2FTMB

Crystal structure of trypsin complexed with the bpti variant (tyr35->gly)
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVGGGCRAKRNNFKSAEDCMRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Rigidification of a Flexible Protease Inhibitor Variant upon Binding to Trypsin.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Bos taurus
molecule keywords Cationic trypsin
total genus 11
structure length 58
sequence length 58
ec nomenclature
pdb deposition date 2006-01-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2ftmB00
1BUNB 3TGJI 4WXVC 2FI3I 3P95E 2M99A 4NTXB 3FP6I 1P2II 1AAPA 1BRBI 1UUAA 8PTIA 1B0CA 3OFWA 1BZXI 3WNYA 1DEMA 1D0DB 1P2QB 2TPII 3BTEI 5JB4A 2IJOI 3BTMI 3GYMI 1FAKI 3T62D 1TAWB 1BRCI 1KIGI 2R9PE 1T8OB 4BQDA 1BF0A 1P2KI 1BTIA 3TGKI 4PTIA 3L33E 3TGII 1BHCA 1P2OB 1YKTB 4DTGK 1F5RI 2KCRA 1T7CB 2KNTA 1KUNA 1P2NB 3AUBA 4DG4C 4ISNB 1T8NB 1P2MB 2FTLI 3AUGA 3BTTI 1D0DA 3LDMA 6PTIA 2UUXA 1Y62A 4U30W 2PTCI 1SHPA 2CA7A 5PTIA 4ISLB 1BTHP 1F7ZI 2W8XA 1IRHA 1PITA 1TAPA 1YLCB 5JB7A 3TPII 1G6XA 2J6DA 1AALA 1TOCR 2FI4I 4BNRI 4BD9B 3L3TE 1LD5A 1YLDB 3AUCA 3OTJI 3LDIA 2ZJXA 1K6UA 1BIKA 1T8LB 1DTXA 9PTIA 1FY8I 1BZ5A 1JV9A 1ADZA 2LFKA 1BPIA 2RA3C 1JC6A 1CA0D 2DDJA 3AUDA 1QLQA 3AUHA 1DENA 4WWYC 3AUIA 3UOUB 3LDJA 3P92E 4NTWB 2HEXA 3FP8I 4ISOB 1P2JI 3BTFI 7PTIA 1JV8A 2KAII 5JB5A 3BTHI 1TFXC 4TPII 3CI7A 3BTGI 1CO7I 2ODYE 2M01A 1ZR0B 1KNTA 1YC0I 1T8MB 1TCPA 3AUEA 1UUBA 1ZJDB 2LFLA 3U1JE 1FANA 3D65I 3BTQI 5JB6A 4NTYB 1KTHA 2ZVXA 3M7QB 1BPTA 1MTND 1TPAI 2UUYB 2DDIA 2FTMB 3BYBA 3BTWI 4Y0YI 2JOTA 1OA55 4Y0ZI 1EAWB 3BTDI 2TGPI 1NAGA 5C67C 2FI5I 1CBWD 1LD6A 4Y10I 4U32X 1OA65 1DTKA 3BTKI 4Y11I 3UIRC 3FP7J 1EJMB
chains in the Genus database with same CATH superfamily
1BUNB 3TGJI 4WXVC 2FI3I 3P95E 2M99A 4NTXB 3FP6I 1P2II 1AAPA 1BRBI 1UUAA 8PTIA 1B0CA 3OFWA 1BZXI 3WNYA 1DEMA 1D0DB 1P2QB 2TPII 3BTEI 5JB4A 2IJOI 3BTMI 3GYMI 1FAKI 3T62D 1TAWB 1BRCI 1KIGI 2R9PE 1T8OB 4BQDA 1BF0A 1P2KI 1BTIA 3TGKI 4PTIA 3L33E 3TGII 1BHCA 1P2OB 1YKTB 4DTGK 1F5RI 2KCRA 1T7CB 2KNTA 1KUNA 1P2NB 3AUBA 4DG4C 4ISNB 1T8NB 1P2MB 2FTLI 3AUGA 3BTTI 1D0DA 3LDMA 6PTIA 2UUXA 1Y62A 4U30W 2PTCI 1SHPA 2CA7A 5PTIA 4ISLB 1BTHP 1F7ZI 2W8XA 1IRHA 1PITA 1TAPA 1YLCB 5JB7A 3TPII 1G6XA 2J6DA 1AALA 1TOCR 2FI4I 4BNRI 4BD9B 3L3TE 1LD5A 1YLDB 3AUCA 3OTJI 3LDIA 2ZJXA 1K6UA 1BIKA 1T8LB 1DTXA 