2E2IF

Rna polymerase ii elongation complex in 5 mm mg+2 with 2'-dgtp
Total Genus 17
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
17
sequence length
86
structure length
86
Chain Sequence
KEKAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRIAMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
pubmed doi rcsb
molecule tags Transcription,transferase/dna-rna hybrid
molecule keywords 5'-R(*AP*UP*CP*GP*AP*GP*AP*GP*GP*A)-3'
total genus 17
structure length 86
sequence length 86
ec nomenclature
pdb deposition date 2006-11-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
F PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 2e2iF00
3S15F 4MQ9E 4C3JF 1K83F 2YU9F 2JA7F 3GTGF 2JA6F 4KMUE 3GTMF 4C3HF 3M3YF 4G7ZE 2B63F 2O5IE 4YFKE 3GTOF 4G7HE 3WODE 5C3EF 4XSZE 2NVYF 4JK1E 5M5YF 4A3GF 4KN4E 2NVXF 3GTQF 2WAQK 4A3DF 4XLNE 4LLGE 4YG2E 4BBSF 1TWGF 3HOXF 4Q4ZE 4A3EF 3HOVF 1I3QF 4A3FF 3HOUF 4OIQE 3H0GF 2WB1I 4Q5SE 3S1QF 3S1NF 4GZYE 3M4OF 3HOYF 5D4DE 1IW7E 3FKIF 4OIPE 2E2HF 3S16F 3S17F 2R92F 5D4EE 1I6HF 2E2JF 3HOZF 5M3FF 5D4CE 4Y52F 5C44F 4LJZE 1R9TF 4A3BF 3RZDF 4LK1E 4A3IF 4G7OE 1Y1WF 1SFOF 5C4XF 4XSXE 3HOWF 2R7ZF 3CQZF 3GTLF 2A6EE 2CW0E 1I6VE 1HQME 4OINE 3S1MF 4A3JF 4A93F 3GTPF 1Y1VF 5TMFE 5IYBF 5TMCE 4AYBK 4BBRF 5M3MF 2NVQF 2A6HE 3RZOF 3PO3F 3EQLE 5IYCF 2JA8F 1WCMF 4A3KF 5IPLE 4OIRE 1ZYRE 4ZH4E 1I50F 3PO2F 5M5WF 4X6AF 3K7AF 1QKLA 1TWFF 4C2MF 4A3LF 4BXXF 1TWHF 2A69E 5FJ8F 4KN7E 3I4MF 2NVTF 5M5XF 2E2IF 3S2HF 4YFNE 4MEXE 2BE5E 2Y0SI 2O5JE 3GTJF 3S2DF 4BY1F 4MEYE 2R93F 3S1RF 4Y7NF 2JA5F 3I4NF 5IYDF 3GTKF 1YNJK 2VUMF 5IP7F 3S14F 3H3VG 2A68E 3DXJE 5E18E 1SMYE 3HKZK 4LK0E 5FLMF 5BYHE 1TWCF 5IP9F 4OIOE 4BY7F 5C4JF 1YNNK 4A3CF 1TWAF 2PPBE 4YFXE 4A3MF 2PMZK 4C3IF 5E17E 4XLPE
chains in the Genus database with same CATH superfamily
