1ZYRE

Structure of thermus thermophilus rna polymerase holoenzyme in complex with the antibiotic streptolydigin
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
95
structure length
95
Chain Sequence
AEPGIDKLFGMVDSKYRLTVVVAKRAQQLLRHGFKNTVLEPEERPKMQTLEGLFDDPNAETWAMKELLTGRLVFGENLVPEDRLQKEMERIYPGE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.
pubmed doi rcsb
molecule tags Transcription,transferase
molecule keywords DNA-directed RNA polymerase alpha chain
total genus 15
structure length 95
sequence length 95
chains with identical sequence O
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2005-06-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 1zyrE00
3WODE 5M3FF 1I50F 3GTLF 1TWGF 3DXJE 4A3EF 5M5YF 1TWAF 4YFKE 4A3FF 2CW0E 4A3CF 3PO2F 4BY1F 1Y1VF 5TMCE 5TMFE 4C3JF 2O5JE 3M3YF 4XLNE 5D4CE 3FKIF 2NVTF 5IPLE 5M5XF 3GTMF 2NVYF 3HOZF 4OIQE 4A3LF 4GZYE 4G7OE 4LJZE 4YG2E 2R92F 2E2HF 2JA5F 1Y1WF 4LK0E 3S1RF 1TWFF 5FJ8F 4C2MF 3HOUF 2YU9F 4C3HF 4A3GF 3HOYF 4A3JF 2E2JF 4BXXF 3I4NF 5BYHE 4X6AF 4A3DF 2JA7F 4YFNE 2JA8F 3S14F 3HKZK 1WCMF 1ZYRE 4G7ZE 4A3IF 5IYDF 1TWCF 4OIRE 4JK1E 4A93F 2A68E 3HOVF 1QKLA 1I6VE 2R93F 1SMYE 5IYCF 3GTGF 2O5IE 4Y7NF 1YNNK 4A3MF 3RZDF 2PMZK 5IP7F 3S2DF 5E17E 5FLMF 2R7ZF 4BBRF 4XSXE 4G7HE 4XSZE 2BE5E 1K83F 3GTOF 2PPBE 1IW7E 1I6HF 3S15F 3S17F 5D4EE 3GTJF 5C44F 3HOXF 4LLGE 4A3BF 5M5WF 3K7AF 4XLPE 2JA6F 4KN4E 4Q5SE 3S2HF 2A6EE 2A6HE 5C3EF 2E2IF 2B63F 3M4OF 1I3QF 4OIPE 4KN7E 4KMUE 4YFXE 5M3MF 2WB1I 5C4JF 3H0GF 3HOWF 4MQ9E 4Y52F 3PO3F 1SFOF 2Y0SI 4C3IF 4AYBK 4Q4ZE 4A3KF 3GTQF 3GTKF 1TWHF 3S1NF 5IYBF 3I4MF 2A69E 1YNJK 5C4XF 3RZOF 2NVXF 4MEYE 2NVQF 4MEXE 1HQME 3S16F 4BBSF 3EQLE 5D4DE 4OIOE 3S1MF 3CQZF 3H3VG 4OINE 1R9TF 2VUMF 3GTPF 5E18E 3S1QF 4BY7F 4ZH4E 4LK1E 2WAQK 5IP9F
chains in the Genus database with same CATH superfamily
3WODE 5M3FF 1I50F 3GTLF 2E2JE 1TWGF 3DXJE 3I4NE 4BXXE 4X6AE 4A3EF 5M5YF 1TWAF 4YFKE 4A3FF 1K83E 2CW0E 2JA7E 4A3CF 2JA8E 3S14E 3S15E 3PO2F 3S17E 3HOXE 4BY1F 1Y1VF 5TMCE 5TMFE 4C3JF 4A3BE 2O5JE 3HKZH 3M3YF 4XLNE 5D4CE 3FKIF 4A3IE 2NVTF 2Y0SH 5IPLE 5IYDE 5M5XF 3GTMF 2NVYF 3HOZF 4OIQE 3S2HE 4A3LF 4GZYE 2E2IE 4G7OE 4LJZE 4YG2E 2R92F 3M4OE 2E2HF 2JA5F 1Y1WF 4LK0E 