1TWHE

Rna polymerase ii complexed with 2'datp
Total Genus 67
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
67
sequence length
215
structure length
215
Chain Sequence
MDQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSAMKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of transcription: nucleotide selection by rotation in the RNA polymerase II active center.
pubmed doi rcsb
molecule tags Transcription
molecule keywords DNA-directed RNA polymerase II largest subunit
total genus 67
structure length 215
sequence length 215
ec nomenclature
pdb deposition date 2004-06-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01191 RNA_pol_Rpb5_C RNA polymerase Rpb5, C-terminal domain
E PF03871 RNA_pol_Rpb5_N RNA polymerase Rpb5, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1340.10 Alpha Beta 3-Layer(aba) Sandwich Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1 RNA polymerase, Rpb5, N-terminal domain 1twhE01
3.90.940.20 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit RPB5-like RNA polymerase subunit 1twhE02
2E2JE 4BXXE 3I4NE 4X6AE 1K83E 2JA7E 2JA8E 3S14E 3S15E 3S17E 3HOXE 4A3BE 3HKZH 4A3IE 2Y0SH 5IYDE 3S2HE 2E2IE 3M4OE 5M3ME 5C4JE 5IYCE 3GTGE 3H0GE 4Y7NE 4A3ME 3S2DE 5FLME 1SFOE 2R7ZE 2PMZH 4BBRE 3H3VF 3GTOE 3GTKE 1TWHE 1I6HE 3S1NE 2WB1H 3GTJE 5C44E 4A3GE 3RZOE 5M5WE 2JA6E 5C3EE 2B63E 1I3QE 1EIKA 4BBSE 3S1ME 3CQZE 1R9TE 2VUME 3GTPE 3S1QE 3HOWE 5IP9E 4Y52E 3PO3E 4C3IE 1TWAE 4A3FE 4A3KE 3GTQE 1Y1VE 4C3JE 5IYBE 3M3YE 3I4ME 5C4XE 3GTME 2NVXE 2E2HE 2NVQE 3S1RE 1TWFE 3S16E 3HOUE 2YU9E 4QIWH 4A3JE 4BY7E 3K7AE 5M3FE 1I50E 3GTLE 1TWGE 4A3DE 2WAQH 1DZFA 4A3EE 5M5YE 4A3CE 3PO2E 1WCME 4AYBH 4BY1E 3FKIE 1TWCE 2NVTE 5M5XE 3HOZE 2NVYE 4A93E 4A3LE 2R92E 2JA5E 1Y1WE 3HOVE 5FJ8E 2R93E 4C2ME 3RZDE 5IP7E 4C3HE 3HOYE
chains in the Genus database with same CATH superfamily
3WODE 5M3FF 1I50F 3GTLF 2E2JE 4BXXE 1TWGF 3I4NE 3DXJE 4X6AE 4A3EF 5M5YF 1TWAF 4YFKE 4A3FF 1K83E 2CW0E 2JA7E 4A3CF 2JA8E 3S14E 3S15E 3PO2F 3S17E 3HOXE 4BY1F 1Y1VF 5TMCE 5TMFE 4A3BE 4C3JF 2O5JE 3HKZH 3M3YF 4XLNE 5D4CE 3FKIF 4A3IE 2NVTF 2Y0SH 5IPLE 5IYDE 5M5XF 3GTMF 2NVYF 3HOZF 4OIQE 3S2HE 4A3LF 4GZYE 2E2IE 4G7OE 3M4OE 4LJZE 4YG2E 2R92F 2E2HF 2JA5F 1Y1WF 4LK0E 3S1RF 1TWFF 5FJ8F 5M3ME 4C2MF 3HOUF 5C4JE 5IYCE 3GTGE 3H0GE 2YU9F 4Y7NE 4A3ME 4C3HF 3S2DE 4A3GF 3HOYF 4A3JF 5FLME 1SFOE 2R7ZE 2PMZH 2E2JF 3GTGF 5BYHE 3I4NF 4BXXF 