2LFKA

Nmr solution structure of native tdpi-short
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
57
structure length
57
Chain Sequence
GDKEECTVPIGWSEPVKGLCKARFTRYYCMGNCCKVYEGCYTGGYSRMGECARNCPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Oxidative folding and structural analyses of a kunitz-related inhibitor and its disulfide intermediates: functional implications.
pubmed doi rcsb
molecule keywords Tryptase inhibitor
molecule tags Hydrolase inhibitor
source organism Rhipicephalus appendiculatus
total genus 3
structure length 57
sequence length 57
ec nomenclature
pdb deposition date 2011-07-06
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2lfkA01
2J6DA 1YC0I 4BQDA 1BTHP 2UUXA 1BPIA 3BTFI 4TPII 2FTLI 1D0DB 3AUGA 1BRBI 1LD5A 3AUBA 1P2II 2W8XA 1AAPA 1BRCI 1DTXA 3TGKI 1IRHA 1UUAA 3OFWA 1F5RI 5JB5A 1JC6A 4BNRI 3TGJI 1BPTA 4ISOB 1P2QB 4DG4C 5PTIA 2FTMB 1D0DA 3BTWI 8PTIA 1CBWD 2KNTA 4BD9B 1T8LB 2HEXA 1DTKA 1KUNA 1TCPA 3GYMI 1FANA 1F7ZI 1EJMB 3BTHI 3FP7J 2TPII 3BYBA 2KAII 3TGII 3L33E 1BZ5A 4ISNB 1BZXI 3AUEA 2DDIA 4NTWB 3OTJI 1ZJDB 1P2KI 3U1JE 4NTXB 9PTIA 1EAWB 3UIRC 1DEMA 1OA65 3P92E 4U30W 1P2JI 3AUIA 4ISLB 1T8NB 3BTQI 1K6UA 3UOUB 3AUHA 3P95E 2M99A 1BHCA 1UUBA 6PTIA 5JB7A 1JV9A 1YKTB 1SHPA 3BTMI 3AUDA 2CA7A 3LDJA 1FAKI 2RA3C 3BTGI 5JB4A 1LD6A 1CA0D 1TOCR 1QLQA 3LDIA 3WNYA 1ADZA 1BTIA 5C67C 2LFKA 1TPAI 1BUNB 3BTDI 2KCRA 2PTCI 1AALA 3LDMA 3M7QB 1NAGA 1TAWB 4Y0ZI 4WXVC 5JB6A 1T8MB 2FI4I 1KNTA 1P2NB 4NTYB 1CO7I 1OA55 3FP8I 1DENA 2R9PE 1PITA 2TGPI 2JOTA 2ODYE 4Y11I 3FP6I 1FY8I 1TAPA 1YLCB 4PTIA 1P2OB 2FI3I 1B0CA 3BTEI 3D65I 7PTIA 3L3TE 1Y62A 1TFXC 3TPII 2M01A 2LFLA 1BIKA 2UUYB 4WWYC 2ZVXA 4Y10I 3T62D 1T7CB 1MTND 2ZJXA 3AUCA 3BTKI 1KIGI 3CI7A 1JV8A 1P2MB 1G6XA 1KTHA 2IJOI 4DTGK 4U32X 3BTTI 2FI5I 1T8OB 1ZR0B 1YLDB 1BF0A 4Y0YI 2DDJA
chains in the Genus database with same CATH superfamily
2J6DA 1YC0I 4BQDA 1BTHP 2UUXA 1BPIA 3BTFI 4TPII 2FTLI 1D0DB 3AUGA 1BRBI 1LD5A 3AUBA 1P2II 2W8XA 1AAPA 1BRCI 1DTXA 3TGKI 1IRHA 1UUAA 3OFWA 1F5RI 5JB5A 1JC6A 4BNRI 3TGJI 1BPTA 4ISOB 1P2QB 4DG4C 5PTIA 2FTMB 1D0DA 3BTWI 8PTIA 1CBWD 2KNTA 4BD9B 1T8LB 2HEXA 1DTKA 1KUNA 1TCPA 3GYMI 1FANA 1F7ZI 1EJMB 3BTHI 3FP7J 2TPII 3BYBA 2KAII 3TGII 3L33E 1BZ5A 4ISNB 1BZXI 3AUEA 2DDIA 4NTWB 3OTJI 1ZJDB 1P2KI 3U1JE 4NTXB 9PTIA 1EAWB 3UIRC 1DEMA 1OA65 3P92E 4U30W 1P2JI 3AUIA 4ISLB 1T8NB 3BTQI 1K6UA 3UOUB 