2E2HE

Rna polymerase ii elongation complex at 5 mm mg2+ with gtp
Total Genus 31
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
31
sequence length
213
structure length
193
Chain Sequence
QENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDRPQRKMMSFQANPTEESISKFPDMGSLWVEFTFVIHIQEKNFQTGIFVTPSAMKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
pubmed doi rcsb
molecule tags Transcription,transferase/dna-rna hybrid
molecule keywords 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3'
total genus 31
structure length 193
sequence length 213
ec nomenclature
pdb deposition date 2006-11-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01191 RNA_pol_Rpb5_C RNA polymerase Rpb5, C-terminal domain
E PF03871 RNA_pol_Rpb5_N RNA polymerase Rpb5, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1340.10 Alpha Beta 3-Layer(aba) Sandwich Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1 RNA polymerase, Rpb5, N-terminal domain 2e2hE01
3.90.940.20 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit RPB5-like RNA polymerase subunit 2e2hE02
1TWGE 3GTME 5M5WE 4A3CE 4BY1E 1Y1VE 2WB1H 4X6AE 5FJ8E 1Y1WE 2E2HE 1TWFE 4A3LE 2NVTE 4QIWH 5IP7E 4BY7E 1I6HE 3M4OE 3GTJE 3GTKE 3H3VF 4A3DE 1K83E 3GTGE 3RZDE 5M5YE 1TWCE 2VUME 4A3FE 5IYBE 3S1QE 2JA6E 3I4NE 3S15E 4AYBH 4A3IE 3I4ME 4C2ME 4C3JE 4A93E 2PMZH 4A3BE 3S2HE 5M5XE 3HOZE 4BBSE 1EIKA 3PO3E 4A3EE 3GTPE 2JA7E 1I3QE 3S2DE 3HOUE 3S1NE 3FKIE 2E2IE 3S16E 1WCME 3PO2E 2JA8E 5M3FE 2B63E 2R92E 3HOYE 1TWAE 3S1RE 2NVYE 4BBRE 4C3IE 3S14E 1SFOE 2E2JE 3RZOE 1R9TE 4A3ME 4Y7NE 4C3HE 1I50E 5M3ME 3GTQE 3HOXE 3S17E 3GTOE 5C4XE 3S1ME 2Y0SH 5FLME 5C4JE 3HKZH 1TWHE 4A3GE 4A3KE 2R7ZE 2R93E 3HOWE 3M3YE 2JA5E 2NVXE 3K7AE 3GTLE 3CQZE 1DZFA 5C44E 4BXXE 2YU9E 4Y52E 4A3JE 2WAQH 5IYCE 3HOVE 5C3EE 5IP9E 2NVQE 3H0GE 5IYDE
chains in the Genus database with same CATH superfamily
2E2JF 3HOZF 5D4CE 1TWGE 3RZOF 4OIQE 3GTME 5M5WE 4A3CE 1QKLA 4BY1E 1Y1VE 2WB1H 4A3MF 4OINE 4X6AE 5FJ8E 1Y1WE 4LK0E 2E2HE 4Y7NF 2O5JE 3S2DF 4C3HF 1I50F 1TWFE 4A3LE 5TMCE 4YFXE 3HOXF 3S17F 5BYHE 2E2IF 2NVTE 4MEXE 3GTOF 2CW0E 4QIWH 5C4XF 5IP7E 4BY7E 1I6HE 3M4OE 4LK1E 1WCMF 3S1MF 3GTJE 5FLMF 3GTKE 5C4JF 5D4EE 4XSXE 5M3FF 2A69E 4A3KF 3H3VF 2R7ZF 3HOYF 4A3GF 3M3YF 4A3DE 1K83E 3GTGE 4MEYE 3RZDE 5D4DE 2JA5F 2NVXF 5IPLE 5M5YE 1TWCE 3CQZF 3K7AF 3WODE 5C44F 2VUME 4A3FE 4AYBK 5IYBE 3S1QE 2JA6E 4KN4E 3I4NE 3S15E 4AYBH 