3PO2E 3S15F 4X6AE 4MQ9E 4C3JF 1K83F 1TWFE 4C2ME 2YU9F 4QIWH 2JA7F 3GTGF 2JA6F 1TWHE 4KMUE 4A3LE 4A3CE 2WAQH 3GTMF 3I4ME 4C3HF 2NVTE 5M5XE 2E2IE 3S2HE 3M3YF 4G7ZE 2B63F 2O5IE 4YFKE 3GTOF 4G7HE 3WODE 5C3EF 4BY1E 3S2DE 4XSZE 2PMZH 2NVYF 4JK1E 5M5YF 4C3JE 3S1RE 4KN4E 4A3GF 2NVXF 3GTQF 2WAQK 3GTGE 3I4NE 4A3DF 4XLNE 5IYDE 3GTKE 4LLGE 4YG2E 4BBSF 1TWGF 3HOXF 4Q4ZE 4A3EF 3HOVF 1I3QF 4A3FF 5IP7E 2VUME 4OIQE 3HOUF 3H0GF 3S14E 2WB1I 4Q5SE 3S1QF 3S1NF 4GZYE 3M4OF 2NVYE 3HOYF 1TWCE 4A3GE 5IP9E 5D4DE 1IW7E 3FKIF 4OIPE 2E2HF 5C4JE 3S16F 3S17F 1TWAE 2R92F 5D4EE 1I3QE 1I6HF 4A3FE 2E2JF 3HOZF 4A3ME 5M3FF 3H0GE 5D4CE 4Y52F 5C44F 2Y0SH 4C3IE 4LJZE 3M4OE 1R9TF 4A3BF 3RZDF 4LK1E 3HOYE 1EIKA 3S15E 4A3IF 4G7OE 2YU9E 1K83E 1Y1WF 1SFOF 2JA7E 5C4XF 4XSXE 2JA6E 3HOWF 2R7ZF 3S16E 3H3VF 3CQZF 3S17E 3GTLF 3GTME 4C3HE 2KRXA 2E2JE 3M3YE 2A6EE 2CW0E 2B63E 4Y52E 1I6VE 1HQME 3GTOE 4OINE 3S1MF 4A3BE 5C3EE 4A3JF 3GTPF 4A93F 1Y1VF 5TMFE 4A3IE 5IYBF 1DZFA 5M5YE 1Y1WE 5TMCE 2NVXE 4AYBK 3GTQE 4BBRF 5M3MF 2NVQF 2R7ZE 3CQZE 2A6HE 4A3DE 4BBSE 1TWGE 3HOXE 4A3EE 3HOVE 3RZOF 3PO3F 3EQLE 5IYCF 3HOUE 2JA8F 1WCMF 4A3KF 3S1QE 5IPLE 4OIRE 1ZYRE 4ZH4E 1I50F 2WB1H 5M5WF 3PO2F 3K7AF 1QKLA 4A93E 1TWFF 4C2MF 3S1NE 4A3LF 4BXXF 1TWHF 2A69E 5FJ8F 3FKIE 2NVQE 4KN7E 3I4MF 2E2HE 2NVTF 5M5XF 2E2IF 3RZOE 4YFNE 4MEXE 4AYBH 3S2HF 2BE5E 2Y0SI 2R92E 2O5JE 3HOZE 5IYCE 1I6HE 3GTJF 2JA8E 5M3FE 1WCME 4A3KE 4X6AF 3S2DF 4BY1F 4MEYE 5C44E 2R93F 1I50E 5M5WE 3K7AE 3S1RF 4Y7NF 1R9TE 3RZDE 2JA5F 3I4NF 4BXXE 5IYDF 3GTKF 5FJ8E 1SFOE 5C4XE 1YNJK 3HOWE 2VUMF 5IP7F 3GTLE 3S14F 3H3VG 2A68E 3DXJE 3GTJE 5E18E 1SMYE 3HKZK 4LK0E 2R93E 5FLMF 5BYHE 4QIWK 1TWCF 4Y7NE 5IP9F 4OIOE 4BY7F 4A3JE 2JA5E 3GTPE 3S1ME 1Y1VE 5IYBE 5C4JF 1YNNK 4A3CF 1TWAF 4BBRE 5M3ME 2PPBE 4YFXE 4A3MF 3PO3E 2PMZK 5FLME 4C3IF 5E17E 3HKZH 4XLPE 4BY7E
chains in the Genus database with same CATH topology
3S15F 4MQ9E 4C3JF 1K83F 2YU9F 2JA7F 3GTGF 2JA6F 4KMUE 3GTMF 4C3HF 3M3YF 4G7ZE 2B63F 2O5IE 4YFKE 3GTOF 4G7HE 3WODE 5C3EF 4XSZE 2NVYF 4JK1E 5M5YF 4A3GF 4KN4E 2NVXF 3GTQF 2WAQK 4A3DF 4XLNE 4LLGE 4YG2E 4BBSF 1TWGF 3HOXF 4Q4ZE 4A3EF 3HOVF 1I3QF 4A3FF 3HOUF 4OIQE 3H0GF 2WB1I 4Q5SE 3S1QF 3S1NF 4GZYE 3M4OF 3HOYF 5D4DE 1IW7E 3FKIF 4OIPE 2E2HF 3S16F 3S17F 2R92F 5D4EE 1I6HF 2E2JF 3HOZF 5M3FF 5D4CE 4Y52F 5C44F 4LJZE 1R9TF 4A3BF 3RZDF 4LK1E 4A3IF 