9PTIA 1FY8I 1BZ5A 1JV9A 1ADZA 2LFKA 1BPIA 2RA3C 1JC6A 1CA0D 2DDJA 3AUDA 1QLQA 3AUHA 1DENA 4WWYC 3AUIA 3UOUB 3LDJA 3P92E 4NTWB 2HEXA 3FP8I 4ISOB 1P2JI 3BTFI 7PTIA 1JV8A 2KAII 5JB5A 3BTHI 1TFXC 4TPII 3CI7A 3BTGI 1CO7I 2ODYE 2M01A 1ZR0B 1KNTA 1YC0I 1T8MB 1TCPA 3AUEA 1UUBA 1ZJDB 2LFLA 3U1JE 1FANA 3D65I 3BTQI 5JB6A 4NTYB 1KTHA 2ZVXA 3M7QB 1BPTA 1MTND 1TPAI 2UUYB 2DDIA 2FTMB 3BYBA 3BTWI 4Y0YI 2JOTA 1OA55 4Y0ZI 1EAWB 3BTDI 2TGPI 1NAGA 5C67C 2FI5I 1CBWD 1LD6A 4Y10I 4U32X 1OA65 1DTKA 3BTKI 4Y11I 3UIRC 3FP7J 1EJMB
chains in the Genus database with same CATH topology
1BUNB 3TGJI 4WXVC 2FI3I 3P95E 2M99A 4NTXB 3FP6I 1P2II 1AAPA 1BRBI 1UUAA 8PTIA 1B0CA 3OFWA 1BZXI 3WNYA 1DEMA 1D0DB 1P2QB 2TPII 3BTEI 5JB4A 2IJOI 3BTMI 3GYMI 1FAKI 3T62D 1TAWB 1BRCI 1KIGI 2R9PE 1T8OB 4BQDA 1BF0A 1P2KI 1BTIA 3TGKI 4PTIA 3L33E 3TGII 1BHCA 1P2OB 1YKTB 4DTGK 1F5RI 2KCRA 1T7CB 2KNTA 1KUNA 1P2NB 3AUBA 4DG4C 4ISNB 1T8NB 1P2MB 2FTLI 3AUGA 3BTTI 1D0DA 3LDMA 6PTIA 2UUXA 1Y62A 4U30W 2PTCI 1SHPA 2CA7A 5PTIA 4ISLB 1BTHP 1F7ZI 2W8XA 1IRHA 1PITA 1TAPA 1YLCB 5JB7A 3TPII 1G6XA 2J6DA 1AALA 1TOCR 2FI4I 4BNRI 4BD9B 3L3TE 1LD5A 1YLDB 3AUCA 3OTJI 3LDIA 2ZJXA 1K6UA 1BIKA 1T8LB 1DTXA 9PTIA 1FY8I 1BZ5A 1JV9A 1ADZA 2LFKA 1BPIA 2RA3C 1JC6A 1CA0D 2DDJA 3AUDA 1QLQA 3AUHA 1DENA 4WWYC 3AUIA 3UOUB 3LDJA 3P92E 4NTWB 2HEXA 3FP8I 4ISOB 1P2JI 3BTFI 7PTIA 1JV8A 2KAII 5JB5A 3BTHI 1TFXC 4TPII 3CI7A 3BTGI 1CO7I 2ODYE 2M01A 1ZR0B 1KNTA 1YC0I 1T8MB 1TCPA 3AUEA 1UUBA 1ZJDB 2LFLA 3U1JE 1FANA 3D65I 3BTQI 5JB6A 4NTYB 1KTHA 2ZVXA 3M7QB 1BPTA 1MTND 1TPAI 2UUYB 2DDIA 2FTMB 3BYBA 3BTWI 4Y0YI 2JOTA 1OA55 4Y0ZI 1EAWB 3BTDI 2TGPI 1NAGA 5C67C 2FI5I 1CBWD 1LD6A 4Y10I 4U32X 1OA65 1DTKA 3BTKI 4Y11I 3UIRC 3FP7J 1EJMB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1BUN B;  3TGJ I;  4WXV C;  2FI3 I;  3P95 E;  2M99 A;  4NTX B;  3FP6 I;  1P2I I;  1AAP A;  1BRB I;  1UUA A;  8PTI A;  1B0C A;  3OFW A;  1BZX I;  3WNY A;  1DEM A;  1D0D B;  1P2Q B;  2TPI I;  3BTE I;  5JB4 A;  2IJO I;  3BTM I;  3GYM I;  1FAK I;  3T62 D;  1TAW B;  1BRC I;  1KIG I;  2R9P E;  1T8O B;  4BQD A;  1BF0 A;  1P2K I;  1BTI A;  3TGK I;  4PTI A;  3L33 E;  3TGI I;  1BHC A;  1P2O B;  1YKT B;  4DTG K;  1F5R I;  2KCR A;  1T7C B;  2KNT A;  1KUN A;  1P2N B;  3AUB A;  4DG4 C;  4ISN B;  1T8N B;  1P2M B;  2FTL I;  3AUG A;  3BTT I;  1D0D A;  3LDM A;  6PTI A;  2UUX A;  1Y62 