2A69E

Crystal structure of the t. thermophilus rna polymerase holoenzyme in complex with antibiotic rifapentin
Total Genus 19
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
19
sequence length
95
structure length
95
Chain Sequence
AEPGIDKLFGMVDSKYRLTVVVAKRAQQLLRHGFKNTVLEPEERPKMQTLEGLFDDPNAETWAMKELLTGRLVFGENLVPEDRLQKEMERIYPGE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
pubmed doi rcsb
molecule tags Transferase
molecule keywords DNA-directed RNA polymerase alpha chain
total genus 19
structure length 95
sequence length 95
chains with identical sequence O
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2005-07-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 2a69E00
2B63F 3GTOF 4A3EF 3HOXF 3M3YF 2O5IE 3GTQF 4A3BF 4OIQE 3HOYF 4C3HF 4OINE 5IP7F 2A68E 4BY7F 4C3IF 3M4OF 1I50F 4A3JF 2CW0E 1WCMF 2JA5F 3WODE 4G7OE 4A3GF 4JK1E 3H0GF 3CQZF 4XSXE 3S17F 3S1NF 4YFNE 5M5WF 4BBRF 4OIRE 2JA7F 4AYBK 2NVTF 5IYDF 2O5JE 1TWHF 3I4NF 1YNJK 5TMFE 4XLNE 1TWCF 3S15F 2WAQK 4A3CF 4XSZE 3GTKF 4A93F 4Q5SE 2WB1I 3K7AF 4MEXE 1SFOF 3DXJE 4A3IF 3S2DF 4LJZE 4A3KF 4Y7NF 4OIOE 1R9TF 3PO3F 2R7ZF 4MEYE 2NVQF 4BBSF 5E17E 1QKLA 4OIPE 3GTLF 3H3VG 4YG2E 1Y1VF 3RZOF 4X6AF 5E18E 3S14F 2PMZK 5M3FF 5IPLE 3HOVF 1HQME 3RZDF 4C2MF 3HOUF 2Y0SI 3S1RF 2E2IF 4LK1E 2A6EE 4BY1F 2E2JF 3PO2F 4KN7E 3EQLE 2BE5E 2PPBE 5IP9F 5C4XF 1I6VE 4A3DF 4A3FF 2JA8F 4LLGE 4C3JF 5M5YF 4Y52F 1IW7E 3HOWF 3S1QF 2YU9F 5IYCF 4G7HE 5IYBF 3I4MF 5FJ8F 2NVYF 4A3MF 2VUMF 5TMCE 5C44F 3HOZF 1I6HF 4KMUE 5C4JF 2NVXF 4BXXF 4YFXE 1ZYRE 1TWAF 5C3EF 5M3MF 3GTPF 3FKIF 1Y1WF 1TWFF 5BYHE 2JA6F 2R92F 4MQ9E 4YFKE 1K83F 5D4EE 3S2HF 1TWGF 4A3LF 2R93F 4ZH4E 2A69E 3S1MF 4G7ZE 2E2HF 4GZYE 1I3QF 5FLMF 1SMYE 3HKZK 3GTJF 1YNNK 4LK0E 5D4DE 3GTGF 4XLPE 2A6HE 3GTMF 4KN4E 3S16F 5M5XF 5D4CE 4Q4ZE
chains in the Genus database with same CATH superfamily
3GTOE 4A3EE 3HOXE 2B63F 3M3YE 3K7AE 4A93E 3S2DE 4GZYE 4A3BE 4A3KE 4A3EF 3HOXF 4Y7NE 3GTOF 4C3HE 3HOYE 3M3YF 2O5IE 4BY7E 1I50E 3GTQF 4A3BF 4OIQE 3PO3E 3HOYF 2Y0SH 4C3HF 4OINE 5IP7F 2A68E 4BY7F 2R7ZE 4A3GE 4C3IF 3M4OF 1I50F 4A3JF 3CQZE 2CW0E 1WCMF 2JA5F 1Y1VE 3WODE 4G7OE 3RZOE 3S17E 4JK1E 4A3GF 4X6AE 3H0GF 3CQZF 5M5WE 2JA7E 2WAQH 2NVTE 4XSXE 5IYDE 