3S1RF 1TWFF 5FJ8F 4C2MF 5M3ME 3HOUF 5C4JE 5IYCE 3GTGE 3H0GE 2YU9F 4Y7NE 4A3ME 4C3HF 3S2DE 4A3GF 3HOYF 4A3JF 5FLME 1SFOE 2PMZH 2E2JF 2R7ZE 3I4NF 5BYHE 4BXXF 4X6AF 4BBRE 4A3DF 2JA7F 3H3VF 4YFNE 2JA8F 3S14F 3GTOE 3GTKE 1TWHE 3HKZK 3S1NE 1I6HE 2WB1H 3GTPE 1WCMF 3GTJE 5C44E 1ZYRE 4G7ZE 4A3GE 4A3IF 3RZOE 5M5WE 5IYDF 2JA6E 1TWCF 4OIRE 4JK1E 4A93F 2A68E 4C3HE 5C3EE 2B63E 1I3QE 1EIKA 4BBSE 3HOVF 1QKLA 3S1ME 3CQZE 1I6VE 1R9TE 1SMYE 5IYCF 2VUME 3GTGF 2O5IE 4Y7NF 1YNNK 4A3MF 3RZDF 2PMZK 5IP7F 3S1QE 3S2DF 3HOWE 5E17E 5IP9E 5FLMF 4Y52E 2R7ZF 3PO3E 4BBRF 4C3IE 1TWAE 4A3FE 4XSXE 4G7HE 4XSZE 2BE5E 1K83F 3GTOF 4A3KE 2PPBE 1IW7E 1I6HF 3GTQE 1Y1VE 3S15F 3S17F 4C3JE 5D4EE 3GTJF 5C44F 3HOXF 4LLGE 5IYBE 3M3YE 3I4ME 4A3BF 5C4XE 5M5WF 3K7AF 4XLPE 2JA6F 3GTME 4KN4E 2NVXE 4Q5SE 3S2HF 2A6EE 2A6HE 5C3EF 2E2IF 2E2HE 2B63F 2NVQE 3M4OF 1I3QF 1TWFE 3S1RE 4QIWK 4OIPE 4KN7E 3S16E 3HOUE 4KMUE 4YFXE 5M3MF 2WB1I 2YU9E 5C4JF 4QIWH 3H0GF 3HOWF 2KRXA 4MQ9E 4Y52F 4A3JE 4BY7E 3K7AE 2R93F 3PO3F 5M3FE 1I50E 2Y0SI 1SFOF 4C3IF 1TWGE 3GTLE 4A3DE 2WAQH 1DZFA 4AYBK 4A3EE 4Q4ZE 5M5YE 4A3KF 3GTQF 4A3CE 3HOYE 3PO2E 3GTKF 1TWHF 3S1NF 1WCME 4AYBH 4BY1E 5IYBF 3I4MF 2A69E 1YNJK 5C4XF 3FKIE 3RZOF 1TWCE 2NVTE 2NVXF 2R93E 5M5XE 3HOZE 2NVYE 4A93E 4MEYE 4A3LE 2NVQF 2R92E 2JA5E 4MEXE 1Y1WE 3HOVE 1HQME 5FJ8E 3S16F 4BBSF 3EQLE 5D4DE 4OIOE 4C2ME 3CQZF 3S1MF 3H3VG 4OINE 3RZDE 1R9TF 2VUMF 3GTPF 5IP7E 5E18E 3S1QF 4BY7F 4ZH4E 4LK1E 2WAQK 5IP9F
chains in the Genus database with same CATH topology
3WODE 5M3FF 1I50F 3GTLF 1TWGF 3DXJE 4A3EF 5M5YF 1TWAF 4YFKE 4A3FF 2CW0E 4A3CF 3PO2F 4BY1F 1Y1VF 5TMCE 5TMFE 4C3JF 2O5JE 3M3YF 4XLNE 5D4CE 3FKIF 2NVTF 5IPLE 5M5XF 3GTMF 2NVYF 3HOZF 4OIQE 4A3LF 4GZYE 4G7OE 4LJZE 4YG2E 2R92F 2E2HF 2JA5F 1Y1WF 4LK0E 3S1RF 1TWFF 5FJ8F 4C2MF 3HOUF 2YU9F 4C3HF 4A3GF 3HOYF 4A3JF 2E2JF 4BXXF 3I4NF 5BYHE 4X6AF 4A3DF 2JA7F 4YFNE 2JA8F 3S14F 3HKZK 1WCMF 1ZYRE 4G7ZE 4A3IF 5IYDF 1TWCF 4OIRE 4JK1E 4A93F 2A68E 3HOVF 1QKLA 1I6VE 2R93F 1SMYE 5IYCF 3GTGF 2O5IE 4Y7NF 1YNNK 4A3MF 3RZDF 2PMZK 5IP7F 3S2DF 5E17E 5FLMF 2R7ZF 4BBRF 4XSXE 4G7HE 4XSZE 2BE5E 1K83F 3GTOF 2PPBE 1IW7E 1I6HF 3S15F 3S17F 5D4EE 3GTJF 5C44F 3HOXF 4LLGE 4A3BF 5M5WF 3K7AF 4XLPE 2JA6F 4KN4E 4Q5SE 3S2HF 