2ZVXA

Structure of a bpti-[5,55] variant containing gly/val at the 14/38th positions
Total Genus 8
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
8
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPGKARIIRYFYNAKAGLAQTFVYGGVRAKRNNFKSAEDALRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Thermodynamic and structural analysis of highly stabilized BPTIs by single and double mutations
pubmed doi rcsb
molecule tags Hydrolase inhibitor
source organism Bos taurus
molecule keywords Pancreatic trypsin inhibitor
total genus 8
structure length 58
sequence length 58
chains with identical sequence B
ec nomenclature
pdb deposition date 2008-11-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2zvxA00
6PTIA 1BPTA 2ZVXA 2FI5I 2KNTA 3AUHA 1P2MB 3AUCA 1Y62A 4U32X 1CA0D 4TPII 8PTIA 3LDJA 3L3TE 3AUGA 1DTXA 1BPIA 1PITA 2J6DA 4BQDA 1BZXI 2FI3I 2HEXA 2UUYB 1BF0A 1TAPA 3LDIA 2KAII 2DDIA 5PTIA 3TGKI 1BUNB 1UUAA 3M7QB 1QLQA 3BTEI 1EJMB 5JB4A 2FTLI 3TPII 1FANA 1OA65 3LDMA 4ISNB 1T8OB 1AALA 4BNRI 4NTWB 1ADZA 1YLDB 3AUIA 1JC6A 3AUBA 3BTFI 1ZJDB 1NAGA 3BTMI 1OA55 3D65I 3FP6I 1YC0I 1D0DB 3AUEA 3BTGI 1P2QB 3FP7J 3P95E 2ZJXA 1BZ5A 1P2KI 2RA3C 2UUXA 2TPII 1P2JI 1JV8A 3BTTI 5JB6A 1DENA 3BTQI 1BTIA 2LFKA 1KNTA 3BYBA 3T62D 1KIGI 3BTKI 1CBWD 4ISOB 4DG4C 2M99A 1TAWB 3AUDA 4DTGK 1B0CA 9PTIA 4WWYC 4NTXB 4BD9B 1T8LB 4Y11I 1KUNA 3OTJI 1T8NB 1DEMA 7PTIA 4Y0ZI 1LD6A 3UIRC 1TCPA 1BIKA 3BTWI 1TOCR 1G6XA 2LFLA 1FY8I 1YLCB 4U30W 4Y0YI 5C67C 1BRCI 1UUBA 1T8MB 1TFXC 3BTHI 3CI7A 2M01A 2JOTA 2KCRA 3U1JE 3FP8I 4ISLB 2FTMB 2ODYE 1TPAI 1SHPA 1CO7I 2W8XA 1P2NB 1F5RI 1AAPA 1P2OB 5JB5A 4NTYB 1ZR0B 1P2II 2CA7A 2DDJA 1IRHA 1T7CB 3L33E 1EAWB 1KTHA 3BTDI 1BRBI 2R9PE 1LD5A 1BTHP 4Y10I 3GYMI 2IJOI 4WXVC 2PTCI 3WNYA 2TGPI 2FI4I 1FAKI 1YKTB 3OFWA 1K6UA 3P92E 1JV9A 1DTKA 1F7ZI 5JB7A 3UOUB 3TGJI 1MTND 4PTIA 1D0DA 3TGII 1BHCA
chains in the Genus database with same CATH superfamily
6PTIA 1BPTA 2ZVXA 2FI5I 2KNTA 3AUHA 1P2MB 3AUCA 1Y62A 4U32X 1CA0D 4TPII 8PTIA 3LDJA 3L3TE 3AUGA 1DTXA 1BPIA 1PITA 2J6DA 4BQDA 1BZXI 2FI3I 2HEXA 2UUYB 1BF0A 1TAPA 3LDIA 2KAII 2DDIA 5PTIA 3TGKI 1BUNB 1UUAA 3M7QB 1QLQA 3BTEI 1EJMB 5JB4A 2FTLI 3TPII 1FANA 1OA65 3LDMA 4ISNB 1T8OB 1AALA 4BNRI 4NTWB 1ADZA 1YLDB 3AUIA 1JC6A 3AUBA 3BTFI 1ZJDB 1NAGA 3BTMI 1OA55 3D65I 3FP6I 1YC0I 1D0DB 3AUEA 3BTGI 1P2QB 3FP7J 3P95E 2ZJXA 1BZ5A 1P2KI 2RA3C 2UUXA 2TPII 1P2JI 1JV8A 