2A6EE

Crystal structure of the t. thermophilus rna polymerase holoenzyme
Total Genus 18
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
18
sequence length
95
structure length
95
Chain Sequence
AEPGIDKLFGMVDSKYRLTVVVAKRAQQLLRHGFKNTVLEPEERPKMQTLEGLFDDPNAETWAMKELLTGRLVFGENLVPEDRLQKEMERIYPGE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
pubmed doi rcsb
molecule tags Transferase
molecule keywords DNA-directed RNA polymerase alpha chain
total genus 18
structure length 95
sequence length 95
chains with identical sequence O
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2005-07-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 2a6eE00
2A6EE 4LJZE 4ZH4E 3S1QF 2JA6F 3EQLE 4LLGE 4BY1F 4XLNE 5IP7F 4OIOE 5E17E 4OINE 3S2DF 3S1NF 2YU9F 5M3FF 3I4MF 1I6HF 3GTPF 4A93F 2NVYF 5IYBF 4MEXE 4LK0E 3M3YF 3S1RF 1Y1VF 4A3JF 5M3MF 2BE5E 4XLPE 3K7AF 4A3EF 1K83F 3WODE 2CW0E 1SMYE 1IW7E 3M4OF 3PO2F 2B63F 3I4NF 1WCMF 4BBRF 4A3LF 4BY7F 4G7OE 3H3VG 4Q4ZE 5D4EE 4G7ZE 3S17F 1SFOF 4OIQE 3HOWF 5M5YF 5IPLE 2R7ZF 4GZYE 3GTJF 4A3GF 1I50F 5M5XF 4A3IF 2A6HE 4MQ9E 4Y7NF 3HKZK 3HOXF 2E2IF 3GTLF 4Q5SE 5IYCF 3DXJE 3GTQF 2O5JE 2NVXF 5C4XF 5FLMF 4YFNE 2WAQK 4YG2E 3GTOF 4C3IF 1YNNK 4KN7E 1HQME 2PMZK 4XSZE 4AYBK 5IP9F 4Y52F 2E2JF 5TMCE 1TWAF 2JA5F 3HOVF 1TWFF 2E2HF 3S15F 3S14F 5BYHE 4A3MF 3HOYF 1QKLA 5FJ8F 3RZDF 4OIRE 1YNJK 4C3HF 5M5WF 4A3BF 2JA7F 3FKIF 2VUMF 3S2HF 4A3FF 3GTGF 4KN4E 4BXXF 4C2MF 1I6VE 4YFKE 4A3DF 5C3EF 2PPBE 2O5IE 3CQZF 5D4DE 1TWGF 5TMFE 3HOZF 1Y1WF 2Y0SI 5C4JF 3HOUF 5IYDF 1ZYRE 5E18E 2NVQF 2A69E 4JK1E 2R93F 4MEYE 2WB1I 4C3JF 1R9TF 3S16F 1I3QF 5D4CE 3GTMF 4X6AF 4A3CF 2JA8F 1TWHF 4XSXE 4BBSF 3S1MF 4OIPE 4KMUE 5C44F 4A3KF 3GTKF 1TWCF 4YFXE 2A68E 4G7HE 3H0GF 2R92F 3PO3F 3RZOF 4LK1E 2NVTF
chains in the Genus database with same CATH superfamily
3HOXE 3GTQE 2A6EE 4LJZE 5C4XE 4C2ME 2NVXE 4A3DE 5C3EE 3HOYE 4ZH4E 3CQZE 5FLME 1TWGE 3GTOE 3S1QF 1Y1WE 2JA6F 3EQLE 4LLGE 4BY1F 4XLNE 5IP7F 4OIOE 5E17E 4OINE 3S2DF 5IYDE 3S1NF 2YU9F 5M3FF 2JA5E 3I4MF 1I6HF 3GTPF 2R93E 4A93F 2NVYF 5IYBF 4MEXE 4LK0E 4C3JE 3S1RF 1Y1VF 4A3JF 5M3MF 3M3YF 2BE5E 4XLPE 3GTLF 3K7AF 4A3EF 1K83F 3WODE 3S16E 3GTME 2CW0E 1SMYE 1IW7E 3M4OF 4A3CE 3PO2F 4C3HE 