2A6HE

Crystal structure of the t. thermophilus rna polymerase holoenzyme in complex with antibiotic sterptolydigin
Total Genus 19
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
19
sequence length
95
structure length
95
Chain Sequence
AEPGIDKLFGMVDSKYRLTVVVAKRAQQLLRHGFKNTVLEPEERPKMQTLEGLFDDPNAETWAMKELLTGRLVFGENLVPEDRLQKEMERIYPGE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of transcription inhibition by antibiotic streptolydigin.
pubmed doi rcsb
molecule tags Transferase
molecule keywords DNA-directed RNA polymerase alpha chain
total genus 19
structure length 95
sequence length 95
chains with identical sequence O
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2005-07-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 2a6hE00
4LK0E 1R9TF 5M5XF 5M5WF 2NVXF 2VUMF 3GTOF 2CW0E 5C4XF 1QKLA 3S2DF 4G7HE 3GTMF 4KN7E 1TWFF 1TWGF 4BXXF 1K83F 5IP7F 4C3IF 4OIQE 4JK1E 3S14F 4OIOE 1Y1WF 2E2HF 3S1RF 4Q5SE 3GTKF 1SFOF 3HOZF 3HOVF 3S16F 4A3EF 4XLNE 1YNNK 4XSXE 4Y7NF 1TWHF 4LLGE 3RZOF 3GTJF 3FKIF 4A3KF 3H0GF 5IYDF 3K7AF 5E18E 4GZYE 1I50F 3HOUF 2WAQK 5FJ8F 4C3JF 3HOYF 4OIRE 1I6HF 1IW7E 5D4EE 4A3JF 4A3DF 4ZH4E 4BY1F 1SMYE 4G7OE 3M4OF 4A3IF 3I4NF 2PMZK 2R7ZF 1TWAF 4LJZE 3HKZK 5TMFE 5D4DE 5FLMF 3S1NF 5D4CE 3HOXF 1HQME 2R92F 1TWCF 2NVTF 4A3MF 3M3YF 3EQLE 4YFNE 3HOWF 4A3LF 2A6HE 4YFXE 2Y0SI 1I6VE 2JA8F 2E2JF 4BBRF 4OIPE 2A6EE 1Y1VF 4A3BF 5TMCE 4A3GF 4G7ZE 3DXJE 5BYHE 4X6AF 4LK1E 2YU9F 4A3CF 2E2IF 3S1MF 4MEYE 5M3MF 5C3EF 4KN4E 3S1QF 4C2MF 4YFKE 2NVYF 3I4MF 1WCMF 2BE5E 5IP9F 4AYBK 4A93F 2PPBE 3RZDF 2JA7F 5C4JF 4C3HF 4MEXE 4OINE 3H3VG 5IYBF 2WB1I 3S17F 4BBSF 1ZYRE 2A69E 2O5JE 5M3FF 5E17E 5C44F 2R93F 3GTPF 4MQ9E 2JA5F 3GTGF 5IYCF 2JA6F 3PO3F 5M5YF 3S15F 4Y52F 3GTLF 4BY7F 3S2HF 2NVQF 4XSZE 2B63F 3CQZF 4YG2E 2O5IE 4Q4ZE 1I3QF 3WODE 3GTQF 5IPLE 4XLPE 4A3FF 3PO2F 1YNJK 4KMUE 2A68E
chains in the Genus database with same CATH superfamily