2A6EE 2A6HE 5C3EF 2E2IF 2B63F 3M4OF 1I3QF 4QIWK 4OIPE 4KN7E 4KMUE 4YFXE 5M3MF 2WB1I 5C4JF 3H0GF 3HOWF 2KRXA 4MQ9E 4Y52F 3PO3F 1SFOF 2Y0SI 4C3IF 4AYBK 4Q4ZE 4A3KF 3GTQF 3GTKF 1TWHF 3S1NF 5IYBF 3I4MF 2A69E 1YNJK 5C4XF 3RZOF 2NVXF 4MEYE 2NVQF 4MEXE 1HQME 3S16F 4BBSF 3EQLE 5D4DE 4OIOE 3S1MF 3CQZF 3H3VG 4OINE 1R9TF 2VUMF 3GTPF 5E18E 3S1QF 4BY7F 4ZH4E 4LK1E 2WAQK 5IP9F
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3WOD E;  5M3F F;  1I50 F;  3GTL F;  1TWG F;  3DXJ E;  4A3E F;  5M5Y F;  1TWA F;  4YFK E;  4A3F F;  2CW0 E;  4A3C F;  3PO2 F;  4BY1 F;  1Y1V F;  5TMC E;  5TMF E;  4C3J F;  2O5J E;  3M3Y F;  4XLN E;  5D4C E;  3FKI F;  2NVT F;  5IPL E;  5M5X F;  3GTM F;  2NVY F;  3HOZ F;  4OIQ E;  4A3L F;  4GZY E;  4G7O E;  4LJZ E;  4YG2 E;  2R92 F;  2E2H F;  2JA5 F;  1Y1W F;  4LK0 E;  3S1R F;  1TWF F;  5FJ8 F;  4C2M F;  3HOU F;  2YU9 F;  4C3H F;  4A3G F;  3HOY F;  4A3J F;  2E2J F;  4BXX F;  3I4N F;  5BYH E;  4X6A F;  4A3D F;  2JA7 F;  4YFN E;  2JA8 F;  3S14 F;  3HKZ K;  1WCM F;  1ZYR E;  4G7Z E;  4A3I F;  5IYD F;  1TWC F;  4OIR E;  4JK1 E;  4A93 F;  2A68 E;  3HOV F;  1QKL A;  1I6V E;  2R93 F;  1SMY E;  5IYC F;  3GTG F;  2O5I E;  4Y7N F;  1YNN K;  4A3M F;  3RZD F;  2PMZ K;  5IP7 F;  3S2D F;  5E17 E;  5FLM F;  2R7Z F;  4BBR F;  4XSX E;  4G7H E;  4XSZ E;  2BE5 E;  1K83 F;  3GTO F;  2PPB E;  1IW7 E;  1I6H F;  3S15 F;  3S17 F;  5D4E E;  3GTJ F;  5C44 F;  3HOX F;  4LLG E;  4A3B F;  5M5W F;  3K7A F;  4XLP E;  2JA6 F;  4KN4 E;  4Q5S E;  3S2H F;  2A6E E;  2A6H E;  5C3E F;  2E2I F;  2B63 F;  3M4O F;  1I3Q F;  4OIP E;  4KN7 E;  4KMU E;  4YFX E;  5M3M F;  2WB1 I;  5C4J F;  3H0G F;  3HOW F;  4MQ9 E;  4Y52 F;  3PO3 F;  1SFO F;  2Y0S I;  4C3I F;  4AYB K;  4Q4Z E;  4A3K F;  3GTQ F;  3GTK F;  1TWH F;  3S1N F;  5IYB F;  3I4M F;  2A69 E;  1YNJ K;  5C4X F;  3RZO F;  2NVX F;  4MEY E;  2NVQ F;  4MEX E;  1HQM E;  3S16 F;  4BBS F;  3EQL E;  5D4D E;  4OIO E;  3S1M F;  3CQZ F;  3H3V G;  4OIN E;  1R9T F;  2VUM F;  3GTP F;  5E18 E;  3S1Q F;  4BY7 F;  4ZH4 E;  4LK1 E;  2WAQ K;  5IP9 F; 
#chains in the Genus database with same CATH topology
