2LFLA

Nmr solution structure of the intermediate iiib of tdpi-short
Total Genus 8
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
8
sequence length
57
structure length
57
Chain Sequence
GDKEECTVPIGWSEPVKGLCKARFTRYYCMGNCCKVYEGCYTGGYSRMGECARNCPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Oxidative folding and structural analyses of a kunitz-related inhibitor and its disulfide intermediates: functional implications.
pubmed doi rcsb
molecule tags Hydrolase inhibitor
source organism Rhipicephalus appendiculatus
molecule keywords Tryptase inhibitor
total genus 8
structure length 57
sequence length 57
ec nomenclature
pdb deposition date 2011-07-06
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2lflA01
1EAWB 3FP6I 3GYMI 2KAII 2KNTA 2ZJXA 2DDJA 1FY8I 1BHCA 1BTIA 3AUEA 1UUAA 1DENA 1CO7I 3AUGA 2ODYE 1TAWB 1TFXC 1OA65 1TAPA 5C67C 3BYBA 2PTCI 4U30W 1T8MB 3WNYA 4BNRI 1JC6A 1OA55 4DTGK 1KTHA 3BTQI 3BTMI 3TGKI 1BTHP 5JB6A 1TOCR 1P2QB 1ZJDB 3TPII 3BTEI 2UUYB 1BF0A 4BD9B 1T7CB 3P95E 2R9PE 3AUBA 1FAKI 1DEMA 1KNTA 1D0DA 1AALA 2TGPI 1BRBI 4NTYB 1Y62A 4NTXB 1BZ5A 1T8LB 2M01A 1YLCB 1KIGI 1D0DB 1T8NB 2UUXA 3BTKI 3P92E 4ISNB 1AAPA 1TCPA 3LDJA 2KCRA 4Y10I 3BTGI 1P2OB 1EJMB 5JB4A 1LD5A 1P2KI 1F5RI 1P2II 1YKTB 1T8OB 1ZR0B 1BZXI 1UUBA 4DG4C 1F7ZI 3TGII 4Y0YI 4BQDA 1BPIA 1LD6A 5JB5A 3M7QB 1CBWD 4ISLB 4Y11I 1ADZA 2J6DA 1G6XA 3OTJI 3AUHA 3BTFI 1YC0I 2FI4I 3AUIA 1BUNB 2HEXA 4ISOB 2W8XA 1TPAI 2LFLA 3OFWA 3UIRC 4PTIA 1FANA 3L3TE 4WXVC 3UOUB 1SHPA 1JV9A 3T62D 7PTIA 2FI3I 8PTIA 3L33E 5JB7A 1BRCI 4TPII 1B0CA 2M99A 3BTDI 4Y0ZI 1JV8A 1MTND 2FI5I 2FTLI 3AUCA 2TPII 2JOTA 3LDIA 3BTWI 2LFKA 3BTHI 9PTIA 1KUNA 1P2MB 3LDMA 1QLQA 2DDIA 2ZVXA 1K6UA 3AUDA 2FTMB 3FP7J 3CI7A 3TGJI 6PTIA 3FP8I 1IRHA 1BIKA 3U1JE 4U32X 1BPTA 4NTWB 1PITA 1DTKA 1YLDB 1P2NB 1P2JI 1NAGA 1CA0D 2CA7A 2RA3C 3BTTI 5PTIA 4WWYC 2IJOI 1DTXA 3D65I
chains in the Genus database with same CATH superfamily
1EAWB 3FP6I 3GYMI 2KAII 2KNTA 2ZJXA 2DDJA 1FY8I 1BHCA 1BTIA 3AUEA 1UUAA 1DENA 1CO7I 3AUGA 2ODYE 1TAWB 1TFXC 1OA65 1TAPA 5C67C 3BYBA 2PTCI 4U30W 1T8MB 3WNYA 4BNRI 1JC6A 1OA55 4DTGK 1KTHA 3BTQI 3BTMI 3TGKI 1BTHP 5JB6A 1TOCR 1P2QB 1ZJDB 3TPII 3BTEI 2UUYB 1BF0A 4BD9B 1T7CB 3P95E 2R9PE 3AUBA 1FAKI 1DEMA 1KNTA 1D0DA 1AALA 2TGPI 1BRBI 4NTYB 1Y62A 4NTXB 1BZ5A 1T8LB 2M01A 1YLCB 1KIGI 1D0DB 1T8NB 2UUXA 3BTKI 3P92E 4ISNB 1AAPA 1TCPA 3LDJA 2KCRA 4Y10I 3BTGI 