4LK0E 3GTME 1R9TF 1TWFE 5M5XF 5M5WF 2NVXF 2VUMF 1TWGE 3GTOF 1K83E 5IP7E 4C3IE 4BXXE 2CW0E 5C4XF 3S14E 1QKLA 3S2DF 1Y1WE 4G7HE 2E2HE 3GTMF 3I4NE 4KN7E 3GTKE 1SFOE 1TWFF 3HOZE 3HOVE 1TWGF 4BXXF 1K83F 5IP7F 4C3IF 4A3EE 4OIQE 3S16E 4JK1E 3HOXE 3S14F 4OIOE 1Y1WF 2E2HF 3S1RF 4Y7NE 1TWHE 4Q5SE 3GTKF 3RZOE 1SFOF 3HOZF 3HOVF 3GTJE 3S16F 4A3EF 3FKIE 4A3KE 3H0GE 5IYDE 3K7AE 4XLNE 1YNNK 1I50E 4XSXE 4Y7NF 1TWHF 4LLGE 3HOUE 2E2JE 3RZOF 5FJ8E 3GTJF 3FKIF 4A3KF 4C3JE 3HOYE 3H0GF 5IYDF 3K7AF 5E18E 4GZYE 1I6HE 1I50F 4A3JE 3HOUF 2WAQK 4A3DE 5FJ8F 4BY1E 4QIWH 2WB1H 4C3JF 3M4OE 4A3IE 4OIRE 3HOYF 4BBSF 1I6HF 2R7ZE 1IW7E 1TWAE 2NVYE 4C2ME 5D4EE 4A3JF 4A3DF 4ZH4E 4A93E 5FLME 3S1NE 2Y0SH 4BY1F 1SMYE 4G7OE 3M4OF 2R92E 4A3IF 3I4NF 1DZFA 2PMZK 1TWCE 3S2DE 2NVTE 2R7ZF 1TWAF 4LJZE 4A3ME 3HKZK 3M3YE 5TMFE 5D4DE 5FLMF 3HOWE 3S1NF 4A3LE 5D4CE 3HOXF 1HQME 2R93E 2R92F 2JA8E 1TWCF 2NVTF 4A3MF 4BBRE 3EQLE 3M3YF 4YFNE 3HOWF 4A3LF 2A6HE 1Y1VE 4YFXE 4A3BE 2Y0SI 2KRXA 2NVQE 1I6VE 4A3GE 2JA8F 3CQZE 4X6AE 2E2JF 2YU9E 4BBRF 4OIPE 4A3CE 2A6EE 1Y1VF 2E2IE 3S1ME 5TMCE 4A3BF 5M3ME 5C3EE 4A3GF 4G7ZE 3DXJE 5BYHE 3S1QE 3I4ME 1WCME 5IP9E 4LK1E 2YU9F 4A3CF 4X6AF 3RZDE 2JA7E 5C4JE 2E2IF 3S1MF 4C3HE 4MEYE 5M3MF 5IYBE 5C3EF 4KN4E 3H3VF 3S17E 4BBSE 3S1QF 4C2MF 4YFKE 2NVYF 3I4MF 1WCMF 2BE5E 5IP9F 4AYBK 2NVXE 2VUME 4A93F 2PPBE 1EIKA 5M3FE 3RZDF 2JA7F 5C4XE 5C4JF 4C3HF 3HKZH 5C44E 4MEXE 4OINE 5IYBF 3H3VG 2WB1I 2JA5E 3GTGE 3GTPE 3S17F 1ZYRE 4QIWK 2A69E 5IYCE 2JA6E 3PO3E 2O5JE 5M5YE 3S15E 5M3FF 3GTLE 4Y52E 4BY7E 5E17E 3S2HE 5C44F 2R93F 2B63E 3GTPF 4MQ9E 3S1RE 2JA5F 3GTGF 5IYCF 2JA6F 3PO3F 1I3QE 5M5YF 3S15F 4Y52F 3GTLF 4BY7F 3S2HF 2WAQH 2NVQF 4XSZE 2B63F 3CQZF 4YG2E 2O5IE 4Q4ZE 3GTQE 4A3FE 3PO2E 1I3QF 3WODE 1R9TE 3GTQF 5M5XE 5M5WE 5IPLE 4XLPE 3GTOE 4A3FF 3PO2F 2PMZH 1YNJK 4KMUE 4AYBH 2A68E
chains in the Genus database with same CATH topology
4LK0E 1R9TF 5M5XF 5M5WF 2NVXF 2VUMF 3GTOF 2CW0E 5C4XF 1QKLA 3S2DF 4G7HE 3GTMF 4KN7E 1TWFF 1TWGF 4BXXF 1K83F 5IP7F 4C3IF 4OIQE 4JK1E 3S14F 4OIOE 1Y1WF 2E2HF 3S1RF 4Q5SE 3GTKF 1SFOF 3HOZF 3HOVF 3S16F 4A3EF 4XLNE 1YNNK 4XSXE 4Y7NF 1TWHF 4LLGE 3RZOF 3GTJF 3FKIF 4A3KF 3H0GF 5IYDF 3K7AF 5E18E 4GZYE 1I50F 3HOUF 2WAQK 5FJ8F 4C3JF 3HOYF 4OIRE 1I6HF 1IW7E 5D4EE 4A3JF 4A3DF 4ZH4E 4BY1F 1SMYE 4G7OE 3M4OF 4A3IF 3I4NF 2PMZK 2R7ZF 1TWAF 4LJZE 3HKZK 5TMFE 5D4DE 5FLMF 3S1NF 5D4CE 3HOXF 1HQME 2R92F 1TWCF 2NVTF 4A3MF 3M3YF 3EQLE 4YFNE 3HOWF 4A3LF 2A6HE 4YFXE 2Y0SI 2KRXA 1I6VE 2JA8F 2E2JF 4BBRF 4OIPE 2A6EE 1Y1VF 4A3BF 5TMCE 4A3GF 4G7ZE 3DXJE 5BYHE 4X6AF 