 3WOD E;  5M3F F;  1I50 F;  3GTL F;  2E2J E;  1TWG F;  3DXJ E;  3I4N E;  4BXX E;  4X6A E;  4A3E F;  5M5Y F;  1TWA F;  4YFK E;  4A3F F;  1K83 E;  2CW0 E;  2JA7 E;  4A3C F;  2JA8 E;  3S14 E;  3S15 E;  3PO2 F;  3S17 E;  3HOX E;  4BY1 F;  1Y1V F;  5TMC E;  5TMF E;  4C3J F;  4A3B E;  2O5J E;  3HKZ H;  3M3Y F;  4XLN E;  5D4C E;  3FKI F;  4A3I E;  2NVT F;  2Y0S H;  5IPL E;  5IYD E;  5M5X F;  3GTM F;  2NVY F;  3HOZ F;  4OIQ E;  3S2H E;  4A3L F;  4GZY E;  2E2I E;  4G7O E;  4LJZ E;  4YG2 E;  2R92 F;  3M4O E;  2E2H F;  2JA5 F;  1Y1W F;  4LK0 E;  3S1R F;  1TWF F;  5FJ8 F;  4C2M F;  5M3M E;  3HOU F;  5C4J E;  5IYC E;  3GTG E;  3H0G E;  2YU9 F;  4Y7N E;  4A3M E;  4C3H F;  3S2D E;  4A3G F;  3HOY F;  4A3J F;  5FLM E;  1SFO E;  2PMZ H;  2E2J F;  2R7Z E;  3I4N F;  5BYH E;  4BXX F;  4X6A F;  4BBR E;  4A3D F;  2JA7 F;  3H3V F;  4YFN E;  2JA8 F;  3S14 F;  3GTO E;  3GTK E;  1TWH E;  3HKZ K;  3S1N E;  1I6H E;  2WB1 H;  3GTP E;  1WCM F;  3GTJ E;  5C44 E;  1ZYR E;  4G7Z E;  4A3G E;  4A3I F;  3RZO E;  5M5W E;  5IYD F;  2JA6 E;  1TWC F;  4OIR E;  4JK1 E;  4A93 F;  2A68 E;  4C3H E;  5C3E E;  2B63 E;  1I3Q E;  1EIK A;  4BBS E;  3HOV F;  1QKL A;  3S1M E;  3CQZ E;  1I6V E;  1R9T E;  1SMY E;  5IYC F;  2VUM E;  3GTG F;  2O5I E;  4Y7N F;  1YNN K;  4A3M F;  3RZD F;  2PMZ K;  5IP7 F;  3S1Q E;  3S2D F;  3HOW E;  5E17 E;  5IP9 E;  5FLM F;  4Y52 E;  2R7Z F;  3PO3 E;  4BBR F;  4C3I E;  1TWA E;  4A3F E;  4XSX E;  4G7H E;  4XSZ E;  2BE5 E;  1K83 F;  3GTO F;  4A3K E;  2PPB E;  1IW7 E;  1I6H F;  3GTQ E;  1Y1V E;  3S15 F;  3S17 F;  4C3J E;  5D4E E;  3GTJ F;  5C44 F;  3HOX F;  4LLG E;  5IYB E;  3M3Y E;  3I4M E;  4A3B F;  5C4X E;  5M5W F;  3K7A F;  4XLP E;  2JA6 F;  3GTM E;  4KN4 E;  2NVX E;  4Q5S E;  3S2H F;  2A6E E;  2A6H E;  5C3E F;  2E2I F;  2E2H E;  2B63 F;  2NVQ E;  3M4O F;  1I3Q F;  1TWF E;  3S1R E;  4QIW K;  4OIP E;  4KN7 E;  3S16 E;  3HOU E;  4KMU E;  4YFX E;  5M3M F;  2WB1 I;  2YU9 E;  5C4J F;  4QIW H;  3H0G F;  3HOW F;  2KRX A;  4MQ9 E;  4Y52 F;  4A3J E;  4BY7 E;  3K7A E;  2R93 F;  3PO3 F;  5M3F E;  1I50 E;  2Y0S I;  1SFO F;  4C3I F;  1TWG E;  3GTL E;  4A3D E;  2WAQ H;  1DZF A;  4AYB K;  4A3E E;  4Q4Z E;  5M5Y E;  4A3K F;  3GTQ F;  4A3C E;  3HOY E;  3PO2 E;  3GTK F;  1TWH F;  3S1N F;  1WCM E;  4AYB H;  4BY1 E;  5IYB F;  3I4M F;  2A69 E;  