2NVXE

Rna polymerase ii elongation complex in 5 mm mg+2 with 2'-dutp
Total Genus 41
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
41
sequence length
214
structure length
214
Chain Sequence
DQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSAMKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
pubmed doi rcsb
molecule tags Transcription,transferase/dna-rna hybrid
molecule keywords 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3'
total genus 41
structure length 214
sequence length 214
ec nomenclature
pdb deposition date 2006-11-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01191 RNA_pol_Rpb5_C RNA polymerase Rpb5, C-terminal domain
E PF03871 RNA_pol_Rpb5_N RNA polymerase Rpb5, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1340.10 Alpha Beta 3-Layer(aba) Sandwich Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1 RNA polymerase, Rpb5, N-terminal domain 2nvxE01
3.90.940.20 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit RPB5-like RNA polymerase subunit 2nvxE02
3S2HE 3HOXE 1DZFA 3M4OE 2NVTE 5M5YE 2E2JE 3K7AE 3S16E 3GTJE 3GTQE 5M3FE 2WAQH 4A3ME 4BXXE 2YU9E 4A3BE 2JA5E 1WCME 3S1RE 2E2IE 2JA6E 4C2ME 2B63E 4X6AE 2E2HE 1TWHE 1I3QE 3HOYE 1I6HE 3GTLE 3I4ME 3HOUE 3S15E 5FLME 2R92E 3PO3E 4C3HE 5M5XE 3RZOE 3HOZE 5C4XE 3H3VF 2JA8E 2Y0SH 1TWFE 2WB1H 1R9TE 2VUME 3GTME 3S1QE 1SFOE 4BBRE 4A3EE 3RZDE 1TWAE 3HKZH 3S17E 4A3JE 3HOVE 4Y52E 3S1NE 2R93E 1I50E 2NVQE 3GTOE 3GTGE 4A93E 4QIWH 4A3IE 3GTPE 3S1ME 5IYDE 5C44E 3H0GE 5M3ME 2NVYE 3GTKE 3HOWE 1K83E 3S14E 4C3JE 4Y7NE 2PMZH 4A3DE 4A3CE 4BBSE 4A3KE 4A3FE 1EIKA 4AYBH 1TWGE 3M3YE 5C4JE 3FKIE 3CQZE 5IP7E 3PO2E 5IYBE 2R7ZE 4A3LE 3I4NE 4BY7E 5IYCE 4C3IE 5FJ8E 1Y1VE 4BY1E 5IP9E 5M5WE 2JA7E 4A3GE 3S2DE 1Y1WE 2NVXE 1TWCE 5C3EE
chains in the Genus database with same CATH superfamily
3S2HE 3HOXE 2PMZK 3S1RF 1DZFA 4C3IF 3M4OE 2NVTE 4BY1F 5M5YE 2JA6F 5IP9F 2E2JE 3K7AE 2PPBE 3S16E 5M5WF 2B63F 2JA7F 4KMUE 3GTJE 3GTQE 4XSZE 1ZYRE 4OIOE 5M3FE 1Y1WF 4OINE 2WAQH 1I3QF 2NVXF 4A3ME 3S2HF 4LK1E 4BXXE 3S15F 2YU9E 4A3BE 2A6EE 3M4OF 5M5YF 2JA5E 4XLPE 1WCME 1YNNK 3PO3F 3S1RE 2E2IE 4C3HF 5TMCE 3GTJF 2JA6E 4G7HE 4JK1E 4C2ME 2B63E 1TWFF 4YFKE 5M3FF 3DXJE 4X6AE 2E2HE 1TWHE 4Q4ZE 4A3MF 4BXXF 1I3QE 3HOYE 4A3EF 1I6HE 2JA5F 2WB1I 1WCMF 3GTLE 3I4ME 3HOUE 2E2IF 3S15E 5FLME 2R92E 3PO3E 2A6HE 4C2MF 4C3HE 5M5XE 3RZOE 3HOZE 4A3JF 4X6AF 5C4XE 3H3VF 