4LK1E 2YU9F 4A3CF 2E2IF 3S1MF 4MEYE 5M3MF 5C3EF 4KN4E 3S1QF 4C2MF 4YFKE 2NVYF 3I4MF 1WCMF 2BE5E 5IP9F 4AYBK 4A93F 2PPBE 3RZDF 2JA7F 5C4JF 4C3HF 4MEXE 4OINE 3H3VG 5IYBF 2WB1I 3S17F 4BBSF 1ZYRE 4QIWK 2A69E 2O5JE 5M3FF 5E17E 5C44F 2R93F 3GTPF 4MQ9E 2JA5F 3GTGF 5IYCF 2JA6F 3PO3F 5M5YF 3S15F 4Y52F 3GTLF 4BY7F 3S2HF 2NVQF 4XSZE 2B63F 3CQZF 4YG2E 2O5IE 4Q4ZE 1I3QF 3WODE 3GTQF 5IPLE 4XLPE 4A3FF 3PO2F 1YNJK 4KMUE 2A68E
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LK0 E;  1R9T F;  5M5X F;  5M5W F;  2NVX F;  2VUM F;  3GTO F;  2CW0 E;  5C4X F;  1QKL A;  3S2D F;  4G7H E;  3GTM F;  4KN7 E;  1TWF F;  1TWG F;  4BXX F;  1K83 F;  5IP7 F;  4C3I F;  4OIQ E;  4JK1 E;  3S14 F;  4OIO E;  1Y1W F;  2E2H F;  3S1R F;  4Q5S E;  3GTK F;  1SFO F;  3HOZ F;  3HOV F;  3S16 F;  4A3E F;  4XLN E;  1YNN K;  4XSX E;  4Y7N F;  1TWH F;  4LLG E;  3RZO F;  3GTJ F;  3FKI F;  4A3K F;  3H0G F;  5IYD F;  3K7A F;  5E18 E;  4GZY E;  1I50 F;  3HOU F;  2WAQ K;  5FJ8 F;  4C3J F;  3HOY F;  4OIR E;  1I6H F;  1IW7 E;  5D4E E;  4A3J F;  4A3D F;  4ZH4 E;  4BY1 F;  1SMY E;  4G7O E;  3M4O F;  4A3I F;  3I4N F;  2PMZ K;  2R7Z F;  1TWA F;  4LJZ E;  3HKZ K;  5TMF E;  5D4D E;  5FLM F;  3S1N F;  5D4C E;  3HOX F;  1HQM E;  2R92 F;  1TWC F;  2NVT F;  4A3M F;  3M3Y F;  3EQL E;  4YFN E;  3HOW F;  4A3L F;  2A6H E;  4YFX E;  2Y0S I;  1I6V E;  2JA8 F;  2E2J F;  4BBR F;  4OIP E;  2A6E E;  1Y1V F;  4A3B F;  5TMC E;  4A3G F;  4G7Z E;  3DXJ E;  5BYH E;  4X6A F;  4LK1 E;  2YU9 F;  4A3C F;  2E2I F;  3S1M F;  4MEY E;  5M3M F;  5C3E F;  4KN4 E;  3S1Q F;  4C2M F;  4YFK E;  2NVY F;  3I4M F;  1WCM F;  2BE5 E;  5IP9 F;  4AYB K;  4A93 F;  2PPB E;  3RZD F;  2JA7 F;  5C4J F;  4C3H F;  4MEX E;  4OIN E;  3H3V G;  5IYB F;  2WB1 I;  3S17 F;  4BBS F;  1ZYR E;  2A69 E;  2O5J E;  5M3F F;  5E17 E;  5C44 F;  2R93 F;  3GTP F;  4MQ9 E;  2JA5 F;  3GTG F;  5IYC F;  2JA6 F;  3PO3 F;  5M5Y F;  3S15 F;  4Y52 F;  3GTL F;  4BY7 F;  3S2H F;  2NVQ F;  4XSZ E;  2B63 F;  3CQZ F;  4YG2 E;  2O5I E;  4Q4Z E;  1I3Q F;  3WOD E;  3GTQ F;  5IPL E;  4XLP E;  4A3F F;  3PO2 F;  1YNJ K;  4KMU E;  2A68 E; 
#chains in the Genus database with same CATH topology
