2TPII

On the disordered activation domain in trypsinogen. chemical labelling and low-temperature crystallography
Total Genus 8
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
8
sequence length
56
structure length
56
Chain Sequence
PDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title On the Disordered Activation Domain in Trypsinogen. Chemical Labelling and Low-Temperature Crystallography
pubmed rcsb
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords TRYPSINOGEN
total genus 8
structure length 56
sequence length 56
ec nomenclature
pdb deposition date 1981-10-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2tpiI00
2ZJXA 1BIKA 1TCPA 1BZ5A 2FI5I 1YLDB 3TGII 1TOCR 1KIGI 1Y62A 2KAII 1P2OB 6PTIA 2J6DA 3FP7J 5C67C 3LDMA 1KNTA 4BD9B 1MTND 3P92E 1NAGA 2UUYB 1YKTB 1P2MB 1CO7I 4BNRI 1DENA 1AAPA 3LDIA 3AUEA 2R9PE 1BTIA 4WXVC 7PTIA 2M99A 4DG4C 5JB7A 3TGKI 9PTIA 3L33E 1DTKA 3UOUB 2PTCI 4NTXB 1YLCB 2TPII 3FP8I 3BTTI 1BTHP 2FTLI 1CA0D 2ODYE 3AUHA 3TPII 4Y10I 3FP6I 4Y0ZI 1QLQA 8PTIA 1P2II 3T62D 1ADZA 1OA55 1YC0I 1ZJDB 1G6XA 3BTFI 4ISNB 4WWYC 2KCRA 1FANA 3BTHI 2RA3C 5PTIA 1T8MB 1DEMA 1JV9A 4TPII 2KNTA 1BPIA 2LFLA 3OTJI 1KTHA 2IJOI 5JB4A 1BRBI 3AUBA 1LD6A 2HEXA 3CI7A 2LFKA 2DDJA 1T8OB 2DDIA 2ZVXA 1TFXC 1K6UA 1BRCI 3U1JE 2CA7A 1KUNA 3OFWA 1T8LB 1IRHA 1P2KI 2W8XA 3BTKI 1F7ZI 1FY8I 1P2QB 3AUDA 3M7QB 4PTIA 3UIRC 1LD5A 1TAWB 4BQDA 1BUNB 3BTQI 1BZXI 1TPAI 1AALA 1TAPA 3AUGA 3BTWI 3P95E 4ISLB 5JB6A 1UUBA 2UUXA 2FTMB 1JV8A 1D0DB 1JC6A 2TGPI 3BTGI 3L3TE 3BTMI 3GYMI 1BF0A 1SHPA 1UUAA 1CBWD 1EAWB 3D65I 1BHCA 5JB5A 1ZR0B 2JOTA 4Y11I 3TGJI 1D0DA 4Y0YI 1PITA 3BTEI 1FAKI 4NTYB 4U32X 1P2NB 1F5RI 4ISOB 1P2JI 4U30W 3WNYA 2FI4I 1EJMB 1DTXA 3AUIA 3LDJA 1B0CA 1T8NB 2FI3I 3BTDI 2M01A 1BPTA 4DTGK 1OA65 4NTWB 1T7CB 3AUCA 3BYBA
chains in the Genus database with same CATH superfamily
2ZJXA 1BIKA 1TCPA 1BZ5A 2FI5I 1YLDB 3TGII 1TOCR 1KIGI 1Y62A 2KAII 1P2OB 6PTIA 2J6DA 3FP7J 5C67C 3LDMA 1KNTA 4BD9B 1MTND 3P92E 1NAGA 2UUYB 1YKTB 1P2MB 1CO7I 4BNRI 1DENA 1AAPA 3LDIA 3AUEA 2R9PE 1BTIA 4WXVC 7PTIA 2M99A 4DG4C 5JB7A 3TGKI 9PTIA 3L33E 1DTKA 3UOUB 2PTCI 4NTXB 1YLCB 2TPII 3FP8I 3BTTI 1BTHP 2FTLI 1CA0D 2ODYE 3AUHA 3TPII 4Y10I 3FP6I 4Y0ZI 1QLQA 8PTIA 1P2II 3T62D 1ADZA 1OA55 1YC0I 1ZJDB 1G6XA 3BTFI 4ISNB 4WWYC 2KCRA 1FANA 3BTHI 2RA3C 5PTIA 1T8MB 1DEMA 1JV9A 4TPII 2KNTA 1BPIA 2LFLA 3OTJI 1KTHA 2IJOI 5JB4A 1BRBI 