2O5JE

Crystal structure of the t. thermophilus rnap polymerase elongation complex with the ntp substrate analog
Total Genus 19
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
19
sequence length
95
structure length
95
Chain Sequence
AEPGIDKLFGMVDSKYRLTVVVAKRAQQLLRHGFKNTVLEPEERPKMQTLEGLFDDPNAVTWAMKELLTGRLVFGENLVPEDRLQKEMERLYPVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for substrate loading in bacterial RNA polymerase.
pubmed doi rcsb
molecule tags Transferase/dna-rna hybrid
molecule keywords 5'-D(P*CP*CP*CP*TP*GP*TP*CP*TP*GP*GP*CP*GP*TP*TP*CP*GP*CP*GP
total genus 19
structure length 95
sequence length 95
chains with identical sequence O
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2006-12-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 2o5jE00
2NVYF 4AYBK 5D4CE 1I6HF 1IW7E 5M5YF 3M3YF 5TMFE 2WB1I 5IP9F 1TWFF 2A69E 3S1MF 4BXXF 4G7OE 5M3MF 4KN4E 4BY7F 2O5IE 4KN7E 5FLMF 3CQZF 2A68E 4A3BF 4GZYE 1I50F 3S2HF 4XSZE 5BYHE 3H3VG 3PO2F 1SFOF 5FJ8F 4MEYE 4X6AF 2CW0E 4A93F 5D4DE 1WCMF 2B63F 3S17F 4JK1E 5M3FF 2E2HF 3HOYF 1YNJK 3HOWF 1TWHF 4A3MF 1HQME 1QKLA 4Q4ZE 4YFKE 1I3QF 4A3LF 1ZYRE 5IP7F 2R92F 4C3JF 2R93F 1K83F 3S1RF 5C3EF 2JA8F 4YFNE 4G7HE 5TMCE 3GTKF 5M5XF 4A3EF 1Y1VF 4OIQE 3HKZK 2NVXF 3GTGF 2PMZK 2JA5F 2BE5E 5E17E 2Y0SI 5C4JF 2JA7F 4A3CF 4G7ZE 2PPBE 2NVQF 2NVTF 3I4NF 2WAQK 3S2DF 4A3FF 3HOZF 4OIPE 3HOXF 1TWCF 3RZOF 4OIRE 4C2MF 4A3JF 2E2JF 4XLPE 3RZDF 1R9TF 2E2IF 4C3IF 3S1QF 1I6VE 3DXJE 4A3IF 4OINE 5M5WF 2JA6F 4Q5SE 1SMYE 1YNNK 2YU9F 4MQ9E 4MEXE 4A3GF 4YG2E 5E18E 5IPLE 3GTJF 4Y52F 4LK0E 4XSXE 3H0GF 3GTLF 4ZH4E 3M4OF 2O5JE 2A6EE 3K7AF 4Y7NF 4BY1F 5IYCF 1Y1WF 4XLNE 3S16F 4BBRF 2VUMF 3FKIF 3GTMF 3EQLE 4BBSF 2A6HE 4YFXE 3GTOF 5C44F 4LK1E 3S15F 3HOVF 3S1NF 4KMUE 3WODE 1TWAF 4OIOE 2R7ZF 4A3KF 3GTPF 3PO3F 3GTQF 5C4XF 5IYBF 4LJZE 1TWGF 4C3HF 3HOUF 3S14F 5IYDF 5D4EE 3I4MF 4LLGE 4A3DF
chains in the Genus database with same CATH superfamily