3BTTI 5JB6A 1DENA 3BTQI 1BTIA 2LFKA 1KNTA 3BYBA 3T62D 1KIGI 3BTKI 1CBWD 4ISOB 4DG4C 2M99A 1TAWB 3AUDA 4DTGK 1B0CA 9PTIA 4WWYC 4NTXB 4BD9B 1T8LB 4Y11I 1KUNA 3OTJI 1T8NB 1DEMA 7PTIA 4Y0ZI 1LD6A 3UIRC 1TCPA 1BIKA 3BTWI 1TOCR 1G6XA 2LFLA 1FY8I 1YLCB 4U30W 4Y0YI 5C67C 1BRCI 1UUBA 1T8MB 1TFXC 3BTHI 3CI7A 2M01A 2JOTA 2KCRA 3U1JE 3FP8I 4ISLB 2FTMB 2ODYE 1TPAI 1SHPA 1CO7I 2W8XA 1P2NB 1F5RI 1AAPA 1P2OB 5JB5A 4NTYB 1ZR0B 1P2II 2CA7A 2DDJA 1IRHA 1T7CB 3L33E 1EAWB 1KTHA 3BTDI 1BRBI 2R9PE 1LD5A 1BTHP 4Y10I 3GYMI 2IJOI 4WXVC 2PTCI 3WNYA 2TGPI 2FI4I 1FAKI 1YKTB 3OFWA 1K6UA 3P92E 1JV9A 1DTKA 1F7ZI 5JB7A 3UOUB 3TGJI 1MTND 4PTIA 1D0DA 3TGII 1BHCA
chains in the Genus database with same CATH topology
6PTIA 1BPTA 2ZVXA 2FI5I 2KNTA 3AUHA 1P2MB 3AUCA 1Y62A 4U32X 1CA0D 4TPII 8PTIA 3LDJA 3L3TE 3AUGA 1DTXA 1BPIA 1PITA 2J6DA 4BQDA 1BZXI 2FI3I 2HEXA 2UUYB 1BF0A 1TAPA 3LDIA 2KAII 2DDIA 5PTIA 3TGKI 1BUNB 1UUAA 3M7QB 1QLQA 3BTEI 1EJMB 5JB4A 2FTLI 3TPII 1FANA 1OA65 3LDMA 4ISNB 1T8OB 1AALA 4BNRI 4NTWB 1ADZA 1YLDB 3AUIA 1JC6A 3AUBA 3BTFI 1ZJDB 1NAGA 3BTMI 1OA55 3D65I 3FP6I 1YC0I 1D0DB 3AUEA 3BTGI 1P2QB 3FP7J 3P95E 2ZJXA 1BZ5A 1P2KI 2RA3C 2UUXA 2TPII 1P2JI 1JV8A 3BTTI 5JB6A 1DENA 3BTQI 1BTIA 2LFKA 1KNTA 3BYBA 3T62D 1KIGI 3BTKI 1CBWD 4ISOB 4DG4C 2M99A 1TAWB 3AUDA 4DTGK 1B0CA 9PTIA 4WWYC 4NTXB 4BD9B 1T8LB 4Y11I 1KUNA 3OTJI 1T8NB 1DEMA 7PTIA 4Y0ZI 1LD6A 3UIRC 1TCPA 1BIKA 3BTWI 1TOCR 1G6XA 2LFLA 1FY8I 1YLCB 4U30W 4Y0YI 5C67C 1BRCI 1UUBA 1T8MB 1TFXC 3BTHI 3CI7A 2M01A 2JOTA 2KCRA 3U1JE 3FP8I 4ISLB 2FTMB 2ODYE 1TPAI 1SHPA 1CO7I 2W8XA 1P2NB 1F5RI 1AAPA 1P2OB 5JB5A 4NTYB 1ZR0B 1P2II 2CA7A 2DDJA 1IRHA 1T7CB 3L33E 1EAWB 1KTHA 3BTDI 1BRBI 2R9PE 1LD5A 1BTHP 4Y10I 3GYMI 2IJOI 4WXVC 2PTCI 3WNYA 2TGPI 2FI4I 1FAKI 1YKTB 3OFWA 1K6UA 3P92E 1JV9A 1DTKA 1F7ZI 5JB7A 3UOUB 3TGJI 1MTND 4PTIA 1D0DA 3TGII 1BHCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 6PTI A;  1BPT A;  2ZVX A;  2FI5 I;  2KNT A;  3AUH A;  1P2M B;  3AUC A;  1Y62 A;  4U32 X;  1CA0 D;  4TPI I;  8PTI A;  3LDJ A;  3L3T E;  3AUG A;  1DTX A;  1BPI A;  1PIT A;  2J6D A;  4BQD A;  1BZX I;  2FI3 I;  2HEX A;  2UUY B;  1BF0 A;  1TAP A;  3LDI A;  2KAI I;  2DDI A;  5PTI A;  3TGK I;  1BUN B;  1UUA A;  3M7Q B;  1QLQ A;  3BTE I;  1EJM B;  5JB4 A;  2FTL I;  3TPI I;  1FAN A;  1OA6 5;  3LDM A;  4ISN B;  1T8O B;  1AAL A;  4BNR I;  4NTW B;  1ADZ A;  1YLD B;  3AUI A;  1JC6 A;  3AUB A;  