4X6AF 4BBRE 4A3DF 3H3VF 2JA7F 4YFNE 2JA8F 3S14F 3GTOE 3GTKE 1TWHE 1I6HE 3S1NE 3HKZK 2WB1H 1WCMF 3GTJE 5C44E 1ZYRE 4A3GE 4BY7F 4G7ZE 4A3IF 3RZOE 5M5WE 5IYDF 2JA6E 1TWCF 4OIRE 4JK1E 4LK1E 4A93F 2A68E 5C3EE 2B63E 1I3QE 1EIKA 4BBSE 3HOVF 1QKLA 3S1ME 3CQZE 1I6VE 1R9TE 2VUME 3GTPE 1SMYE 5IYCF 2O5IE 4Y7NF 3S1QE 1YNNK 4A3MF 2PMZK 5IP7F 3RZDF 3S2DF 3HOWE 5E17E 5IP9E 4Y52E 5FLMF 2R7ZF 3PO3E 4BBRF 4C3IE 1TWAE 4A3FE 4XSXE 4G7HE 4XSZE 2BE5E 1K83F 3GTOF 4A3KE 3GTQE 1IW7E 2PPBE 1I6HF 1Y1VE 3S15F 3S17F 4C3JE 5D4EE 3GTJF 5C44F 3HOXF 4LLGE 5IYBE 3M3YE 3I4ME 4A3BF 5C4XE 5M5WF 4XLPE 3GTME 2JA6F 4KN4E 2NVXE 4Q5SE 3S2HF 2E2HE 2A6EE 2A6HE 5C3EF 2NVQE 2E2IF 2B63F 3M4OF 3S1MF 3S1RE 1TWFE 1I3QF 4QIWK 4OIPE 4KN7E 3S16E 3HOUE 4KMUE 4YFXE 5M3MF 2YU9E 2WB1I 5C4JF 4QIWH 3H0GF 3HOWF 2KRXA 4MQ9E 4Y52F 4A3JE 4BY7E 3K7AE 2R93F 3PO3F 5M3FE 1I50E 3GTLE 2Y0SI 4C3IF 1TWGE 4A3DE 1SFOF 2WAQH 1DZFA 4A3EE 4AYBK 5M5YE 4Q4ZE 4A3KF 3GTQF 4A3CE 3PO2E 3GTKF 1TWHF 3S1NF 1WCME 4AYBH 4BY1E 5IYBF 3I4MF 2A69E 1YNJK 5C4XF 3FKIE 3RZOF 1TWCE 2NVTE 2NVXF 5M5XE 3HOZE 2NVYE 4A93E 4A3LE 4MEYE 2NVQF 2R92E 2JA5E 4MEXE 1Y1WE 3HOVE 1HQME 5FJ8E 3S16F 2WAQK 4BBSF 3EQLE 2R93E 5D4DE 4C2ME 3CQZF 4OIOE 3H3VG 4OINE 3RZDE 1R9TF 2VUMF 3GTPF 5IP7E 5E18E 3S1QF 4C3HE 4ZH4E 3K7AF 3HOYE 5IP9F
chains in the Genus database with same CATH topology
2E2JE 4BXXE 3I4NE 4X6AE 1K83E 2JA7E 2JA8E 3S14E 3S15E 3S17E 3HOXE 4A3BE 3HKZH 4A3IE 2Y0SH 5IYDE 3S2HE 2E2IE 3M4OE 5M3ME 5C4JE 5IYCE 3GTGE 3H0GE 4Y7NE 4A3ME 3S2DE 5FLME 1SFOE 2R7ZE 2PMZH 4BBRE 3H3VF 3GTOE 3GTKE 1TWHE 1I6HE 3S1NE 2WB1H 3GTJE 5C44E 4A3GE 3RZOE 5M5WE 2JA6E 5C3EE 2B63E 1I3QE 1EIKA 4BBSE 3S1ME 3CQZE 1R9TE 2VUME 3GTPE 3S1QE 3HOWE 5IP9E 4Y52E 3PO3E 4C3IE 1TWAE 4A3FE 4A3KE 3GTQE 1Y1VE 4C3JE 5IYBE 3M3YE 3I4ME 5C4XE 3GTME 2NVXE 2E2HE 2NVQE 3S1RE 1TWFE 3S16E 3HOUE 2YU9E 4QIWH 4A3JE 4BY7E 3K7AE 5M3FE 1I50E 3GTLE 1TWGE 4A3DE 2WAQH 1DZFA 4A3EE 5M5YE 4A3CE 3PO2E 1WCME 4AYBH 4BY1E 3FKIE 1TWCE 2NVTE 5M5XE 3HOZE 2NVYE 4A93E 4A3LE 2R92E 2JA5E 1Y1WE 3HOVE 5FJ8E 2R93E 4C2ME 3RZDE 5IP7E 4C3HE 3HOYE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2E2J E;  4BXX E;  3I4N E;  4X6A E;  1K83 E;  2JA7 E;  2JA8 E;  3S14 E;  3S15 E;  3S17 E;  3HOX E;  4A3B E;  3HKZ H;  4A3I E;  2Y0S H;  5IYD E;  3S2H E;  2E2I E;  3M4O E;  5M3M E;  5C4J E;  5IYC E;  3GTG E;  3H0G E;  4Y7N E;  4A3M E;  3S2D E;  5FLM E;  1SFO E;  2R7Z E;  2PMZ H;  4BBR E;  3H3V