2TGPI

The geometry of the reactive site and of the peptide groups in trypsin, trypsinogen and its complexes with inhibitors
Total Genus 12
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and its Complexes with Inhibitors
pubmed rcsb
molecule tags Complex (proteinase/inhibitor)
source organism Bos taurus
molecule keywords TRYPSINOGEN
total genus 12
structure length 58
sequence length 58
ec nomenclature
pdb deposition date 1982-09-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2tgpI00
1K6UA 1BPIA 1MTND 3D65I 4NTWB 2M99A 3T62D 2KNTA 4Y10I 2LFLA 1JV9A 3BYBA 6PTIA 2UUYB 3UIRC 1JV8A 1EAWB 3WNYA 2PTCI 1DTKA 1YKTB 2DDJA 1KUNA 3BTKI 1T7CB 3FP6I 1QLQA 1YC0I 5JB5A 3BTMI 4Y0ZI 1D0DB 2FI3I 1FY8I 1SHPA 3OTJI 1DEMA 2FI5I 2ZJXA 8PTIA 2FTLI 1BIKA 1P2II 1NAGA 1B0CA 3TGKI 3AUGA 3AUIA 2JOTA 1D0DA 1T8MB 3L33E 3AUDA 2DDIA 4DTGK 2CA7A 2KCRA 5JB6A 1YLDB 4NTXB 4U32X 1BUNB 1TAPA 2LFKA 1OA55 3FP7J 3GYMI 3AUHA 4WXVC 5JB7A 1BTHP 4BQDA 1CO7I 1TAWB 1FANA 3AUCA 3AUEA 4ISOB 1OA65 1KTHA 1JC6A 3OFWA 1YLCB 2TGPI 1TOCR 1P2JI 1EJMB 1ZR0B 2J6DA 2HEXA 1UUBA 1CBWD 3TGII 3LDMA 4NTYB 3AUBA 1TPAI 1P2QB 3CI7A 1BZXI 1BHCA 1DTXA 1G6XA 1AALA 3BTTI 1UUAA 3LDIA 3BTGI 4Y0YI 1KIGI 2IJOI 3U1JE 4WWYC 3M7QB 1F7ZI 3BTEI 1P2OB 1BRCI 1BPTA 4TPII 1T8NB 3BTWI 1P2NB 1PITA 1P2KI 4PTIA 4DG4C 3BTDI 3UOUB 2KAII 7PTIA 3P95E 1IRHA 2ZVXA 1T8LB 3L3TE 5PTIA 3TPII 2W8XA 4BNRI 2RA3C 1AAPA 1TFXC 1LD6A 1T8OB 3BTHI 9PTIA 3BTFI 3FP8I 1F5RI 3TGJI 2FI4I 1BRBI 1CA0D 1ADZA 3P92E 4BD9B 1LD5A 2R9PE 2TPII 4U30W 1KNTA 4ISNB 1DENA 5JB4A 2M01A 1BF0A 1Y62A 2ODYE 4Y11I 5C67C 1BTIA 1BZ5A 3BTQI 1ZJDB 4ISLB 1FAKI 1P2MB 2UUXA 2FTMB 3LDJA 1TCPA
chains in the Genus database with same CATH superfamily
1K6UA 1BPIA 1MTND 3D65I 4NTWB 2M99A 3T62D 2KNTA 4Y10I 2LFLA 1JV9A 3BYBA 6PTIA 2UUYB 3UIRC 1JV8A 1EAWB 3WNYA 2PTCI 1DTKA 1YKTB 2DDJA 1KUNA 3BTKI 1T7CB 3FP6I 1QLQA 1YC0I 5JB5A 3BTMI 4Y0ZI 1D0DB 2FI3I 1FY8I 1SHPA 3OTJI 1DEMA 2FI5I 2ZJXA 8PTIA 2FTLI 1BIKA 1P2II 1NAGA 1B0CA 3TGKI 3AUGA 3AUIA 2JOTA 1D0DA 1T8MB 3L33E 3AUDA 2DDIA 4DTGK 2CA7A 2KCRA 5JB6A 1YLDB 4NTXB 4U32X 1BUNB 1TAPA 2LFKA 1OA55 3FP7J 3GYMI 3AUHA 4WXVC 5JB7A 1BTHP 4BQDA 1CO7I 1TAWB 1FANA 3AUCA 3AUEA 4ISOB 1OA65 1KTHA 1JC6A 3OFWA 1YLCB 2TGPI 1TOCR 1P2JI 1EJMB 1ZR0B 2J6DA 2HEXA 1UUBA 1CBWD 3TGII 3LDMA 4NTYB 3AUBA 1TPAI 1P2QB 3CI7A 1BZXI 1BHCA 