3AUHA 3P95E 2M99A 1BHCA 1UUBA 6PTIA 5JB7A 1JV9A 1YKTB 1SHPA 3BTMI 3AUDA 2CA7A 3LDJA 1FAKI 2RA3C 3BTGI 5JB4A 1LD6A 1CA0D 1TOCR 1QLQA 3LDIA 3WNYA 1ADZA 1BTIA 5C67C 2LFKA 1TPAI 1BUNB 3BTDI 2KCRA 2PTCI 1AALA 3LDMA 3M7QB 1NAGA 1TAWB 4Y0ZI 4WXVC 5JB6A 1T8MB 2FI4I 1KNTA 1P2NB 4NTYB 1CO7I 1OA55 3FP8I 1DENA 2R9PE 1PITA 2TGPI 2JOTA 2ODYE 4Y11I 3FP6I 1FY8I 1TAPA 1YLCB 4PTIA 1P2OB 2FI3I 1B0CA 3BTEI 3D65I 7PTIA 3L3TE 1Y62A 1TFXC 3TPII 2M01A 2LFLA 1BIKA 2UUYB 4WWYC 2ZVXA 4Y10I 3T62D 1T7CB 1MTND 2ZJXA 3AUCA 3BTKI 1KIGI 3CI7A 1JV8A 1P2MB 1G6XA 1KTHA 2IJOI 4DTGK 4U32X 3BTTI 2FI5I 1T8OB 1ZR0B 1YLDB 1BF0A 4Y0YI 2DDJA
chains in the Genus database with same CATH topology
2J6DA 1YC0I 4BQDA 1BTHP 2UUXA 1BPIA 3BTFI 4TPII 2FTLI 1D0DB 3AUGA 1BRBI 1LD5A 3AUBA 1P2II 2W8XA 1AAPA 1BRCI 1DTXA 3TGKI 1IRHA 1UUAA 3OFWA 1F5RI 5JB5A 1JC6A 4BNRI 3TGJI 1BPTA 4ISOB 1P2QB 4DG4C 5PTIA 2FTMB 1D0DA 3BTWI 8PTIA 1CBWD 2KNTA 4BD9B 1T8LB 2HEXA 1DTKA 1KUNA 1TCPA 3GYMI 1FANA 1F7ZI 1EJMB 3BTHI 3FP7J 2TPII 3BYBA 2KAII 3TGII 3L33E 1BZ5A 4ISNB 1BZXI 3AUEA 2DDIA 4NTWB 3OTJI 1ZJDB 1P2KI 3U1JE 4NTXB 9PTIA 1EAWB 3UIRC 1DEMA 1OA65 3P92E 4U30W 1P2JI 3AUIA 4ISLB 1T8NB 3BTQI 1K6UA 3UOUB 3AUHA 3P95E 2M99A 1BHCA 1UUBA 6PTIA 5JB7A 1JV9A 1YKTB 1SHPA 3BTMI 3AUDA 2CA7A 3LDJA 1FAKI 2RA3C 3BTGI 5JB4A 1LD6A 1CA0D 1TOCR 1QLQA 3LDIA 3WNYA 1ADZA 1BTIA 5C67C 2LFKA 1TPAI 1BUNB 3BTDI 2KCRA 2PTCI 1AALA 3LDMA 3M7QB 1NAGA 1TAWB 4Y0ZI 4WXVC 5JB6A 1T8MB 2FI4I 1KNTA 1P2NB 4NTYB 1CO7I 1OA55 3FP8I 1DENA 2R9PE 1PITA 2TGPI 2JOTA 2ODYE 4Y11I 3FP6I 1FY8I 1TAPA 1YLCB 4PTIA 1P2OB 2FI3I 1B0CA 3BTEI 3D65I 7PTIA 3L3TE 1Y62A 1TFXC 3TPII 2M01A 2LFLA 1BIKA 2UUYB 4WWYC 2ZVXA 4Y10I 3T62D 1T7CB 1MTND 2ZJXA 3AUCA 3BTKI 1KIGI 3CI7A 1JV8A 1P2MB 1G6XA 1KTHA 2IJOI 4DTGK 4U32X 3BTTI 2FI5I 1T8OB 1ZR0B 1YLDB 1BF0A 4Y0YI 2DDJA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2J6D A;  1YC0 I;  4BQD A;  1BTH P;  2UUX A;  1BPI A;  3BTF I;  4TPI I;  2FTL I;  1D0D B;  3AUG A;  1BRB I;  1LD5 A;  3AUB A;  1P2I I;  2W8X A;  1AAP A;  1BRC I;  1DTX A;  3TGK I;  1IRH A;  1UUA A;  3OFW A;  1F5R I;  5JB5 A;  1JC6 A;  4BNR I;  3TGJ I;  1BPT A;  4ISO B;  1P2Q B;  4DG4 C;  5PTI A;  2FTM B;  1D0D A;  3BTW I;  8PTI A;  1CBW D;  2KNT A;  4BD9 B;  1T8L B;  2HEX A;  1DTK A;  1KUN A;  1TCP A;  3GYM I;  1FAN A;  1F7Z I;  1EJM B;  3BTH I;  3FP7 J;  2TPI I;  3BYB A;  2KAI I;  3TGI I;  3L33 E;  1BZ5 