4C2ME 1TWHE 3RZDE 3I4NE 3S17F 3S1NF 4YFNE 5M5WF 4BBRF 4OIRE 1TWCE 2JA7F 4AYBK 2NVTF 5IYDF 2O5JE 1TWHF 3I4NF 1YNJK 4A3CE 5TMFE 4XLNE 1TWCF 2KRXA 3S15F 2WAQK 1SFOE 1EIKA 4A3CF 4XSZE 4A3IE 3GTKF 4A93F 4Q5SE 4A3FE 2WB1I 3K7AF 4MEXE 1SFOF 3DXJE 4A3IF 3S2DF 1R9TE 4LJZE 4A3KF 4Y7NF 4OIOE 2PMZH 2NVQE 4BBSE 1R9TF 3PO3F 2YU9E 3GTLE 5IYCE 2R7ZF 4MEYE 2NVQF 4BBSF 5E17E 3S14E 1QKLA 5M3FE 4OIPE 3HOVE 3GTLF 3H3VG 4YG2E 1Y1VF 3HOZE 3RZOF 4X6AF 5E18E 1I6HE 3HOUE 3S14F 2PMZK 5M3FF 3S1RE 3HOVF 1HQME 5IPLE 2E2IE 5M3ME 3PO2E 3RZDF 4C2MF 2E2JE 4BY1E 3GTPE 3HOUF 2Y0SI 3S1RF 2E2IF 4LK1E 2A6EE 4BY1F 2E2JF 3PO2F 5C4XE 5IP9E 3S2HE 2R93E 4KN7E 4A3DE 2E2HE 3EQLE 2BE5E 3GTJE 2JA8E 2PPBE 5IP9F 5C4XF 1DZFA 1I6VE 4QIWH 4A3DF 4A3FF 3GTME 2JA8F 4C3JE 5M5YE 4Y52E 5M5XE 3HOWE 3S1QE 3I4ME 5IYBE 4LLGE 5FJ8E 4C3JF 2NVYE 5M5YF 4Y52F 4A3ME 2VUME 1IW7E 3HOWF 3S1QF 2YU9F 4QIWK 5IYCF 5C44E 5IYBF 4G7HE 3I4MF 5FJ8F 5C4JE 2NVYF 4A3MF 2NVXE 2VUMF 5TMCE 4BXXE 1TWAE 5C44F 5C3EE 3HOZF 1I6HF 4KMUE 3FKIE 5C4JF 1Y1WE 3GTQE 2NVXF 4BXXF 4YFXE 1ZYRE 1TWFE 1TWAF 5C3EF 5IP7E 3HKZH 5M3MF 2JA6E 4C3IE 3M4OE 3GTPF 3FKIF 4A3JE 1K83E 1Y1WF 4A3LE 1TWGE 2R92E 1WCME 3H3VF 1TWFF 5BYHE 2JA5E 3S1ME 2JA6F 1I3QE 3H0GE 5FLME 4MQ9E 4YFKE 1K83F 4AYBH 5D4EE 1TWGF 2R92F 3S2HF 4ZH4E 2A69E 3GTGE 4A3LF 2R93F 3S1MF 4G7ZE 2E2HF 2WB1H 1I3QF 5FLMF 1SMYE 3HKZK 3GTJF 3S16E 4BBRE 3S1NE 1YNNK 4LK0E 5D4DE 3GTGF 4XLPE 2A6HE 3GTMF 4KN4E 3S16F 5M5XF 5D4CE 2B63E 3S15E 3GTKE 4Q4ZE
chains in the Genus database with same CATH topology
2B63F 3GTOF 4A3EF 3HOXF 3M3YF 2O5IE 3GTQF 4A3BF 4OIQE 3HOYF 4C3HF 4OINE 5IP7F 2A68E 4BY7F 4C3IF 3M4OF 1I50F 4A3JF 2CW0E 1WCMF 2JA5F 3WODE 4G7OE 4A3GF 4JK1E 3H0GF 3CQZF 4XSXE 3S17F 3S1NF 4YFNE 5M5WF 4BBRF 4OIRE 2JA7F 4AYBK 2NVTF 5IYDF 2O5JE 1TWHF 3I4NF 1YNJK 5TMFE 4XLNE 1TWCF 2KRXA 3S15F 2WAQK 4A3CF 4XSZE 3GTKF 4A93F 4Q5SE 2WB1I 3K7AF 4MEXE 1SFOF 3DXJE 4A3IF 3S2DF 4LJZE 4A3KF 4Y7NF 4OIOE 1R9TF 3PO3F 2R7ZF 4MEYE 2NVQF 4BBSF 5E17E 1QKLA 4OIPE 3GTLF 3H3VG 4YG2E 1Y1VF 3RZOF 4X6AF 5E18E 3S14F 2PMZK 5M3FF 5IPLE 3HOVF 1HQME 3RZDF 4C2MF 3HOUF 2Y0SI 3S1RF 2E2IF 4LK1E 2A6EE 4BY1F 2E2JF 3PO2F 4KN7E 3EQLE 2BE5E 2PPBE 5IP9F 5C4XF 1I6VE 4A3DF 4A3FF 2JA8F 4LLGE 4C3JF 5M5YF 4Y52F 1IW7E 