3AUBA 1LD6A 2HEXA 3CI7A 2LFKA 2DDJA 1T8OB 2DDIA 2ZVXA 1TFXC 1K6UA 1BRCI 3U1JE 2CA7A 1KUNA 3OFWA 1T8LB 1IRHA 1P2KI 2W8XA 3BTKI 1F7ZI 1FY8I 1P2QB 3AUDA 3M7QB 4PTIA 3UIRC 1LD5A 1TAWB 4BQDA 1BUNB 3BTQI 1BZXI 1TPAI 1AALA 1TAPA 3AUGA 3BTWI 3P95E 4ISLB 5JB6A 1UUBA 2UUXA 2FTMB 1JV8A 1D0DB 1JC6A 2TGPI 3BTGI 3L3TE 3BTMI 3GYMI 1BF0A 1SHPA 1UUAA 1CBWD 1EAWB 3D65I 1BHCA 5JB5A 1ZR0B 2JOTA 4Y11I 3TGJI 1D0DA 4Y0YI 1PITA 3BTEI 1FAKI 4NTYB 4U32X 1P2NB 1F5RI 4ISOB 1P2JI 4U30W 3WNYA 2FI4I 1EJMB 1DTXA 3AUIA 3LDJA 1B0CA 1T8NB 2FI3I 3BTDI 2M01A 1BPTA 4DTGK 1OA65 4NTWB 1T7CB 3AUCA 3BYBA
chains in the Genus database with same CATH topology
2ZJXA 1BIKA 1TCPA 1BZ5A 2FI5I 1YLDB 3TGII 1TOCR 1KIGI 1Y62A 2KAII 1P2OB 6PTIA 2J6DA 3FP7J 5C67C 3LDMA 1KNTA 4BD9B 1MTND 3P92E 1NAGA 2UUYB 1YKTB 1P2MB 1CO7I 4BNRI 1DENA 1AAPA 3LDIA 3AUEA 2R9PE 1BTIA 4WXVC 7PTIA 2M99A 4DG4C 5JB7A 3TGKI 9PTIA 3L33E 1DTKA 3UOUB 2PTCI 4NTXB 1YLCB 2TPII 3FP8I 3BTTI 1BTHP 2FTLI 1CA0D 2ODYE 3AUHA 3TPII 4Y10I 3FP6I 4Y0ZI 1QLQA 8PTIA 1P2II 3T62D 1ADZA 1OA55 1YC0I 1ZJDB 1G6XA 3BTFI 4ISNB 4WWYC 2KCRA 1FANA 3BTHI 2RA3C 5PTIA 1T8MB 1DEMA 1JV9A 4TPII 2KNTA 1BPIA 2LFLA 3OTJI 1KTHA 2IJOI 5JB4A 1BRBI 3AUBA 1LD6A 2HEXA 3CI7A 2LFKA 2DDJA 1T8OB 2DDIA 2ZVXA 1TFXC 1K6UA 1BRCI 3U1JE 2CA7A 1KUNA 3OFWA 1T8LB 1IRHA 1P2KI 2W8XA 3BTKI 1F7ZI 1FY8I 1P2QB 3AUDA 3M7QB 4PTIA 3UIRC 1LD5A 1TAWB 4BQDA 1BUNB 3BTQI 1BZXI 1TPAI 1AALA 1TAPA 3AUGA 3BTWI 3P95E 4ISLB 5JB6A 1UUBA 2UUXA 2FTMB 1JV8A 1D0DB 1JC6A 2TGPI 3BTGI 3L3TE 3BTMI 3GYMI 1BF0A 1SHPA 1UUAA 1CBWD 1EAWB 3D65I 1BHCA 5JB5A 1ZR0B 2JOTA 4Y11I 3TGJI 1D0DA 4Y0YI 1PITA 3BTEI 1FAKI 4NTYB 4U32X 1P2NB 1F5RI 4ISOB 1P2JI 4U30W 3WNYA 2FI4I 1EJMB 1DTXA 3AUIA 3LDJA 1B0CA 1T8NB 2FI3I 3BTDI 2M01A 1BPTA 4DTGK 1OA65 4NTWB 1T7CB 3AUCA 3BYBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ZJX A;  1BIK A;  1TCP A;  1BZ5 A;  2FI5 I;  1YLD B;  3TGI I;  1TOC R;  1KIG I;  1Y62 A;  2KAI I;  1P2O B;  6PTI A;  2J6D A;  3FP7 J;  5C67 C;  3LDM A;  1KNT A;  4BD9 B;  1MTN D;  3P92 E;  1NAG A;  2UUY B;  1YKT B;  1P2M B;  1CO7 I;  4BNR I;  1DEN A;  1AAP A;  3LDI A;  3AUE A;  2R9P E;  1BTI A;  4WXV C;  7PTI A;  2M99 A;  4DG4 C;  5JB7 A;  3TGK I;  9PTI A;  3L33 E;  1DTK A;  3UOU B;  2PTC I;  4NTX B;  1YLC B;  2TPI I;  3FP8 I;  3BTT I;  1BTH P;  2FTL I;  1CA0 D;  2ODY E;  3AUH A;  3TPI I;  4Y10 I;  3FP6 I;  4Y0Z I;  1QLQ A;  8PTI A;  1P2I I;  3T62 