2FTLI

Crystal structure of trypsin complexed with bpti at 100k
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
57
structure length
57
Chain Sequence
PDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
source organism Bos taurus
publication title Rigidification of a Flexible Protease Inhibitor Variant upon Binding to Trypsin.
pubmed doi rcsb
molecule keywords Cationic trypsin
total genus 11
structure length 57
sequence length 57
ec nomenclature
pdb deposition date 2006-01-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2ftlI00
5PTIA 3TGJI 1EJMB 4BQDA 4BNRI 5C67C 1AAPA 1Y62A 3D65I 2FI4I 1CBWD 3FP8I 2J6DA 2UUYB 1T8MB 1CO7I 1MTND 3T62D 3AUCA 1FY8I 1TPAI 1BZXI 1BIKA 4WWYC 3UIRC 1BRCI 1P2OB 1F7ZI 4Y0YI 3BTQI 3CI7A 2UUXA 3BYBA 1P2II 5JB7A 7PTIA 1DTXA 3M7QB 4NTYB 1P2QB 4TPII 1UUBA 1TAPA 2ODYE 1BTHP 2KCRA 3L33E 2FTLI 1P2KI 2R9PE 3LDMA 4U30W 3U1JE 1BRBI 1BUNB 1P2NB 4BD9B 1ZJDB 2W8XA 1JV8A 1QLQA 1D0DB 5JB5A 3TGKI 3BTMI 3BTHI 3BTEI 4Y0ZI 4WXVC 1BF0A 1ZR0B 6PTIA 1BZ5A 1TOCR 1CA0D 5JB4A 8PTIA 1LD6A 1PITA 3AUDA 2ZJXA 1AALA 1DEMA 1P2JI 4U32X 3WNYA 9PTIA 2FI5I 2FI3I 4ISOB 2M99A 3AUGA 1KUNA 4Y11I 1BHCA 2JOTA 3L3TE 1KIGI 1BPIA 2ZVXA 4PTIA 1ADZA 1SHPA 1YLCB 1TCPA 3TPII 1TFXC 1NAGA 1T8OB 2TPII 3OFWA 2LFKA 4NTXB 4DG4C 1FANA 3AUIA 4Y10I 3LDJA 2KAII 1LD5A 1EAWB 1F5RI 1KTHA 1BPTA 1P2MB 1T8NB 3P95E 1K6UA 1OA65 2HEXA 2DDJA 2KNTA 1D0DA 1DENA 3BTGI 1T8LB 3TGII 2TGPI 2DDIA 2IJOI 3BTDI 3FP7J 1YLDB 1JV9A 1YC0I 2LFLA 2CA7A 3P92E 3BTTI 1B0CA 2M01A 3AUEA 3BTFI 2RA3C 1T7CB 1JC6A 1TAWB 1YKTB 1G6XA 4NTWB 2FTMB 1BTIA 3AUBA 3FP6I 1OA55 1IRHA 4DTGK 3BTKI 3OTJI 4ISLB 3GYMI 4ISNB 1KNTA 5JB6A 1DTKA 3BTWI 2PTCI 3AUHA 3UOUB 3LDIA 1FAKI 1UUAA
chains in the Genus database with same CATH superfamily
5PTIA 3TGJI 1EJMB 4BQDA 4BNRI 5C67C 1AAPA 1Y62A 3D65I 2FI4I 1CBWD 3FP8I 2J6DA 2UUYB 1T8MB 1CO7I 1MTND 3T62D 3AUCA 1FY8I 1TPAI 1BZXI 1BIKA 4WWYC 3UIRC 1BRCI 1P2OB 1F7ZI 4Y0YI 3BTQI 3CI7A 2UUXA 3BYBA 1P2II 5JB7A 7PTIA 1DTXA 3M7QB 4NTYB 1P2QB 4TPII 1UUBA 1TAPA 2ODYE 1BTHP 2KCRA 3L33E 2FTLI 1P2KI 2R9PE 3LDMA 4U30W 3U1JE 1BRBI 1BUNB 1P2NB 4BD9B 1ZJDB 2W8XA 1JV8A 1QLQA 1D0DB 5JB5A 3TGKI 3BTMI 3BTHI 3BTEI 4Y0ZI 4WXVC 1BF0A 1ZR0B 6PTIA 1BZ5A 1TOCR 1CA0D 5JB4A 8PTIA 1LD6A 1PITA 3AUDA 2ZJXA 1AALA 1DEMA 1P2JI 4U32X 3WNYA 9PTIA 2FI5I 2FI3I 4ISOB 2M99A 3AUGA 1KUNA 4Y11I 1BHCA 2JOTA 3L3TE 