4G7OE 1Y1WF 1SFOF 5C4XF 4XSXE 3HOWF 2R7ZF 3CQZF 3GTLF 2KRXA 2A6EE 2CW0E 1I6VE 1HQME 4OINE 3S1MF 4A3JF 4A93F 3GTPF 1Y1VF 5TMFE 5IYBF 5TMCE 4AYBK 4BBRF 5M3MF 2NVQF 2A6HE 3RZOF 3PO3F 3EQLE 5IYCF 2JA8F 1WCMF 4A3KF 5IPLE 4OIRE 1ZYRE 4ZH4E 1I50F 3PO2F 5M5WF 4X6AF 3K7AF 1QKLA 1TWFF 4C2MF 4A3LF 4BXXF 1TWHF 2A69E 5FJ8F 4KN7E 3I4MF 2NVTF 5M5XF 2E2IF 3S2HF 4YFNE 4MEXE 2BE5E 2Y0SI 2O5JE 3GTJF 3S2DF 4BY1F 4MEYE 2R93F 3S1RF 4Y7NF 2JA5F 3I4NF 5IYDF 3GTKF 1YNJK 2VUMF 5IP7F 3S14F 3H3VG 2A68E 3DXJE 5E18E 1SMYE 3HKZK 4LK0E 5FLMF 5BYHE 4QIWK 1TWCF 5IP9F 4OIOE 4BY7F 5C4JF 1YNNK 4A3CF 1TWAF 2PPBE 4YFXE 4A3MF 2PMZK 4C3IF 5E17E 4XLPE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3S15 F;  4MQ9 E;  4C3J F;  1K83 F;  2YU9 F;  2JA7 F;  3GTG F;  2JA6 F;  4KMU E;  3GTM F;  4C3H F;  3M3Y F;  4G7Z E;  2B63 F;  2O5I E;  4YFK E;  3GTO F;  4G7H E;  3WOD E;  5C3E F;  4XSZ E;  2NVY F;  4JK1 E;  5M5Y F;  4A3G F;  4KN4 E;  2NVX F;  3GTQ F;  2WAQ K;  4A3D F;  4XLN E;  4LLG E;  4YG2 E;  4BBS F;  1TWG F;  3HOX F;  4Q4Z E;  4A3E F;  3HOV F;  1I3Q F;  4A3F F;  3HOU F;  4OIQ E;  3H0G F;  2WB1 I;  4Q5S E;  3S1Q F;  3S1N F;  4GZY E;  3M4O F;  3HOY F;  5D4D E;  1IW7 E;  3FKI F;  4OIP E;  2E2H F;  3S16 F;  3S17 F;  2R92 F;  5D4E E;  1I6H F;  2E2J F;  3HOZ F;  5M3F F;  5D4C E;  4Y52 F;  5C44 F;  4LJZ E;  1R9T F;  4A3B F;  3RZD F;  4LK1 E;  4A3I F;  4G7O E;  1Y1W F;  1SFO F;  5C4X F;  4XSX E;  3HOW F;  2R7Z F;  3CQZ F;  3GTL F;  2A6E E;  2CW0 E;  1I6V E;  1HQM E;  4OIN E;  3S1M F;  4A3J F;  4A93 F;  3GTP F;  1Y1V F;  5TMF E;  5IYB F;  5TMC E;  4AYB K;  4BBR F;  5M3M F;  2NVQ F;  2A6H E;  3RZO F;  3PO3 F;  3EQL E;  5IYC F;  2JA8 F;  1WCM F;  4A3K F;  5IPL E;  4OIR E;  1ZYR E;  4ZH4 E;  1I50 F;  3PO2 F;  5M5W F;  4X6A F;  3K7A F;  1QKL A;  1TWF F;  4C2M F;  4A3L F;  4BXX F;  1TWH F;  2A69 E;  5FJ8 F;  4KN7 E;  3I4M F;  2NVT F;  5M5X F;  2E2I F;  3S2H F;  4YFN E;  4MEX E;  2BE5 E;  2Y0S I;  2O5J E;  3GTJ F;  3S2D F;  4BY1 F;  4MEY E;  2R93 F;  3S1R F;  4Y7N F;  2JA5 F;  3I4N F;  5IYD F;  3GTK F;  1YNJ K;  2VUM F;  5IP7 F;  3S14 F;  3H3V G;  2A68 E;  3DXJ E;  5E18 E;  1SMY E;  3HKZ K;  4LK0 E;  5FLM F;  5BYH E;  1TWC F;  5IP9 F;  4OIO E;  4BY7 F;  5C4J F;  1YNN K;  4A3C F;  1TWA F;  2PPB E;  4YFX E;  4A3M F;  2PMZ K;  4C3I F;  5E17 E;  4XLP E; 