3HOWF 3S1QF 2YU9F 4QIWK 5IYCF 4G7HE 5IYBF 3I4MF 5FJ8F 2NVYF 4A3MF 2VUMF 5TMCE 5C44F 3HOZF 1I6HF 4KMUE 5C4JF 2NVXF 4BXXF 4YFXE 1ZYRE 1TWAF 5C3EF 5M3MF 3GTPF 3FKIF 1Y1WF 1TWFF 5BYHE 2JA6F 2R92F 4MQ9E 4YFKE 1K83F 5D4EE 3S2HF 1TWGF 4A3LF 2R93F 4ZH4E 2A69E 3S1MF 4G7ZE 2E2HF 4GZYE 1I3QF 5FLMF 1SMYE 3HKZK 3GTJF 1YNNK 4LK0E 5D4DE 3GTGF 4XLPE 2A6HE 3GTMF 4KN4E 3S16F 5M5XF 5D4CE 4Q4ZE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2B63 F;  3GTO F;  4A3E F;  3HOX F;  3M3Y F;  2O5I E;  3GTQ F;  4A3B F;  4OIQ E;  3HOY F;  4C3H F;  4OIN E;  5IP7 F;  2A68 E;  4BY7 F;  4C3I F;  3M4O F;  1I50 F;  4A3J F;  2CW0 E;  1WCM F;  2JA5 F;  3WOD E;  4G7O E;  4A3G F;  4JK1 E;  3H0G F;  3CQZ F;  4XSX E;  3S17 F;  3S1N F;  4YFN E;  5M5W F;  4BBR F;  4OIR E;  2JA7 F;  4AYB K;  2NVT F;  5IYD F;  2O5J E;  1TWH F;  3I4N F;  1YNJ K;  5TMF E;  4XLN E;  1TWC F;  3S15 F;  2WAQ K;  4A3C F;  4XSZ E;  3GTK F;  4A93 F;  4Q5S E;  2WB1 I;  3K7A F;  4MEX E;  1SFO F;  3DXJ E;  4A3I F;  3S2D F;  4LJZ E;  4A3K F;  4Y7N F;  4OIO E;  1R9T F;  3PO3 F;  2R7Z F;  4MEY E;  2NVQ F;  4BBS F;  5E17 E;  1QKL A;  4OIP E;  3GTL F;  3H3V G;  4YG2 E;  1Y1V F;  3RZO F;  4X6A F;  5E18 E;  3S14 F;  2PMZ K;  5M3F F;  5IPL E;  3HOV F;  1HQM E;  3RZD F;  4C2M F;  3HOU F;  2Y0S I;  3S1R F;  2E2I F;  4LK1 E;  2A6E E;  4BY1 F;  2E2J F;  3PO2 F;  4KN7 E;  3EQL E;  2BE5 E;  2PPB E;  5IP9 F;  5C4X F;  1I6V E;  4A3D F;  4A3F F;  2JA8 F;  4LLG E;  4C3J F;  5M5Y F;  4Y52 F;  1IW7 E;  3HOW F;  3S1Q F;  2YU9 F;  5IYC F;  4G7H E;  5IYB F;  3I4M F;  5FJ8 F;  2NVY F;  4A3M F;  2VUM F;  5TMC E;  5C44 F;  3HOZ F;  1I6H F;  4KMU E;  5C4J F;  2NVX F;  4BXX F;  4YFX E;  1ZYR E;  1TWA F;  5C3E F;  5M3M F;  3GTP F;  3FKI F;  1Y1W F;  1TWF F;  5BYH E;  2JA6 F;  2R92 F;  4MQ9 E;  4YFK E;  1K83 F;  5D4E E;  3S2H F;  1TWG F;  4A3L F;  2R93 F;  4ZH4 E;  2A69 E;  3S1M F;  4G7Z E;  2E2H F;  4GZY E;  1I3Q F;  5FLM F;  1SMY E;  3HKZ K;  3GTJ F;  1YNN K;  4LK0 E;  5D4D E;  3GTG F;  4XLP E;  2A6H E;  3GTM F;  4KN4 E;  3S16 F;  5M5X F;  5D4C E;  4Q4Z E; 
#chains in the Genus database with same CATH topology