1TWHE 2O5JE 2B63F 3I4NF 1WCMF 4BBRF 3S1ME 4A3BE 2JA7E 3S2HE 5C44E 4A3FE 3GTGE 3GTKE 4A3LF 1TWCE 4BY7F 4G7OE 2R92E 3PO3E 3H3VG 4Q4ZE 3RZOE 5D4EE 4G7ZE 3S17F 1SFOF 3HOZE 4OIQE 3HOWF 5C4JE 5M5YF 3HOUE 1DZFA 5IPLE 2R7ZF 4GZYE 3GTJF 4A3GF 3HKZH 2NVQE 3S1QE 1I50F 4BY1E 5IP7E 2WAQH 5M5XF 3S2DE 4A3IF 2A6HE 4MQ9E 3H3VF 4Y7NF 3HKZK 3HOXF 2E2IF 2YU9E 2PMZH 4Q5SE 3DXJE 5IYCF 5M3FE 2NVXF 4AYBH 3GTQF 1R9TE 3GTPE 1I3QE 5FLMF 2NVYE 2WAQK 4YG2E 4YFNE 4X6AE 3GTOF 4C3IF 1YNNK 4KN7E 1Y1VE 4A3JE 5M3ME 1HQME 2PMZK 2WB1H 3S1RE 4XSZE 2JA8E 4BBSE 5IP9F 4AYBK 4A3EE 1K83E 4Y52F 4A3KE 5TMCE 1TWAF 2E2JF 2JA5F 3PO2E 3HOVF 1TWFF 3H0GE 1WCME 4A3LE 2E2HF 2NVTE 4BY7E 3S15F 3S14F 5BYHE 4A3MF 3HOYF 1QKLA 5FJ8F 3RZDF 4OIRE 1YNJK 3I4ME 4C3HF 1SFOE 1EIKA 5M5WF 2JA6E 4A3BF 2Y0SH 2KRXA 3FKIF 2JA7F 2VUMF 4A3FF 3GTGF 4KN4E 3S2HF 4BXXF 4C2MF 1I6VE 1I50E 4YFKE 5C3EF 2PPBE 4A3DF 4A93E 2O5IE 3CQZF 5IYBE 1I6HE 5D4DE 1TWGF 5TMFE 4A3IE 3HOZF 3M3YE 1Y1WF 2Y0SI 4Y7NE 2E2IE 5C4JF 3GTLE 3HOUF 5IYCE 4QIWH 3K7AE 5IYDF 1ZYRE 5E18E 2NVQF 4C3IE 3M4OE 2A69E 4JK1E 2R93F 4QIWK 5IP9E 2B63E 4MEYE 4BBRE 3I4NE 2WB1I 4C3JF 4Y52E 2E2JE 1TWAE 3HOVE 1R9TF 1TWFE 1I3QF 5D4CE 3S16F 3GTMF 4X6AF 4A3CF 2JA8F 2E2HE 1TWHF 4XSXE 3S17E 4BBSF 3S15E 3S14E 3HOWE 3S1MF 5M5YE 4BXXE 4OIPE 4A3ME 4KMUE 5C44F 4A3KF 5FJ8E 3RZDE 1TWCF 2R7ZE 3GTKF 4YFXE 3GTJE 4A3GE 2A68E 4G7HE 3S1NE 3H0GF 2R92F 5M5WE 3PO3F 5C4XF 3RZOF 3FKIE 4LK1E 5M5XE 2VUME 2NVTF
chains in the Genus database with same CATH topology
2A6EE 4LJZE 4ZH4E 3S1QF 2JA6F 3EQLE 4LLGE 4BY1F 4XLNE 5IP7F 4OIOE 5E17E 4OINE 3S2DF 3S1NF 2YU9F 5M3FF 3I4MF 1I6HF 3GTPF 4A93F 2NVYF 5IYBF 4MEXE 4LK0E 3M3YF 3S1RF 1Y1VF 4A3JF 5M3MF 2BE5E 4XLPE 3K7AF 4A3EF 1K83F 3WODE 2CW0E 1SMYE 1IW7E 3M4OF 3PO2F 2B63F 3I4NF 1WCMF 4BBRF 4A3LF 4BY7F 4G7OE 3H3VG 4Q4ZE 5D4EE 4G7ZE 3S17F 1SFOF 4OIQE 3HOWF 5M5YF 5IPLE 2R7ZF 4GZYE 3GTJF 4A3GF 1I50F 5M5XF 4A3IF 2A6HE 4MQ9E 4Y7NF 3HKZK 3HOXF 2E2IF 3GTLF 4Q5SE 5IYCF 3DXJE 3GTQF 2O5JE 2NVXF 5C4XF 5FLMF 4YFNE 2WAQK 4YG2E 3GTOF 4C3IF 1YNNK 4KN7E 1HQME 2PMZK 4XSZE 4AYBK 5IP9F 4Y52F 2E2JF 5TMCE 1TWAF 2JA5F 3HOVF 1TWFF 2E2HF 3S15F 3S14F 5BYHE 4A3MF 3HOYF 1QKLA 5FJ8F 3RZDF 4OIRE 1YNJK 4C3HF 5M5WF 4A3BF 2KRXA 3FKIF 2JA7F 2VUMF 