1TWHF 2E2HF 2JA8E 2Y0SH 3S1NF 1TWFE 2WB1H 1R9TE 1I6VE 4OIQE 2VUME 3EQLE 3HOYF 2O5IE 1I6HF 3GTME 2R93F 3GTLF 3GTOF 3S1QE 3HOUF 4G7ZE 3I4MF 1SFOE 5D4CE 4BBRE 4A3EE 3RZDE 5FLMF 4A93F 2R92F 4YFNE 2WAQK 5M5XF 3HOZF 3RZOF 1TWAE 4YG2E 5D4DE 5C4XF 5E17E 3HKZH 5BYHE 5TMFE 5M3MF 2JA8F 2NVYF 1R9TF 3S17E 4ZH4E 2VUMF 4A3JE 2BE5E 2O5JE 3GTMF 3HOVE 4Y52E 3S1NE 4C3JF 3S1QF 2R93E 4Y7NF 1I50E 3WODE 1SFOF 4BBRF 3RZDF 2NVQE 3GTOE 3GTGE 4A3DF 1TWAF 4A93E 5IPLE 4QIWH 4A3IE 3GTPE 3S1ME 3S17F 3HOVF 5IYDE 4KN4E 5C44E 4Y52F 3H0GE 5M3ME 1SMYE 3M3YF 2NVYE 3GTKE 1QKLA 1I50F 3HOWE 1K83E 3S14E 2NVQF 4LJZE 4C3JE 3CQZF 5D4EE 4Y7NE 5IP7F 3GTGF 2PMZH 3H3VG 4A3DE 4A3IF 3GTPF 3S1MF 2CW0E 4A3CE 2R7ZF 4GZYE 5IYDF 5C44F 3H0GF 3I4NF 3GTKF 4BBSE 4A3KE 1K83F 4A3FE 5IYCF 3HOWF 3S14F 1EIKA 4AYBH 4KN7E 1Y1VF 5FJ8F 1TWGE 3M3YE 5C4JE 1IW7E 2A69E 3FKIE 3HKZK 4G7OE 4A3GF 4XLNE 3CQZE 5IP7E 3S2DF 4A3CF 4Q5SE 3PO2E 4LLGE 4AYBK 5E18E 5IYBE 1TWCF 4MEYE 5C3EF 2R7ZE 4A3LE 3HOXF 4A3FF 4A3KF 1HQME 4BBSF 2NVTF 3I4NE 2A68E 1TWGF 4MQ9E 4BY7E 2E2JF 3K7AF 5IYCE 5C4JF 3S16F 4C3IE 2KRXA 5FJ8E 3FKIF 1Y1VE 4BY1E 1YNJK 4QIWK 4MEXE 3GTQF 4OIRE 5IP9E 5M5WE 4YFXE 3PO2F 2JA7E 4A3GE 5IYBF 4OIPE 4XSXE 3S2DE 4A3LF 4LK0E 1Y1WE 2YU9F 4A3BF 2NVXE 1TWCE 2Y0SI 4BY7F 5C3EE
chains in the Genus database with same CATH topology
3S2HE 3HOXE 1DZFA 3M4OE 2NVTE 5M5YE 2E2JE 3K7AE 3S16E 3GTJE 3GTQE 5M3FE 2WAQH 4A3ME 4BXXE 2YU9E 4A3BE 2JA5E 1WCME 3S1RE 2E2IE 2JA6E 4C2ME 2B63E 4X6AE 2E2HE 1TWHE 1I3QE 3HOYE 1I6HE 3GTLE 3I4ME 3HOUE 3S15E 5FLME 2R92E 3PO3E 4C3HE 5M5XE 3RZOE 3HOZE 5C4XE 3H3VF 2JA8E 2Y0SH 1TWFE 2WB1H 1R9TE 2VUME 3GTME 3S1QE 1SFOE 4BBRE 4A3EE 3RZDE 1TWAE 3HKZH 3S17E 4A3JE 3HOVE 4Y52E 3S1NE 2R93E 1I50E 2NVQE 3GTOE 3GTGE 4A93E 4QIWH 4A3IE 3GTPE 3S1ME 5IYDE 5C44E 3H0GE 5M3ME 2NVYE 3GTKE 3HOWE 1K83E 3S14E 4C3JE 4Y7NE 2PMZH 4A3DE 4A3CE 4BBSE 4A3KE 4A3FE 1EIKA 4AYBH 1TWGE 3M3YE 5C4JE 3FKIE 3CQZE 5IP7E 3PO2E 5IYBE 2R7ZE 4A3LE 3I4NE 4BY7E 5IYCE 4C3IE 5FJ8E 1Y1VE 4BY1E 5IP9E 5M5WE 2JA7E 4A3GE 3S2DE 1Y1WE 2NVXE 1TWCE 5C3EE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3S2H E;  3HOX E;  1DZF A;  3M4O E;  2NVT E;  5M5Y E;  2E2J E;  3K7A E;  3S16 E;  3GTJ E;  3GTQ E;  5M3F E;  2WAQ H;  4A3M E;  4BXX E;  2YU9 E;  4A3B E;  2JA5 E;  1WCM E;  3S1R E;  2E2I E;  2JA6 E;  4C2M E;  2B63 E;  4X6A E;  2E2H E;  1TWH E;  1I3Q E;  3HOY E;  1I6H E;  3GTL E;  3I4M E;  3HOU E;  3S15 E;  