2FI3I

Crystal structure of a bpti variant (cys14->ser, cys38->ser) in complex with trypsin
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPSKARIIRYFYNAKAGLCQTFVYGGSRAKRNNFKSAEDCMRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Functional and structural roles of the Cys14-Cys38 disulfide of bovine pancreatic trypsin inhibitor.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Bos taurus
molecule keywords Cationic trypsin
total genus 11
structure length 58
sequence length 58
ec nomenclature
pdb deposition date 2005-12-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2fi3I00
2FI5I 4ISLB 4WXVC 2TGPI 3TGII 3P95E 4Y0ZI 1P2II 2J6DA 1T8NB 1YLCB 2KAII 1BIKA 1JC6A 5JB7A 1EJMB 2W8XA 3M7QB 1B0CA 3FP8I 1BRBI 1TPAI 4NTYB 1K6UA 2M01A 3AUCA 1YLDB 3T62D 1BRCI 3L3TE 5JB6A 4U30W 4NTXB 1D0DA 1UUBA 2KNTA 3AUHA 3TGJI 2UUXA 9PTIA 1AAPA 1NAGA 1YC0I 1T7CB 1CO7I 1AALA 3BTEI 8PTIA 1F5RI 1TAPA 1DEMA 1G6XA 1T8MB 2LFKA 1OA65 2LFLA 4Y0YI 2RA3C 3LDMA 4DG4C 1FY8I 2PTCI 3L33E 3AUEA 1UUAA 4Y10I 1DTKA 4BNRI 1BPIA 3TPII 2R9PE 2FI3I 1BHCA 3OTJI 4Y11I 1DTXA 4WWYC 3BTHI 1P2OB 5C67C 1TCPA 3LDJA 1BUNB 3GYMI 1BZ5A 3FP6I 4ISNB 1P2JI 1IRHA 1YKTB 1QLQA 3BTKI 3BTFI 2DDIA 1T8OB 5JB5A 3TGKI 1P2KI 3UIRC 1P2NB 1BTIA 1MTND 3BTWI 1KTHA 3BTGI 3D65I 1JV9A 6PTIA 3OFWA 4BD9B 1LD5A 1TOCR 3BTDI 1BPTA 5PTIA 1EAWB 3AUBA 1CBWD 1T8LB 7PTIA 1P2QB 4PTIA 2JOTA 4TPII 3WNYA 1F7ZI 4NTWB 2CA7A 2ZVXA 1BZXI 1PITA 4U32X 1FANA 2ODYE 3BTQI 2DDJA 1KNTA 2KCRA 1JV8A 1CA0D 2FTLI 1TFXC 4BQDA 2IJOI 3BTTI 2HEXA 1FAKI 1BF0A 2FI4I 1SHPA 3BTMI 2UUYB 1LD6A 2FTMB 4DTGK 1KUNA 1TAWB 3P92E 1Y62A 3UOUB 2M99A 1DENA 1OA55 3AUGA 3AUDA 3U1JE 3BYBA 1KIGI 2ZJXA 1D0DB 3AUIA 2TPII 1P2MB 1ZJDB 3CI7A 4ISOB 1ADZA 5JB4A 1ZR0B 3FP7J 1BTHP 3LDIA
chains in the Genus database with same CATH superfamily
2FI5I 4ISLB 4WXVC 2TGPI 3TGII 3P95E 4Y0ZI 1P2II 2J6DA 1T8NB 1YLCB 2KAII 1BIKA 1JC6A 5JB7A 1EJMB 2W8XA 3M7QB 1B0CA 3FP8I 1BRBI 1TPAI 4NTYB 1K6UA 2M01A 3AUCA 1YLDB 3T62D 1BRCI 3L3TE 5JB6A 4U30W 4NTXB 1D0DA 1UUBA 2KNTA 3AUHA 3TGJI 2UUXA 9PTIA 1AAPA 1NAGA 1YC0I 1T7CB 1CO7I 1AALA 3BTEI 8PTIA 1F5RI 1TAPA 1DEMA 1G6XA 1T8MB 2LFKA 1OA65 2LFLA 4Y0YI 2RA3C 3LDMA 4DG4C 1FY8I 2PTCI 3L33E 3AUEA 1UUAA 4Y10I 1DTKA 4BNRI 1BPIA 3TPII 2R9PE 2FI3I 1BHCA 3OTJI 4Y11I 1DTXA 4WWYC 3BTHI 1P2OB 5C67C 1TCPA 3LDJA 1BUNB 3GYMI 1BZ5A 3FP6I 4ISNB 1P2JI 1IRHA 1YKTB 1QLQA 