G F;  2JA8 E;  1WCM F;  2E2I F;  5M3M E;  2JA7 F;  4BXX F;  3S2D F;  3S2D E;  1DZF A;  2R93 E;  1TWG E;  3S1R F;  3S17 F;  2NVY F;  3S1N E;  4BY1 F;  4YFK E;  4OIO E;  1K83 F;  4A3B F;  1TWH E;  5IYB E;  4XSZ E;  4Q5S E;  3S1Q E;  5D4D E;  3CQZ F;  2YU9 F;  3M3Y E;  4OIQ E;  1Y1W F;  5M3F E;  3HOW E;  1R9T E;  2O5J E;  3HOU F;  5IYD F;  2CW0 E;  1TWC E;  4LK1 E;  3WOD E;  3H0G E;  3HOY E;  2KRX A;  3GTK F;  2E2H E;  4GZY E;  3HOX F;  4C3I E;  2A6E E;  2A69 E;  3S1M F;  1TWF E;  5C3E F;  4AYB H;  3S16 F;  5M5Y E;  1HQM E;  4A3I F;  2JA6 F;  4X6A E;  3HKZ K;  4A93 E;  3HKZ H;  4A3F E;  4MEY E;  4BY7 E;  5BYH E;  3S14 E;  2VUM E;  5FJ8 F;  3RZO F;  4A3J E;  1Y1V E;  4A3C E;  3RZD F;  1I3Q E;  4A3G E;  2BE5 E;  2PPB E;  1WCM E;  2E2I E;  2JA7 E;  4BXX E;  3H3V F;  1I6H F;  2O5I E;  3GTG F;  5FLM F;  4LK0 E;  2JA5 F;  2NVX F;  1YNN K;  3S1R E;  3S17 E;  2NVY E;  4BY1 E;  4A3B E;  4YFX E;  5C4J F;  1K83 E;  5TMC E;  3I4M F;  2Y0S I;  4KMU E;  4BBR F;  4Y7N F;  5M5W F;  1SFO F;  1QKL A;  3S2H F;  3S2H E;  2B63 F;  2YU9 E;  4BBS F;  3CQZ E;  5IP9 F;  5D4C E;  1I6V E;  5C4X F;  1Y1W E;  2NVQ F;  1I50 F;  4Y52 F;  3HOU E;  2NVT F;  5IYD E;  3GTO F;  2R7Z F;  5C44 F;  4A3M F;  3FKI F;  3GTK E;  3HOX E;  2Y0S H;  4A3K F;  2R92 F;  3S1M E;  4KN7 E;  4ZH4 E;  4LJZ E;  5C3E E;  3S16 E;  2WAQ K;  4A3I E;  2JA6 E;  4XLN E;  1TWA F;  3GTJ F;  4MEX E;  4C3J F;  4OIP E;  5IP7 F;  5FJ8 E;  3K7A F;  3RZO E;  4YFN E;  3RZD E;  1EIK A;  1I6H E;  4Q4Z E;  3I4N F;  2A6H E;  4QIW K;  4MQ9 E;  3GTG E;  5FLM E;  2JA5 E;  2NVQ E;  2NVX E;  4QIW H;  3GTM F;  3HOV F;  5C4J E;  3I4M E;  3GTP F;  3PO3 F;  4BBR E;  5M5W E;  4Y7N E;  1SFO E;  4OIN E;  4LLG E;  4BBS E;  4G7Z E;  2B63 E;  5IP9 E;  5C4X E;  3GTQ F;  4JK1 E;  1I50 E;  2NVT E;  3GTO E;  4Y52 E;  3EQL E;  3PO2 F;  2E2J F;  2R7Z E;  4C2M F;  5C44 E;  4A3M E;  4A3E F;  4OIR E;  3FKI E;  3H3V G;  3HOZ F;  3S15 F;  4A3L F;  4G7O E;  3GTL F;  2R92 E;  4A3K E;  2WB1 I;  3DXJ E;  5E18 E;  4C3H F; 
#chains in the Genus database with same CATH homology
 2WAQ H;  1TWA E;  3GTJ E;  4C3J E;  5IP7 E;  3K7A E;  2WB1 H;  5IYC E;  3M4O E;  3I4N E;  3GTM E;  3HOV E;  3GTP E;  3PO3 E;  3GTQ E;  2PMZ H;  3PO2 E;  4A3D E;  2E2J E;  4C2M E;  3S15 E;  4A3E E;  3HOZ E;  4A3L E;  3GTL E;  5M5X E;  4C3H E;  2JA8 E;  5M3M E;  3S2D E;  1DZF A;  2R93 E;  1TWG E;  3S1N E;  1TWH E;  5IYB E;  3S1Q E;  3M3Y E;  5M3F E;  3HOW E;  1R9T E;  1TWC E;  3H0G E;  3HOY E;  2E2H E;  4C3I E;  1TWF E;  4AYB H;  5M5Y E;  4X6A E;  4A93 E;  3HKZ H;  4A3F E;  4BY7 E;  3S14 E;  2VUM E;  4A3J E;  1Y1V E;  4A3C E;  1I3Q E;  4A3G E;  1WCM E;  2E2I E;  2JA7 E;  4BXX E;  3H3V F;  3S1R E;  3S17 E;  2NVY E;  4BY1 E;  4A3B E;  1K83 E;  3S2H E;  2YU9 E;  3CQZ E;  1Y1W E;  3HOU E;  5IYD E;  3GTK E;  3HOX E;  2Y0S H;  3S1M E;  5C3E E;  3S16 E;  4A3I E;  2JA6 E;  5FJ8 E;  3RZO E;  3RZD E;  1EIK A;  1I6H E;  3GTG E;  5FLM E;  2JA5 E;  2NVQ E;  2NVX E;  4QIW H;  5C4J E;  3I4M E;  4BBR E;  5M5W E;  4Y7N E;  1SFO E;  4BBS E;  2B63 E;  5IP9 E;  5C4X E;  1I50 E;  2NVT E;  3GTO E;  4Y52 E;  2R7Z E;  5C44 E;  4A3M E;  3FKI E;  2R92 E;  4A3K E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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