5FLM E;  2R92 E;  3PO3 E;  4C3H E;  5M5X E;  3RZO E;  3HOZ E;  5C4X E;  3H3V F;  2JA8 E;  2Y0S H;  1TWF E;  2WB1 H;  1R9T E;  2VUM E;  3GTM E;  3S1Q E;  1SFO E;  4BBR E;  4A3E E;  3RZD E;  1TWA E;  3HKZ H;  3S17 E;  4A3J E;  3HOV E;  4Y52 E;  3S1N E;  2R93 E;  1I50 E;  2NVQ E;  3GTO E;  3GTG E;  4A93 E;  4QIW H;  4A3I E;  3GTP E;  3S1M E;  5IYD E;  5C44 E;  3H0G E;  5M3M E;  2NVY E;  3GTK E;  3HOW E;  1K83 E;  3S14 E;  4C3J E;  4Y7N E;  2PMZ H;  4A3D E;  4A3C E;  4BBS E;  4A3K E;  4A3F E;  1EIK A;  4AYB H;  1TWG E;  3M3Y E;  5C4J E;  3FKI E;  3CQZ E;  5IP7 E;  3PO2 E;  5IYB E;  2R7Z E;  4A3L E;  3I4N E;  4BY7 E;  5IYC E;  4C3I E;  5FJ8 E;  1Y1V E;  4BY1 E;  5IP9 E;  5M5W E;  2JA7 E;  4A3G E;  3S2D E;  1Y1W E;  2NVX E;  1TWC E;  5C3E E; 
#chains in the Genus database with same CATH topology
 3S2H E;  3HOX E;  2PMZ K;  3S1R F;  1DZF A;  4C3I F;  3M4O E;  2NVT E;  4BY1 F;  5M5Y E;  2JA6 F;  5IP9 F;  2E2J E;  3K7A E;  2PPB E;  3S16 E;  5M5W F;  2B63 F;  2JA7 F;  4KMU E;  3GTJ E;  3GTQ E;  4XSZ E;  1ZYR E;  4OIO E;  5M3F E;  1Y1W F;  4OIN E;  2WAQ H;  1I3Q F;  2NVX F;  4A3M E;  3S2H F;  4LK1 E;  4BXX E;  3S15 F;  2YU9 E;  4A3B E;  2A6E E;  3M4O F;  5M5Y F;  2JA5 E;  4XLP E;  1WCM E;  1YNN K;  3PO3 F;  3S1R E;  2E2I E;  4C3H F;  5TMC E;  3GTJ F;  2JA6 E;  4G7H E;  4JK1 E;  4C2M E;  2B63 E;  1TWF F;  4YFK E;  5M3F F;  3DXJ E;  4X6A E;  2E2H E;  1TWH E;  4Q4Z E;  4A3M F;  4BXX F;  1I3Q E;  3HOY E;  4A3E F;  1I6H E;  2JA5 F;  2WB1 I;  1WCM F;  3GTL E;  3I4M E;  3HOU E;  2E2I F;  3S15 E;  5FLM E;  2R92 E;  3PO3 E;  2A6H E;  4C2M F;  4C3H E;  5M5X E;  3RZO E;  3HOZ E;  4A3J F;  4X6A F;  5C4X E;  3H3V F;  1TWH F;  2E2H F;  2JA8 E;  2Y0S H;  3S1N F;  1TWF E;  2WB1 H;  1R9T E;  1I6V E;  4OIQ E;  2VUM E;  3EQL E;  3HOY F;  2O5I E;  1I6H F;  3GTM E;  2R93 F;  3GTL F;  3GTO F;  3S1Q E;  3HOU F;  4G7Z E;  3I4M F;  1SFO E;  5D4C E;  4BBR E;  4A3E E;  3RZD E;  5FLM F;  4A93 F;  2R92 F;  4YFN E;  2WAQ K;  5M5X F;  3HOZ F;  3RZO F;  1TWA E;  4YG2 E;  5D4D E;  5C4X F;  5E17 E;  3HKZ H;  5BYH E;  5TMF E;  5M3M F;  2JA8 F;  2NVY F;  1R9T F;  3S17 E;  4ZH4 E;  2VUM F;  4A3J E;  2BE5 E;  2O5J E;  3GTM F;  3HOV E;  4Y52 E;  3S1N E;  4C3J F;  3S1Q F;  2R93 E;  4Y7N F;  1I50 E;  3WOD E;  1SFO F;  4BBR F;  3RZD F;  2NVQ E;  3GTO E;  3GTG E;  4A3D F;  1TWA F;  4A93 E;  5IPL E;  4QIW H;  4A3I E;  3GTP E;  3S1M E;  