 4LK0 E;  3GTM E;  1R9T F;  1TWF E;  5M5X F;  5M5W F;  2NVX F;  2VUM F;  1TWG E;  3GTO F;  1K83 E;  5IP7 E;  4C3I E;  4BXX E;  2CW0 E;  5C4X F;  3S14 E;  1QKL A;  3S2D F;  1Y1W E;  4G7H E;  2E2H E;  3GTM F;  3I4N E;  4KN7 E;  3GTK E;  1SFO E;  1TWF F;  3HOZ E;  3HOV E;  1TWG F;  4BXX F;  1K83 F;  5IP7 F;  4C3I F;  4A3E E;  4OIQ E;  3S16 E;  4JK1 E;  3HOX E;  3S14 F;  4OIO E;  1Y1W F;  2E2H F;  3S1R F;  4Y7N E;  1TWH E;  4Q5S E;  3GTK F;  3RZO E;  1SFO F;  3HOZ F;  3HOV F;  3GTJ E;  3S16 F;  4A3E F;  3FKI E;  4A3K E;  3H0G E;  5IYD E;  3K7A E;  4XLN E;  1YNN K;  1I50 E;  4XSX E;  4Y7N F;  1TWH F;  4LLG E;  3HOU E;  2E2J E;  3RZO F;  5FJ8 E;  3GTJ F;  3FKI F;  4A3K F;  4C3J E;  3HOY E;  3H0G F;  5IYD F;  3K7A F;  5E18 E;  4GZY E;  1I6H E;  1I50 F;  4A3J E;  3HOU F;  2WAQ K;  4A3D E;  5FJ8 F;  4BY1 E;  4QIW H;  2WB1 H;  4C3J F;  3M4O E;  4A3I E;  4OIR E;  3HOY F;  4BBS F;  1I6H F;  2R7Z E;  1IW7 E;  1TWA E;  2NVY E;  4C2M E;  5D4E E;  4A3J F;  4A3D F;  4ZH4 E;  4A93 E;  5FLM E;  3S1N E;  2Y0S H;  4BY1 F;  1SMY E;  4G7O E;  3M4O F;  2R92 E;  4A3I F;  3I4N F;  1DZF A;  2PMZ K;  1TWC E;  3S2D E;  2NVT E;  2R7Z F;  1TWA F;  4LJZ E;  4A3M E;  3HKZ K;  3M3Y E;  5TMF E;  5D4D E;  5FLM F;  3HOW E;  3S1N F;  4A3L E;  5D4C E;  3HOX F;  1HQM E;  2R93 E;  2R92 F;  2JA8 E;  1TWC F;  2NVT F;  4A3M F;  4BBR E;  3EQL E;  3M3Y F;  4YFN E;  3HOW F;  4A3L F;  2A6H E;  1Y1V E;  4YFX E;  4A3B E;  2Y0S I;  2KRX A;  2NVQ E;  1I6V E;  4A3G E;  2JA8 F;  3CQZ E;  4X6A E;  2E2J F;  2YU9 E;  4BBR F;  4OIP E;  4A3C E;  2A6E E;  1Y1V F;  2E2I E;  3S1M E;  5TMC E;  4A3B F;  5M3M E;  5C3E E;  4A3G F;  4G7Z E;  3DXJ E;  5BYH E;  3S1Q E;  3I4M E;  1WCM E;  5IP9 E;  4LK1 E;  2YU9 F;  4A3C F;  4X6A F;  3RZD E;  2JA7 E;  5C4J E;  2E2I F;  3S1M F;  4C3H E;  4MEY E;  5M3M F;  5IYB E;  5C3E F;  4KN4 E;  3H3V F;  3S17 E;  4BBS E;  3S1Q F;  4C2M F;  4YFK E;  2NVY F;  3I4M F;  1WCM F;  2BE5 E;  5IP9 F;  4AYB K;  2NVX E;  2VUM E;  4A93 F;  2PPB E;  1EIK A;  5M3F E;  3RZD F;  2JA7 F;  5C4X E;  5C4J F;  4C3H F;  3HKZ H;  5C44 E;  4MEX E;  4OIN E;  5IYB F;  3H3V G;  2WB1 I;  2JA5 E;  3GTG E;  3GTP E;  3S17 F;  1ZYR E;  4QIW K;  2A69 E;  5IYC E;  2JA6 E;  3PO3 E;  2O5J E;  5M5Y E;  3S15 E;  5M3F F;  3GTL E;  4Y52 E;  4BY7 E;  5E17 E;  