2JXYA

Solution structure of the hemopexin-like domain of mmp12
Total Genus 17
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
17
sequence length
194
structure length
194
Chain Sequence
MEPALCDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Evidence of reciprocal reorientation of the catalytic and hemopexin-like domains of full-length MMP-12
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Macrophage metalloelastase
total genus 17
structure length 194
sequence length 194
ec nomenclature ec 3.4.24.65: Macrophage elastase.
pdb deposition date 2007-12-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00045 Hemopexin Hemopexin
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.110.10.10 Mainly Beta 4 Propeller Hemopexin Hemopexin-like domain 2jxyA00
4AUOA 3BA0A 1SU3A 4LL2A 1GXDA 1RTGA 4FVLA 1HXNA 1GENA 1QHUA 2JXYA 1ITVA 4G0DA 1QJSA 3C7XA 1CK7A 1FBLA 4FU4A 2CLTA 4YEHA 1PEXA 4HSDA 2MQSA 4OEIA 3OYOA 3V6NA 4RT6B 3LP9A 3S18A
chains in the Genus database with same CATH superfamily
4AUOA 3BA0A 1SU3A 4LL2A 1GXDA 1RTGA 4FVLA 1HXNA 1GENA 1QHUA 2JXYA 1ITVA 4G0DA 1QJSA 3C7XA 1CK7A 1FBLA 4FU4A 2CLTA 4YEHA 1PEXA 4HSDA 2MQSA 4OEIA 3OYOA 3V6NA 4RT6B 3LP9A 3S18A
chains in the Genus database with same CATH topology
4AUOA 3BA0A 1SU3A 4LL2A 1GXDA 1RTGA 4FVLA 1HXNA 1GENA 1QHUA 2JXYA 1ITVA 4G0DA 1QJSA 3C7XA 1CK7A 1FBLA 4FU4A 2CLTA 4YEHA 1PEXA 4HSDA 2MQSA 4OEIA 3OYOA 3V6NA 4RT6B 3LP9A 3S18A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4AUO A;  3BA0 A;  1SU3 A;  4LL2 A;  1GXD A;  1RTG A;  4FVL A;  1HXN A;  1GEN A;  1QHU A;  2JXY A;  1ITV A;  4G0D A;  1QJS A;  3C7X A;  1CK7 A;  1FBL A;  4FU4 A;  2CLT A;  4YEH A;  1PEX A;  4HSD A;  2MQS A;  4OEI A;  3OYO A;  3V6N A;  4RT6 B;  3LP9 A;  3S18 A; 
#chains in the Genus database with same CATH topology
 4AUO A;  3BA0 A;  1SU3 A;  4LL2 A;  1GXD A;  1RTG A;  4FVL A;  1HXN A;  1GEN A;  1QHU A;  2JXY A;  1ITV A;  4G0D A;  1QJS A;  3C7X A;  1CK7 A;  1FBL A;  4FU4 A;  2CLT A;  4YEH A;  1PEX A;  4HSD A;  2MQS A;  4OEI A;  3OYO A;  3V6N A;  4RT6 B;  3LP9 A;  3S18 A; 
#chains in the Genus database with same CATH homology
 4AUO A;  3BA0 A;  1SU3 A;  4LL2 A;  1GXD A;  1RTG A;  4FVL A;  1HXN A;  1GEN A;  1QHU A;  2JXY A;  1ITV A;  4G0D A;  1QJS A;  3C7X A;  1CK7 A;  1FBL A;  4FU4 A;  2CLT A;  4YEH A;  1PEX A;  4HSD A;  2MQS A;  4OEI A;  3OYO A;  3V6N A;  4RT6 B;  3LP9 A;  3S18 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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