1P2OB 1EJMB 5JB4A 1LD5A 1P2KI 1F5RI 1P2II 1YKTB 1T8OB 1ZR0B 1BZXI 1UUBA 4DG4C 1F7ZI 3TGII 4Y0YI 4BQDA 1BPIA 1LD6A 5JB5A 3M7QB 1CBWD 4ISLB 4Y11I 1ADZA 2J6DA 1G6XA 3OTJI 3AUHA 3BTFI 1YC0I 2FI4I 3AUIA 1BUNB 2HEXA 4ISOB 2W8XA 1TPAI 2LFLA 3OFWA 3UIRC 4PTIA 1FANA 3L3TE 4WXVC 3UOUB 1SHPA 1JV9A 3T62D 7PTIA 2FI3I 8PTIA 3L33E 5JB7A 1BRCI 4TPII 1B0CA 2M99A 3BTDI 4Y0ZI 1JV8A 1MTND 2FI5I 2FTLI 3AUCA 2TPII 2JOTA 3LDIA 3BTWI 2LFKA 3BTHI 9PTIA 1KUNA 1P2MB 3LDMA 1QLQA 2DDIA 2ZVXA 1K6UA 3AUDA 2FTMB 3FP7J 3CI7A 3TGJI 6PTIA 3FP8I 1IRHA 1BIKA 3U1JE 4U32X 1BPTA 4NTWB 1PITA 1DTKA 1YLDB 1P2NB 1P2JI 1NAGA 1CA0D 2CA7A 2RA3C 3BTTI 5PTIA 4WWYC 2IJOI 1DTXA 3D65I
chains in the Genus database with same CATH topology
1EAWB 3FP6I 3GYMI 2KAII 2KNTA 2ZJXA 2DDJA 1FY8I 1BHCA 1BTIA 3AUEA 1UUAA 1DENA 1CO7I 3AUGA 2ODYE 1TAWB 1TFXC 1OA65 1TAPA 5C67C 3BYBA 2PTCI 4U30W 1T8MB 3WNYA 4BNRI 1JC6A 1OA55 4DTGK 1KTHA 3BTQI 3BTMI 3TGKI 1BTHP 5JB6A 1TOCR 1P2QB 1ZJDB 3TPII 3BTEI 2UUYB 1BF0A 4BD9B 1T7CB 3P95E 2R9PE 3AUBA 1FAKI 1DEMA 1KNTA 1D0DA 1AALA 2TGPI 1BRBI 4NTYB 1Y62A 4NTXB 1BZ5A 1T8LB 2M01A 1YLCB 1KIGI 1D0DB 1T8NB 2UUXA 3BTKI 3P92E 4ISNB 1AAPA 1TCPA 3LDJA 2KCRA 4Y10I 3BTGI 1P2OB 1EJMB 5JB4A 1LD5A 1P2KI 1F5RI 1P2II 1YKTB 1T8OB 1ZR0B 1BZXI 1UUBA 4DG4C 1F7ZI 3TGII 4Y0YI 4BQDA 1BPIA 1LD6A 5JB5A 3M7QB 1CBWD 4ISLB 4Y11I 1ADZA 2J6DA 1G6XA 3OTJI 3AUHA 3BTFI 1YC0I 2FI4I 3AUIA 1BUNB 2HEXA 4ISOB 2W8XA 1TPAI 2LFLA 3OFWA 3UIRC 4PTIA 1FANA 3L3TE 4WXVC 3UOUB 1SHPA 1JV9A 3T62D 7PTIA 2FI3I 8PTIA 3L33E 5JB7A 1BRCI 4TPII 1B0CA 2M99A 3BTDI 4Y0ZI 1JV8A 1MTND 2FI5I 2FTLI 3AUCA 2TPII 2JOTA 3LDIA 3BTWI 2LFKA 3BTHI 9PTIA 1KUNA 1P2MB 3LDMA 1QLQA 2DDIA 2ZVXA 1K6UA 3AUDA 2FTMB 3FP7J 3CI7A 3TGJI 6PTIA 3FP8I 1IRHA 1BIKA 3U1JE 4U32X 1BPTA 4NTWB 1PITA 1DTKA 1YLDB 1P2NB 1P2JI 1NAGA 1CA0D 2CA7A 2RA3C 3BTTI 5PTIA 4WWYC 2IJOI 1DTXA 3D65I
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1EAW B;  3FP6 I;  3GYM I;  2KAI I;  2KNT A;  2ZJX A;  2DDJ A;  1FY8 I;  1BHC A;  1BTI A;  3AUE A;  1UUA A;  1DEN A;  1CO7 I;  3AUG A;  2ODY E;  1TAW B;  1TFX C;  1OA6 5;  1TAP A;  5C67 C;  3BYB A;  2PTC I;  4U30 W;  1T8M B;  3WNY A;  4BNR I;  1JC6 A;  1OA5 5;  4DTG K;  1KTH A;  3BTQ I;  3BTM I;  3TGK I;  1BTH P;  5JB6 A;  1TOC R;  1P2Q B;  1ZJD B;  3TPI I;  3BTE I;  2UUY B;  1BF0 A;  4BD9 B;  1T7C B;  3P95 E;  2R9P E;  3AUB A;  1FAK I;  1DEM A;  1KNT A;  1D0D A;  1AAL A;  2TGP