4A3FF 3GTGF 4KN4E 3S2HF 4BXXF 4C2MF 1I6VE 4YFKE 4A3DF 5C3EF 2PPBE 2O5IE 3CQZF 5D4DE 1TWGF 5TMFE 3HOZF 1Y1WF 2Y0SI 5C4JF 3HOUF 5IYDF 1ZYRE 5E18E 2NVQF 2A69E 4JK1E 2R93F 4QIWK 4MEYE 2WB1I 4C3JF 1R9TF 3S16F 1I3QF 5D4CE 3GTMF 4X6AF 4A3CF 2JA8F 1TWHF 4XSXE 4BBSF 3S1MF 4OIPE 4KMUE 5C44F 4A3KF 3GTKF 1TWCF 4YFXE 2A68E 4G7HE 3H0GF 2R92F 3PO3F 3RZOF 4LK1E 2NVTF
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2A6E E;  4LJZ E;  4ZH4 E;  3S1Q F;  2JA6 F;  3EQL E;  4LLG E;  4BY1 F;  4XLN E;  5IP7 F;  4OIO E;  5E17 E;  4OIN E;  3S2D F;  3S1N F;  2YU9 F;  5M3F F;  3I4M F;  1I6H F;  3GTP F;  4A93 F;  2NVY F;  5IYB F;  4MEX E;  4LK0 E;  3M3Y F;  3S1R F;  1Y1V F;  4A3J F;  5M3M F;  2BE5 E;  4XLP E;  3K7A F;  4A3E F;  1K83 F;  3WOD E;  2CW0 E;  1SMY E;  1IW7 E;  3M4O F;  3PO2 F;  2B63 F;  3I4N F;  1WCM F;  4BBR F;  4A3L F;  4BY7 F;  4G7O E;  3H3V G;  4Q4Z E;  5D4E E;  4G7Z E;  3S17 F;  1SFO F;  4OIQ E;  3HOW F;  5M5Y F;  5IPL E;  2R7Z F;  4GZY E;  3GTJ F;  4A3G F;  1I50 F;  5M5X F;  4A3I F;  2A6H E;  4MQ9 E;  4Y7N F;  3HKZ K;  3HOX F;  2E2I F;  3GTL F;  4Q5S E;  5IYC F;  3DXJ E;  3GTQ F;  2O5J E;  2NVX F;  5C4X F;  5FLM F;  4YFN E;  2WAQ K;  4YG2 E;  3GTO F;  4C3I F;  1YNN K;  4KN7 E;  1HQM E;  2PMZ K;  4XSZ E;  4AYB K;  5IP9 F;  4Y52 F;  2E2J F;  5TMC E;  1TWA F;  2JA5 F;  3HOV F;  1TWF F;  2E2H F;  3S15 F;  3S14 F;  5BYH E;  4A3M F;  3HOY F;  1QKL A;  5FJ8 F;  3RZD F;  4OIR E;  1YNJ K;  4C3H F;  5M5W F;  4A3B F;  2JA7 F;  3FKI F;  2VUM F;  3S2H F;  4A3F F;  3GTG F;  4KN4 E;  4BXX F;  4C2M F;  1I6V E;  4YFK E;  4A3D F;  5C3E F;  2PPB E;  2O5I E;  3CQZ F;  5D4D E;  1TWG F;  5TMF E;  3HOZ F;  1Y1W F;  2Y0S I;  5C4J F;  3HOU F;  5IYD F;  1ZYR E;  5E18 E;  2NVQ F;  2A69 E;  4JK1 E;  2R93 F;  4MEY E;  2WB1 I;  4C3J F;  1R9T F;  3S16 F;  1I3Q F;  5D4C E;  3GTM F;  4X6A F;  4A3C F;  2JA8 F;  1TWH F;  4XSX E;  4BBS F;  3S1M F;  4OIP E;  4KMU E;  5C44 F;  4A3K F;  3GTK F;  1TWC F;  4YFX E;  2A68 E;  4G7H E;  3H0G F;  2R92 F;  3PO3 F;  3RZO F;  4LK1 E;  2NVT F; 
#chains in the Genus database with same CATH topology