4A3IE 3I4ME 2PMZK 1SFOF 3H3VG 4C2ME 4C3JE 4Q5SE 4A93E 1R9TF 2PMZH 4A3BE 1SMYE 4KMUE 3HOVF 3S2HE 3EQLE 5M5XE 2A6HE 3HOZE 2WB1I 4BBSE 5M3MF 4JK1E 3GTQF 5IP9F 3PO3E 1EIKA 4A3EE 3GTPE 2NVQF 3H0GF 5IYDF 5E18E 2JA7E 1TWGF 4ZH4E 3GTMF 1I3QE 4A3CF 4OIOE 3S2DE 4BY1F 1Y1VF 4Q4ZE 1TWHF 2BE5E 3HOUE 2R93F 3HOWF 5FJ8F 3S1NE 3FKIE 2E2IE 4XLNE 3GTLF 2A6EE 4LLGE 1TWFF 3S16E 1WCME 3PO2E 2A68E 4A3LF 4BXXF 2JA8E 4XLPE 2YU9F 2NVTF 5M3FE 2B63E 2R92E 3HOYE 4Y52F 4A3JF 5IP7F 1TWAE 3S1RE 2KRXA 4YG2E 5TMFE 4BY7F 3M4OF 3GTJF 3DXJE 3GTKF 5IYCF 2NVYE 1I6VE 4G7HE 4GZYE 4BBRE 4A3DF 1K83F 5C3EF 4C3IE 3S14E 4LJZE 1SFOE 2E2JE 3RZOE 5M5YF 1TWCF 3GTGF 1R9TE 2VUMF 4A3FF 1ZYRE 5IYBF 3S1QF 4A3ME 3I4NF 3S15F 4A3IF 5M5WF 4C2MF 4Y7NE 4C3JF 4A93F 4YFKE 4C3HE 1I50E 5M3ME 3GTQE 4A3BF 3S2HF 3HOXE 4X6AF 3S17E 3GTOE 1Y1WF 5M5XF 2E2HF 2PPBE 5C4XE 4BBSF 3S1ME 3PO3F 4OIPE 4A3EF 3GTPF 3HKZK 2Y0SH 5FLME 4G7OE 5C4JE 3HKZH 1TWHE 2JA7F 4A3GE 4A3KE 2R7ZE 2Y0SI 2R93E 3HOWE 3M3YE 1I3QF 1I6HF 5E17E 2JA5E 2O5IE 2NVXE 3K7AE 3GTLE 3CQZE 4XSZE 1DZFA 5C44E 4BXXE 4QIWK 3HOUF 2YU9E 3FKIF 3S1NF 4OIRE 3RZDF 4Y52E 4A3JE 1YNJK 1IW7E 1YNNK 1HQME 2WAQK 4YFNE 3S16F 3PO2F 2JA8F 2WAQH 5IYCE 4G7ZE 2B63F 2JA6F 3HOVE 2R92F 1TWAF 4MQ9E 3S1RF 3I4MF 5C3EE 4KN7E 5IP9E 2NVYF 3S14F 2NVQE 4BBRF 3H0GE 4C3IF 5IYDE
chains in the Genus database with same CATH topology
1TWGE 3GTME 5M5WE 4A3CE 4BY1E 1Y1VE 2WB1H 4X6AE 5FJ8E 1Y1WE 2E2HE 1TWFE 4A3LE 2NVTE 4QIWH 5IP7E 4BY7E 1I6HE 3M4OE 3GTJE 3GTKE 3H3VF 4A3DE 1K83E 3GTGE 3RZDE 5M5YE 1TWCE 2VUME 4A3FE 5IYBE 3S1QE 2JA6E 3I4NE 3S15E 4AYBH 4A3IE 3I4ME 4C2ME 4C3JE 4A93E 2PMZH 4A3BE 3S2HE 5M5XE 3HOZE 4BBSE 1EIKA 3PO3E 4A3EE 3GTPE 2JA7E 1I3QE 3S2DE 3HOUE 3S1NE 3FKIE 2E2IE 3S16E 1WCME 3PO2E 2JA8E 5M3FE 2B63E 2R92E 3HOYE 1TWAE 3S1RE 2NVYE 4BBRE 4C3IE 3S14E 1SFOE 2E2JE 3RZOE 1R9TE 4A3ME 4Y7NE 4C3HE 1I50E 5M3ME 3GTQE 3HOXE 3S17E 3GTOE 5C4XE 3S1ME 2Y0SH 5FLME 5C4JE 3HKZH 1TWHE 4A3GE 4A3KE 2R7ZE 2R93E 3HOWE 3M3YE 2JA5E 2NVXE 3K7AE 3GTLE 3CQZE 1DZFA 5C44E 4BXXE 2YU9E 4Y52E 4A3JE 2WAQH 5IYCE 3HOVE 5C3EE 5IP9E 2NVQE 3H0GE 5IYDE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1TWG E;  3GTM E;  5M5W E;  4A3C E;  4BY1 E;  1Y1V E;  2WB1 H;  4X6A E;  5FJ8 E;  1Y1W E;  2E2H E;  1TWF E;  4A3L E;  2NVT E;  4QIW H;  5IP7 E;  4BY7 E;  1I6H E;  3M4O E;  3GTJ E;  3GTK E;  3H3V F;  4A3D E;  1K83 E;  3GTG E;  3RZD E;  5M5Y E;  1TWC E;  2VUM E;  4A3F E;  5IYB E;  3S1Q