3BTKI 3BTFI 2DDIA 1T8OB 5JB5A 3TGKI 1P2KI 3UIRC 1P2NB 1BTIA 1MTND 3BTWI 1KTHA 3BTGI 3D65I 1JV9A 6PTIA 3OFWA 4BD9B 1LD5A 1TOCR 3BTDI 1BPTA 5PTIA 1EAWB 3AUBA 1CBWD 1T8LB 7PTIA 1P2QB 4PTIA 2JOTA 4TPII 3WNYA 1F7ZI 4NTWB 2CA7A 2ZVXA 1BZXI 1PITA 4U32X 1FANA 2ODYE 3BTQI 2DDJA 1KNTA 2KCRA 1JV8A 1CA0D 2FTLI 1TFXC 4BQDA 2IJOI 3BTTI 2HEXA 1FAKI 1BF0A 2FI4I 1SHPA 3BTMI 2UUYB 1LD6A 2FTMB 4DTGK 1KUNA 1TAWB 3P92E 1Y62A 3UOUB 2M99A 1DENA 1OA55 3AUGA 3AUDA 3U1JE 3BYBA 1KIGI 2ZJXA 1D0DB 3AUIA 2TPII 1P2MB 1ZJDB 3CI7A 4ISOB 1ADZA 5JB4A 1ZR0B 3FP7J 1BTHP 3LDIA
chains in the Genus database with same CATH topology
2FI5I 4ISLB 4WXVC 2TGPI 3TGII 3P95E 4Y0ZI 1P2II 2J6DA 1T8NB 1YLCB 2KAII 1BIKA 1JC6A 5JB7A 1EJMB 2W8XA 3M7QB 1B0CA 3FP8I 1BRBI 1TPAI 4NTYB 1K6UA 2M01A 3AUCA 1YLDB 3T62D 1BRCI 3L3TE 5JB6A 4U30W 4NTXB 1D0DA 1UUBA 2KNTA 3AUHA 3TGJI 2UUXA 9PTIA 1AAPA 1NAGA 1YC0I 1T7CB 1CO7I 1AALA 3BTEI 8PTIA 1F5RI 1TAPA 1DEMA 1G6XA 1T8MB 2LFKA 1OA65 2LFLA 4Y0YI 2RA3C 3LDMA 4DG4C 1FY8I 2PTCI 3L33E 3AUEA 1UUAA 4Y10I 1DTKA 4BNRI 1BPIA 3TPII 2R9PE 2FI3I 1BHCA 3OTJI 4Y11I 1DTXA 4WWYC 3BTHI 1P2OB 5C67C 1TCPA 3LDJA 1BUNB 3GYMI 1BZ5A 3FP6I 4ISNB 1P2JI 1IRHA 1YKTB 1QLQA 3BTKI 3BTFI 2DDIA 1T8OB 5JB5A 3TGKI 1P2KI 3UIRC 1P2NB 1BTIA 1MTND 3BTWI 1KTHA 3BTGI 3D65I 1JV9A 6PTIA 3OFWA 4BD9B 1LD5A 1TOCR 3BTDI 1BPTA 5PTIA 1EAWB 3AUBA 1CBWD 1T8LB 7PTIA 1P2QB 4PTIA 2JOTA 4TPII 3WNYA 1F7ZI 4NTWB 2CA7A 2ZVXA 1BZXI 1PITA 4U32X 1FANA 2ODYE 3BTQI 2DDJA 1KNTA 2KCRA 1JV8A 1CA0D 2FTLI 1TFXC 4BQDA 2IJOI 3BTTI 2HEXA 1FAKI 1BF0A 2FI4I 1SHPA 3BTMI 2UUYB 1LD6A 2FTMB 4DTGK 1KUNA 1TAWB 3P92E 1Y62A 3UOUB 2M99A 1DENA 1OA55 3AUGA 3AUDA 3U1JE 3BYBA 1KIGI 2ZJXA 1D0DB 3AUIA 2TPII 1P2MB 1ZJDB 3CI7A 4ISOB 1ADZA 5JB4A 1ZR0B 3FP7J 1BTHP 3LDIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2FI5 I;  4ISL B;  4WXV C;  2TGP I;  3TGI I;  3P95 E;  4Y0Z I;  1P2I I;  2J6D A;  1T8N B;  1YLC B;  2KAI I;  1BIK A;  1JC6 A;  5JB7 A;  1EJM B;  2W8X A;  3M7Q B;  1B0C A;  3FP8 I;  1BRB I;  1TPA I;  4NTY B;  1K6U A;  2M01 A;  3AUC A;  1YLD B;  3T62 D;  1BRC I;  3L3T E;  5JB6 A;  4U30 W;  4NTX B;  1D0D A;  1UUB A;  2KNT A;  3AUH A;  3TGJ I;  2UUX A;  9PTI A;  1AAP A;  1NAG A;  1YC0 I;  1T7C B;  1CO7 I;  1AAL A;  3BTE I;  8PTI A;  1F5R I;  1TAP A;  1DEM A;  1G6X A;  1T8M B;  2LFK A;  1OA6 5;  2LFL A;  4Y0Y I;  2RA3 C;  3LDM A;  4DG4 C;  1FY8 