#chains in the Genus database with same CATH topology
 3PO2 E;  3S15 F;  4X6A E;  4MQ9 E;  4C3J F;  1K83 F;  1TWF E;  4C2M E;  2YU9 F;  4QIW H;  2JA7 F;  3GTG F;  2JA6 F;  1TWH E;  4KMU E;  4A3L E;  4A3C E;  2WAQ H;  3GTM F;  3I4M E;  4C3H F;  2NVT E;  5M5X E;  2E2I E;  3S2H E;  3M3Y F;  4G7Z E;  2B63 F;  2O5I E;  4YFK E;  3GTO F;  4G7H E;  3WOD E;  5C3E F;  4BY1 E;  3S2D E;  4XSZ E;  2PMZ H;  2NVY F;  4JK1 E;  5M5Y F;  4C3J E;  3S1R E;  4KN4 E;  4A3G F;  2NVX F;  3GTQ F;  2WAQ K;  3GTG E;  3I4N E;  4A3D F;  4XLN E;  5IYD E;  3GTK E;  4LLG E;  4YG2 E;  4BBS F;  1TWG F;  3HOX F;  4Q4Z E;  4A3E F;  3HOV F;  1I3Q F;  4A3F F;  5IP7 E;  2VUM E;  4OIQ E;  3HOU F;  3H0G F;  3S14 E;  2WB1 I;  4Q5S E;  3S1Q F;  3S1N F;  4GZY E;  3M4O F;  2NVY E;  3HOY F;  1TWC E;  4A3G E;  5IP9 E;  5D4D E;  1IW7 E;  3FKI F;  4OIP E;  2E2H F;  5C4J E;  3S16 F;  3S17 F;  1TWA E;  2R92 F;  5D4E E;  1I3Q E;  1I6H F;  4A3F E;  2E2J F;  3HOZ F;  4A3M E;  5M3F F;  3H0G E;  5D4C E;  4Y52 F;  5C44 F;  2Y0S H;  4C3I E;  4LJZ E;  3M4O E;  1R9T F;  4A3B F;  3RZD F;  4LK1 E;  3HOY E;  1EIK A;  3S15 E;  4A3I F;  4G7O E;  2YU9 E;  1K83 E;  1Y1W F;  1SFO F;  2JA7 E;  5C4X F;  4XSX E;  2JA6 E;  3HOW F;  2R7Z F;  3S16 E;  3H3V F;  3CQZ F;  3S17 E;  3GTL F;  3GTM E;  4C3H E;  2KRX A;  2E2J E;  3M3Y E;  2A6E E;  2CW0 E;  2B63 E;  4Y52 E;  1I6V E;  1HQM E;  3GTO E;  4OIN E;  3S1M F;  4A3B E;  5C3E E;  4A3J F;  3GTP F;  4A93 F;  1Y1V F;  5TMF E;  4A3I E;  5IYB F;  1DZF A;  5M5Y E;  1Y1W E;  5TMC E;  2NVX E;  4AYB K;  3GTQ E;  4BBR F;  5M3M F;  2NVQ F;  2R7Z E;  3CQZ E;  2A6H E;  4A3D E;  4BBS E;  1TWG E;  3HOX E;  4A3E E;  3HOV E;  3RZO F;  3PO3 F;  3EQL E;  5IYC F;  3HOU E;  2JA8 F;  1WCM F;  4A3K F;  3S1Q E;  5IPL E;  4OIR E;  1ZYR E;  4ZH4 E;  1I50 F;  2WB1 H;  5M5W F;  3PO2 F;  