E;  2JA6 E;  3I4N E;  3S15 E;  4AYB H;  4A3I E;  3I4M E;  4C2M E;  4C3J E;  4A93 E;  2PMZ H;  4A3B E;  3S2H E;  5M5X E;  3HOZ E;  4BBS E;  1EIK A;  3PO3 E;  4A3E E;  3GTP E;  2JA7 E;  1I3Q E;  3S2D E;  3HOU E;  3S1N E;  3FKI E;  2E2I E;  3S16 E;  1WCM E;  3PO2 E;  2JA8 E;  5M3F E;  2B63 E;  2R92 E;  3HOY E;  1TWA E;  3S1R E;  2NVY E;  4BBR E;  4C3I E;  3S14 E;  1SFO E;  2E2J E;  3RZO E;  1R9T E;  4A3M E;  4Y7N E;  4C3H E;  1I50 E;  5M3M E;  3GTQ E;  3HOX E;  3S17 E;  3GTO E;  5C4X E;  3S1M E;  2Y0S H;  5FLM E;  5C4J E;  3HKZ H;  1TWH E;  4A3G E;  4A3K E;  2R7Z E;  2R93 E;  3HOW E;  3M3Y E;  2JA5 E;  2NVX E;  3K7A E;  3GTL E;  3CQZ E;  1DZF A;  5C44 E;  4BXX E;  2YU9 E;  4Y52 E;  4A3J E;  2WAQ H;  5IYC E;  3HOV E;  5C3E E;  5IP9 E;  2NVQ E;  3H0G E;  5IYD E; 
#chains in the Genus database with same CATH topology
 2E2J F;  3HOZ F;  5D4C E;  1TWG E;  3RZO F;  4OIQ E;  3GTM E;  5M5W E;  4A3C E;  1QKL A;  4BY1 E;  1Y1V E;  2WB1 H;  4A3M F;  4OIN E;  4X6A E;  5FJ8 E;  1Y1W E;  4LK0 E;  2E2H E;  4Y7N F;  2O5J E;  3S2D F;  4C3H F;  1I50 F;  1TWF E;  4A3L E;  5TMC E;  4YFX E;  3HOX F;  3S17 F;  5BYH E;  2E2I F;  2NVT E;  4MEX E;  3GTO F;  2CW0 E;  4QIW H;  5C4X F;  5IP7 E;  4BY7 E;  1I6H E;  3M4O E;  4LK1 E;  1WCM F;  3S1M F;  3GTJ E;  5FLM F;  3GTK E;  5C4J F;  5D4E E;  4XSX E;  5M3F F;  2A69 E;  4A3K F;  3H3V F;  2R7Z F;  3HOY F;  4A3G F;  3M3Y F;  4A3D E;  1K83 E;  3GTG E;  4MEY E;  3RZD E;  5D4D E;  2JA5 F;  2NVX F;  5IPL E;  5M5Y E;  1TWC E;  3CQZ F;  3K7A F;  3WOD E;  5C44 F;  2VUM E;  4A3F E;  4AYB K;  5IYB E;  3S1Q E;  2JA6 E;  4KN4 E;  3I4N E;  3S15 E;  4AYB H;  4A3I E;  3I4M E;  2PMZ K;  1SFO F;  3H3V G;  4C2M E;  4C3J E;  4Q5S E;  4A93 E;  1R9T F;  2PMZ H;  4A3B E;  1SMY E;  4KMU E;  3HOV F;  3S2H E;  3EQL E;  5M5X E;  2A6H E;  3HOZ E;  2WB1 I;  4BBS E;  5M3M F;  4JK1 E;  3GTQ F;  5IP9 F;  3PO3 E;  1EIK A;  4A3E E;  3GTP E;  2NVQ F;  3H0G F;  5IYD F;  5E18 E;  2JA7 E;  1TWG F;  4ZH4 E;  3GTM F;  1I3Q E;  4A3C F;  4OIO E;  3S2D E;  4BY1 F;  1Y1V F;  4Q4Z E;  1TWH F;  2BE5 E;  3HOU E;  2R93 F;  3HOW F;  5FJ8 F;  3S1N E;  3FKI E;  2E2I E;  4XLN E;  3GTL F;  2A6E E;  4LLG E;  1TWF F;  3S16 E;  1WCM E;  3PO2 E;  2A68 E;  4A3L F;  4BXX F;  2JA8 E;  4XLP E;  2YU9 F;  2NVT F;  5M3F E;  2B63 E;  2R92 E;  3HOY E;  4Y52 F;  4A3J F;  5IP7 F;  1TWA E;  3S1R E;  2KRX A;  4YG2 E;  5TMF E;  4BY7 F;  3M4O F;  