2NVYF 4AYBK 5D4CE 3S1RE 1IW7E 1R9TE 5M5YF 4C3IE 2E2IE 1I6HF 2JA8E 3M3YF 5TMFE 2WB1I 5IP9F 4A3IE 1TWFF 2A69E 4A3EE 3S1MF 4BXXF 4G7OE 1Y1VE 5M3MF 4KN4E 2NVXE 5M5WE 2JA6E 4AYBH 4BY7F 2O5IE 4KN7E 5FLMF 3GTGE 3CQZF 2A68E 4A3BF 4GZYE 5C4JE 1I50F 3S2HF 3GTJE 4Y52E 4XSZE 5BYHE 3H3VG 3I4NE 3PO2F 1SFOF 5FJ8F 4MEYE 4X6AF 2CW0E 2PMZH 3S2DE 4A93F 5D4DE 1WCMF 4A3FE 2B63F 3S17F 4JK1E 3HOXE 5M3FF 1TWCE 2Y0SH 2E2HF 3HOYF 1YNJK 3HOWF 4BY1E 4C2ME 4A3JE 3RZDE 1TWHF 4A3MF 1HQME 1QKLA 4Q4ZE 4YFKE 3S16E 3S1QE 1ZYRE 5IP7F 2R92F 4C3JF 4A3LF 2R93F 1K83F 4BBRE 2WAQH 3S1RF 5C3EF 2JA8F 3FKIE 4YFNE 4G7HE 5TMCE 3GTKF 5M5XF 4A3EF 1Y1VF 3GTOE 3S15E 4OIQE 3HKZK 3HOVE 2NVXF 2YU9E 3GTGF 2PMZK 2JA5F 4A3KE 4A3GE 3H3VF 5C4XE 2BE5E 5E17E 2Y0SI 3HOUE 5C4JF 2JA7F 4A3CF 3HKZH 4G7ZE 3H0GE 3GTLE 2PPBE 3M3YE 3M4OE 2NVQF 2NVTF 1TWFE 3I4NF 4BXXE 2WAQK 3K7AE 5M3ME 3S2DF 4A3FF 3HOZF 4OIPE 4Y7NE 5IYCE 3HOXF 1TWCF 1Y1WE 3RZOF 4OIRE 4C2MF 4A3JF 2E2JF 4XLPE 3RZDF 1R9TF 2VUME 2E2IF 3S2HE 4C3IF 3S1QF 3S15F 1I6VE 3DXJE 4A3IF 3GTME 4BBSE 4OINE 5C44E 3PO2E 1SFOE 3S1NE 1TWAE 5M5WF 2JA6F 4A93E 4Q5SE 2R7ZE 2B63E 5D4EE 3GTPE 1SMYE 1YNNK 3GTQE 1DZFA 2E2HE 5IYBE 2YU9F 4MQ9E 4MEXE 1TWGE 4C3HE 4A3GF 3S14E 2KRXA 4YG2E 4QIWK 5E18E 3PO3E 5IYDE 1I3QE 1TWHE 3I4ME 4A3DE 2NVYE 3GTJF 1I6HE 4Y52F 5IPLE 5M5YE 4A3LE 4LK0E 2R93E 4C3JE 5IP9E 4XSXE 5C3EE 3H0GF 3GTLF 3S1ME 4ZH4E 4QIWH 3M4OF 3GTKE 2A6EE 5M5XE 2O5JE 3K7AF 4BY7E 5FLME 2R92E 4Y7NF 4BY1F 3CQZE 5IYCF 1Y1WF 4A3BE 1EIKA 2JA5E 4XLNE 2WB1H 1I50E 3S16F 4BBRF 2VUMF 2JA7E 4A3CE 3FKIF 3I4MF 5FJ8E 3EQLE 3GTMF 4X6AE 4BBSF 2A6HE 4YFXE 3GTOF 1WCME 4LK1E 5C44F 2NVQE 2NVTE 3S17E 5M3FE 3HOVF 4KMUE 3WODE 1TWAF 3HOYE 4OIOE 3S1NF 2R7ZF 4A3KF 3GTPF 3HOWE 3GTQF 3PO3F 3HOZE 5C4XF 5IYBF 4A3ME 4LJZE 3RZOE 1TWGF 4C3HF 3HOUF 3S14F 5IP7E 2E2JE 5IYDF 1I3QF 1K83E 4LLGE 4A3DF
chains in the Genus database with same CATH topology
2NVYF 4AYBK 5D4CE 1I6HF 1IW7E 5M5YF 3M3YF 5TMFE 2WB1I 5IP9F 1TWFF 2A69E 3S1MF 4BXXF 4G7OE 5M3MF 4KN4E 4BY7F 2O5IE 4KN7E 5FLMF 3CQZF 2A68E 4A3BF 4GZYE 1I50F 3S2HF 4XSZE 5BYHE 3H3VG 3PO2F 1SFOF 5FJ8F 4MEYE 4X6AF 2CW0E 4A93F 5D4DE 1WCMF 2B63F 3S17F 4JK1E 5M3FF 2E2HF 3HOYF 1YNJK 3HOWF 1TWHF 4A3MF 1HQME 1QKLA 4Q4ZE 4YFKE 1I3QF 4A3LF 1ZYRE 5IP7F 2R92F 4C3JF 2R93F 1K83F 3S1RF 5C3EF 2JA8F 4YFNE 4G7HE 5TMCE 3GTKF 5M5XF 4A3EF 1Y1VF 4OIQE 3HKZK 2NVXF 3GTGF 2PMZK 2JA5F 2BE5E 5E17E 2Y0SI 5C4JF 2JA7F 4A3CF 4G7ZE 2PPBE 2NVQF 2NVTF 3I4NF 2WAQK 3S2DF 4A3FF 3HOZF 4OIPE 3HOXF 1TWCF 3RZOF 4OIRE 4C2MF 4A3JF 2E2JF 4XLPE 3RZDF 1R9TF 2E2IF 4C3IF 