 3GTO E;  4A3E E;  3HOX E;  2B63 F;  3M3Y E;  3K7A E;  4A93 E;  3S2D E;  4GZY E;  4A3B E;  4A3K E;  4A3E F;  3HOX F;  4Y7N E;  3GTO F;  4C3H E;  3HOY E;  3M3Y F;  2O5I E;  4BY7 E;  1I50 E;  3GTQ F;  4A3B F;  4OIQ E;  3PO3 E;  3HOY F;  2Y0S H;  4C3H F;  4OIN E;  5IP7 F;  2A68 E;  4BY7 F;  2R7Z E;  4A3G E;  4C3I F;  3M4O F;  1I50 F;  4A3J F;  3CQZ E;  2CW0 E;  1WCM F;  2JA5 F;  1Y1V E;  3WOD E;  4G7O E;  3RZO E;  3S17 E;  4JK1 E;  4A3G F;  4X6A E;  3H0G F;  3CQZ F;  5M5W E;  2JA7 E;  2WAQ H;  2NVT E;  4XSX E;  5IYD E;  4C2M E;  1TWH E;  3RZD E;  3I4N E;  3S17 F;  3S1N F;  4YFN E;  5M5W F;  4BBR F;  4OIR E;  1TWC E;  2JA7 F;  4AYB K;  2NVT F;  5IYD F;  2O5J E;  1TWH F;  3I4N F;  1YNJ K;  4A3C E;  5TMF E;  4XLN E;  1TWC F;  2KRX A;  3S15 F;  2WAQ K;  1SFO E;  1EIK A;  4A3C F;  4XSZ E;  4A3I E;  3GTK F;  4A93 F;  4Q5S E;  4A3F E;  2WB1 I;  3K7A F;  4MEX E;  1SFO F;  3DXJ E;  4A3I F;  3S2D F;  1R9T E;  4LJZ E;  4A3K F;  4Y7N F;  4OIO E;  2PMZ H;  2NVQ E;  4BBS E;  1R9T F;  3PO3 F;  2YU9 E;  3GTL E;  5IYC E;  2R7Z F;  4MEY E;  2NVQ F;  4BBS F;  5E17 E;  3S14 E;  1QKL A;  5M3F E;  4OIP E;  3HOV E;  3GTL F;  3H3V G;  4YG2 E;  1Y1V F;  3HOZ E;  3RZO F;  4X6A F;  5E18 E;  1I6H E;  3HOU E;  3S14 F;  2PMZ K;  5M3F F;  3S1R E;  3HOV F;  1HQM E;  5IPL E;  2E2I E;  5M3M E;  3PO2 E;  3RZD F;  4C2M F;  2E2J E;  4BY1 E;  3GTP E;  3HOU F;  2Y0S I;  3S1R F;  2E2I F;  4LK1 E;  2A6E E;  4BY1 F;  2E2J F;  3PO2 F;  5C4X E;  5IP9 E;  3S2H E;  2R93 E;  4KN7 E;  4A3D E;  2E2H E;  3EQL E;  2BE5 E;  3GTJ E;  2JA8 E;  2PPB E;  5IP9 F;  5C4X F;  1DZF A;  1I6V E;  4QIW H;  4A3D F;  4A3F F;  3GTM E;  2JA8 F;  4C3J E;  5M5Y E;  4Y52 E;  5M5X E;  3HOW E;  3S1Q E;  3I4M E;  5IYB E;  4LLG E;  5FJ8 E;  4C3J F;  2NVY E;  5M5Y F;  4Y52 F;  4A3M E;  2VUM E;  1IW7 E;  3HOW F;  3S1Q F;  2YU9 F;  4QIW K;  5IYC F;  5C44 E;  5IYB F;  4G7H E;  3I4M F;  5FJ8 F;  5C4J E;  2NVY F;  4A3M F;  2NVX E;  2VUM F;  5TMC E;  4BXX E;  1TWA E;  5C44 F;  5C3E E;  3HOZ F;  1I6H F;  4KMU E;  3FKI E;  5C4J F;  1Y1W E;  3GTQ E;  2NVX F;  4BXX F;  4YFX E;  1ZYR E;  1TWF E;  1TWA F;  5C3E F;  5IP7 E;  3HKZ H;  5M3M F;  2JA6 E;  4C3I E;  3M4O E;  3GTP F;  3FKI F;  4A3J E;  1K83 E;  1Y1W F;  4A3L E;  1TWG E;  2R92 E;  1WCM E;  3H3V F;  1TWF F;  5BYH E;  2JA5 E;  3S1M