A;  4ISN B;  1BZX I;  3AUE A;  2DDI A;  4NTW B;  3OTJ I;  1ZJD B;  1P2K I;  3U1J E;  4NTX B;  9PTI A;  1EAW B;  3UIR C;  1DEM A;  1OA6 5;  3P92 E;  4U30 W;  1P2J I;  3AUI A;  4ISL B;  1T8N B;  3BTQ I;  1K6U A;  3UOU B;  3AUH A;  3P95 E;  2M99 A;  1BHC A;  1UUB A;  6PTI A;  5JB7 A;  1JV9 A;  1YKT B;  1SHP A;  3BTM I;  3AUD A;  2CA7 A;  3LDJ A;  1FAK I;  2RA3 C;  3BTG I;  5JB4 A;  1LD6 A;  1CA0 D;  1TOC R;  1QLQ A;  3LDI A;  3WNY A;  1ADZ A;  1BTI A;  5C67 C;  2LFK A;  1TPA I;  1BUN B;  3BTD I;  2KCR A;  2PTC I;  1AAL A;  3LDM A;  3M7Q B;  1NAG A;  1TAW B;  4Y0Z I;  4WXV C;  5JB6 A;  1T8M B;  2FI4 I;  1KNT A;  1P2N B;  4NTY B;  1CO7 I;  1OA5 5;  3FP8 I;  1DEN A;  2R9P E;  1PIT A;  2TGP I;  2JOT A;  2ODY E;  4Y11 I;  3FP6 I;  1FY8 I;  1TAP A;  1YLC B;  4PTI A;  1P2O B;  2FI3 I;  1B0C A;  3BTE I;  3D65 I;  7PTI A;  3L3T E;  1Y62 A;  1TFX C;  3TPI I;  2M01 A;  2LFL A;  1BIK A;  2UUY B;  4WWY C;  2ZVX A;  4Y10 I;  3T62 D;  1T7C B;  1MTN D;  2ZJX A;  3AUC A;  3BTK I;  1KIG I;  3CI7 A;  1JV8 A;  1P2M B;  1G6X A;  1KTH A;  2IJO I;  4DTG K;  4U32 X;  3BTT I;  2FI5 I;  1T8O B;  1ZR0 B;  1YLD B;  1BF0 A;  4Y0Y I;  2DDJ A; 
#chains in the Genus database with same CATH topology
 2J6D A;  1YC0 I;  4BQD A;  1BTH P;  2UUX A;  1BPI A;  3BTF I;  4TPI I;  2FTL I;  1D0D B;  3AUG A;  1BRB I;  1LD5 A;  3AUB A;  1P2I I;  2W8X A;  1AAP A;  1BRC I;  1DTX A;  3TGK I;  1IRH A;  1UUA A;  3OFW A;  1F5R I;  5JB5 A;  1JC6 A;  4BNR I;  3TGJ I;  1BPT A;  4ISO B;  1P2Q B;  4DG4 C;  5PTI A;  2FTM B;  1D0D A;  3BTW I;  8PTI A;  1CBW D;  2KNT A;  4BD9 B;  1T8L B;  2HEX A;  1DTK A;  1KUN A;  1TCP A;  3GYM I;  1FAN A;  1F7Z I;  1EJM B;  3BTH I;  3FP7 J;  2TPI I;  3BYB A;  2KAI I;  3TGI I;  3L33 E;  1BZ5 A;  4ISN B;  1BZX I;  3AUE A;  2DDI A;  4NTW B;  3OTJ I;  1ZJD B;  1P2K I;  3U1J E;  4NTX B;  9PTI A;  1EAW B;  3UIR C;  1DEM A;  1OA6 5;  3P92 E;  4U30 W;  1P2J I;  3AUI A;  4ISL B;  1T8N B;  3BTQ I;  1K6U A;  3UOU B;  3AUH A;  3P95 E;  2M99 A;  1BHC A;  1UUB A;  6PTI A;  5JB7 A;  1JV9 A;  1YKT B;  1SHP A;  3BTM I;  3AUD A;  2CA7 A;  3LDJ A;  1FAK I;  2RA3 C;  3BTG I;  5JB4 A;  1LD6 A;  1CA0 D;  1TOC R;  1QLQ A;  3LDI A;  3WNY A;  1ADZ A;  1BTI A;  5C67 C;  2LFK A;  1TPA I;  1BUN B;  3BTD I;  2KCR A;  2PTC I;  1AAL A;  3LDM A;  3M7Q B;  1NAG A;  1TAW B;  4Y0Z I;  4WXV C;  5JB6 A;  1T8M B;  2FI4 I;  1KNT A;  