3S1QF 1I6VE 3DXJE 4A3IF 4OINE 5M5WF 2JA6F 4Q5SE 1SMYE 1YNNK 2YU9F 4MQ9E 4MEXE 4A3GF 2KRXA 4YG2E 4QIWK 5E18E 5IPLE 3GTJF 4Y52F 4LK0E 4XSXE 3H0GF 3GTLF 4ZH4E 3M4OF 2O5JE 2A6EE 3K7AF 4Y7NF 4BY1F 5IYCF 1Y1WF 4XLNE 3S16F 4BBRF 2VUMF 3FKIF 3GTMF 3EQLE 4BBSF 2A6HE 4YFXE 3GTOF 5C44F 4LK1E 3S15F 3HOVF 3S1NF 4KMUE 3WODE 1TWAF 4OIOE 2R7ZF 4A3KF 3GTPF 3PO3F 3GTQF 5C4XF 5IYBF 4LJZE 1TWGF 4C3HF 3HOUF 3S14F 5IYDF 5D4EE 3I4MF 4LLGE 4A3DF
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NVY F;  4AYB K;  5D4C E;  1I6H F;  1IW7 E;  5M5Y F;  3M3Y F;  5TMF E;  2WB1 I;  5IP9 F;  1TWF F;  2A69 E;  3S1M F;  4BXX F;  4G7O E;  5M3M F;  4KN4 E;  4BY7 F;  2O5I E;  4KN7 E;  5FLM F;  3CQZ F;  2A68 E;  4A3B F;  4GZY E;  1I50 F;  3S2H F;  4XSZ E;  5BYH E;  3H3V G;  3PO2 F;  1SFO F;  5FJ8 F;  4MEY E;  4X6A F;  2CW0 E;  4A93 F;  5D4D E;  1WCM F;  2B63 F;  3S17 F;  4JK1 E;  5M3F F;  2E2H F;  3HOY F;  1YNJ K;  3HOW F;  1TWH F;  4A3M F;  1HQM E;  1QKL A;  4Q4Z E;  4YFK E;  1I3Q F;  4A3L F;  1ZYR E;  5IP7 F;  2R92 F;  4C3J F;  2R93 F;  1K83 F;  3S1R F;  5C3E F;  2JA8 F;  4YFN E;  4G7H E;  5TMC E;  3GTK F;  5M5X F;  4A3E F;  1Y1V F;  4OIQ E;  3HKZ K;  2NVX F;  3GTG F;  2PMZ K;  2JA5 F;  2BE5 E;  5E17 E;  2Y0S I;  5C4J F;  2JA7 F;  4A3C F;  4G7Z E;  2PPB E;  2NVQ F;  2NVT F;  3I4N F;  2WAQ K;  3S2D F;  4A3F F;  3HOZ F;  4OIP E;  3HOX F;  1TWC F;  3RZO F;  4OIR E;  4C2M F;  4A3J F;  2E2J F;  4XLP E;  3RZD F;  1R9T F;  2E2I F;  4C3I F;  3S1Q F;  1I6V E;  3DXJ E;  4A3I F;  4OIN E;  5M5W F;  2JA6 F;  4Q5S E;  1SMY E;  1YNN K;  2YU9 F;  4MQ9 E;  4MEX E;  4A3G F;  4YG2 E;  5E18 E;  5IPL E;  3GTJ F;  4Y52 F;  4LK0 E;  4XSX E;  3H0G F;  3GTL F;  4ZH4 E;  3M4O F;  2O5J E;  2A6E E;  3K7A F;  4Y7N F;  4BY1 F;  5IYC F;  1Y1W F;  4XLN E;  3S16 F;  4BBR F;  2VUM F;  3FKI F;  3GTM F;  3EQL E;  4BBS F;  2A6H E;  4YFX E;  3GTO F;  5C44 F;  4LK1 E;  3S15 F;  3HOV F;  3S1N F;  4KMU E;  3WOD E;  1TWA F;  4OIO E;  2R7Z F;  4A3K F;  3GTP F;  3PO3 F;  3GTQ F;  5C4X F;  5IYB F;  4LJZ E;  1TWG F;  4C3H F;  3HOU F;  3S14 F;  5IYD F;  5D4E E;  3I4M F;  4LLG E;  4A3D F; 
#chains in the Genus database with same CATH topology