D;  1ADZ A;  1OA5 5;  1YC0 I;  1ZJD B;  1G6X A;  3BTF I;  4ISN B;  4WWY C;  2KCR A;  1FAN A;  3BTH I;  2RA3 C;  5PTI A;  1T8M B;  1DEM A;  1JV9 A;  4TPI I;  2KNT A;  1BPI A;  2LFL A;  3OTJ I;  1KTH A;  2IJO I;  5JB4 A;  1BRB I;  3AUB A;  1LD6 A;  2HEX A;  3CI7 A;  2LFK A;  2DDJ A;  1T8O B;  2DDI A;  2ZVX A;  1TFX C;  1K6U A;  1BRC I;  3U1J E;  2CA7 A;  1KUN A;  3OFW A;  1T8L B;  1IRH A;  1P2K I;  2W8X A;  3BTK I;  1F7Z I;  1FY8 I;  1P2Q B;  3AUD A;  3M7Q B;  4PTI A;  3UIR C;  1LD5 A;  1TAW B;  4BQD A;  1BUN B;  3BTQ I;  1BZX I;  1TPA I;  1AAL A;  1TAP A;  3AUG A;  3BTW I;  3P95 E;  4ISL B;  5JB6 A;  1UUB A;  2UUX A;  2FTM B;  1JV8 A;  1D0D B;  1JC6 A;  2TGP I;  3BTG I;  3L3T E;  3BTM I;  3GYM I;  1BF0 A;  1SHP A;  1UUA A;  1CBW D;  1EAW B;  3D65 I;  1BHC A;  5JB5 A;  1ZR0 B;  2JOT A;  4Y11 I;  3TGJ I;  1D0D A;  4Y0Y I;  1PIT A;  3BTE I;  1FAK I;  4NTY B;  4U32 X;  1P2N B;  1F5R I;  4ISO B;  1P2J I;  4U30 W;  3WNY A;  2FI4 I;  1EJM B;  1DTX A;  3AUI A;  3LDJ A;  1B0C A;  1T8N B;  2FI3 I;  3BTD I;  2M01 A;  1BPT A;  4DTG K;  1OA6 5;  4NTW B;  1T7C B;  3AUC A;  3BYB A; 
#chains in the Genus database with same CATH topology
 2ZJX A;  1BIK A;  1TCP A;  1BZ5 A;  2FI5 I;  1YLD B;  3TGI I;  1TOC R;  1KIG I;  1Y62 A;  2KAI I;  1P2O B;  6PTI A;  2J6D A;  3FP7 J;  5C67 C;  3LDM A;  1KNT A;  4BD9 B;  1MTN D;  3P92 E;  1NAG A;  2UUY B;  1YKT B;  1P2M B;  1CO7 I;  4BNR I;  1DEN A;  1AAP A;  3LDI A;  3AUE A;  2R9P E;  1BTI A;  4WXV C;  7PTI A;  2M99 A;  4DG4 C;  5JB7 A;  3TGK I;  9PTI A;  3L33 E;  1DTK A;  3UOU B;  2PTC I;  4NTX B;  1YLC B;  2TPI I;  3FP8 I;  3BTT I;  1BTH P;  2FTL I;  1CA0 D;  2ODY E;  3AUH A;  3TPI I;  4Y10 I;  3FP6 I;  4Y0Z I;  1QLQ A;  8PTI A;  1P2I I;  3T62 D;  1ADZ A;  1OA5 5;  1YC0 I;  1ZJD B;  1G6X A;  3BTF I;  4ISN B;  4WWY C;  2KCR A;  1FAN A;  3BTH I;  2RA3 C;  5PTI A;  1T8M B;  1DEM A;  1JV9 A;  4TPI I;  2KNT A;  1BPI A;  2LFL A;  3OTJ I;  1KTH A;  2IJO I;  5JB4 A;  1BRB I;  3AUB A;  1LD6 A;  2HEX A;  3CI7 A;  2LFK A;  2DDJ A;  1T8O B;  2DDI A;  2ZVX A;  1TFX C;  1K6U A;  1BRC I;  3U1J E;  2CA7 A;  1KUN A;  3OFW A;  1T8L B;  1IRH A;  1P2K I;  2W8X A;  3BTK I;  1F7Z I;  1FY8 I;  1P2Q B;  3AUD A;  3M7Q B;  4PTI A;  3UIR C;  1LD5 A;  1TAW B;  4BQD A;  1BUN B;  3BTQ I;  1BZX I;  1TPA I;  1AAL A;  1TAP A;  3AUG A;  3BTW I;  3P95 E;  4ISL B;  5JB6 A;  1UUB A;  2UUX A;  