 3HOX E;  3GTQ E;  2A6E E;  4LJZ E;  5C4X E;  4C2M E;  2NVX E;  4A3D E;  5C3E E;  3HOY E;  4ZH4 E;  3CQZ E;  5FLM E;  1TWG E;  3GTO E;  3S1Q F;  1Y1W E;  2JA6 F;  3EQL E;  4LLG E;  4BY1 F;  4XLN E;  5IP7 F;  4OIO E;  5E17 E;  4OIN E;  3S2D F;  5IYD E;  3S1N F;  2YU9 F;  5M3F F;  2JA5 E;  3I4M F;  1I6H F;  3GTP F;  2R93 E;  4A93 F;  2NVY F;  5IYB F;  4MEX E;  4LK0 E;  4C3J E;  3S1R F;  1Y1V F;  4A3J F;  5M3M F;  3M3Y F;  2BE5 E;  4XLP E;  3GTL F;  3K7A F;  4A3E F;  1K83 F;  3WOD E;  3S16 E;  3GTM E;  2CW0 E;  1SMY E;  1IW7 E;  3M4O F;  4A3C E;  3PO2 F;  4C3H E;  1TWH E;  2O5J E;  2B63 F;  3I4N F;  1WCM F;  4BBR F;  3S1M E;  4A3B E;  2JA7 E;  3S2H E;  5C44 E;  4A3F E;  3GTG E;  3GTK E;  4A3L F;  1TWC E;  4BY7 F;  4G7O E;  2R92 E;  3PO3 E;  3H3V G;  4Q4Z E;  3RZO E;  5D4E E;  4G7Z E;  3S17 F;  1SFO F;  3HOZ E;  4OIQ E;  3HOW F;  5C4J E;  5M5Y F;  3HOU E;  1DZF A;  5IPL E;  2R7Z F;  4GZY E;  3GTJ F;  4A3G F;  3HKZ H;  2NVQ E;  3S1Q E;  1I50 F;  4BY1 E;  5IP7 E;  2WAQ H;  5M5X F;  3S2D E;  4A3I F;  2A6H E;  4MQ9 E;  3H3V F;  4Y7N F;  3HKZ K;  3HOX F;  2E2I F;  2YU9 E;  2PMZ H;  4Q5S E;  3DXJ E;  5IYC F;  5M3F E;  2NVX F;  4AYB H;  3GTQ F;  1R9T E;  3GTP E;  1I3Q E;  5FLM F;  2NVY E;  2WAQ K;  4YG2 E;  4YFN E;  4X6A E;  3GTO F;  4C3I F;  1YNN K;  4KN7 E;  1Y1V E;  4A3J E;  5M3M E;  1HQM E;  2PMZ K;  2WB1 H;  3S1R E;  4XSZ E;  2JA8 E;  4BBS E;  5IP9 F;  4AYB K;  4A3E E;  1K83 E;  4Y52 F;  4A3K E;  5TMC E;  1TWA F;  2E2J F;  2JA5 F;  3PO2 E;  3HOV F;  1TWF F;  3H0G E;  1WCM E;  4A3L E;  2E2H F;  2NVT E;  4BY7 E;  3S15 F;  3S14 F;  5BYH E;  4A3M F;  3HOY F;  1QKL A;  5FJ8 F;  3RZD F;  4OIR E;  1YNJ K;  3I4M E;  4C3H F;  1SFO E;  1EIK A;  5M5W F;  2JA6 E;  4A3B F;  2Y0S H;  2KRX A;  3FKI F;  2JA7 F;  2VUM F;  4A3F F;  3GTG F;  4KN4 E;  3S2H F;  4BXX F;  4C2M F;  1I6V E;  1I50 E;  4YFK E;  5C3E F;  2PPB E;  4A3D F;  4A93 E;  2O5I E;  3CQZ F;  5IYB E;  1I6H E;  5D4D E;  1TWG F;  5TMF E;  4A3I E;  3HOZ F;  3M3Y E;  1Y1W F;  2Y0S I;  4Y7N E;  2E2I E;  5C4J F;  3GTL E;  3HOU F;  5IYC E;  4QIW H;  3K7A E;  5IYD F;  1ZYR E;  5E18 E;  2NVQ F;  4C3I E;  3M4O E;  2A69 E;  4JK1 E;  2R93 F;  4QIW K;  5IP9 E;  2B63 E;  4MEY E;  4BBR E;  3I4N E;  2WB1 I;  4C3J F;  4Y52 E;  2E2J E;  1TWA E;  3HOV E;  1R9T F;  1TWF E;  1I3Q F;  5D4C