I;  1BRB I;  4NTY B;  1Y62 A;  4NTX B;  1BZ5 A;  1T8L B;  2M01 A;  1YLC B;  1KIG I;  1D0D B;  1T8N B;  2UUX A;  3BTK I;  3P92 E;  4ISN B;  1AAP A;  1TCP A;  3LDJ A;  2KCR A;  4Y10 I;  3BTG I;  1P2O B;  1EJM B;  5JB4 A;  1LD5 A;  1P2K I;  1F5R I;  1P2I I;  1YKT B;  1T8O B;  1ZR0 B;  1BZX I;  1UUB A;  4DG4 C;  1F7Z I;  3TGI I;  4Y0Y I;  4BQD A;  1BPI A;  1LD6 A;  5JB5 A;  3M7Q B;  1CBW D;  4ISL B;  4Y11 I;  1ADZ A;  2J6D A;  1G6X A;  3OTJ I;  3AUH A;  3BTF I;  1YC0 I;  2FI4 I;  3AUI A;  1BUN B;  2HEX A;  4ISO B;  2W8X A;  1TPA I;  2LFL A;  3OFW A;  3UIR C;  4PTI A;  1FAN A;  3L3T E;  4WXV C;  3UOU B;  1SHP A;  1JV9 A;  3T62 D;  7PTI A;  2FI3 I;  8PTI A;  3L33 E;  5JB7 A;  1BRC I;  4TPI I;  1B0C A;  2M99 A;  3BTD I;  4Y0Z I;  1JV8 A;  1MTN D;  2FI5 I;  2FTL I;  3AUC A;  2TPI I;  2JOT A;  3LDI A;  3BTW I;  2LFK A;  3BTH I;  9PTI A;  1KUN A;  1P2M B;  3LDM A;  1QLQ A;  2DDI A;  2ZVX A;  1K6U A;  3AUD A;  2FTM B;  3FP7 J;  3CI7 A;  3TGJ I;  6PTI A;  3FP8 I;  1IRH A;  1BIK A;  3U1J E;  4U32 X;  1BPT A;  4NTW B;  1PIT A;  1DTK A;  1YLD B;  1P2N B;  1P2J I;  1NAG A;  1CA0 D;  2CA7 A;  2RA3 C;  3BTT I;  5PTI A;  4WWY C;  2IJO I;  1DTX A;  3D65 I; 
#chains in the Genus database with same CATH topology
 1EAW B;  3FP6 I;  3GYM I;  2KAI I;  2KNT A;  2ZJX A;  2DDJ A;  1FY8 I;  1BHC A;  1BTI A;  3AUE A;  1UUA A;  1DEN A;  1CO7 I;  3AUG A;  2ODY E;  1TAW B;  1TFX C;  1OA6 5;  1TAP A;  5C67 C;  3BYB A;  2PTC I;  4U30 W;  1T8M B;  3WNY A;  4BNR I;  1JC6 A;  1OA5 5;  4DTG K;  1KTH A;  3BTQ I;  3BTM I;  3TGK I;  1BTH P;  5JB6 A;  1TOC R;  1P2Q B;  1ZJD B;  3TPI I;  3BTE I;  2UUY B;  1BF0 A;  4BD9 B;  1T7C B;  3P95 E;  2R9P E;  3AUB A;  1FAK I;  1DEM A;  1KNT A;  1D0D A;  1AAL A;  2TGP I;  1BRB I;  4NTY B;  1Y62 A;  4NTX B;  1BZ5 A;  1T8L B;  2M01 A;  1YLC B;  1KIG I;  1D0D B;  1T8N B;  2UUX A;  3BTK I;  3P92 E;  4ISN B;  1AAP A;  1TCP A;  3LDJ A;  2KCR A;  4Y10 I;  3BTG I;  1P2O B;  1EJM B;  5JB4 A;  1LD5 A;  1P2K I;  1F5R I;  1P2I I;  1YKT B;  1T8O B;  1ZR0 B;  1BZX I;  1UUB A;  4DG4 C;  1F7Z I;  3TGI I;  4Y0Y I;  4BQD A;  1BPI A;  1LD6 A;  5JB5 A;  3M7Q B;  1CBW D;  4ISL B;  4Y11 I;  1ADZ A;  2J6D A;  1G6X A;  3OTJ I;  3AUH A;  3BTF I;  1YC0 I;  2FI4 I;  3AUI A;  1BUN B;  2HEX A;  4ISO B;  2W8X A;  1TPA I;  2LFL A;  3OFW A;  3UIR C;  4PTI A;  1FAN A;  3L3T E;  4WXV C;  3UOU B;  1SHP A;  1JV9 A;  3T62 