 2NVY F;  4AYB K;  5D4C E;  3S1R E;  1IW7 E;  1R9T E;  5M5Y F;  4C3I E;  2E2I E;  1I6H F;  2JA8 E;  3M3Y F;  5TMF E;  2WB1 I;  5IP9 F;  4A3I E;  1TWF F;  2A69 E;  4A3E E;  3S1M F;  4BXX F;  4G7O E;  1Y1V E;  5M3M F;  4KN4 E;  2NVX E;  5M5W E;  2JA6 E;  4AYB H;  4BY7 F;  2O5I E;  4KN7 E;  5FLM F;  3GTG E;  3CQZ F;  2A68 E;  4A3B F;  4GZY E;  5C4J E;  1I50 F;  3S2H F;  3GTJ E;  4Y52 E;  4XSZ E;  5BYH E;  3H3V G;  3I4N E;  3PO2 F;  1SFO F;  5FJ8 F;  4MEY E;  4X6A F;  2CW0 E;  2PMZ H;  3S2D E;  4A93 F;  5D4D E;  1WCM F;  4A3F E;  2B63 F;  3S17 F;  4JK1 E;  3HOX E;  5M3F F;  1TWC E;  2Y0S H;  2E2H F;  3HOY F;  1YNJ K;  3HOW F;  4BY1 E;  4C2M E;  4A3J E;  3RZD E;  1TWH F;  4A3M F;  1HQM E;  1QKL A;  4Q4Z E;  4YFK E;  3S16 E;  3S1Q E;  1ZYR E;  5IP7 F;  2R92 F;  4C3J F;  4A3L F;  2R93 F;  1K83 F;  4BBR E;  2WAQ H;  3S1R F;  5C3E F;  2JA8 F;  3FKI E;  4YFN E;  4G7H E;  5TMC E;  3GTK F;  5M5X F;  4A3E F;  1Y1V F;  3GTO E;  3S15 E;  4OIQ E;  3HKZ K;  3HOV E;  2NVX F;  2YU9 E;  3GTG F;  2PMZ K;  2JA5 F;  4A3K E;  4A3G E;  3H3V F;  5C4X E;  2BE5 E;  5E17 E;  2Y0S I;  3HOU E;  5C4J F;  2JA7 F;  4A3C F;  3HKZ H;  4G7Z E;  3H0G E;  3GTL E;  2PPB E;  3M3Y E;  3M4O E;  2NVQ F;  2NVT F;  1TWF E;  3I4N F;  4BXX E;  2WAQ K;  3K7A E;  5M3M E;  3S2D F;  4A3F F;  3HOZ F;  4OIP E;  4Y7N E;  5IYC E;  3HOX F;  1TWC F;  1Y1W E;  3RZO F;  4OIR E;  4C2M F;  4A3J F;  2E2J F;  4XLP E;  3RZD F;  1R9T F;  2VUM E;  2E2I F;  3S2H E;  4C3I F;  3S1Q F;  3S15 F;  1I6V E;  3DXJ E;  4A3I F;  3GTM E;  4BBS E;  4OIN E;  5C44 E;  3PO2 E;  1SFO E;  3S1N E;  1TWA E;  5M5W F;  2JA6 F;  4A93 E;  4Q5S E;  2R7Z E;  2B63 E;  5D4E E;  3GTP E;  1SMY E;  1YNN K;  3GTQ E;  1DZF A;  2E2H E;  5IYB E;  2YU9 F;  4MQ9 E;  4MEX E;  1TWG E;  4C3H E;  4A3G F;  3S14 E;  2KRX A;  4YG2 E;  4QIW K;  5E18 E;  3PO3 E;  5IYD E;  1I3Q E;  1TWH E;  3I4M E;  4A3D E;  2NVY E;  3GTJ F;  1I6H E;  4Y52 F;  5IPL E;  5M5Y E;  4A3L E;  4LK0 E;  2R93 E;  4C3J E;  5IP9 E;  4XSX E;  5C3E E;  3H0G F;  3GTL F;  3S1M E;  4ZH4 E;  4QIW H;  3M4O F;  3GTK E;  2A6E E;  5M5X E;  2O5J E;  3K7A F;  4BY7 E;  5FLM E;  2R92 E;  4Y7N F;  4BY1 F;  3CQZ E;  5IYC F;  1Y1W F;  4A3B E;  1EIK A;  2JA5 E;  4XLN E;  2WB1 H;  1I50 E;  3S16 F;  4BBR F;  2VUM F;  2JA7 E;  4A3C E;  3FKI