2FTM B;  1JV8 A;  1D0D B;  1JC6 A;  2TGP I;  3BTG I;  3L3T E;  3BTM I;  3GYM I;  1BF0 A;  1SHP A;  1UUA A;  1CBW D;  1EAW B;  3D65 I;  1BHC A;  5JB5 A;  1ZR0 B;  2JOT A;  4Y11 I;  3TGJ I;  1D0D A;  4Y0Y I;  1PIT A;  3BTE I;  1FAK I;  4NTY B;  4U32 X;  1P2N B;  1F5R I;  4ISO B;  1P2J I;  4U30 W;  3WNY A;  2FI4 I;  1EJM B;  1DTX A;  3AUI A;  3LDJ A;  1B0C A;  1T8N B;  2FI3 I;  3BTD I;  2M01 A;  1BPT A;  4DTG K;  1OA6 5;  4NTW B;  1T7C B;  3AUC A;  3BYB A; 
#chains in the Genus database with same CATH homology
 2ZJX A;  1BIK A;  1TCP A;  1BZ5 A;  2FI5 I;  1YLD B;  3TGI I;  1TOC R;  1KIG I;  1Y62 A;  2KAI I;  1P2O B;  6PTI A;  2J6D A;  3FP7 J;  5C67 C;  3LDM A;  1KNT A;  4BD9 B;  1MTN D;  3P92 E;  1NAG A;  2UUY B;  1YKT B;  1P2M B;  1CO7 I;  4BNR I;  1DEN A;  1AAP A;  3LDI A;  3AUE A;  2R9P E;  1BTI A;  4WXV C;  7PTI A;  2M99 A;  4DG4 C;  5JB7 A;  3TGK I;  9PTI A;  3L33 E;  1DTK A;  3UOU B;  2PTC I;  4NTX B;  1YLC B;  2TPI I;  3FP8 I;  3BTT I;  1BTH P;  2FTL I;  1CA0 D;  2ODY E;  3AUH A;  3TPI I;  4Y10 I;  3FP6 I;  4Y0Z I;  1QLQ A;  8PTI A;  1P2I I;  3T62 D;  1ADZ A;  1OA5 5;  1YC0 I;  1ZJD B;  1G6X A;  3BTF I;  4ISN B;  4WWY C;  2KCR A;  1FAN A;  3BTH I;  2RA3 C;  5PTI A;  1T8M B;  1DEM A;  1JV9 A;  4TPI I;  2KNT A;  1BPI A;  2LFL A;  3OTJ I;  1KTH A;  2IJO I;  5JB4 A;  1BRB I;  3AUB A;  1LD6 A;  2HEX A;  3CI7 A;  2LFK A;  2DDJ A;  1T8O B;  2DDI A;  2ZVX A;  1TFX C;  1K6U A;  1BRC I;  3U1J E;  2CA7 A;  1KUN A;  3OFW A;  1T8L B;  1IRH A;  1P2K I;  2W8X A;  3BTK I;  1F7Z I;  1FY8 I;  1P2Q B;  3AUD A;  3M7Q B;  4PTI A;  3UIR C;  1LD5 A;  1TAW B;  4BQD A;  1BUN B;  3BTQ I;  1BZX I;  1TPA I;  1AAL A;  1TAP A;  3AUG A;  3BTW I;  3P95 E;  4ISL B;  5JB6 A;  1UUB A;  2UUX A;  2FTM B;  1JV8 A;  1D0D B;  1JC6 A;  2TGP I;  3BTG I;  3L3T E;  3BTM I;  3GYM I;  1BF0 A;  1SHP A;  1UUA A;  1CBW D;  1EAW B;  3D65 I;  1BHC A;  5JB5 A;  1ZR0 B;  2JOT A;  4Y11 I;  3TGJ I;  1D0D A;  4Y0Y I;  1PIT A;  3BTE I;  1FAK I;  4NTY B;  4U32 X;  1P2N B;  1F5R I;  4ISO B;  1P2J I;  4U30 W;  3WNY A;  2FI4 I;  1EJM B;  1DTX A;  3AUI A;  3LDJ A;  1B0C A;  1T8N B;  2FI3 I;  3BTD I;  2M01 A;  1BPT A;  4DTG K;  1OA6 5;  4NTW B;  1T7C B;  3AUC A;  3BYB A; 
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similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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