A;  4U30 W;  2PTC I;  1SHP A;  2CA7 A;  5PTI A;  4ISL B;  1BTH P;  1F7Z I;  2W8X A;  1IRH A;  1PIT A;  1TAP A;  1YLC B;  5JB7 A;  3TPI I;  1G6X A;  2J6D A;  1AAL A;  1TOC R;  2FI4 I;  4BNR I;  4BD9 B;  3L3T E;  1LD5 A;  1YLD B;  3AUC A;  3OTJ I;  3LDI A;  2ZJX A;  1K6U A;  1BIK A;  1T8L B;  1DTX A;  9PTI A;  1FY8 I;  1BZ5 A;  1JV9 A;  1ADZ A;  2LFK A;  1BPI A;  2RA3 C;  1JC6 A;  1CA0 D;  2DDJ A;  3AUD A;  1QLQ A;  3AUH A;  1DEN A;  4WWY C;  3AUI A;  3UOU B;  3LDJ A;  3P92 E;  4NTW B;  2HEX A;  3FP8 I;  4ISO B;  1P2J I;  3BTF I;  7PTI A;  1JV8 A;  2KAI I;  5JB5 A;  3BTH I;  1TFX C;  4TPI I;  3CI7 A;  3BTG I;  1CO7 I;  2ODY E;  2M01 A;  1ZR0 B;  1KNT A;  1YC0 I;  1T8M B;  1TCP A;  3AUE A;  1UUB A;  1ZJD B;  2LFL A;  3U1J E;  1FAN A;  3D65 I;  3BTQ I;  5JB6 A;  4NTY B;  1KTH A;  2ZVX A;  3M7Q B;  1BPT A;  1MTN D;  1TPA I;  2UUY B;  2DDI A;  2FTM B;  3BYB A;  3BTW I;  4Y0Y I;  2JOT A;  1OA5 5;  4Y0Z I;  1EAW B;  3BTD I;  2TGP I;  1NAG A;  5C67 C;  2FI5 I;  1CBW D;  1LD6 A;  4Y10 I;  4U32 X;  1OA6 5;  1DTK A;  3BTK I;  4Y11 I;  3UIR C;  3FP7 J;  1EJM B; 
#chains in the Genus database with same CATH topology
 1BUN B;  3TGJ I;  4WXV C;  2FI3 I;  3P95 E;  2M99 A;  4NTX B;  3FP6 I;  1P2I I;  1AAP A;  1BRB I;  1UUA A;  8PTI A;  1B0C A;  3OFW A;  1BZX I;  3WNY A;  1DEM A;  1D0D B;  1P2Q B;  2TPI I;  3BTE I;  5JB4 A;  2IJO I;  3BTM I;  3GYM I;  1FAK I;  3T62 D;  1TAW B;  1BRC I;  1KIG I;  2R9P E;  1T8O B;  4BQD A;  1BF0 A;  1P2K I;  1BTI A;  3TGK I;  4PTI A;  3L33 E;  3TGI I;  1BHC A;  1P2O B;  1YKT B;  4DTG K;  1F5R I;  2KCR A;  1T7C B;  2KNT A;  1KUN A;  1P2N B;  3AUB A;  4DG4 C;  4ISN B;  1T8N B;  1P2M B;  2FTL I;  3AUG A;  3BTT I;  1D0D A;  3LDM A;  6PTI A;  2UUX A;  1Y62 A;  4U30 W;  2PTC I;  1SHP A;  2CA7 A;  5PTI A;  4ISL B;  1BTH P;  1F7Z I;  2W8X A;  1IRH A;  1PIT A;  1TAP A;  1YLC B;  5JB7 A;  3TPI I;  1G6X A;  2J6D A;  1AAL A;  1TOC R;  2FI4 I;  4BNR I;  4BD9 B;  3L3T E;  1LD5 A;  1YLD B;  3AUC A;  3OTJ I;  3LDI A;  2ZJX A;  1K6U A;  1BIK A;  1T8L B;  1DTX A;  9PTI A;  1FY8 I;  1BZ5 A;  1JV9 A;  1ADZ A;  2LFK A;  1BPI A;  2RA3 C;  1JC6 A;  1CA0 D;  2DDJ A;  3AUD A;  1QLQ A;  3AUH A;  1DEN A;  4WWY C;  3AUI A;  3UOU B;  3LDJ A;  3P92 E;  4NTW B;  2HEX A;  3FP8 I;  4ISO B;  1P2J I;  3BTF I;  7PTI A;  1JV8 A;  2KAI I;  5JB5 A;  3BTH I;  1TFX