F;  3GTO E;  3GTK E;  1TWH E;  1I6H E;  3S1N E;  2WB1 H;  3GTJ E;  5C44 E;  4A3G E;  3RZO E;  5M5W E;  2JA6 E;  5C3E E;  2B63 E;  1I3Q E;  1EIK A;  4BBS E;  3S1M E;  3CQZ E;  1R9T E;  2VUM E;  3GTP E;  3S1Q E;  3HOW E;  5IP9 E;  4Y52 E;  3PO3 E;  4C3I E;  1TWA E;  4A3F E;  4A3K E;  3GTQ E;  1Y1V E;  4C3J E;  5IYB E;  3M3Y E;  3I4M E;  5C4X E;  3GTM E;  2NVX E;  2E2H E;  2NVQ E;  3S1R E;  1TWF E;  3S16 E;  3HOU E;  2YU9 E;  4QIW H;  4A3J E;  4BY7 E;  3K7A E;  5M3F E;  1I50 E;  3GTL E;  1TWG E;  4A3D E;  2WAQ H;  1DZF A;  4A3E E;  5M5Y E;  4A3C E;  3PO2 E;  1WCM E;  4AYB H;  4BY1 E;  3FKI E;  1TWC E;  2NVT E;  5M5X E;  3HOZ E;  2NVY E;  4A93 E;  4A3L E;  2R92 E;  2JA5 E;  1Y1W E;  3HOV E;  5FJ8 E;  2R93 E;  4C2M E;  3RZD E;  5IP7 E;  4C3H E;  3HOY E; 
#chains in the Genus database with same CATH topology
 3WOD E;  5M3F F;  1I50 F;  3GTL F;  2E2J E;  4BXX E;  1TWG F;  3I4N E;  3DXJ E;  4X6A E;  4A3E F;  5M5Y F;  1TWA F;  4YFK E;  4A3F F;  1K83 E;  2CW0 E;  2JA7 E;  4A3C F;  2JA8 E;  3S14 E;  3S15 E;  3PO2 F;  3S17 E;  3HOX E;  4BY1 F;  1Y1V F;  5TMC E;  5TMF E;  4A3B E;  4C3J F;  2O5J E;  3HKZ H;  3M3Y F;  4XLN E;  5D4C E;  3FKI F;  4A3I E;  2NVT F;  2Y0S H;  5IPL E;  5IYD E;  5M5X F;  3GTM F;  2NVY F;  3HOZ F;  4OIQ E;  3S2H E;  4A3L F;  4GZY E;  2E2I E;  4G7O E;  3M4O E;  4LJZ E;  4YG2 E;  2R92 F;  2E2H F;  2JA5 F;  1Y1W F;  4LK0 E;  3S1R F;  1TWF F;  5FJ8 F;  5M3M E;  4C2M F;  3HOU F;  5C4J E;  5IYC E;  3GTG E;  3H0G E;  2YU9 F;  4Y7N E;  4A3M E;  4C3H F;  3S2D E;  4A3G F;  3HOY F;  4A3J F;  5FLM E;  1SFO E;  2R7Z E;  2PMZ H;  2E2J F;  3GTG F;  5BYH E;  3I4N F;  4BXX F;  4X6A F;  4BBR E;  4A3D F;  3H3V F;  2JA7 F;  4YFN E;  2JA8 F;  3S14 F;  3GTO E;  3GTK E;  1TWH E;  1I6H E;  3S1N E;  3HKZ K;  2WB1 H;  1WCM F;  3GTJ E;  5C44 E;  1ZYR E;  4A3G E;  4BY7 F;  4G7Z E;  4A3I F;  3RZO E;  5M5W E;  5IYD F;  2JA6 E;  1TWC F;  4OIR E;  4JK1 E;  4LK1 E;  4A93 F;  2A68 E;  5C3E E;  2B63 E;  1I3Q E;  1EIK A;  4BBS E;  3HOV F;  1QKL A;  3S1M E;  3CQZ E;  1I6V E;  1R9T E;  2VUM E;  3GTP E;  1SMY E;  5IYC F;  2O5I E;  4Y7N F;  3S1Q E;  1YNN K;  4A3M F;  2PMZ K;  5IP7 F;  3RZD F;  3S2D F;  3HOW E;  5E17 E;  5IP9 E;  4Y52 E;  5FLM F;  2R7Z F;  3PO3 E;  4BBR F;  4C3I E;  1TWA E;  4A3F E;  4XSX E;  4G7H E;  4XSZ E;  2BE5 E;  1K83 F;  3GTO F;  4A3K E;  3GTQ E;  1IW7 E;  2PPB E;  1I6H F;  1Y1V E;  3S15 F;  3S17 