I;  2PTC I;  3L33 E;  3AUE A;  1UUA A;  4Y10 I;  1DTK A;  4BNR I;  1BPI A;  3TPI I;  2R9P E;  2FI3 I;  1BHC A;  3OTJ I;  4Y11 I;  1DTX A;  4WWY C;  3BTH I;  1P2O B;  5C67 C;  1TCP A;  3LDJ A;  1BUN B;  3GYM I;  1BZ5 A;  3FP6 I;  4ISN B;  1P2J I;  1IRH A;  1YKT B;  1QLQ A;  3BTK I;  3BTF I;  2DDI A;  1T8O B;  5JB5 A;  3TGK I;  1P2K I;  3UIR C;  1P2N B;  1BTI A;  1MTN D;  3BTW I;  1KTH A;  3BTG I;  3D65 I;  1JV9 A;  6PTI A;  3OFW A;  4BD9 B;  1LD5 A;  1TOC R;  3BTD I;  1BPT A;  5PTI A;  1EAW B;  3AUB A;  1CBW D;  1T8L B;  7PTI A;  1P2Q B;  4PTI A;  2JOT A;  4TPI I;  3WNY A;  1F7Z I;  4NTW B;  2CA7 A;  2ZVX A;  1BZX I;  1PIT A;  4U32 X;  1FAN A;  2ODY E;  3BTQ I;  2DDJ A;  1KNT A;  2KCR A;  1JV8 A;  1CA0 D;  2FTL I;  1TFX C;  4BQD A;  2IJO I;  3BTT I;  2HEX A;  1FAK I;  1BF0 A;  2FI4 I;  1SHP A;  3BTM I;  2UUY B;  1LD6 A;  2FTM B;  4DTG K;  1KUN A;  1TAW B;  3P92 E;  1Y62 A;  3UOU B;  2M99 A;  1DEN A;  1OA5 5;  3AUG A;  3AUD A;  3U1J E;  3BYB A;  1KIG I;  2ZJX A;  1D0D B;  3AUI A;  2TPI I;  1P2M B;  1ZJD B;  3CI7 A;  4ISO B;  1ADZ A;  5JB4 A;  1ZR0 B;  3FP7 J;  1BTH P;  3LDI A; 
#chains in the Genus database with same CATH topology
 2FI5 I;  4ISL B;  4WXV C;  2TGP I;  3TGI I;  3P95 E;  4Y0Z I;  1P2I I;  2J6D A;  1T8N B;  1YLC B;  2KAI I;  1BIK A;  1JC6 A;  5JB7 A;  1EJM B;  2W8X A;  3M7Q B;  1B0C A;  3FP8 I;  1BRB I;  1TPA I;  4NTY B;  1K6U A;  2M01 A;  3AUC A;  1YLD B;  3T62 D;  1BRC I;  3L3T E;  5JB6 A;  4U30 W;  4NTX B;  1D0D A;  1UUB A;  2KNT A;  3AUH A;  3TGJ I;  2UUX A;  9PTI A;  1AAP A;  1NAG A;  1YC0 I;  1T7C B;  1CO7 I;  1AAL A;  3BTE I;  8PTI A;  1F5R I;  1TAP A;  1DEM A;  1G6X A;  1T8M B;  2LFK A;  1OA6 5;  2LFL A;  4Y0Y I;  2RA3 C;  3LDM A;  4DG4 C;  1FY8 I;  2PTC I;  3L33 E;  3AUE A;  1UUA A;  4Y10 I;  1DTK A;  4BNR I;  1BPI A;  3TPI I;  2R9P E;  2FI3 I;  1BHC A;  3OTJ I;  4Y11 I;  1DTX A;  4WWY C;  3BTH I;  1P2O B;  5C67 C;  1TCP A;  3LDJ A;  1BUN B;  3GYM I;  1BZ5 A;  3FP6 I;  4ISN B;  1P2J I;  1IRH A;  1YKT B;  1QLQ A;  3BTK I;  3BTF I;  2DDI A;  1T8O B;  5JB5 A;  3TGK I;  1P2K I;  3UIR C;  1P2N B;  1BTI A;  1MTN D;  3BTW I;  1KTH A;  3BTG I;  3D65 I;  1JV9 A;  6PTI A;  3OFW A;  4BD9 B;  1LD5 A;  1TOC R;  3BTD I;  1BPT A;  5PTI A;  1EAW B;  3AUB A;  1CBW D;  1T8L B;  7PTI A;  1P2Q B;  4PTI A;  2JOT A;  4TPI I;  3WNY A;  1F7Z I;  4NTW B;  