D;  7PTI A;  2FI3 I;  8PTI A;  3L33 E;  5JB7 A;  1BRC I;  4TPI I;  1B0C A;  2M99 A;  3BTD I;  4Y0Z I;  1JV8 A;  1MTN D;  2FI5 I;  2FTL I;  3AUC A;  2TPI I;  2JOT A;  3LDI A;  3BTW I;  2LFK A;  3BTH I;  9PTI A;  1KUN A;  1P2M B;  3LDM A;  1QLQ A;  2DDI A;  2ZVX A;  1K6U A;  3AUD A;  2FTM B;  3FP7 J;  3CI7 A;  3TGJ I;  6PTI A;  3FP8 I;  1IRH A;  1BIK A;  3U1J E;  4U32 X;  1BPT A;  4NTW B;  1PIT A;  1DTK A;  1YLD B;  1P2N B;  1P2J I;  1NAG A;  1CA0 D;  2CA7 A;  2RA3 C;  3BTT I;  5PTI A;  4WWY C;  2IJO I;  1DTX A;  3D65 I; 
#chains in the Genus database with same CATH homology
 1EAW B;  3FP6 I;  3GYM I;  2KAI I;  2KNT A;  2ZJX A;  2DDJ A;  1FY8 I;  1BHC A;  1BTI A;  3AUE A;  1UUA A;  1DEN A;  1CO7 I;  3AUG A;  2ODY E;  1TAW B;  1TFX C;  1OA6 5;  1TAP A;  5C67 C;  3BYB A;  2PTC I;  4U30 W;  1T8M B;  3WNY A;  4BNR I;  1JC6 A;  1OA5 5;  4DTG K;  1KTH A;  3BTQ I;  3BTM I;  3TGK I;  1BTH P;  5JB6 A;  1TOC R;  1P2Q B;  1ZJD B;  3TPI I;  3BTE I;  2UUY B;  1BF0 A;  4BD9 B;  1T7C B;  3P95 E;  2R9P E;  3AUB A;  1FAK I;  1DEM A;  1KNT A;  1D0D A;  1AAL A;  2TGP I;  1BRB I;  4NTY B;  1Y62 A;  4NTX B;  1BZ5 A;  1T8L B;  2M01 A;  1YLC B;  1KIG I;  1D0D B;  1T8N B;  2UUX A;  3BTK I;  3P92 E;  4ISN B;  1AAP A;  1TCP A;  3LDJ A;  2KCR A;  4Y10 I;  3BTG I;  1P2O B;  1EJM B;  5JB4 A;  1LD5 A;  1P2K I;  1F5R I;  1P2I I;  1YKT B;  1T8O B;  1ZR0 B;  1BZX I;  1UUB A;  4DG4 C;  1F7Z I;  3TGI I;  4Y0Y I;  4BQD A;  1BPI A;  1LD6 A;  5JB5 A;  3M7Q B;  1CBW D;  4ISL B;  4Y11 I;  1ADZ A;  2J6D A;  1G6X A;  3OTJ I;  3AUH A;  3BTF I;  1YC0 I;  2FI4 I;  3AUI A;  1BUN B;  2HEX A;  4ISO B;  2W8X A;  1TPA I;  2LFL A;  3OFW A;  3UIR C;  4PTI A;  1FAN A;  3L3T E;  4WXV C;  3UOU B;  1SHP A;  1JV9 A;  3T62 D;  7PTI A;  2FI3 I;  8PTI A;  3L33 E;  5JB7 A;  1BRC I;  4TPI I;  1B0C A;  2M99 A;  3BTD I;  4Y0Z I;  1JV8 A;  1MTN D;  2FI5 I;  2FTL I;  3AUC A;  2TPI I;  2JOT A;  3LDI A;  3BTW I;  2LFK A;  3BTH I;  9PTI A;  1KUN A;  1P2M B;  3LDM A;  1QLQ A;  2DDI A;  2ZVX A;  1K6U A;  3AUD A;  2FTM B;  3FP7 J;  3CI7 A;  3TGJ I;  6PTI A;  3FP8 I;  1IRH A;  1BIK A;  3U1J E;  4U32 X;  1BPT A;  4NTW B;  1PIT A;  1DTK A;  1YLD B;  1P2N B;  1P2J I;  1NAG A;  1CA0 D;  2CA7 A;  2RA3 C;  3BTT I;  5PTI A;  4WWY C;  2IJO I;  1DTX A;  3D65 I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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