2LFKA

Nmr solution structure of native tdpi-short
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
57
structure length
57
Chain Sequence
GDKEECTVPIGWSEPVKGLCKARFTRYYCMGNCCKVYEGCYTGGYSRMGECARNCPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Oxidative folding and structural analyses of a kunitz-related inhibitor and its disulfide intermediates: functional implications.
pubmed doi rcsb
molecule tags Hydrolase inhibitor
source organism Rhipicephalus appendiculatus
molecule keywords Tryptase inhibitor
total genus 3
structure length 57
sequence length 57
ec nomenclature
pdb deposition date 2011-07-06
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2lfkA01
3AUBA 3L33E 2ODYE 4NTYB 1BUNB 4U32X 2LFLA 1B0CA 4NTXB 5C67C 1CO7I 1T8MB 3FP7J 4TPII 1G6XA 2TPII 2FI3I 1UUAA 2KAII 1P2JI 1DEMA 1Y62A 6PTIA 2HEXA 1BTHP 1T8OB 1P2NB 3BTFI 1K6UA 1P2MB 1BZXI 3TGJI 2M99A 9PTIA 2KCRA 3LDMA 1CBWD 1BPIA 1T8NB 2ZJXA 5PTIA 1DENA 1PITA 1AALA 2JOTA 3AUIA 3BTKI 3OFWA 1BIKA 4ISNB 3UOUB 4Y0ZI 1ADZA 3UIRC 3FP6I 1LD6A 3BTTI 3FP8I 2R9PE 3T62D 1KTHA 3P95E 4DG4C 2UUYB 1KIGI 3WNYA 1TAPA 3BTGI 2KNTA 1YKTB 3AUDA 3BTHI 1YLDB 3LDIA 3U1JE 3CI7A 2RA3C 1JV9A 4BNRI 3BTEI 1T7CB 2DDIA 1QLQA 4U30W 1EJMB 1OA55 1AAPA 3L3TE 1MTND 1EAWB 1UUBA 3AUEA 4NTWB 1IRHA 2M01A 1CA0D 1BRCI 1JC6A 1T8LB 3P92E 2LFKA 5JB7A 2W8XA 1BRBI 1P2II 2FTMB 1F7ZI 1FY8I 2CA7A 2DDJA 4DTGK 3BTWI 1BF0A 1TOCR 1P2KI 1DTXA 3TPII 4ISOB 3TGII 5JB5A 7PTIA 1LD5A 4PTIA 2J6DA 2FTLI 1YC0I 1FANA 3GYMI 1P2OB 3BTDI 4ISLB 1F5RI 1P2QB 1BHCA 1FAKI 1BZ5A 3BTQI 2IJOI 1KUNA 4WWYC 4Y11I 2ZVXA 4Y0YI 4BD9B 2UUXA 1SHPA 3D65I 1NAGA 1BTIA 2FI4I 3AUHA 3AUCA 2PTCI 5JB6A 3AUGA 1KNTA 1OA65 1TAWB 3OTJI 1TCPA 1D0DB 1TFXC 3LDJA 2FI5I 3TGKI 4WXVC 1YLCB 3BYBA 1BPTA 3BTMI 1D0DA 1ZJDB 8PTIA 4BQDA 5JB4A 1TPAI 3M7QB 4Y10I 1DTKA 1JV8A 1ZR0B 2TGPI
chains in the Genus database with same CATH superfamily
3AUBA 3L33E 2ODYE 4NTYB 1BUNB 4U32X 2LFLA 1B0CA 4NTXB 5C67C 1CO7I 1T8MB 3FP7J 4TPII 1G6XA 2TPII 2FI3I 1UUAA 2KAII 1P2JI 1DEMA 1Y62A 6PTIA 2HEXA 1BTHP 1T8OB 1P2NB 3BTFI 1K6UA 1P2MB 1BZXI 3TGJI 2M99A 9PTIA 2KCRA 3LDMA 1CBWD 1BPIA 1T8NB 2ZJXA 5PTIA 1DENA 1PITA 1AALA 2JOTA 3AUIA 3BTKI 3OFWA 1BIKA 4ISNB 3UOUB 4Y0ZI 1ADZA 3UIRC 3FP6I 1LD6A 3BTTI 3FP8I 2R9PE 3T62D 1KTHA 3P95E 4DG4C 2UUYB 1KIGI 3WNYA 1TAPA 3BTGI 2KNTA 1YKTB 3AUDA 3BTHI 1YLDB 3LDIA 3U1JE 3CI7A 2RA3C 1JV9A 4BNRI 3BTEI 1T7CB 