1DTXA 1G6XA 1AALA 3BTTI 1UUAA 3LDIA 3BTGI 4Y0YI 1KIGI 2IJOI 3U1JE 4WWYC 3M7QB 1F7ZI 3BTEI 1P2OB 1BRCI 1BPTA 4TPII 1T8NB 3BTWI 1P2NB 1PITA 1P2KI 4PTIA 4DG4C 3BTDI 3UOUB 2KAII 7PTIA 3P95E 1IRHA 2ZVXA 1T8LB 3L3TE 5PTIA 3TPII 2W8XA 4BNRI 2RA3C 1AAPA 1TFXC 1LD6A 1T8OB 3BTHI 9PTIA 3BTFI 3FP8I 1F5RI 3TGJI 2FI4I 1BRBI 1CA0D 1ADZA 3P92E 4BD9B 1LD5A 2R9PE 2TPII 4U30W 1KNTA 4ISNB 1DENA 5JB4A 2M01A 1BF0A 1Y62A 2ODYE 4Y11I 5C67C 1BTIA 1BZ5A 3BTQI 1ZJDB 4ISLB 1FAKI 1P2MB 2UUXA 2FTMB 3LDJA 1TCPA
chains in the Genus database with same CATH topology
1K6UA 1BPIA 1MTND 3D65I 4NTWB 2M99A 3T62D 2KNTA 4Y10I 2LFLA 1JV9A 3BYBA 6PTIA 2UUYB 3UIRC 1JV8A 1EAWB 3WNYA 2PTCI 1DTKA 1YKTB 2DDJA 1KUNA 3BTKI 1T7CB 3FP6I 1QLQA 1YC0I 5JB5A 3BTMI 4Y0ZI 1D0DB 2FI3I 1FY8I 1SHPA 3OTJI 1DEMA 2FI5I 2ZJXA 8PTIA 2FTLI 1BIKA 1P2II 1NAGA 1B0CA 3TGKI 3AUGA 3AUIA 2JOTA 1D0DA 1T8MB 3L33E 3AUDA 2DDIA 4DTGK 2CA7A 2KCRA 5JB6A 1YLDB 4NTXB 4U32X 1BUNB 1TAPA 2LFKA 1OA55 3FP7J 3GYMI 3AUHA 4WXVC 5JB7A 1BTHP 4BQDA 1CO7I 1TAWB 1FANA 3AUCA 3AUEA 4ISOB 1OA65 1KTHA 1JC6A 3OFWA 1YLCB 2TGPI 1TOCR 1P2JI 1EJMB 1ZR0B 2J6DA 2HEXA 1UUBA 1CBWD 3TGII 3LDMA 4NTYB 3AUBA 1TPAI 1P2QB 3CI7A 1BZXI 1BHCA 1DTXA 1G6XA 1AALA 3BTTI 1UUAA 3LDIA 3BTGI 4Y0YI 1KIGI 2IJOI 3U1JE 4WWYC 3M7QB 1F7ZI 3BTEI 1P2OB 1BRCI 1BPTA 4TPII 1T8NB 3BTWI 1P2NB 1PITA 1P2KI 4PTIA 4DG4C 3BTDI 3UOUB 2KAII 7PTIA 3P95E 1IRHA 2ZVXA 1T8LB 3L3TE 5PTIA 3TPII 2W8XA 4BNRI 2RA3C 1AAPA 1TFXC 1LD6A 1T8OB 3BTHI 9PTIA 3BTFI 3FP8I 1F5RI 3TGJI 2FI4I 1BRBI 1CA0D 1ADZA 3P92E 4BD9B 1LD5A 2R9PE 2TPII 4U30W 1KNTA 4ISNB 1DENA 5JB4A 2M01A 1BF0A 1Y62A 2ODYE 4Y11I 5C67C 1BTIA 1BZ5A 3BTQI 1ZJDB 4ISLB 1FAKI 1P2MB 2UUXA 2FTMB 3LDJA 1TCPA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1K6U A;  1BPI A;  1MTN D;  3D65 I;  4NTW B;  2M99 A;  3T62 D;  2KNT A;  4Y10 I;  2LFL A;  1JV9 A;  3BYB A;  6PTI A;  2UUY B;  3UIR C;  1JV8 A;  1EAW B;  3WNY A;  2PTC I;  1DTK A;  1YKT B;  2DDJ A;  1KUN A;  3BTK I;  1T7C B;  3FP6 I;  1QLQ A;  1YC0 I;  5JB5 A;  3BTM I;  4Y0Z I;  1D0D B;  2FI3 I;  1FY8 I;  1SHP A;  3OTJ I;  1DEM A;  2FI5 I;  2ZJX A;  8PTI A;  2FTL I;  1BIK A;  1P2I I;  1NAG A;  1B0C A;  3TGK I;  3AUG A;  3AUI A;  2JOT A;  1D0D A;  1T8M B;  3L33 E;  3AUD A;  2DDI A;  4DTG K;  2CA7 A;  2KCR A;  5JB6 A;  1YLD B;  4NTX B;  4U32 X;  1BUN B;  1TAP A;  2LFK