3S17 F;  3HOV F;  5IYD E;  4KN4 E;  5C44 E;  4Y52 F;  3H0G E;  5M3M E;  1SMY E;  3M3Y F;  2NVY E;  3GTK E;  1QKL A;  1I50 F;  3HOW E;  1K83 E;  3S14 E;  2NVQ F;  4LJZ E;  4C3J E;  3CQZ F;  5D4E E;  4Y7N E;  5IP7 F;  3GTG F;  2PMZ H;  3H3V G;  4A3D E;  4A3I F;  3GTP F;  3S1M F;  2CW0 E;  4A3C E;  2R7Z F;  4GZY E;  5IYD F;  5C44 F;  3H0G F;  3I4N F;  3GTK F;  4BBS E;  4A3K E;  1K83 F;  4A3F E;  5IYC F;  3HOW F;  3S14 F;  1EIK A;  4AYB H;  4KN7 E;  1Y1V F;  5FJ8 F;  1TWG E;  3M3Y E;  5C4J E;  1IW7 E;  2A69 E;  3FKI E;  3HKZ K;  4G7O E;  4A3G F;  4XLN E;  3CQZ E;  5IP7 E;  3S2D F;  4A3C F;  4Q5S E;  3PO2 E;  4LLG E;  4AYB K;  5E18 E;  5IYB E;  1TWC F;  4MEY E;  5C3E F;  2R7Z E;  4A3L E;  3HOX F;  4A3F F;  4A3K F;  1HQM E;  4BBS F;  2NVT F;  3I4N E;  2A68 E;  1TWG F;  4MQ9 E;  4BY7 E;  2E2J F;  3K7A F;  5IYC E;  5C4J F;  3S16 F;  4C3I E;  2KRX A;  5FJ8 E;  3FKI F;  1Y1V E;  4BY1 E;  1YNJ K;  4QIW K;  4MEX E;  3GTQ F;  4OIR E;  5IP9 E;  5M5W E;  4YFX E;  3PO2 F;  2JA7 E;  4A3G E;  5IYB F;  4OIP E;  4XSX E;  3S2D E;  4A3L F;  4LK0 E;  1Y1W E;  2YU9 F;  4A3B F;  2NVX E;  1TWC E;  2Y0S I;  4BY7 F;  5C3E E; 
#chains in the Genus database with same CATH homology
 3S2H E;  3HOX E;  1DZF A;  3M4O E;  2NVT E;  5M5Y E;  2E2J E;  3K7A E;  3S16 E;  3GTJ E;  3GTQ E;  5M3F E;  2WAQ H;  4A3M E;  4BXX E;  2YU9 E;  4A3B E;  2JA5 E;  1WCM E;  3S1R E;  2E2I E;  2JA6 E;  4C2M E;  2B63 E;  4X6A E;  2E2H E;  1TWH E;  1I3Q E;  3HOY E;  1I6H E;  3GTL E;  3I4M E;  3HOU E;  3S15 E;  5FLM E;  2R92 E;  3PO3 E;  4C3H E;  5M5X E;  3RZO E;  3HOZ E;  5C4X E;  3H3V F;  2JA8 E;  2Y0S H;  1TWF E;  2WB1 H;  1R9T E;  2VUM E;  3GTM E;  3S1Q E;  1SFO E;  4BBR E;  4A3E E;  3RZD E;  1TWA E;  3HKZ H;  3S17 E;  4A3J E;  3HOV E;  4Y52 E;  3S1N E;  2R93 E;  1I50 E;  2NVQ E;  3GTO E;  3GTG E;  4A93 E;  4QIW H;  4A3I E;  3GTP E;  3S1M E;  5IYD E;  5C44 E;  3H0G E;  5M3M E;  2NVY E;  3GTK E;  3HOW E;  1K83 E;  3S14 E;  4C3J E;  4Y7N E;  2PMZ H;  4A3D E;  4A3C E;  4BBS E;  4A3K E;  4A3F E;  1EIK A;  4AYB H;  1TWG E;  3M3Y E;  5C4J E;  3FKI E;  3CQZ E;  5IP7 E;  3PO2 E;  5IYB E;  2R7Z E;  4A3L E;  3I4N E;  4BY7 E;  5IYC E;  4C3I E;  5FJ8 E;  1Y1V E;  4BY1 E;  5IP9 E;  5M5W E;  2JA7 E;  4A3G E;  3S2D E;  1Y1W E;  2NVX E;  1TWC E;  5C3E E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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