2BE5E

Crystal structure of the t. thermophilus rna polymerase holoenzyme in complex with inhibitor tagetitoxin
Total Genus 20
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
20
sequence length
95
structure length
95
Chain Sequence
AEPGIDKLFGMVDSKYRLTVVVAKRAQQLLRHGFKNTVLEPEERPKMQTLEGLFDDPNAETWAMKELLTGRLVFGENLVPEDRLQKEMERIYPGE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for transcription inhibition by tagetitoxin
pubmed doi rcsb
molecule tags Transferase
molecule keywords DNA-directed RNA polymerase alpha chain
total genus 20
structure length 95
sequence length 95
chains with identical sequence O
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2005-10-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 2be5E00
4XLPE 1YNNK 4C3IF 2R7ZF 3GTLF 3HOUF 2Y0SI 1YNJK 2NVTF 4MQ9E 3S14F 4A3DF 4JK1E 1I3QF 1ZYRE 4A3MF 3S2HF 4C2MF 4Y52F 5C44F 1SMYE 2WB1I 3WODE 4OIQE 2A6EE 4YFNE 2JA5F 3S2DF 4C3HF 3M3YF 4KN4E 1HQME 5TMFE 3S1QF 3PO2F 4BXXF 2A69E 3HOXF 4LLGE 2O5IE 4Y7NF 3EQLE 3K7AF 4A3KF 4BBSF 4A3GF 2CW0E 5BYHE 5IPLE 2YU9F 2A68E 4G7ZE 3S1MF 1Y1WF 1K83F 5IP7F 2B63F 5M3FF 1I6VE 5D4DE 4YFKE 4G7HE 4LK1E 4A3CF 1I6HF 5TMCE 3GTOF 2WAQK 4MEYE 4X6AF 2JA8F 1SFOF 5IYBF 5E18E 5C3EF 4YG2E 4GZYE 3S1RF 5IYCF 1TWHF 3HOWF 3S1NF 1TWAF 2NVQF 3HOYF 4KMUE 3S15F 1QKLA 4A3BF 1TWCF 1IW7E 3GTKF 4A3LF 3PO3F 3FKIF 4YFXE 2E2IF 4XLNE 4LK0E 5C4XF 5M5YF 4MEXE 4Q4ZE 3I4MF 2JA6F 3GTPF 4A93F 3HKZK 2NVXF 4OINE 4A3IF 3GTGF 4A3JF 5FLMF 2E2JF 5D4CE 3RZDF 1TWFF 4XSZE 5M5XF 3RZOF 2O5JE 5M3MF 5E17E 5D4EE 1Y1VF 3GTQF 4ZH4E 2VUMF 4LJZE 1I50F 5FJ8F 3H3VG 2PPBE 2BE5E 4BY7F 3I4NF 4G7OE 2NVYF 5IYDF 4A3FF 5IP9F 3H0GF 1WCMF 4OIPE 3DXJE 3CQZF 3GTJF 3HOVF 3S16F 2PMZK 4A3EF 4AYBK 4BBRF 4XSXE 2A6HE 3GTMF 2R92F 2JA7F 4OIOE 5M5WF 1TWGF 4OIRE 1R9TF 4KN7E 4Q5SE 2E2HF 2R93F 4BY1F 5C4JF 3HOZF 4C3JF 3S17F 3M4OF
chains in the Genus database with same CATH superfamily