A;  1OA5 5;  3FP7 J;  3GYM I;  3AUH A;  4WXV C;  5JB7 A;  1BTH P;  4BQD A;  1CO7 I;  1TAW B;  1FAN A;  3AUC A;  3AUE A;  4ISO B;  1OA6 5;  1KTH A;  1JC6 A;  3OFW A;  1YLC B;  2TGP I;  1TOC R;  1P2J I;  1EJM B;  1ZR0 B;  2J6D A;  2HEX A;  1UUB A;  1CBW D;  3TGI I;  3LDM A;  4NTY B;  3AUB A;  1TPA I;  1P2Q B;  3CI7 A;  1BZX I;  1BHC A;  1DTX A;  1G6X A;  1AAL A;  3BTT I;  1UUA A;  3LDI A;  3BTG I;  4Y0Y I;  1KIG I;  2IJO I;  3U1J E;  4WWY C;  3M7Q B;  1F7Z I;  3BTE I;  1P2O B;  1BRC I;  1BPT A;  4TPI I;  1T8N B;  3BTW I;  1P2N B;  1PIT A;  1P2K I;  4PTI A;  4DG4 C;  3BTD I;  3UOU B;  2KAI I;  7PTI A;  3P95 E;  1IRH A;  2ZVX A;  1T8L B;  3L3T E;  5PTI A;  3TPI I;  2W8X A;  4BNR I;  2RA3 C;  1AAP A;  1TFX C;  1LD6 A;  1T8O B;  3BTH I;  9PTI A;  3BTF I;  3FP8 I;  1F5R I;  3TGJ I;  2FI4 I;  1BRB I;  1CA0 D;  1ADZ A;  3P92 E;  4BD9 B;  1LD5 A;  2R9P E;  2TPI I;  4U30 W;  1KNT A;  4ISN B;  1DEN A;  5JB4 A;  2M01 A;  1BF0 A;  1Y62 A;  2ODY E;  4Y11 I;  5C67 C;  1BTI A;  1BZ5 A;  3BTQ I;  1ZJD B;  4ISL B;  1FAK I;  1P2M B;  2UUX A;  2FTM B;  3LDJ A;  1TCP A; 
#chains in the Genus database with same CATH topology
 1K6U A;  1BPI A;  1MTN D;  3D65 I;  4NTW B;  2M99 A;  3T62 D;  2KNT A;  4Y10 I;  2LFL A;  1JV9 A;  3BYB A;  6PTI A;  2UUY B;  3UIR C;  1JV8 A;  1EAW B;  3WNY A;  2PTC I;  1DTK A;  1YKT B;  2DDJ A;  1KUN A;  3BTK I;  1T7C B;  3FP6 I;  1QLQ A;  1YC0 I;  5JB5 A;  3BTM I;  4Y0Z I;  1D0D B;  2FI3 I;  1FY8 I;  1SHP A;  3OTJ I;  1DEM A;  2FI5 I;  2ZJX A;  8PTI A;  2FTL I;  1BIK A;  1P2I I;  1NAG A;  1B0C A;  3TGK I;  3AUG A;  3AUI A;  2JOT A;  1D0D A;  1T8M B;  3L33 E;  3AUD A;  2DDI A;  4DTG K;  2CA7 A;  2KCR A;  5JB6 A;  1YLD B;  4NTX B;  4U32 X;  1BUN B;  1TAP A;  2LFK A;  1OA5 5;  3FP7 J;  3GYM I;  3AUH A;  4WXV C;  5JB7 A;  1BTH P;  4BQD A;  1CO7 I;  1TAW B;  1FAN A;  3AUC A;  3AUE A;  4ISO B;  1OA6 5;  1KTH A;  1JC6 A;  3OFW A;  1YLC B;  2TGP I;  1TOC R;  1P2J I;  1EJM B;  1ZR0 B;  2J6D A;  2HEX A;  1UUB A;  1CBW D;  3TGI I;  3LDM A;  4NTY B;  3AUB A;  1TPA I;  1P2Q B;  3CI7 A;  1BZX I;  1BHC A;  1DTX A;  1G6X A;  1AAL A;  3BTT I;  1UUA A;  3LDI A;  3BTG I;  4Y0Y I;  1KIG I;  2IJO I;  3U1J E;  4WWY C;  3M7Q B;  1F7Z I;  3BTE I;  1P2O B;  1BRC I;  1BPT A;  4TPI I;  1T8N B;  3BTW I;  1P2N B;  1PIT A;  1P2K I;  4PTI A;  4DG4 C;  3BTD I;  3UOU B;  2KAI I;  7PTI A;  3P95 E;  1IRH A;  2ZVX A;  1T8L B;  3L3T E;  5PTI A;  3TPI I;  2W8X A;  4BNR I;  2RA3 C;  1AAP A;  1TFX C;  1LD6 A;  1T8O B;  3BTH I;  9PTI A;  3BTF I;  3FP8 I;  1F5R I;  3TGJ I;  2FI4 I;  1BRB I;  1CA0 D;  1ADZ A;  3P92 E;  4BD9 B;  1LD5 A;  2R9P E;  2TPI I;  4U30 W;  1KNT A;  4ISN B;  1DEN A;  5JB4 A;  2M01 A;  1BF0 A;  1Y62 A;  2ODY E;  4Y11 I;  5C67 C;  1BTI A;  1BZ5 A;  3BTQ I;  1ZJD B;  4ISL B;  1FAK I;  1P2M B;  2UUX A;  2FTM B;  3LDJ A;  1TCP A; 
#chains in the Genus database with same CATH homology
 1K6U A;  1BPI A;  1MTN D;  3D65 I;  4NTW B;  2M99 A;  3T62 D;  2KNT A;  4Y10 I;  2LFL A;  1JV9 A;  3BYB A;  6PTI A;  2UUY B;  3UIR C;  1JV8 A;  1EAW B;  3WNY A;  2PTC I;  1DTK A;  1YKT B;  2DDJ A;  1KUN A;  3BTK I;  1T7C B;  3FP6 I;  1QLQ A;  1YC0 I;  5JB5 A;  3BTM I;  4Y0Z I;  1D0D B;  2FI3 I;  1FY8 I;  1SHP A;  3OTJ I;  1DEM A;  2FI5 I;  2ZJX A;  8PTI A;  2FTL I;  1BIK A;  1P2I I;  1NAG A;  1B0C A;  3TGK I;  3AUG A;  3AUI A;  2JOT A;  1D0D A;  1T8M B;  3L33 E;  3AUD A;  2DDI A;  4DTG K;  2CA7 A;  2KCR A;  5JB6 A;  1YLD B;  4NTX B;  4U32 X;  1BUN B;  1TAP A;  2LFK A;  1OA5 5;  3FP7 J;  3GYM I;  3AUH A;  4WXV C;  5JB7 A;  1BTH P;  4BQD A;  1CO7 I;  1TAW B;  1FAN A;  3AUC A;  3AUE A;  4ISO B;  1OA6 5;  1KTH A;  1JC6 A;  3OFW A;  1YLC B;  2TGP I;  1TOC R;  1P2J I;  1EJM B;  1ZR0 B;  2J6D A;  2HEX A;  1UUB A;  1CBW D;  3TGI I;  3LDM A;  4NTY B;  3AUB A;  1TPA I;  1P2Q B;  3CI7 A;  1BZX I;  1BHC A;  1DTX A;  1G6X A;  1AAL A;  3BTT I;  1UUA A;  3LDI A;  3BTG I;  4Y0Y I;  1KIG I;  2IJO I;  3U1J E;  4WWY C;  3M7Q B;  1F7Z I;  3BTE I;  1P2O B;  1BRC I;  1BPT A;  4TPI I;  1T8N B;  3BTW I;  1P2N B;  1PIT A;  1P2K I;  4PTI A;  4DG4 C;  3BTD I;  3UOU B;  2KAI I;  7PTI A;  3P95 E;  1IRH A;  2ZVX A;  1T8L B;  3L3T E;  5PTI A;  3TPI I;  2W8X A;  4BNR I;  2RA3 C;  1AAP A;  1TFX C;  1LD6 A;  1T8O B;  3BTH I;  9PTI A;  3BTF I;  3FP8 I;  1F5R I;  3TGJ I;  2FI4 I;  1BRB I;  1CA0 D;  1ADZ A;  3P92 E;  4BD9 B;  1LD5 A;  2R9P E;  2TPI I;  4U30 W;  1KNT A;  4ISN B;  1DEN A;  5JB4 A;  2M01 A;  1BF0 A;  1Y62 A;  2ODY E;  4Y11 I;  5C67 C;  1BTI A;  1BZ5 A;  3BTQ I;  1ZJD B;  4ISL B;  1FAK I;  1P2M B;  2UUX A;  2FTM B;  3LDJ A;  1TCP A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...