E;  2JA6 F;  1I3Q E;  3H0G E;  5FLM E;  4MQ9 E;  4YFK E;  1K83 F;  4AYB H;  5D4E E;  1TWG F;  2R92 F;  3S2H F;  4ZH4 E;  2A69 E;  3GTG E;  4A3L F;  2R93 F;  3S1M F;  4G7Z E;  2E2H F;  2WB1 H;  1I3Q F;  5FLM F;  1SMY E;  3HKZ K;  3GTJ F;  3S16 E;  4BBR E;  3S1N E;  1YNN K;  4LK0 E;  5D4D E;  3GTG F;  4XLP E;  2A6H E;  3GTM F;  4KN4 E;  3S16 F;  5M5X F;  5D4C E;  2B63 E;  3S15 E;  3GTK E;  4Q4Z E; 
#chains in the Genus database with same CATH homology
 2B63 F;  3GTO F;  4A3E F;  3HOX F;  3M3Y F;  2O5I E;  3GTQ F;  4A3B F;  4OIQ E;  3HOY F;  4C3H F;  4OIN E;  5IP7 F;  2A68 E;  4BY7 F;  4C3I F;  3M4O F;  1I50 F;  4A3J F;  2CW0 E;  1WCM F;  2JA5 F;  3WOD E;  4G7O E;  4A3G F;  4JK1 E;  3H0G F;  3CQZ F;  4XSX E;  3S17 F;  3S1N F;  4YFN E;  5M5W F;  4BBR F;  4OIR E;  2JA7 F;  4AYB K;  2NVT F;  5IYD F;  2O5J E;  1TWH F;  3I4N F;  1YNJ K;  5TMF E;  4XLN E;  1TWC F;  2KRX A;  3S15 F;  2WAQ K;  4A3C F;  4XSZ E;  3GTK F;  4A93 F;  4Q5S E;  2WB1 I;  3K7A F;  4MEX E;  1SFO F;  3DXJ E;  4A3I F;  3S2D F;  4LJZ E;  4A3K F;  4Y7N F;  4OIO E;  1R9T F;  3PO3 F;  2R7Z F;  4MEY E;  2NVQ F;  4BBS F;  5E17 E;  1QKL A;  4OIP E;  3GTL F;  3H3V G;  4YG2 E;  1Y1V F;  3RZO F;  4X6A F;  5E18 E;  3S14 F;  2PMZ K;  5M3F F;  5IPL E;  3HOV F;  1HQM E;  3RZD F;  4C2M F;  3HOU F;  2Y0S I;  3S1R F;  2E2I F;  4LK1 E;  2A6E E;  4BY1 F;  2E2J F;  3PO2 F;  4KN7 E;  3EQL E;  2BE5 E;  2PPB E;  5IP9 F;  5C4X F;  1I6V E;  4A3D F;  4A3F F;  2JA8 F;  4LLG E;  4C3J F;  5M5Y F;  4Y52 F;  1IW7 E;  3HOW F;  3S1Q F;  2YU9 F;  4QIW K;  5IYC F;  4G7H E;  5IYB F;  3I4M F;  5FJ8 F;  2NVY F;  4A3M F;  2VUM F;  5TMC E;  5C44 F;  3HOZ F;  1I6H F;  4KMU E;  5C4J F;  2NVX F;  4BXX F;  4YFX E;  1ZYR E;  1TWA F;  5C3E F;  5M3M F;  3GTP F;  3FKI F;  1Y1W F;  1TWF F;  5BYH E;  2JA6 F;  2R92 F;  4MQ9 E;  4YFK E;  1K83 F;  5D4E E;  3S2H F;  1TWG F;  4A3L F;  2R93 F;  4ZH4 E;  2A69 E;  3S1M F;  4G7Z E;  2E2H F;  4GZY E;  1I3Q F;  5FLM F;  1SMY E;  3HKZ K;  3GTJ F;  1YNN K;  4LK0 E;  5D4D E;  3GTG F;  4XLP E;  2A6H E;  3GTM F;  4KN4 E;  3S16 F;  5M5X F;  5D4C E;  4Q4Z E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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