4XLPE 3GTOE 1YNNK 4C3IF 2R7ZF 3GTLF 3HOUF 4X6AE 2JA8E 3S1QE 2Y0SI 1YNJK 1SFOE 2NVTF 4MQ9E 5C3EE 3PO2E 3S14F 4A3DF 4JK1E 3S1RE 5IYCE 4BXXE 1EIKA 1I3QF 3HOWE 3S1NE 1ZYRE 4A3MF 2NVQE 3S2HF 4C2MF 4Y52F 5C44F 3HOYE 4Y7NE 1SMYE 2KRXA 2WB1I 3WODE 4OIQE 1TWCE 4A3GF 3GTKE 2A6EE 4YFNE 2PMZH 4AYBH 2JA5F 3FKIE 3S2DF 1DZFA 4C3HF 2E2IE 3M3YF 4KN4E 5C4XE 5M5YE 1HQME 5TMFE 3S1QF 3I4ME 2JA6E 4QIWK 3GTPE 3PO2F 4A93E 3GTGE 4BXXF 2A69E 4A3JE 1I6HE 2Y0SH 3RZDE 3HOXF 4LLGE 2O5IE 4Y7NF 3EQLE 3K7AF 4A3KF 4BBSF 5M3ME 2CW0E 5BYHE 5IYBE 5IPLE 5FJ8E 1I50E 2YU9F 3I4NE 1TWHE 2A68E 2NVYE 4G7ZE 4A3FE 2WB1H 1TWAE 5IP9E 1Y1WF 3S1MF 1K83F 3S15E 3H0GE 1WCME 4A3BE 5IP7F 2B63F 5M3FF 1I6VE 5D4DE 4YFKE 4A3LE 4G7HE 4LK1E 3GTJE 3HOVE 3S16E 3PO3E 1I6HF 4A3CF 5TMCE 3GTOF 2WAQK 4MEYE 3GTME 4X6AF 2JA7E 2JA8F 1SFOF 5M5WE 5IYBF 5E18E 5C3EF 4YG2E 2NVXE 3S1RF 4QIWH 5IYCF 4A3IE 1R9TE 4GZYE 2E2HE 5FLME 2E2JE 2R93E 1TWHF 3HOWF 3S1NF 1TWAF 1TWFE 2NVQF 3S17E 3M4OE 3HOYF 4KMUE 5M5XE 1QKLA 3RZOE 3S15F 4C3IE 4A3BF 1TWCF 1Y1VE 1IW7E 3GTLE 3GTKF 3GTQE 2VUME 4A3LF 3PO3F 3FKIF 4YFXE 2E2IF 4XLNE 3S14E 4BY7E 4LK0E 5IYDE 5M5YF 5C4XF 4MEXE 1I3QE 4Q4ZE 3I4MF 2JA6F 3GTPF 4A93F 3HKZK 2NVXF 4C2ME 4A3IF 5C44E 3CQZE 4OINE 3GTGF 3S2HE 4A3JF 5FLMF 2E2JF 4A3EE 5D4CE 4BBRE 3RZDF 1TWFF 4XSZE 2R92E 2WAQH 3S2DE 5M5XF 3RZOF 4C3HE 3M3YE 5M3MF 2O5JE 5D4EE 1Y1VF 3GTQF 5E17E 1TWGE 4ZH4E 2VUMF 4LJZE 1I50F 5FJ8F 3H3VG 2PPBE 2BE5E 4BY7F 5C4JE 4BY1E 2NVYF 3I4NF 3HOZE 4G7OE 5IYDF 4C3JE 5IP9F 4A3FF 3H0GF 2R7ZE 1WCMF 4OIPE 3HOUE 3DXJE 3HOXE 4A3GE 3CQZF 4A3KE 3K7AE 3GTJF 2NVTE 3HOVF 3S16F 2PMZK 4A3EF 4BBSE 4AYBK 4BBRF 4XSXE 4A3CE 4A3DE 2A6HE 3H3VF 3GTMF 2YU9E 2R92F 2JA7F 4OIOE 5M5WF 1TWGF 4A3ME 1Y1WE 4OIRE 1K83E 1R9TF 4KN7E 3S1ME 4Q5SE 4Y52E 3HKZH 2E2HF 2R93F 4BY1F 5IP7E 5C4JF 5M3FE 2B63E 3HOZF 4C3JF 3S17F 2JA5E 3M4OF
chains in the Genus database with same CATH topology
4XLPE 1YNNK 4C3IF 2R7ZF 3GTLF 3HOUF 2Y0SI 1YNJK 2NVTF 4MQ9E 3S14F 4A3DF 4JK1E 1I3QF 1ZYRE 4A3MF 3S2HF 4C2MF 4Y52F 5C44F 1SMYE 2KRXA 2WB1I 3WODE 4OIQE 2A6EE 4YFNE 2JA5F 3S2DF 4C3HF 3M3YF 4KN4E 1HQME 5TMFE 3S1QF 4QIWK 3PO2F 4BXXF 2A69E 3HOXF 4LLGE 2O5IE 4Y7NF 3EQLE 3K7AF 4A3KF 4BBSF 4A3GF 2CW0E 5BYHE 5IPLE 2YU9F 2A68E 4G7ZE 3S1MF 1Y1WF 1K83F 5IP7F 2B63F 5M3FF 1I6VE 5D4DE 4YFKE 4G7HE 4LK1E 4A3CF 1I6HF 5TMCE 3GTOF 2WAQK 4MEYE 4X6AF 2JA8F 1SFOF 5IYBF 5E18E 5C3EF 4YG2E 4GZYE 3S1RF 5IYCF 1TWHF 3HOWF 3S1NF 1TWAF 2NVQF 3HOYF 4KMUE 3S15F 1QKLA 4A3BF 1TWCF 1IW7E 3GTKF 4A3LF 3PO3F 3FKIF 4YFXE 2E2IF 4XLNE 4LK0E 5C4XF 5M5YF 4MEXE 4Q4ZE 3I4MF 2JA6F 3GTPF 4A93F 