1KIGI 1BPIA 2ZVXA 4PTIA 1ADZA 1SHPA 1YLCB 1TCPA 3TPII 1TFXC 1NAGA 1T8OB 2TPII 3OFWA 2LFKA 4NTXB 4DG4C 1FANA 3AUIA 4Y10I 3LDJA 2KAII 1LD5A 1EAWB 1F5RI 1KTHA 1BPTA 1P2MB 1T8NB 3P95E 1K6UA 1OA65 2HEXA 2DDJA 2KNTA 1D0DA 1DENA 3BTGI 1T8LB 3TGII 2TGPI 2DDIA 2IJOI 3BTDI 3FP7J 1YLDB 1JV9A 1YC0I 2LFLA 2CA7A 3P92E 3BTTI 1B0CA 2M01A 3AUEA 3BTFI 2RA3C 1T7CB 1JC6A 1TAWB 1YKTB 1G6XA 4NTWB 2FTMB 1BTIA 3AUBA 3FP6I 1OA55 1IRHA 4DTGK 3BTKI 3OTJI 4ISLB 3GYMI 4ISNB 1KNTA 5JB6A 1DTKA 3BTWI 2PTCI 3AUHA 3UOUB 3LDIA 1FAKI 1UUAA
chains in the Genus database with same CATH topology
5PTIA 3TGJI 1EJMB 4BQDA 4BNRI 5C67C 1AAPA 1Y62A 3D65I 2FI4I 1CBWD 3FP8I 2J6DA 2UUYB 1T8MB 1CO7I 1MTND 3T62D 3AUCA 1FY8I 1TPAI 1BZXI 1BIKA 4WWYC 3UIRC 1BRCI 1P2OB 1F7ZI 4Y0YI 3BTQI 3CI7A 2UUXA 3BYBA 1P2II 5JB7A 7PTIA 1DTXA 3M7QB 4NTYB 1P2QB 4TPII 1UUBA 1TAPA 2ODYE 1BTHP 2KCRA 3L33E 2FTLI 1P2KI 2R9PE 3LDMA 4U30W 3U1JE 1BRBI 1BUNB 1P2NB 4BD9B 1ZJDB 2W8XA 1JV8A 1QLQA 1D0DB 5JB5A 3TGKI 3BTMI 3BTHI 3BTEI 4Y0ZI 4WXVC 1BF0A 1ZR0B 6PTIA 1BZ5A 1TOCR 1CA0D 5JB4A 8PTIA 1LD6A 1PITA 3AUDA 2ZJXA 1AALA 1DEMA 1P2JI 4U32X 3WNYA 9PTIA 2FI5I 2FI3I 4ISOB 2M99A 3AUGA 1KUNA 4Y11I 1BHCA 2JOTA 3L3TE 1KIGI 1BPIA 2ZVXA 4PTIA 1ADZA 1SHPA 1YLCB 1TCPA 3TPII 1TFXC 1NAGA 1T8OB 2TPII 3OFWA 2LFKA 4NTXB 4DG4C 1FANA 3AUIA 4Y10I 3LDJA 2KAII 1LD5A 1EAWB 1F5RI 1KTHA 1BPTA 1P2MB 1T8NB 3P95E 1K6UA 1OA65 2HEXA 2DDJA 2KNTA 1D0DA 1DENA 3BTGI 1T8LB 3TGII 2TGPI 2DDIA 2IJOI 3BTDI 3FP7J 1YLDB 1JV9A 1YC0I 2LFLA 2CA7A 3P92E 3BTTI 1B0CA 2M01A 3AUEA 3BTFI 2RA3C 1T7CB 1JC6A 1TAWB 1YKTB 1G6XA 4NTWB 2FTMB 1BTIA 3AUBA 3FP6I 1OA55 1IRHA 4DTGK 3BTKI 3OTJI 4ISLB 3GYMI 4ISNB 1KNTA 5JB6A 1DTKA 3BTWI 2PTCI 3AUHA 3UOUB 3LDIA 1FAKI 1UUAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5PTI A;  3TGJ I;  1EJM B;  4BQD A;  4BNR I;  5C67 C;  1AAP A;  1Y62 A;  3D65 I;  2FI4 I;  1CBW D;  3FP8 I;  2J6D A;  2UUY B;  1T8M B;  1CO7 I;  1MTN D;  3T62 D;  3AUC A;  1FY8 I;  1TPA I;  1BZX I;  1BIK A;  4WWY C;  3UIR C;  1BRC I;  1P2O B;  1F7Z I;  4Y0Y I;  3BTQ I;  3CI7 A;  2UUX A;  3BYB A;  1P2I I;  5JB7 A;  7PTI A;  1DTX A;  3M7Q B;  4NTY B;  1P2Q B;  4TPI I;  1UUB A;  1TAP A;  2ODY E;  1BTH P;  2KCR A;  3L33 E;  2FTL I;  1P2K I;  2R9P E;  3LDM A;  4U30 W;  3U1J E;  1BRB I;  1BUN B;  1P2N B;  4BD9 B;  1ZJD B;  2W8X A;  1JV8 A;  1QLQ A;  1D0D B;  5JB5 A;  3TGK