2CA7 A;  2ZVX A;  1BZX I;  1PIT A;  4U32 X;  1FAN A;  2ODY E;  3BTQ I;  2DDJ A;  1KNT A;  2KCR A;  1JV8 A;  1CA0 D;  2FTL I;  1TFX C;  4BQD A;  2IJO I;  3BTT I;  2HEX A;  1FAK I;  1BF0 A;  2FI4 I;  1SHP A;  3BTM I;  2UUY B;  1LD6 A;  2FTM B;  4DTG K;  1KUN A;  1TAW B;  3P92 E;  1Y62 A;  3UOU B;  2M99 A;  1DEN A;  1OA5 5;  3AUG A;  3AUD A;  3U1J E;  3BYB A;  1KIG I;  2ZJX A;  1D0D B;  3AUI A;  2TPI I;  1P2M B;  1ZJD B;  3CI7 A;  4ISO B;  1ADZ A;  5JB4 A;  1ZR0 B;  3FP7 J;  1BTH P;  3LDI A; 
#chains in the Genus database with same CATH homology
 2FI5 I;  4ISL B;  4WXV C;  2TGP I;  3TGI I;  3P95 E;  4Y0Z I;  1P2I I;  2J6D A;  1T8N B;  1YLC B;  2KAI I;  1BIK A;  1JC6 A;  5JB7 A;  1EJM B;  2W8X A;  3M7Q B;  1B0C A;  3FP8 I;  1BRB I;  1TPA I;  4NTY B;  1K6U A;  2M01 A;  3AUC A;  1YLD B;  3T62 D;  1BRC I;  3L3T E;  5JB6 A;  4U30 W;  4NTX B;  1D0D A;  1UUB A;  2KNT A;  3AUH A;  3TGJ I;  2UUX A;  9PTI A;  1AAP A;  1NAG A;  1YC0 I;  1T7C B;  1CO7 I;  1AAL A;  3BTE I;  8PTI A;  1F5R I;  1TAP A;  1DEM A;  1G6X A;  1T8M B;  2LFK A;  1OA6 5;  2LFL A;  4Y0Y I;  2RA3 C;  3LDM A;  4DG4 C;  1FY8 I;  2PTC I;  3L33 E;  3AUE A;  1UUA A;  4Y10 I;  1DTK A;  4BNR I;  1BPI A;  3TPI I;  2R9P E;  2FI3 I;  1BHC A;  3OTJ I;  4Y11 I;  1DTX A;  4WWY C;  3BTH I;  1P2O B;  5C67 C;  1TCP A;  3LDJ A;  1BUN B;  3GYM I;  1BZ5 A;  3FP6 I;  4ISN B;  1P2J I;  1IRH A;  1YKT B;  1QLQ A;  3BTK I;  3BTF I;  2DDI A;  1T8O B;  5JB5 A;  3TGK I;  1P2K I;  3UIR C;  1P2N B;  1BTI A;  1MTN D;  3BTW I;  1KTH A;  3BTG I;  3D65 I;  1JV9 A;  6PTI A;  3OFW A;  4BD9 B;  1LD5 A;  1TOC R;  3BTD I;  1BPT A;  5PTI A;  1EAW B;  3AUB A;  1CBW D;  1T8L B;  7PTI A;  1P2Q B;  4PTI A;  2JOT A;  4TPI I;  3WNY A;  1F7Z I;  4NTW B;  2CA7 A;  2ZVX A;  1BZX I;  1PIT A;  4U32 X;  1FAN A;  2ODY E;  3BTQ I;  2DDJ A;  1KNT A;  2KCR A;  1JV8 A;  1CA0 D;  2FTL I;  1TFX C;  4BQD A;  2IJO I;  3BTT I;  2HEX A;  1FAK I;  1BF0 A;  2FI4 I;  1SHP A;  3BTM I;  2UUY B;  1LD6 A;  2FTM B;  4DTG K;  1KUN A;  1TAW B;  3P92 E;  1Y62 A;  3UOU B;  2M99 A;  1DEN A;  1OA5 5;  3AUG A;  3AUD A;  3U1J E;  3BYB A;  1KIG I;  2ZJX A;  1D0D B;  3AUI A;  2TPI I;  1P2M B;  1ZJD B;  3CI7 A;  4ISO B;  1ADZ A;  5JB4 A;  1ZR0 B;  3FP7 J;  1BTH P;  3LDI A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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