1P2N B;  4NTY B;  1CO7 I;  1OA5 5;  3FP8 I;  1DEN A;  2R9P E;  1PIT A;  2TGP I;  2JOT A;  2ODY E;  4Y11 I;  3FP6 I;  1FY8 I;  1TAP A;  1YLC B;  4PTI A;  1P2O B;  2FI3 I;  1B0C A;  3BTE I;  3D65 I;  7PTI A;  3L3T E;  1Y62 A;  1TFX C;  3TPI I;  2M01 A;  2LFL A;  1BIK A;  2UUY B;  4WWY C;  2ZVX A;  4Y10 I;  3T62 D;  1T7C B;  1MTN D;  2ZJX A;  3AUC A;  3BTK I;  1KIG I;  3CI7 A;  1JV8 A;  1P2M B;  1G6X A;  1KTH A;  2IJO I;  4DTG K;  4U32 X;  3BTT I;  2FI5 I;  1T8O B;  1ZR0 B;  1YLD B;  1BF0 A;  4Y0Y I;  2DDJ A; 
#chains in the Genus database with same CATH homology
 2J6D A;  1YC0 I;  4BQD A;  1BTH P;  2UUX A;  1BPI A;  3BTF I;  4TPI I;  2FTL I;  1D0D B;  3AUG A;  1BRB I;  1LD5 A;  3AUB A;  1P2I I;  2W8X A;  1AAP A;  1BRC I;  1DTX A;  3TGK I;  1IRH A;  1UUA A;  3OFW A;  1F5R I;  5JB5 A;  1JC6 A;  4BNR I;  3TGJ I;  1BPT A;  4ISO B;  1P2Q B;  4DG4 C;  5PTI A;  2FTM B;  1D0D A;  3BTW I;  8PTI A;  1CBW D;  2KNT A;  4BD9 B;  1T8L B;  2HEX A;  1DTK A;  1KUN A;  1TCP A;  3GYM I;  1FAN A;  1F7Z I;  1EJM B;  3BTH I;  3FP7 J;  2TPI I;  3BYB A;  2KAI I;  3TGI I;  3L33 E;  1BZ5 A;  4ISN B;  1BZX I;  3AUE A;  2DDI A;  4NTW B;  3OTJ I;  1ZJD B;  1P2K I;  3U1J E;  4NTX B;  9PTI A;  1EAW B;  3UIR C;  1DEM A;  1OA6 5;  3P92 E;  4U30 W;  1P2J I;  3AUI A;  4ISL B;  1T8N B;  3BTQ I;  1K6U A;  3UOU B;  3AUH A;  3P95 E;  2M99 A;  1BHC A;  1UUB A;  6PTI A;  5JB7 A;  1JV9 A;  1YKT B;  1SHP A;  3BTM I;  3AUD A;  2CA7 A;  3LDJ A;  1FAK I;  2RA3 C;  3BTG I;  5JB4 A;  1LD6 A;  1CA0 D;  1TOC R;  1QLQ A;  3LDI A;  3WNY A;  1ADZ A;  1BTI A;  5C67 C;  2LFK A;  1TPA I;  1BUN B;  3BTD I;  2KCR A;  2PTC I;  1AAL A;  3LDM A;  3M7Q B;  1NAG A;  1TAW B;  4Y0Z I;  4WXV C;  5JB6 A;  1T8M B;  2FI4 I;  1KNT A;  1P2N B;  4NTY B;  1CO7 I;  1OA5 5;  3FP8 I;  1DEN A;  2R9P E;  1PIT A;  2TGP I;  2JOT A;  2ODY E;  4Y11 I;  3FP6 I;  1FY8 I;  1TAP A;  1YLC B;  4PTI A;  1P2O B;  2FI3 I;  1B0C A;  3BTE I;  3D65 I;  7PTI A;  3L3T E;  1Y62 A;  1TFX C;  3TPI I;  2M01 A;  2LFL A;  1BIK A;  2UUY B;  4WWY C;  2ZVX A;  4Y10 I;  3T62 D;  1T7C B;  1MTN D;  2ZJX A;  3AUC A;  3BTK I;  1KIG I;  3CI7 A;  1JV8 A;  1P2M B;  1G6X A;  1KTH A;  2IJO I;  4DTG K;  4U32 X;  3BTT I;  2FI5 I;  1T8O B;  1ZR0 B;  1YLD B;  1BF0 A;  4Y0Y I;  2DDJ A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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