2DDIA 1QLQA 4U30W 1EJMB 1OA55 1AAPA 3L3TE 1MTND 1EAWB 1UUBA 3AUEA 4NTWB 1IRHA 2M01A 1CA0D 1BRCI 1JC6A 1T8LB 3P92E 2LFKA 5JB7A 2W8XA 1BRBI 1P2II 2FTMB 1F7ZI 1FY8I 2CA7A 2DDJA 4DTGK 3BTWI 1BF0A 1TOCR 1P2KI 1DTXA 3TPII 4ISOB 3TGII 5JB5A 7PTIA 1LD5A 4PTIA 2J6DA 2FTLI 1YC0I 1FANA 3GYMI 1P2OB 3BTDI 4ISLB 1F5RI 1P2QB 1BHCA 1FAKI 1BZ5A 3BTQI 2IJOI 1KUNA 4WWYC 4Y11I 2ZVXA 4Y0YI 4BD9B 2UUXA 1SHPA 3D65I 1NAGA 1BTIA 2FI4I 3AUHA 3AUCA 2PTCI 5JB6A 3AUGA 1KNTA 1OA65 1TAWB 3OTJI 1TCPA 1D0DB 1TFXC 3LDJA 2FI5I 3TGKI 4WXVC 1YLCB 3BYBA 1BPTA 3BTMI 1D0DA 1ZJDB 8PTIA 4BQDA 5JB4A 1TPAI 3M7QB 4Y10I 1DTKA 1JV8A 1ZR0B 2TGPI
chains in the Genus database with same CATH topology
3AUBA 3L33E 2ODYE 4NTYB 1BUNB 4U32X 2LFLA 1B0CA 4NTXB 5C67C 1CO7I 1T8MB 3FP7J 4TPII 1G6XA 2TPII 2FI3I 1UUAA 2KAII 1P2JI 1DEMA 1Y62A 6PTIA 2HEXA 1BTHP 1T8OB 1P2NB 3BTFI 1K6UA 1P2MB 1BZXI 3TGJI 2M99A 9PTIA 2KCRA 3LDMA 1CBWD 1BPIA 1T8NB 2ZJXA 5PTIA 1DENA 1PITA 1AALA 2JOTA 3AUIA 3BTKI 3OFWA 1BIKA 4ISNB 3UOUB 4Y0ZI 1ADZA 3UIRC 3FP6I 1LD6A 3BTTI 3FP8I 2R9PE 3T62D 1KTHA 3P95E 4DG4C 2UUYB 1KIGI 3WNYA 1TAPA 3BTGI 2KNTA 1YKTB 3AUDA 3BTHI 1YLDB 3LDIA 3U1JE 3CI7A 2RA3C 1JV9A 4BNRI 3BTEI 1T7CB 2DDIA 1QLQA 4U30W 1EJMB 1OA55 1AAPA 3L3TE 1MTND 1EAWB 1UUBA 3AUEA 4NTWB 1IRHA 2M01A 1CA0D 1BRCI 1JC6A 1T8LB 3P92E 2LFKA 5JB7A 2W8XA 1BRBI 1P2II 2FTMB 1F7ZI 1FY8I 2CA7A 2DDJA 4DTGK 3BTWI 1BF0A 1TOCR 1P2KI 1DTXA 3TPII 4ISOB 3TGII 5JB5A 7PTIA 1LD5A 4PTIA 2J6DA 2FTLI 1YC0I 1FANA 3GYMI 1P2OB 3BTDI 4ISLB 1F5RI 1P2QB 1BHCA 1FAKI 1BZ5A 3BTQI 2IJOI 1KUNA 4WWYC 4Y11I 2ZVXA 4Y0YI 4BD9B 2UUXA 1SHPA 3D65I 1NAGA 1BTIA 2FI4I 3AUHA 3AUCA 2PTCI 5JB6A 3AUGA 1KNTA 1OA65 1TAWB 3OTJI 1TCPA 1D0DB 1TFXC 3LDJA 2FI5I 3TGKI 4WXVC 1YLCB 3BYBA 1BPTA 3BTMI 1D0DA 1ZJDB 8PTIA 4BQDA 5JB4A 1TPAI 3M7QB 4Y10I 1DTKA 1JV8A 1ZR0B 2TGPI
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3AUB A;  3L33 E;  2ODY E;  4NTY B;  1BUN B;  4U32 X;  2LFL A;  1B0C A;  4NTX B;  5C67 C;  1CO7 I;  1T8M B;  3FP7 J;  4TPI I;  1G6X A;  2TPI I;  2FI3 I;  1UUA A;  2KAI I;  1P2J I;  1DEM A;  1Y62 A;  6PTI A;  2HEX A;  1BTH P;  1T8O B;  1P2N B;  3BTF I;  1K6U A;  1P2M B;  1BZX I;  3TGJ I;  2M99 A;  9PTI A;  2KCR A;  3LDM A;  1CBW D;  1BPI A;  1T8N B;  2ZJX A;  5PTI A;  1DEN A;  1PIT A;  1AAL A;  2JOT A;  3AUI A;  3BTK I;  3OFW A;  1BIK A;  4ISN B;  3UOU B;  4Y0Z I;  1ADZ A;  3UIR C;  3FP6 I;  1LD6 A;  3BTT