C;  4TPI I;  3CI7 A;  3BTG I;  1CO7 I;  2ODY E;  2M01 A;  1ZR0 B;  1KNT A;  1YC0 I;  1T8M B;  1TCP A;  3AUE A;  1UUB A;  1ZJD B;  2LFL A;  3U1J E;  1FAN A;  3D65 I;  3BTQ I;  5JB6 A;  4NTY B;  1KTH A;  2ZVX A;  3M7Q B;  1BPT A;  1MTN D;  1TPA I;  2UUY B;  2DDI A;  2FTM B;  3BYB A;  3BTW I;  4Y0Y I;  2JOT A;  1OA5 5;  4Y0Z I;  1EAW B;  3BTD I;  2TGP I;  1NAG A;  5C67 C;  2FI5 I;  1CBW D;  1LD6 A;  4Y10 I;  4U32 X;  1OA6 5;  1DTK A;  3BTK I;  4Y11 I;  3UIR C;  3FP7 J;  1EJM B; 
#chains in the Genus database with same CATH homology
 1BUN B;  3TGJ I;  4WXV C;  2FI3 I;  3P95 E;  2M99 A;  4NTX B;  3FP6 I;  1P2I I;  1AAP A;  1BRB I;  1UUA A;  8PTI A;  1B0C A;  3OFW A;  1BZX I;  3WNY A;  1DEM A;  1D0D B;  1P2Q B;  2TPI I;  3BTE I;  5JB4 A;  2IJO I;  3BTM I;  3GYM I;  1FAK I;  3T62 D;  1TAW B;  1BRC I;  1KIG I;  2R9P E;  1T8O B;  4BQD A;  1BF0 A;  1P2K I;  1BTI A;  3TGK I;  4PTI A;  3L33 E;  3TGI I;  1BHC A;  1P2O B;  1YKT B;  4DTG K;  1F5R I;  2KCR A;  1T7C B;  2KNT A;  1KUN A;  1P2N B;  3AUB A;  4DG4 C;  4ISN B;  1T8N B;  1P2M B;  2FTL I;  3AUG A;  3BTT I;  1D0D A;  3LDM A;  6PTI A;  2UUX A;  1Y62 A;  4U30 W;  2PTC I;  1SHP A;  2CA7 A;  5PTI A;  4ISL B;  1BTH P;  1F7Z I;  2W8X A;  1IRH A;  1PIT A;  1TAP A;  1YLC B;  5JB7 A;  3TPI I;  1G6X A;  2J6D A;  1AAL A;  1TOC R;  2FI4 I;  4BNR I;  4BD9 B;  3L3T E;  1LD5 A;  1YLD B;  3AUC A;  3OTJ I;  3LDI A;  2ZJX A;  1K6U A;  1BIK A;  1T8L B;  1DTX A;  9PTI A;  1FY8 I;  1BZ5 A;  1JV9 A;  1ADZ A;  2LFK A;  1BPI A;  2RA3 C;  1JC6 A;  1CA0 D;  2DDJ A;  3AUD A;  1QLQ A;  3AUH A;  1DEN A;  4WWY C;  3AUI A;  3UOU B;  3LDJ A;  3P92 E;  4NTW B;  2HEX A;  3FP8 I;  4ISO B;  1P2J I;  3BTF I;  7PTI A;  1JV8 A;  2KAI I;  5JB5 A;  3BTH I;  1TFX C;  4TPI I;  3CI7 A;  3BTG I;  1CO7 I;  2ODY E;  2M01 A;  1ZR0 B;  1KNT A;  1YC0 I;  1T8M B;  1TCP A;  3AUE A;  1UUB A;  1ZJD B;  2LFL A;  3U1J E;  1FAN A;  3D65 I;  3BTQ I;  5JB6 A;  4NTY B;  1KTH A;  2ZVX A;  3M7Q B;  1BPT A;  1MTN D;  1TPA I;  2UUY B;  2DDI A;  2FTM B;  3BYB A;  3BTW I;  4Y0Y I;  2JOT A;  1OA5 5;  4Y0Z I;  1EAW B;  3BTD I;  2TGP I;  1NAG A;  5C67 C;  2FI5 I;  1CBW D;  1LD6 A;  4Y10 I;  4U32 X;  1OA6 5;  1DTK A;  3BTK I;  4Y11 I;  3UIR C;  3FP7 J;  1EJM B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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