3HKZK 2NVXF 4OINE 4A3IF 3GTGF 4A3JF 5FLMF 2E2JF 5D4CE 3RZDF 1TWFF 4XSZE 5M5XF 3RZOF 2O5JE 5M3MF 5E17E 5D4EE 1Y1VF 3GTQF 4ZH4E 2VUMF 4LJZE 1I50F 5FJ8F 3H3VG 2PPBE 2BE5E 4BY7F 3I4NF 4G7OE 2NVYF 5IYDF 4A3FF 5IP9F 3H0GF 1WCMF 4OIPE 3DXJE 3CQZF 3GTJF 3HOVF 3S16F 2PMZK 4A3EF 4AYBK 4BBRF 4XSXE 2A6HE 3GTMF 2R92F 2JA7F 4OIOE 5M5WF 1TWGF 4OIRE 1R9TF 4KN7E 4Q5SE 2E2HF 2R93F 4BY1F 5C4JF 3HOZF 4C3JF 3S17F 3M4OF
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4XLP E;  1YNN K;  4C3I F;  2R7Z F;  3GTL F;  3HOU F;  2Y0S I;  1YNJ K;  2NVT F;  4MQ9 E;  3S14 F;  4A3D F;  4JK1 E;  1I3Q F;  1ZYR E;  4A3M F;  3S2H F;  4C2M F;  4Y52 F;  5C44 F;  1SMY E;  2WB1 I;  3WOD E;  4OIQ E;  2A6E E;  4YFN E;  2JA5 F;  3S2D F;  4C3H F;  3M3Y F;  4KN4 E;  1HQM E;  5TMF E;  3S1Q F;  3PO2 F;  4BXX F;  2A69 E;  3HOX F;  4LLG E;  2O5I E;  4Y7N F;  3EQL E;  3K7A F;  4A3K F;  4BBS F;  4A3G F;  2CW0 E;  5BYH E;  5IPL E;  2YU9 F;  2A68 E;  4G7Z E;  3S1M F;  1Y1W F;  1K83 F;  5IP7 F;  2B63 F;  5M3F F;  1I6V E;  5D4D E;  4YFK E;  4G7H E;  4LK1 E;  4A3C F;  1I6H F;  5TMC E;  3GTO F;  2WAQ K;  4MEY E;  4X6A F;  2JA8 F;  1SFO F;  5IYB F;  5E18 E;  5C3E F;  4YG2 E;  4GZY E;  3S1R F;  5IYC F;  1TWH F;  3HOW F;  3S1N F;  1TWA F;  2NVQ F;  3HOY F;  4KMU E;  3S15 F;  1QKL A;  4A3B F;  1TWC F;  1IW7 E;  3GTK F;  4A3L F;  3PO3 F;  3FKI F;  4YFX E;  2E2I F;  4XLN E;  4LK0 E;  5C4X F;  5M5Y F;  4MEX E;  4Q4Z E;  3I4M F;  2JA6 F;  3GTP F;  4A93 F;  3HKZ K;  2NVX F;  4OIN E;  4A3I F;  3GTG F;  4A3J F;  5FLM F;  2E2J F;  5D4C E;  3RZD F;  1TWF F;  4XSZ E;  5M5X F;  3RZO F;  2O5J E;  5M3M F;  5E17 E;  5D4E E;  1Y1V F;  3GTQ F;  4ZH4 E;  2VUM F;  4LJZ E;  1I50 F;  5FJ8 F;  3H3V G;  2PPB E;  2BE5 E;  4BY7 F;  3I4N F;  4G7O E;  2NVY F;  5IYD F;  4A3F F;  5IP9 F;  3H0G F;  1WCM F;  4OIP E;  3DXJ E;  3CQZ F;  3GTJ F;  3HOV F;  3S16 F;  2PMZ K;  4A3E F;  4AYB K;  4BBR F;  4XSX E;  2A6H E;  3GTM F;  2R92 F;  2JA7 F;  4OIO E;  5M5W F;  1TWG F;  4OIR E;  1R9T F;  4KN7 E;  4Q5S E;  2E2H F;  2R93 F;  4BY1 F;  5C4J F;  3HOZ F;  4C3J F;  3S17 F;  3M4O F; 
#chains in the Genus database with same CATH topology