I;  3FP8 I;  2R9P E;  3T62 D;  1KTH A;  3P95 E;  4DG4 C;  2UUY B;  1KIG I;  3WNY A;  1TAP A;  3BTG I;  2KNT A;  1YKT B;  3AUD A;  3BTH I;  1YLD B;  3LDI A;  3U1J E;  3CI7 A;  2RA3 C;  1JV9 A;  4BNR I;  3BTE I;  1T7C B;  2DDI A;  1QLQ A;  4U30 W;  1EJM B;  1OA5 5;  1AAP A;  3L3T E;  1MTN D;  1EAW B;  1UUB A;  3AUE A;  4NTW B;  1IRH A;  2M01 A;  1CA0 D;  1BRC I;  1JC6 A;  1T8L B;  3P92 E;  2LFK A;  5JB7 A;  2W8X A;  1BRB I;  1P2I I;  2FTM B;  1F7Z I;  1FY8 I;  2CA7 A;  2DDJ A;  4DTG K;  3BTW I;  1BF0 A;  1TOC R;  1P2K I;  1DTX A;  3TPI I;  4ISO B;  3TGI I;  5JB5 A;  7PTI A;  1LD5 A;  4PTI A;  2J6D A;  2FTL I;  1YC0 I;  1FAN A;  3GYM I;  1P2O B;  3BTD I;  4ISL B;  1F5R I;  1P2Q B;  1BHC A;  1FAK I;  1BZ5 A;  3BTQ I;  2IJO I;  1KUN A;  4WWY C;  4Y11 I;  2ZVX A;  4Y0Y I;  4BD9 B;  2UUX A;  1SHP A;  3D65 I;  1NAG A;  1BTI A;  2FI4 I;  3AUH A;  3AUC A;  2PTC I;  5JB6 A;  3AUG A;  1KNT A;  1OA6 5;  1TAW B;  3OTJ I;  1TCP A;  1D0D B;  1TFX C;  3LDJ A;  2FI5 I;  3TGK I;  4WXV C;  1YLC B;  3BYB A;  1BPT A;  3BTM I;  1D0D A;  1ZJD B;  8PTI A;  4BQD A;  5JB4 A;  1TPA I;  3M7Q B;  4Y10 I;  1DTK A;  1JV8 A;  1ZR0 B;  2TGP I; 
#chains in the Genus database with same CATH topology
 3AUB A;  3L33 E;  2ODY E;  4NTY B;  1BUN B;  4U32 X;  2LFL A;  1B0C A;  4NTX B;  5C67 C;  1CO7 I;  1T8M B;  3FP7 J;  4TPI I;  1G6X A;  2TPI I;  2FI3 I;  1UUA A;  2KAI I;  1P2J I;  1DEM A;  1Y62 A;  6PTI A;  2HEX A;  1BTH P;  1T8O B;  1P2N B;  3BTF I;  1K6U A;  1P2M B;  1BZX I;  3TGJ I;  2M99 A;  9PTI A;  2KCR A;  3LDM A;  1CBW D;  1BPI A;  1T8N B;  2ZJX A;  5PTI A;  1DEN A;  1PIT A;  1AAL A;  2JOT A;  3AUI A;  3BTK I;  3OFW A;  1BIK A;  4ISN B;  3UOU B;  4Y0Z I;  1ADZ A;  3UIR C;  3FP6 I;  1LD6 A;  3BTT I;  3FP8 I;  2R9P E;  3T62 D;  1KTH A;  3P95 E;  4DG4 C;  2UUY B;  1KIG I;  3WNY A;  1TAP A;  3BTG I;  2KNT A;  1YKT B;  3AUD A;  3BTH I;  1YLD B;  3LDI A;  3U1J E;  3CI7 A;  2RA3 C;  1JV9 A;  4BNR I;  3BTE I;  1T7C B;  2DDI A;  1QLQ A;  4U30 W;  1EJM B;  1OA5 5;  1AAP A;  3L3T E;  1MTN D;  1EAW B;  1UUB A;  3AUE A;  4NTW B;  1IRH A;  2M01 A;  1CA0 D;  1BRC I;  1JC6 A;  1T8L B;  3P92 E;  2LFK A;  5JB7 A;  2W8X A;  1BRB I;  1P2I I;  2FTM B;  1F7Z I;  1FY8 I;  2CA7 A;  2DDJ A;  4DTG K;  3BTW I;  1BF0 A;  1TOC R;  1P2K I;  1DTX A;  3TPI I;  4ISO B;  3TGI I;  5JB5 A;  7PTI A;  1LD5 A;  4PTI A;  2J6D A;  2FTL I;  