3GTJ F;  3DXJ E;  3GTK F;  5IYC F;  2NVY E;  1I6V E;  4G7H E;  4GZY E;  4BBR E;  4A3D F;  1K83 F;  5C3E F;  4C3I E;  3S14 E;  4LJZ E;  1SFO E;  2E2J E;  3RZO E;  5M5Y F;  1TWC F;  3GTG F;  1R9T E;  2VUM F;  4A3F F;  1ZYR E;  5IYB F;  3S1Q F;  4A3M E;  3I4N F;  3S15 F;  4A3I F;  5M5W F;  4C2M F;  4Y7N E;  4C3J F;  4A93 F;  4YFK E;  4C3H E;  1I50 E;  5M3M E;  3GTQ E;  4A3B F;  3S2H F;  3HOX E;  4X6A F;  3S17 E;  3GTO E;  1Y1W F;  5M5X F;  2E2H F;  2PPB E;  5C4X E;  4BBS F;  3S1M E;  3PO3 F;  4OIP E;  4A3E F;  3GTP F;  3HKZ K;  2Y0S H;  5FLM E;  4G7O E;  5C4J E;  3HKZ H;  1TWH E;  2JA7 F;  4A3G E;  4A3K E;  2R7Z E;  2Y0S I;  2R93 E;  3HOW E;  3M3Y E;  1I3Q F;  1I6H F;  5E17 E;  2JA5 E;  2O5I E;  2NVX E;  3K7A E;  3GTL E;  3CQZ E;  4XSZ E;  1DZF A;  5C44 E;  4BXX E;  4QIW K;  3HOU F;  2YU9 E;  3FKI F;  3S1N F;  4OIR E;  3RZD F;  4Y52 E;  4A3J E;  1YNJ K;  1IW7 E;  1YNN K;  1HQM E;  2WAQ K;  4YFN E;  3S16 F;  3PO2 F;  2JA8 F;  2WAQ H;  5IYC E;  4G7Z E;  2B63 F;  2JA6 F;  3HOV E;  2R92 F;  1TWA F;  4MQ9 E;  3S1R F;  3I4M F;  5C3E E;  4KN7 E;  5IP9 E;  2NVY F;  3S14 F;  2NVQ E;  4BBR F;  3H0G E;  4C3I F;  5IYD E; 
#chains in the Genus database with same CATH homology
 1TWG E;  3GTM E;  5M5W E;  4A3C E;  4BY1 E;  1Y1V E;  2WB1 H;  4X6A E;  5FJ8 E;  1Y1W E;  2E2H E;  1TWF E;  4A3L E;  2NVT E;  4QIW H;  5IP7 E;  4BY7 E;  1I6H E;  3M4O E;  3GTJ E;  3GTK E;  3H3V F;  4A3D E;  1K83 E;  3GTG E;  3RZD E;  5M5Y E;  1TWC E;  2VUM E;  4A3F E;  5IYB E;  3S1Q E;  2JA6 E;  3I4N E;  3S15 E;  4AYB H;  4A3I E;  3I4M E;  4C2M E;  4C3J E;  4A93 E;  2PMZ H;  4A3B E;  3S2H E;  5M5X E;  3HOZ E;  4BBS E;  1EIK A;  3PO3 E;  4A3E E;  3GTP E;  2JA7 E;  1I3Q E;  3S2D E;  3HOU E;  3S1N E;  3FKI E;  2E2I E;  3S16 E;  1WCM E;  3PO2 E;  2JA8 E;  5M3F E;  2B63 E;  2R92 E;  3HOY E;  1TWA E;  3S1R E;  2NVY E;  4BBR E;  4C3I E;  3S14 E;  1SFO E;  2E2J E;  3RZO E;  1R9T E;  4A3M E;  4Y7N E;  4C3H E;  1I50 E;  5M3M E;  3GTQ E;  3HOX E;  3S17 E;  3GTO E;  5C4X E;  3S1M E;  2Y0S H;  5FLM E;  5C4J E;  3HKZ H;  1TWH E;  4A3G E;  4A3K E;  2R7Z E;  2R93 E;  3HOW E;  3M3Y E;  2JA5 E;  2NVX E;  3K7A E;  3GTL E;  3CQZ E;  1DZF A;  5C44 E;  4BXX E;  2YU9 E;  4Y52 E;  4A3J E;  2WAQ H;  5IYC E;  3HOV E;  5C3E E;  5IP9 E;  2NVQ E;  3H0G E;  5IYD E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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