E;  3S16 F;  3GTM F;  4X6A F;  4A3C F;  2JA8 F;  2E2H E;  1TWH F;  4XSX E;  3S17 E;  4BBS F;  3S15 E;  3S14 E;  3HOW E;  3S1M F;  5M5Y E;  4BXX E;  4OIP E;  4A3M E;  4KMU E;  5C44 F;  4A3K F;  5FJ8 E;  3RZD E;  1TWC F;  2R7Z E;  3GTK F;  4YFX E;  3GTJ E;  4A3G E;  2A68 E;  4G7H E;  3S1N E;  3H0G F;  2R92 F;  5M5W E;  3PO3 F;  5C4X F;  3RZO F;  3FKI E;  4LK1 E;  5M5X E;  2VUM E;  2NVT F; 
#chains in the Genus database with same CATH homology
 2A6E E;  4LJZ E;  4ZH4 E;  3S1Q F;  2JA6 F;  3EQL E;  4LLG E;  4BY1 F;  4XLN E;  5IP7 F;  4OIO E;  5E17 E;  4OIN E;  3S2D F;  3S1N F;  2YU9 F;  5M3F F;  3I4M F;  1I6H F;  3GTP F;  4A93 F;  2NVY F;  5IYB F;  4MEX E;  4LK0 E;  3M3Y F;  3S1R F;  1Y1V F;  4A3J F;  5M3M F;  2BE5 E;  4XLP E;  3K7A F;  4A3E F;  1K83 F;  3WOD E;  2CW0 E;  1SMY E;  1IW7 E;  3M4O F;  3PO2 F;  2B63 F;  3I4N F;  1WCM F;  4BBR F;  4A3L F;  4BY7 F;  4G7O E;  3H3V G;  4Q4Z E;  5D4E E;  4G7Z E;  3S17 F;  1SFO F;  4OIQ E;  3HOW F;  5M5Y F;  5IPL E;  2R7Z F;  4GZY E;  3GTJ F;  4A3G F;  1I50 F;  5M5X F;  4A3I F;  2A6H E;  4MQ9 E;  4Y7N F;  3HKZ K;  3HOX F;  2E2I F;  3GTL F;  4Q5S E;  5IYC F;  3DXJ E;  3GTQ F;  2O5J E;  2NVX F;  5C4X F;  5FLM F;  4YFN E;  2WAQ K;  4YG2 E;  3GTO F;  4C3I F;  1YNN K;  4KN7 E;  1HQM E;  2PMZ K;  4XSZ E;  4AYB K;  5IP9 F;  4Y52 F;  2E2J F;  5TMC E;  1TWA F;  2JA5 F;  3HOV F;  1TWF F;  2E2H F;  3S15 F;  3S14 F;  5BYH E;  4A3M F;  3HOY F;  1QKL A;  5FJ8 F;  3RZD F;  4OIR E;  1YNJ K;  4C3H F;  5M5W F;  4A3B F;  2KRX A;  3FKI F;  2JA7 F;  2VUM F;  4A3F F;  3GTG F;  4KN4 E;  3S2H F;  4BXX F;  4C2M F;  1I6V E;  4YFK E;  4A3D F;  5C3E F;  2PPB E;  2O5I E;  3CQZ F;  5D4D E;  1TWG F;  5TMF E;  3HOZ F;  1Y1W F;  2Y0S I;  5C4J F;  3HOU F;  5IYD F;  1ZYR E;  5E18 E;  2NVQ F;  2A69 E;  4JK1 E;  2R93 F;  4QIW K;  4MEY E;  2WB1 I;  4C3J F;  1R9T F;  3S16 F;  1I3Q F;  5D4C E;  3GTM F;  4X6A F;  4A3C F;  2JA8 F;  1TWH F;  4XSX E;  4BBS F;  3S1M F;  4OIP E;  4KMU E;  5C44 F;  4A3K F;  3GTK F;  1TWC F;  4YFX E;  2A68 E;  4G7H E;  3H0G F;  2R92 F;  3PO3 F;  3RZO F;  4LK1 E;  2NVT F; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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