1YC0 I;  1FAN A;  3GYM I;  1P2O B;  3BTD I;  4ISL B;  1F5R I;  1P2Q B;  1BHC A;  1FAK I;  1BZ5 A;  3BTQ I;  2IJO I;  1KUN A;  4WWY C;  4Y11 I;  2ZVX A;  4Y0Y I;  4BD9 B;  2UUX A;  1SHP A;  3D65 I;  1NAG A;  1BTI A;  2FI4 I;  3AUH A;  3AUC A;  2PTC I;  5JB6 A;  3AUG A;  1KNT A;  1OA6 5;  1TAW B;  3OTJ I;  1TCP A;  1D0D B;  1TFX C;  3LDJ A;  2FI5 I;  3TGK I;  4WXV C;  1YLC B;  3BYB A;  1BPT A;  3BTM I;  1D0D A;  1ZJD B;  8PTI A;  4BQD A;  5JB4 A;  1TPA I;  3M7Q B;  4Y10 I;  1DTK A;  1JV8 A;  1ZR0 B;  2TGP I; 
#chains in the Genus database with same CATH homology
 3AUB A;  3L33 E;  2ODY E;  4NTY B;  1BUN B;  4U32 X;  2LFL A;  1B0C A;  4NTX B;  5C67 C;  1CO7 I;  1T8M B;  3FP7 J;  4TPI I;  1G6X A;  2TPI I;  2FI3 I;  1UUA A;  2KAI I;  1P2J I;  1DEM A;  1Y62 A;  6PTI A;  2HEX A;  1BTH P;  1T8O B;  1P2N B;  3BTF I;  1K6U A;  1P2M B;  1BZX I;  3TGJ I;  2M99 A;  9PTI A;  2KCR A;  3LDM A;  1CBW D;  1BPI A;  1T8N B;  2ZJX A;  5PTI A;  1DEN A;  1PIT A;  1AAL A;  2JOT A;  3AUI A;  3BTK I;  3OFW A;  1BIK A;  4ISN B;  3UOU B;  4Y0Z I;  1ADZ A;  3UIR C;  3FP6 I;  1LD6 A;  3BTT I;  3FP8 I;  2R9P E;  3T62 D;  1KTH A;  3P95 E;  4DG4 C;  2UUY B;  1KIG I;  3WNY A;  1TAP A;  3BTG I;  2KNT A;  1YKT B;  3AUD A;  3BTH I;  1YLD B;  3LDI A;  3U1J E;  3CI7 A;  2RA3 C;  1JV9 A;  4BNR I;  3BTE I;  1T7C B;  2DDI A;  1QLQ A;  4U30 W;  1EJM B;  1OA5 5;  1AAP A;  3L3T E;  1MTN D;  1EAW B;  1UUB A;  3AUE A;  4NTW B;  1IRH A;  2M01 A;  1CA0 D;  1BRC I;  1JC6 A;  1T8L B;  3P92 E;  2LFK A;  5JB7 A;  2W8X A;  1BRB I;  1P2I I;  2FTM B;  1F7Z I;  1FY8 I;  2CA7 A;  2DDJ A;  4DTG K;  3BTW I;  1BF0 A;  1TOC R;  1P2K I;  1DTX A;  3TPI I;  4ISO B;  3TGI I;  5JB5 A;  7PTI A;  1LD5 A;  4PTI A;  2J6D A;  2FTL I;  1YC0 I;  1FAN A;  3GYM I;  1P2O B;  3BTD I;  4ISL B;  1F5R I;  1P2Q B;  1BHC A;  1FAK I;  1BZ5 A;  3BTQ I;  2IJO I;  1KUN A;  4WWY C;  4Y11 I;  2ZVX A;  4Y0Y I;  4BD9 B;  2UUX A;  1SHP A;  3D65 I;  1NAG A;  1BTI A;  2FI4 I;  3AUH A;  3AUC A;  2PTC I;  5JB6 A;  3AUG A;  1KNT A;  1OA6 5;  1TAW B;  3OTJ I;  1TCP A;  1D0D B;  1TFX C;  3LDJ A;  2FI5 I;  3TGK I;  4WXV C;  1YLC B;  3BYB A;  1BPT A;  3BTM I;  1D0D A;  1ZJD B;  8PTI A;  4BQD A;  5JB4 A;  1TPA I;  3M7Q B;  4Y10 I;  1DTK A;  1JV8 A;  1ZR0 B;  2TGP I;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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