 4XLP E;  3GTO E;  1YNN K;  4C3I F;  2R7Z F;  3GTL F;  3HOU F;  4X6A E;  2JA8 E;  3S1Q E;  2Y0S I;  1YNJ K;  1SFO E;  2NVT F;  4MQ9 E;  5C3E E;  3PO2 E;  3S14 F;  4A3D F;  4JK1 E;  3S1R E;  5IYC E;  4BXX E;  1EIK A;  1I3Q F;  3HOW E;  3S1N E;  1ZYR E;  4A3M F;  2NVQ E;  3S2H F;  4C2M F;  4Y52 F;  5C44 F;  3HOY E;  4Y7N E;  1SMY E;  2KRX A;  2WB1 I;  3WOD E;  4OIQ E;  1TWC E;  4A3G F;  3GTK E;  2A6E E;  4YFN E;  2PMZ H;  4AYB H;  2JA5 F;  3FKI E;  3S2D F;  1DZF A;  4C3H F;  2E2I E;  3M3Y F;  4KN4 E;  5C4X E;  5M5Y E;  1HQM E;  5TMF E;  3S1Q F;  3I4M E;  2JA6 E;  4QIW K;  3GTP E;  3PO2 F;  4A93 E;  3GTG E;  4BXX F;  2A69 E;  4A3J E;  1I6H E;  2Y0S H;  3RZD E;  3HOX F;  4LLG E;  2O5I E;  4Y7N F;  3EQL E;  3K7A F;  4A3K F;  4BBS F;  5M3M E;  2CW0 E;  5BYH E;  5IYB E;  5IPL E;  5FJ8 E;  1I50 E;  2YU9 F;  3I4N E;  1TWH E;  2A68 E;  2NVY E;  4G7Z E;  4A3F E;  2WB1 H;  1TWA E;  5IP9 E;  1Y1W F;  3S1M F;  1K83 F;  3S15 E;  3H0G E;  1WCM E;  4A3B E;  5IP7 F;  2B63 F;  5M3F F;  1I6V E;  5D4D E;  4YFK E;  4A3L E;  4G7H E;  4LK1 E;  3GTJ E;  3HOV E;  3S16 E;  3PO3 E;  1I6H F;  4A3C F;  5TMC E;  3GTO F;  2WAQ K;  4MEY E;  3GTM E;  4X6A F;  2JA7 E;  2JA8 F;  1SFO F;  5M5W E;  5IYB F;  5E18 E;  5C3E F;  4YG2 E;  2NVX E;  3S1R F;  4QIW H;  5IYC F;  4A3I E;  1R9T E;  4GZY E;  2E2H E;  5FLM E;  2E2J E;  2R93 E;  1TWH F;  3HOW F;  3S1N F;  1TWA F;  1TWF E;  2NVQ F;  3S17 E;  3M4O E;  3HOY F;  4KMU E;  5M5X E;  1QKL A;  3RZO E;  3S15 F;  4C3I E;  4A3B F;  1TWC F;  1Y1V E;  1IW7 E;  3GTL E;  3GTK F;  3GTQ E;  2VUM E;  4A3L F;  3PO3 F;  3FKI F;  4YFX E;  2E2I F;  4XLN E;  3S14 E;  4BY7 E;  4LK0 E;  5IYD E;  5M5Y F;  5C4X F;  4MEX E;  1I3Q E;  4Q4Z E;  3I4M F;  2JA6 F;  3GTP F;  4A93 F;  3HKZ K;  2NVX F;  4C2M E;  4A3I F;  5C44 E;  3CQZ E;  4OIN E;  3GTG F;  3S2H E;  4A3J F;  5FLM F;  2E2J F;  4A3E E;  5D4C E;  4BBR E;  3RZD F;  1TWF F;  4XSZ E;  2R92 E;  2WAQ H;  3S2D E;  5M5X F;  3RZO F;  4C3H E;  3M3Y E;  5M3M F;  2O5J E;  5D4E E;  1Y1V F;  3GTQ F;  5E17 E;  1TWG E;  4ZH4 E;  2VUM F;  4LJZ E;  1I50 F;  5FJ8 F;  3H3V G;  2PPB E;  2BE5 E;  4BY7 F;  5C4J E;  4BY1 E;  2NVY F;  3I4N F;  3HOZ E;  4G7O E;  5IYD F;  4C3J E;  5IP9 F;  4A3F F;  3H0G F;  2R7Z E;  1WCM F;  4OIP E;  3HOU E;  3DXJ E;  3HOX E;  4A3G E;  3CQZ F;  4A3K E;  3K7A E;  3GTJ F;  2NVT E;  3HOV F;  3S16 F;  2PMZ K;  4A3E F;  4BBS E;  4AYB K;  4BBR F;  4XSX E;  4A3C E;  4A3D E;  2A6H E;  3H3V F;  3GTM F;  2YU9 E;  2R92 F;  2JA7 F;  4OIO E;  5M5W F;  1TWG F;  4A3M E;  1Y1W E;  4OIR E;  1K83 E;  1R9T F;  4KN7 E;  3S1M E;  4Q5S E;  4Y52 E;  3HKZ H;  2E2H F;  2R93 F;  4BY1 F;  5IP7 E;  5C4J F;  5M3F E;  2B63 E;  3HOZ F;  4C3J F;  3S17 F;  2JA5 E;  3M4O F; 
#chains in the Genus database with same CATH homology
 4XLP E;  1YNN K;  4C3I F;  2R7Z F;  3GTL F;  3HOU F;  2Y0S I;  1YNJ K;  2NVT F;  4MQ9 E;  3S14 F;  4A3D F;  4JK1 E;  1I3Q F;  1ZYR E;  4A3M F;  3S2H F;  4C2M F;  4Y52 F;  5C44 F;  1SMY E;  2KRX A;  2WB1 I;  3WOD E;  4OIQ E;  2A6E E;  4YFN E;  2JA5 F;  3S2D F;  4C3H F;  3M3Y F;  4KN4 E;  1HQM E;  5TMF E;  3S1Q F;  4QIW K;  3PO2 F;  4BXX F;  2A69 E;  3HOX F;  4LLG E;  2O5I E;  4Y7N F;  3EQL E;  3K7A F;  4A3K F;  4BBS F;  4A3G F;  2CW0 E;  5BYH E;  5IPL E;  2YU9 F;  2A68 E;  4G7Z E;  3S1M F;  1Y1W F;  1K83 F;  5IP7 F;  2B63 F;  5M3F F;  1I6V E;  5D4D E;  4YFK E;  4G7H E;  4LK1 E;  4A3C F;  1I6H F;  5TMC E;  3GTO F;  2WAQ K;  4MEY E;  4X6A F;  2JA8 F;  1SFO F;  5IYB F;  5E18 E;  5C3E F;  4YG2 E;  4GZY E;  3S1R F;  5IYC F;  1TWH F;  3HOW F;  3S1N F;  1TWA F;  2NVQ F;  3HOY F;  4KMU E;  3S15 F;  1QKL A;  4A3B F;  1TWC F;  1IW7 E;  3GTK F;  4A3L F;  3PO3 F;  3FKI F;  4YFX E;  2E2I F;  4XLN E;  4LK0 E;  5C4X F;  5M5Y F;  4MEX E;  4Q4Z E;  3I4M F;  2JA6 F;  3GTP F;  4A93 F;  3HKZ K;  2NVX F;  4OIN E;  4A3I F;  3GTG F;  4A3J F;  5FLM F;  2E2J F;  5D4C E;  3RZD F;  1TWF F;  4XSZ E;  5M5X F;  3RZO F;  2O5J E;  5M3M F;  5E17 E;  5D4E E;  1Y1V F;  3GTQ F;  4ZH4 E;  2VUM F;  4LJZ E;  1I50 F;  5FJ8 F;  3H3V G;  2PPB E;  2BE5 E;  4BY7 F;  3I4N F;  4G7O E;  2NVY F;  5IYD F;  4A3F F;  5IP9 F;  3H0G F;  1WCM F;  4OIP E;  3DXJ E;  3CQZ F;  3GTJ F;  3HOV F;  3S16 F;  2PMZ K;  4A3E F;  4AYB K;  4BBR F;  4XSX E;  2A6H E;  3GTM F;  2R92 F;  2JA7 F;  4OIO E;  5M5W F;  1TWG F;  4OIR E;  1R9T F;  4KN7 E;  4Q5S E;  2E2H F;  2R93 F;  4BY1 F;  5C4J F;  3HOZ F;  4C3J F;  3S17 F;  3M4O F; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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