F;  4C3J E;  5D4E E;  3GTJ F;  5C44 F;  3HOX F;  4LLG E;  5IYB E;  3M3Y E;  3I4M E;  4A3B F;  5C4X E;  5M5W F;  4XLP E;  3GTM E;  2JA6 F;  4KN4 E;  2NVX E;  4Q5S E;  3S2H F;  2E2H E;  2A6E E;  2A6H E;  5C3E F;  2NVQ E;  2E2I F;  2B63 F;  3M4O F;  3S1M F;  3S1R E;  1TWF E;  1I3Q F;  4QIW K;  4OIP E;  4KN7 E;  3S16 E;  3HOU E;  4KMU E;  4YFX E;  5M3M F;  2YU9 E;  2WB1 I;  5C4J F;  4QIW H;  3H0G F;  3HOW F;  2KRX A;  4MQ9 E;  4Y52 F;  4A3J E;  4BY7 E;  3K7A E;  2R93 F;  3PO3 F;  5M3F E;  1I50 E;  3GTL E;  2Y0S I;  4C3I F;  1TWG E;  4A3D E;  1SFO F;  2WAQ H;  1DZF A;  4A3E E;  4AYB K;  5M5Y E;  4Q4Z E;  4A3K F;  3GTQ F;  4A3C E;  3PO2 E;  3GTK F;  1TWH F;  3S1N F;  1WCM E;  4AYB H;  4BY1 E;  5IYB F;  3I4M F;  2A69 E;  1YNJ K;  5C4X F;  3FKI E;  3RZO F;  1TWC E;  2NVT E;  2NVX F;  5M5X E;  3HOZ E;  2NVY E;  4A93 E;  4A3L E;  4MEY E;  2NVQ F;  2R92 E;  2JA5 E;  4MEX E;  1Y1W E;  3HOV E;  1HQM E;  5FJ8 E;  3S16 F;  2WAQ K;  4BBS F;  3EQL E;  2R93 E;  5D4D E;  4C2M E;  3CQZ F;  4OIO E;  3H3V G;  4OIN E;  3RZD E;  1R9T F;  2VUM F;  3GTP F;  5IP7 E;  5E18 E;  3S1Q F;  4C3H E;  4ZH4 E;  3K7A F;  3HOY E;  5IP9 F; 
#chains in the Genus database with same CATH homology
 2E2J E;  4BXX E;  3I4N E;  4X6A E;  1K83 E;  2JA7 E;  2JA8 E;  3S14 E;  3S15 E;  3S17 E;  3HOX E;  4A3B E;  3HKZ H;  4A3I E;  2Y0S H;  5IYD E;  3S2H E;  2E2I E;  3M4O E;  5M3M E;  5C4J E;  5IYC E;  3GTG E;  3H0G E;  4Y7N E;  4A3M E;  3S2D E;  5FLM E;  1SFO E;  2R7Z E;  2PMZ H;  4BBR E;  3H3V F;  3GTO E;  3GTK E;  1TWH E;  1I6H E;  3S1N E;  2WB1 H;  3GTJ E;  5C44 E;  4A3G E;  3RZO E;  5M5W E;  2JA6 E;  5C3E E;  2B63 E;  1I3Q E;  1EIK A;  4BBS E;  3S1M E;  3CQZ E;  1R9T E;  2VUM E;  3GTP E;  3S1Q E;  3HOW E;  5IP9 E;  4Y52 E;  3PO3 E;  4C3I E;  1TWA E;  4A3F E;  4A3K E;  3GTQ E;  1Y1V E;  4C3J E;  5IYB E;  3M3Y E;  3I4M E;  5C4X E;  3GTM E;  2NVX E;  2E2H E;  2NVQ E;  3S1R E;  1TWF E;  3S16 E;  3HOU E;  2YU9 E;  4QIW H;  4A3J E;  4BY7 E;  3K7A E;  5M3F E;  1I50 E;  3GTL E;  1TWG E;  4A3D E;  2WAQ H;  1DZF A;  4A3E E;  5M5Y E;  4A3C E;  3PO2 E;  1WCM E;  4AYB H;  4BY1 E;  3FKI E;  1TWC E;  2NVT E;  5M5X E;  3HOZ E;  2NVY E;  4A93 E;  4A3L E;  2R92 E;  2JA5 E;  1Y1W E;  3HOV E;  5FJ8 E;  2R93 E;  4C2M E;  3RZD E;  5IP7 E;  4C3H E;  3HOY E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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