3S2H E;  5C44 F;  2R93 F;  2B63 E;  3GTP F;  4MQ9 E;  3S1R E;  2JA5 F;  3GTG F;  5IYC F;  2JA6 F;  3PO3 F;  1I3Q E;  5M5Y F;  3S15 F;  4Y52 F;  3GTL F;  4BY7 F;  3S2H F;  2WAQ H;  2NVQ F;  4XSZ E;  2B63 F;  3CQZ F;  4YG2 E;  2O5I E;  4Q4Z E;  3GTQ E;  4A3F E;  3PO2 E;  1I3Q F;  3WOD E;  1R9T E;  3GTQ F;  5M5X E;  5M5W E;  5IPL E;  4XLP E;  3GTO E;  4A3F F;  3PO2 F;  2PMZ H;  1YNJ K;  4KMU E;  4AYB H;  2A68 E; 
#chains in the Genus database with same CATH homology
 4LK0 E;  1R9T F;  5M5X F;  5M5W F;  2NVX F;  2VUM F;  3GTO F;  2CW0 E;  5C4X F;  1QKL A;  3S2D F;  4G7H E;  3GTM F;  4KN7 E;  1TWF F;  1TWG F;  4BXX F;  1K83 F;  5IP7 F;  4C3I F;  4OIQ E;  4JK1 E;  3S14 F;  4OIO E;  1Y1W F;  2E2H F;  3S1R F;  4Q5S E;  3GTK F;  1SFO F;  3HOZ F;  3HOV F;  3S16 F;  4A3E F;  4XLN E;  1YNN K;  4XSX E;  4Y7N F;  1TWH F;  4LLG E;  3RZO F;  3GTJ F;  3FKI F;  4A3K F;  3H0G F;  5IYD F;  3K7A F;  5E18 E;  4GZY E;  1I50 F;  3HOU F;  2WAQ K;  5FJ8 F;  4C3J F;  3HOY F;  4OIR E;  1I6H F;  1IW7 E;  5D4E E;  4A3J F;  4A3D F;  4ZH4 E;  4BY1 F;  1SMY E;  4G7O E;  3M4O F;  4A3I F;  3I4N F;  2PMZ K;  2R7Z F;  1TWA F;  4LJZ E;  3HKZ K;  5TMF E;  5D4D E;  5FLM F;  3S1N F;  5D4C E;  3HOX F;  1HQM E;  2R92 F;  1TWC F;  2NVT F;  4A3M F;  3M3Y F;  3EQL E;  4YFN E;  3HOW F;  4A3L F;  2A6H E;  4YFX E;  2Y0S I;  2KRX A;  1I6V E;  2JA8 F;  2E2J F;  4BBR F;  4OIP E;  2A6E E;  1Y1V F;  4A3B F;  5TMC E;  4A3G F;  4G7Z E;  3DXJ E;  5BYH E;  4X6A F;  4LK1 E;  2YU9 F;  4A3C F;  2E2I F;  3S1M F;  4MEY E;  5M3M F;  5C3E F;  4KN4 E;  3S1Q F;  4C2M F;  4YFK E;  2NVY F;  3I4M F;  1WCM F;  2BE5 E;  5IP9 F;  4AYB K;  4A93 F;  2PPB E;  3RZD F;  2JA7 F;  5C4J F;  4C3H F;  4MEX E;  4OIN E;  3H3V G;  5IYB F;  2WB1 I;  3S17 F;  4BBS F;  1ZYR E;  4QIW K;  2A69 E;  2O5J E;  5M3F F;  5E17 E;  5C44 F;  2R93 F;  3GTP F;  4MQ9 E;  2JA5 F;  3GTG F;  5IYC F;  2JA6 F;  3PO3 F;  5M5Y F;  3S15 F;  4Y52 F;  3GTL F;  4BY7 F;  3S2H F;  2NVQ F;  4XSZ E;  2B63 F;  3CQZ F;  4YG2 E;  2O5I E;  4Q4Z E;  1I3Q F;  3WOD E;  3GTQ F;  5IPL E;  4XLP E;  4A3F F;  3PO2 F;  1YNJ K;  4KMU E;  2A68 E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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