2BMLA

Ofloxacin-like antibiotics inhibit pneumococcal cell wall degrading virulence factors
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
125
structure length
125
Chain Sequence
YPKDKFEKINGTWYYFDSSGYMLADRWRKHTDGNWYWFDNSGEMATGWKKIADKWYYFNEEGAMKTGWVKYKDTWYYLDAKEGAMVSNAFIQSADGTGWYYLKPDGTLADRPEFTVEPDGLITVK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Ofloxacin-Like Antibiotics Inhibit Pneumococcal Cell Wall-Degrading Virulence Factors
pubmed doi rcsb
molecule keywords AUTOLYSIN
molecule tags Choline-binding domain
source organism Streptococcus pneumoniae
total genus 15
structure length 125
sequence length 125
chains with identical sequence B
ec nomenclature ec 3.5.1.28: N-acetylmuramoyl-L-alanine amidase.
pdb deposition date 2005-03-15

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01473 CW_binding_1 Putative cell wall binding repeat
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.270.10 Mainly Beta Ribbon left handed beta-beta-3-solenoid Cholin Binding 2bmlA00
4NC0A 2J8FA 2X8MA 1HCXA 4X36A 2J8GA 1H09A 4NC2A 2V05A 2V04A 3KLKA 1OBAA 2X8PA 2BMLA 2IXUA 2F6EA 2VYUA 4NBXA 4TTUA 1GVMA 3TTQA 3HZ3A 2IXVA 4AYGA 4NBZA 4TVCA 2G7CA 3KLLA 3TTOA 4NBYA 4TVDA 2X8OA 1H8GA 3HIAA 2QJ6A
chains in the Genus database with same CATH superfamily
4NC0A 2J8FA 2X8MA 1HCXA 4X36A 2J8GA 1H09A 4NC2A 2V05A 2V04A 3KLKA 1OBAA 2X8PA 2BMLA 2IXUA 2F6EA 2VYUA 4NBXA 4TTUA 1GVMA 3TTQA 3HZ3A 2IXVA 4AYGA 4NBZA 4TVCA 2G7CA 3KLLA 3TTOA 4NBYA 4TVDA 2X8OA 1H8GA 3HIAA 2QJ6A
chains in the Genus database with same CATH topology
4NC0A 2J8FA 2X8MA 1HCXA 4X36A 2J8GA 1H09A 4NC2A 2V05A 2V04A 3KLKA 1OBAA 2X8PA 2BMLA 2IXUA 2F6EA 2VYUA 4NBXA 4TTUA 1GVMA 3TTQA 3HZ3A 2IXVA 4AYGA 4NBZA 4TVCA 2G7CA 3KLLA 3TTOA 4NBYA 4TVDA 2X8OA 1H8GA 3HIAA 2QJ6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4NC0 A;  2J8F A;  2X8M A;  1HCX A;  4X36 A;  2J8G A;  1H09 A;  4NC2 A;  2V05 A;  2V04 A;  3KLK A;  1OBA A;  2X8P A;  2BML A;  2IXU A;  2F6E A;  2VYU A;  4NBX A;  4TTU A;  1GVM A;  3TTQ A;  3HZ3 A;  2IXV A;  4AYG A;  4NBZ A;  4TVC A;  2G7C A;  3KLL A;  3TTO A;  4NBY A;  4TVD A;  2X8O A;  1H8G A;  3HIA A;  2QJ6 A; 
#chains in the Genus database with same CATH topology
 4NC0 A;  2J8F A;  2X8M A;  1HCX A;  4X36 A;  2J8G A;  1H09 A;  4NC2 A;  2V05 A;  2V04 A;  3KLK A;  1OBA A;  2X8P A;  2BML A;  2IXU A;  2F6E A;  2VYU A;  4NBX A;  4TTU A;  1GVM A;  3TTQ A;  3HZ3 A;  2IXV A;  4AYG A;  4NBZ A;  4TVC A;  2G7C A;  3KLL A;  3TTO A;  4NBY A;  4TVD A;  2X8O A;  1H8G A;  3HIA A;  2QJ6 A; 
#chains in the Genus database with same CATH homology
 4NC0 A;  2J8F A;  2X8M A;  1HCX A;  4X36 A;  2J8G A;  1H09 A;  4NC2 A;  2V05 A;  2V04 A;  3KLK A;  1OBA A;  2X8P A;  2BML A;  2IXU A;  2F6E A;  2VYU A;  4NBX A;  4TTU A;  1GVM A;  3TTQ A;  3HZ3 A;  2IXV A;  4AYG A;  4NBZ A;  4TVC A;  2G7C A;  3KLL A;  3TTO A;  4NBY A;  4TVD A;  2X8O A;  1H8G A;  3HIA A;  2QJ6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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