3BTF I;  1ZJD B;  1NAG A;  3BTM I;  1OA5 5;  3D65 I;  3FP6 I;  1YC0 I;  1D0D B;  3AUE A;  3BTG I;  1P2Q B;  3FP7 J;  3P95 E;  2ZJX A;  1BZ5 A;  1P2K I;  2RA3 C;  2UUX A;  2TPI I;  1P2J I;  1JV8 A;  3BTT I;  5JB6 A;  1DEN A;  3BTQ I;  1BTI A;  2LFK A;  1KNT A;  3BYB A;  3T62 D;  1KIG I;  3BTK I;  1CBW D;  4ISO B;  4DG4 C;  2M99 A;  1TAW B;  3AUD A;  4DTG K;  1B0C A;  9PTI A;  4WWY C;  4NTX B;  4BD9 B;  1T8L B;  4Y11 I;  1KUN A;  3OTJ I;  1T8N B;  1DEM A;  7PTI A;  4Y0Z I;  1LD6 A;  3UIR C;  1TCP A;  1BIK A;  3BTW I;  1TOC R;  1G6X A;  2LFL A;  1FY8 I;  1YLC B;  4U30 W;  4Y0Y I;  5C67 C;  1BRC I;  1UUB A;  1T8M B;  1TFX C;  3BTH I;  3CI7 A;  2M01 A;  2JOT A;  2KCR A;  3U1J E;  3FP8 I;  4ISL B;  2FTM B;  2ODY E;  1TPA I;  1SHP A;  1CO7 I;  2W8X A;  1P2N B;  1F5R I;  1AAP A;  1P2O B;  5JB5 A;  4NTY B;  1ZR0 B;  1P2I I;  2CA7 A;  2DDJ A;  1IRH A;  1T7C B;  3L33 E;  1EAW B;  1KTH A;  3BTD I;  1BRB I;  2R9P E;  1LD5 A;  1BTH P;  4Y10 I;  3GYM I;  2IJO I;  4WXV C;  2PTC I;  3WNY A;  2TGP I;  2FI4 I;  1FAK I;  1YKT B;  3OFW A;  1K6U A;  3P92 E;  1JV9 A;  1DTK A;  1F7Z I;  5JB7 A;  3UOU B;  3TGJ I;  1MTN D;  4PTI A;  1D0D A;  3TGI I;  1BHC A; 
#chains in the Genus database with same CATH topology
 6PTI A;  1BPT A;  2ZVX A;  2FI5 I;  2KNT A;  3AUH A;  1P2M B;  3AUC A;  1Y62 A;  4U32 X;  1CA0 D;  4TPI I;  8PTI A;  3LDJ A;  3L3T E;  3AUG A;  1DTX A;  1BPI A;  1PIT A;  2J6D A;  4BQD A;  1BZX I;  2FI3 I;  2HEX A;  2UUY B;  1BF0 A;  1TAP A;  3LDI A;  2KAI I;  2DDI A;  5PTI A;  3TGK I;  1BUN B;  1UUA A;  3M7Q B;  1QLQ A;  3BTE I;  1EJM B;  5JB4 A;  2FTL I;  3TPI I;  1FAN A;  1OA6 5;  3LDM A;  4ISN B;  1T8O B;  1AAL A;  4BNR I;  4NTW B;  1ADZ A;  1YLD B;  3AUI A;  1JC6 A;  3AUB A;  3BTF I;  1ZJD B;  1NAG A;  3BTM I;  1OA5 5;  3D65 I;  3FP6 I;  1YC0 I;  1D0D B;  3AUE A;  3BTG I;  1P2Q B;  3FP7 J;  3P95 E;  2ZJX A;  1BZ5 A;  1P2K I;  2RA3 C;  2UUX A;  2TPI I;  1P2J I;  1JV8 A;  3BTT I;  5JB6 A;  1DEN A;  3BTQ I;  1BTI A;  2LFK A;  1KNT A;  3BYB A;  3T62 D;  1KIG I;  3BTK I;  1CBW D;  4ISO B;  4DG4 C;  2M99 A;  1TAW B;  3AUD A;  4DTG K;  1B0C A;  9PTI A;  4WWY C;  4NTX B;  4BD9 B;  1T8L B;  4Y11 I;  1KUN A;  3OTJ I;  1T8N B;  1DEM A;  7PTI A;  4Y0Z I;  1LD6 A;  3UIR C;  1TCP A;  1BIK A;  3BTW I;  1TOC R;  1G6X A;  2LFL A;  1FY8 I;  1YLC B;  4U30 W;  4Y0Y I;  5C67 C;  1BRC I;  1UUB A;  1T8M B;  1TFX