I;  3BTM I;  3BTH I;  3BTE I;  4Y0Z I;  4WXV C;  1BF0 A;  1ZR0 B;  6PTI A;  1BZ5 A;  1TOC R;  1CA0 D;  5JB4 A;  8PTI A;  1LD6 A;  1PIT A;  3AUD A;  2ZJX A;  1AAL A;  1DEM A;  1P2J I;  4U32 X;  3WNY A;  9PTI A;  2FI5 I;  2FI3 I;  4ISO B;  2M99 A;  3AUG A;  1KUN A;  4Y11 I;  1BHC A;  2JOT A;  3L3T E;  1KIG I;  1BPI A;  2ZVX A;  4PTI A;  1ADZ A;  1SHP A;  1YLC B;  1TCP A;  3TPI I;  1TFX C;  1NAG A;  1T8O B;  2TPI I;  3OFW A;  2LFK A;  4NTX B;  4DG4 C;  1FAN A;  3AUI A;  4Y10 I;  3LDJ A;  2KAI I;  1LD5 A;  1EAW B;  1F5R I;  1KTH A;  1BPT A;  1P2M B;  1T8N B;  3P95 E;  1K6U A;  1OA6 5;  2HEX A;  2DDJ A;  2KNT A;  1D0D A;  1DEN A;  3BTG I;  1T8L B;  3TGI I;  2TGP I;  2DDI A;  2IJO I;  3BTD I;  3FP7 J;  1YLD B;  1JV9 A;  1YC0 I;  2LFL A;  2CA7 A;  3P92 E;  3BTT I;  1B0C A;  2M01 A;  3AUE A;  3BTF I;  2RA3 C;  1T7C B;  1JC6 A;  1TAW B;  1YKT B;  1G6X A;  4NTW B;  2FTM B;  1BTI A;  3AUB A;  3FP6 I;  1OA5 5;  1IRH A;  4DTG K;  3BTK I;  3OTJ I;  4ISL B;  3GYM I;  4ISN B;  1KNT A;  5JB6 A;  1DTK A;  3BTW I;  2PTC I;  3AUH A;  3UOU B;  3LDI A;  1FAK I;  1UUA A; 
#chains in the Genus database with same CATH topology
 5PTI A;  3TGJ I;  1EJM B;  4BQD A;  4BNR I;  5C67 C;  1AAP A;  1Y62 A;  3D65 I;  2FI4 I;  1CBW D;  3FP8 I;  2J6D A;  2UUY B;  1T8M B;  1CO7 I;  1MTN D;  3T62 D;  3AUC A;  1FY8 I;  1TPA I;  1BZX I;  1BIK A;  4WWY C;  3UIR C;  1BRC I;  1P2O B;  1F7Z I;  4Y0Y I;  3BTQ I;  3CI7 A;  2UUX A;  3BYB A;  1P2I I;  5JB7 A;  7PTI A;  1DTX A;  3M7Q B;  4NTY B;  1P2Q B;  4TPI I;  1UUB A;  1TAP A;  2ODY E;  1BTH P;  2KCR A;  3L33 E;  2FTL I;  1P2K I;  2R9P E;  3LDM A;  4U30 W;  3U1J E;  1BRB I;  1BUN B;  1P2N B;  4BD9 B;  1ZJD B;  2W8X A;  1JV8 A;  1QLQ A;  1D0D B;  5JB5 A;  3TGK I;  3BTM I;  3BTH I;  3BTE I;  4Y0Z I;  4WXV C;  1BF0 A;  1ZR0 B;  6PTI A;  1BZ5 A;  1TOC R;  1CA0 D;  5JB4 A;  8PTI A;  1LD6 A;  1PIT A;  3AUD A;  2ZJX A;  1AAL A;  1DEM A;  1P2J I;  4U32 X;  3WNY A;  9PTI A;  2FI5 I;  2FI3 I;  4ISO B;  2M99 A;  3AUG A;  1KUN A;  4Y11 I;  1BHC A;  2JOT A;  3L3T E;  1KIG I;  1BPI A;  2ZVX A;  4PTI A;  1ADZ A;  1SHP A;  1YLC B;  1TCP A;  3TPI I;  1TFX C;  1NAG A;  1T8O B;  2TPI I;  3OFW A;  2LFK A;  4NTX B;  4DG4 C;  1FAN A;  3AUI A;  4Y10 I;  3LDJ A;  2KAI I;  1LD5 A;  1EAW B;  1F5R I;  1KTH A;  1BPT A;  1P2M B;  1T8N B;  3P95 E;  1K6U A;  1OA6 