F;  3I4M F;  5FJ8 E;  3EQL E;  3GTM F;  4X6A E;  4BBS F;  2A6H E;  4YFX E;  3GTO F;  1WCM E;  4LK1 E;  5C44 F;  2NVQ E;  2NVT E;  3S17 E;  5M3F E;  3HOV F;  4KMU E;  3WOD E;  1TWA F;  3HOY E;  4OIO E;  3S1N F;  2R7Z F;  4A3K F;  3GTP F;  3HOW E;  3GTQ F;  3PO3 F;  3HOZ E;  5C4X F;  5IYB F;  4A3M E;  4LJZ E;  3RZO E;  1TWG F;  4C3H F;  3HOU F;  3S14 F;  5IP7 E;  2E2J E;  5IYD F;  1I3Q F;  1K83 E;  4LLG E;  4A3D F; 
#chains in the Genus database with same CATH homology
 2NVY F;  4AYB K;  5D4C E;  1I6H F;  1IW7 E;  5M5Y F;  3M3Y F;  5TMF E;  2WB1 I;  5IP9 F;  1TWF F;  2A69 E;  3S1M F;  4BXX F;  4G7O E;  5M3M F;  4KN4 E;  4BY7 F;  2O5I E;  4KN7 E;  5FLM F;  3CQZ F;  2A68 E;  4A3B F;  4GZY E;  1I50 F;  3S2H F;  4XSZ E;  5BYH E;  3H3V G;  3PO2 F;  1SFO F;  5FJ8 F;  4MEY E;  4X6A F;  2CW0 E;  4A93 F;  5D4D E;  1WCM F;  2B63 F;  3S17 F;  4JK1 E;  5M3F F;  2E2H F;  3HOY F;  1YNJ K;  3HOW F;  1TWH F;  4A3M F;  1HQM E;  1QKL A;  4Q4Z E;  4YFK E;  1I3Q F;  4A3L F;  1ZYR E;  5IP7 F;  2R92 F;  4C3J F;  2R93 F;  1K83 F;  3S1R F;  5C3E F;  2JA8 F;  4YFN E;  4G7H E;  5TMC E;  3GTK F;  5M5X F;  4A3E F;  1Y1V F;  4OIQ E;  3HKZ K;  2NVX F;  3GTG F;  2PMZ K;  2JA5 F;  2BE5 E;  5E17 E;  2Y0S I;  5C4J F;  2JA7 F;  4A3C F;  4G7Z E;  2PPB E;  2NVQ F;  2NVT F;  3I4N F;  2WAQ K;  3S2D F;  4A3F F;  3HOZ F;  4OIP E;  3HOX F;  1TWC F;  3RZO F;  4OIR E;  4C2M F;  4A3J F;  2E2J F;  4XLP E;  3RZD F;  1R9T F;  2E2I F;  4C3I F;  3S1Q F;  1I6V E;  3DXJ E;  4A3I F;  4OIN E;  5M5W F;  2JA6 F;  4Q5S E;  1SMY E;  1YNN K;  2YU9 F;  4MQ9 E;  4MEX E;  4A3G F;  2KRX A;  4YG2 E;  4QIW K;  5E18 E;  5IPL E;  3GTJ F;  4Y52 F;  4LK0 E;  4XSX E;  3H0G F;  3GTL F;  4ZH4 E;  3M4O F;  2O5J E;  2A6E E;  3K7A F;  4Y7N F;  4BY1 F;  5IYC F;  1Y1W F;  4XLN E;  3S16 F;  4BBR F;  2VUM F;  3FKI F;  3GTM F;  3EQL E;  4BBS F;  2A6H E;  4YFX E;  3GTO F;  5C44 F;  4LK1 E;  3S15 F;  3HOV F;  3S1N F;  4KMU E;  3WOD E;  1TWA F;  4OIO E;  2R7Z F;  4A3K F;  3GTP F;  3PO3 F;  3GTQ F;  5C4X F;  5IYB F;  4LJZ E;  1TWG F;  4C3H F;  3HOU F;  3S14 F;  5IYD F;  5D4E E;  3I4M F;  4LLG E;  4A3D F; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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