1YNJ K;  5C4X F;  3FKI E;  3RZO F;  1TWC E;  2NVT E;  2NVX F;  2R93 E;  5M5X E;  3HOZ E;  2NVY E;  4A93 E;  4MEY E;  4A3L E;  2NVQ F;  2R92 E;  2JA5 E;  4MEX E;  1Y1W E;  3HOV E;  1HQM E;  5FJ8 E;  3S16 F;  4BBS F;  3EQL E;  5D4D E;  4OIO E;  4C2M E;  3CQZ F;  3S1M F;  3H3V G;  4OIN E;  3RZD E;  1R9T F;  2VUM F;  3GTP F;  5IP7 E;  5E18 E;  3S1Q F;  4BY7 F;  4ZH4 E;  4LK1 E;  2WAQ K;  5IP9 F; 
#chains in the Genus database with same CATH homology
 3WOD E;  5M3F F;  1I50 F;  3GTL F;  1TWG F;  3DXJ E;  4A3E F;  5M5Y F;  1TWA F;  4YFK E;  4A3F F;  2CW0 E;  4A3C F;  3PO2 F;  4BY1 F;  1Y1V F;  5TMC E;  5TMF E;  4C3J F;  2O5J E;  3M3Y F;  4XLN E;  5D4C E;  3FKI F;  2NVT F;  5IPL E;  5M5X F;  3GTM F;  2NVY F;  3HOZ F;  4OIQ E;  4A3L F;  4GZY E;  4G7O E;  4LJZ E;  4YG2 E;  2R92 F;  2E2H F;  2JA5 F;  1Y1W F;  4LK0 E;  3S1R F;  1TWF F;  5FJ8 F;  4C2M F;  3HOU F;  2YU9 F;  4C3H F;  4A3G F;  3HOY F;  4A3J F;  2E2J F;  4BXX F;  3I4N F;  5BYH E;  4X6A F;  4A3D F;  2JA7 F;  4YFN E;  2JA8 F;  3S14 F;  3HKZ K;  1WCM F;  1ZYR E;  4G7Z E;  4A3I F;  5IYD F;  1TWC F;  4OIR E;  4JK1 E;  4A93 F;  2A68 E;  3HOV F;  1QKL A;  1I6V E;  2R93 F;  1SMY E;  5IYC F;  3GTG F;  2O5I E;  4Y7N F;  1YNN K;  4A3M F;  3RZD F;  2PMZ K;  5IP7 F;  3S2D F;  5E17 E;  5FLM F;  2R7Z F;  4BBR F;  4XSX E;  4G7H E;  4XSZ E;  2BE5 E;  1K83 F;  3GTO F;  2PPB E;  1IW7 E;  1I6H F;  3S15 F;  3S17 F;  5D4E E;  3GTJ F;  5C44 F;  3HOX F;  4LLG E;  4A3B F;  5M5W F;  3K7A F;  4XLP E;  2JA6 F;  4KN4 E;  4Q5S E;  3S2H F;  2A6E E;  2A6H E;  5C3E F;  2E2I F;  2B63 F;  3M4O F;  1I3Q F;  4QIW K;  4OIP E;  4KN7 E;  4KMU E;  4YFX E;  5M3M F;  2WB1 I;  5C4J F;  3H0G F;  3HOW F;  2KRX A;  4MQ9 E;  4Y52 F;  3PO3 F;  1SFO F;  2Y0S I;  4C3I F;  4AYB K;  4Q4Z E;  4A3K F;  3GTQ F;  3GTK F;  1TWH F;  3S1N F;  5IYB F;  3I4M F;  2A69 E;  1YNJ K;  5C4X F;  3RZO F;  2NVX F;  4MEY E;  2NVQ F;  4MEX E;  1HQM E;  3S16 F;  4BBS F;  3EQL E;  5D4D E;  4OIO E;  3S1M F;  3CQZ F;  3H3V G;  4OIN E;  1R9T F;  2VUM F;  3GTP F;  5E18 E;  3S1Q F;  4BY7 F;  4ZH4 E;  4LK1 E;  2WAQ K;  5IP9 F; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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