5;  2HEX A;  2DDJ A;  2KNT A;  1D0D A;  1DEN A;  3BTG I;  1T8L B;  3TGI I;  2TGP I;  2DDI A;  2IJO I;  3BTD I;  3FP7 J;  1YLD B;  1JV9 A;  1YC0 I;  2LFL A;  2CA7 A;  3P92 E;  3BTT I;  1B0C A;  2M01 A;  3AUE A;  3BTF I;  2RA3 C;  1T7C B;  1JC6 A;  1TAW B;  1YKT B;  1G6X A;  4NTW B;  2FTM B;  1BTI A;  3AUB A;  3FP6 I;  1OA5 5;  1IRH A;  4DTG K;  3BTK I;  3OTJ I;  4ISL B;  3GYM I;  4ISN B;  1KNT A;  5JB6 A;  1DTK A;  3BTW I;  2PTC I;  3AUH A;  3UOU B;  3LDI A;  1FAK I;  1UUA A; 
#chains in the Genus database with same CATH homology
 5PTI A;  3TGJ I;  1EJM B;  4BQD A;  4BNR I;  5C67 C;  1AAP A;  1Y62 A;  3D65 I;  2FI4 I;  1CBW D;  3FP8 I;  2J6D A;  2UUY B;  1T8M B;  1CO7 I;  1MTN D;  3T62 D;  3AUC A;  1FY8 I;  1TPA I;  1BZX I;  1BIK A;  4WWY C;  3UIR C;  1BRC I;  1P2O B;  1F7Z I;  4Y0Y I;  3BTQ I;  3CI7 A;  2UUX A;  3BYB A;  1P2I I;  5JB7 A;  7PTI A;  1DTX A;  3M7Q B;  4NTY B;  1P2Q B;  4TPI I;  1UUB A;  1TAP A;  2ODY E;  1BTH P;  2KCR A;  3L33 E;  2FTL I;  1P2K I;  2R9P E;  3LDM A;  4U30 W;  3U1J E;  1BRB I;  1BUN B;  1P2N B;  4BD9 B;  1ZJD B;  2W8X A;  1JV8 A;  1QLQ A;  1D0D B;  5JB5 A;  3TGK I;  3BTM I;  3BTH I;  3BTE I;  4Y0Z I;  4WXV C;  1BF0 A;  1ZR0 B;  6PTI A;  1BZ5 A;  1TOC R;  1CA0 D;  5JB4 A;  8PTI A;  1LD6 A;  1PIT A;  3AUD A;  2ZJX A;  1AAL A;  1DEM A;  1P2J I;  4U32 X;  3WNY A;  9PTI A;  2FI5 I;  2FI3 I;  4ISO B;  2M99 A;  3AUG A;  1KUN A;  4Y11 I;  1BHC A;  2JOT A;  3L3T E;  1KIG I;  1BPI A;  2ZVX A;  4PTI A;  1ADZ A;  1SHP A;  1YLC B;  1TCP A;  3TPI I;  1TFX C;  1NAG A;  1T8O B;  2TPI I;  3OFW A;  2LFK A;  4NTX B;  4DG4 C;  1FAN A;  3AUI A;  4Y10 I;  3LDJ A;  2KAI I;  1LD5 A;  1EAW B;  1F5R I;  1KTH A;  1BPT A;  1P2M B;  1T8N B;  3P95 E;  1K6U A;  1OA6 5;  2HEX A;  2DDJ A;  2KNT A;  1D0D A;  1DEN A;  3BTG I;  1T8L B;  3TGI I;  2TGP I;  2DDI A;  2IJO I;  3BTD I;  3FP7 J;  1YLD B;  1JV9 A;  1YC0 I;  2LFL A;  2CA7 A;  3P92 E;  3BTT I;  1B0C A;  2M01 A;  3AUE A;  3BTF I;  2RA3 C;  1T7C B;  1JC6 A;  1TAW B;  1YKT B;  1G6X A;  4NTW B;  2FTM B;  1BTI A;  3AUB A;  3FP6 I;  1OA5 5;  1IRH A;  4DTG K;  3BTK I;  3OTJ I;  4ISL B;  3GYM I;  4ISN B;  1KNT A;  5JB6 A;  1DTK A;  3BTW I;  2PTC I;  3AUH A;  3UOU B;  3LDI A;  1FAK I;  1UUA A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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