C;  3BTH I;  3CI7 A;  2M01 A;  2JOT A;  2KCR A;  3U1J E;  3FP8 I;  4ISL B;  2FTM B;  2ODY E;  1TPA I;  1SHP A;  1CO7 I;  2W8X A;  1P2N B;  1F5R I;  1AAP A;  1P2O B;  5JB5 A;  4NTY B;  1ZR0 B;  1P2I I;  2CA7 A;  2DDJ A;  1IRH A;  1T7C B;  3L33 E;  1EAW B;  1KTH A;  3BTD I;  1BRB I;  2R9P E;  1LD5 A;  1BTH P;  4Y10 I;  3GYM I;  2IJO I;  4WXV C;  2PTC I;  3WNY A;  2TGP I;  2FI4 I;  1FAK I;  1YKT B;  3OFW A;  1K6U A;  3P92 E;  1JV9 A;  1DTK A;  1F7Z I;  5JB7 A;  3UOU B;  3TGJ I;  1MTN D;  4PTI A;  1D0D A;  3TGI I;  1BHC A; 
#chains in the Genus database with same CATH homology
 6PTI A;  1BPT A;  2ZVX A;  2FI5 I;  2KNT A;  3AUH A;  1P2M B;  3AUC A;  1Y62 A;  4U32 X;  1CA0 D;  4TPI I;  8PTI A;  3LDJ A;  3L3T E;  3AUG A;  1DTX A;  1BPI A;  1PIT A;  2J6D A;  4BQD A;  1BZX I;  2FI3 I;  2HEX A;  2UUY B;  1BF0 A;  1TAP A;  3LDI A;  2KAI I;  2DDI A;  5PTI A;  3TGK I;  1BUN B;  1UUA A;  3M7Q B;  1QLQ A;  3BTE I;  1EJM B;  5JB4 A;  2FTL I;  3TPI I;  1FAN A;  1OA6 5;  3LDM A;  4ISN B;  1T8O B;  1AAL A;  4BNR I;  4NTW B;  1ADZ A;  1YLD B;  3AUI A;  1JC6 A;  3AUB A;  3BTF I;  1ZJD B;  1NAG A;  3BTM I;  1OA5 5;  3D65 I;  3FP6 I;  1YC0 I;  1D0D B;  3AUE A;  3BTG I;  1P2Q B;  3FP7 J;  3P95 E;  2ZJX A;  1BZ5 A;  1P2K I;  2RA3 C;  2UUX A;  2TPI I;  1P2J I;  1JV8 A;  3BTT I;  5JB6 A;  1DEN A;  3BTQ I;  1BTI A;  2LFK A;  1KNT A;  3BYB A;  3T62 D;  1KIG I;  3BTK I;  1CBW D;  4ISO B;  4DG4 C;  2M99 A;  1TAW B;  3AUD A;  4DTG K;  1B0C A;  9PTI A;  4WWY C;  4NTX B;  4BD9 B;  1T8L B;  4Y11 I;  1KUN A;  3OTJ I;  1T8N B;  1DEM A;  7PTI A;  4Y0Z I;  1LD6 A;  3UIR C;  1TCP A;  1BIK A;  3BTW I;  1TOC R;  1G6X A;  2LFL A;  1FY8 I;  1YLC B;  4U30 W;  4Y0Y I;  5C67 C;  1BRC I;  1UUB A;  1T8M B;  1TFX C;  3BTH I;  3CI7 A;  2M01 A;  2JOT A;  2KCR A;  3U1J E;  3FP8 I;  4ISL B;  2FTM B;  2ODY E;  1TPA I;  1SHP A;  1CO7 I;  2W8X A;  1P2N B;  1F5R I;  1AAP A;  1P2O B;  5JB5 A;  4NTY B;  1ZR0 B;  1P2I I;  2CA7 A;  2DDJ A;  1IRH A;  1T7C B;  3L33 E;  1EAW B;  1KTH A;  3BTD I;  1BRB I;  2R9P E;  1LD5 A;  1BTH P;  4Y10 I;  3GYM I;  2IJO I;  4WXV C;  2PTC I;  3WNY A;  2TGP I;  2FI4 I;  1FAK I;  1YKT B;  3OFW A;  1K6U A;  3P92 E;  1JV9 A;  1DTK A;  1F7Z I;  5JB7 A;  3UOU B;  3TGJ I;  1MTN D;  4PTI A;  1D0D A;  3TGI I;  1BHC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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