3K7A F;  1QKL A;  4A93 E;  1TWF F;  4C2M F;  3S1N E;  4A3L F;  4BXX F;  1TWH F;  2A69 E;  5FJ8 F;  3FKI E;  2NVQ E;  4KN7 E;  3I4M F;  2E2H E;  2NVT F;  5M5X F;  2E2I F;  3RZO E;  4YFN E;  4MEX E;  4AYB H;  3S2H F;  2BE5 E;  2Y0S I;  2R92 E;  2O5J E;  3HOZ E;  5IYC E;  1I6H E;  3GTJ F;  2JA8 E;  5M3F E;  1WCM E;  4A3K E;  4X6A F;  3S2D F;  4BY1 F;  4MEY E;  5C44 E;  2R93 F;  1I50 E;  5M5W E;  3K7A E;  3S1R F;  4Y7N F;  1R9T E;  3RZD E;  2JA5 F;  3I4N F;  4BXX E;  5IYD F;  3GTK F;  5FJ8 E;  1SFO E;  5C4X E;  1YNJ K;  3HOW E;  2VUM F;  5IP7 F;  3GTL E;  3S14 F;  3H3V G;  2A68 E;  3DXJ E;  3GTJ E;  5E18 E;  1SMY E;  3HKZ K;  4LK0 E;  2R93 E;  5FLM F;  5BYH E;  4QIW K;  1TWC F;  4Y7N E;  5IP9 F;  4OIO E;  4BY7 F;  4A3J E;  2JA5 E;  3GTP E;  3S1M E;  1Y1V E;  5IYB E;  5C4J F;  1YNN K;  4A3C F;  1TWA F;  4BBR E;  5M3M E;  2PPB E;  4YFX E;  4A3M F;  3PO3 E;  2PMZ K;  5FLM E;  4C3I F;  5E17 E;  3HKZ H;  4XLP E;  4BY7 E; 
#chains in the Genus database with same CATH homology
 3S15 F;  4MQ9 E;  4C3J F;  1K83 F;  2YU9 F;  2JA7 F;  3GTG F;  2JA6 F;  4KMU E;  3GTM F;  4C3H F;  3M3Y F;  4G7Z E;  2B63 F;  2O5I E;  4YFK E;  3GTO F;  4G7H E;  3WOD E;  5C3E F;  4XSZ E;  2NVY F;  4JK1 E;  5M5Y F;  4A3G F;  4KN4 E;  2NVX F;  3GTQ F;  2WAQ K;  4A3D F;  4XLN E;  4LLG E;  4YG2 E;  4BBS F;  1TWG F;  3HOX F;  4Q4Z E;  4A3E F;  3HOV F;  1I3Q F;  4A3F F;  3HOU F;  4OIQ E;  3H0G F;  2WB1 I;  4Q5S E;  3S1Q F;  3S1N F;  4GZY E;  3M4O F;  3HOY F;  5D4D E;  1IW7 E;  3FKI F;  4OIP E;  2E2H F;  3S16 F;  3S17 F;  2R92 F;  5D4E E;  1I6H F;  2E2J F;  3HOZ F;  5M3F F;  5D4C E;  4Y52 F;  5C44 F;  4LJZ E;  1R9T F;  4A3B F;  3RZD F;  4LK1 E;  4A3I F;  4G7O E;  1Y1W F;  1SFO F;  5C4X F;  4XSX E;  3HOW F;  2R7Z F;  3CQZ F;  3GTL F;  2KRX A;  2A6E E;  2CW0 E;  1I6V E;  1HQM E;  4OIN E;  3S1M F;  4A3J F;  4A93 F;  3GTP F;  1Y1V F;  5TMF E;  5IYB F;  5TMC E;  4AYB K;  4BBR F;  5M3M F;  2NVQ F;  2A6H E;  3RZO F;  3PO3 F;  3EQL E;  5IYC F;  2JA8 F;  1WCM F;  4A3K F;  5IPL E;  4OIR E;  1ZYR E;  4ZH4 E;  1I50 F;  3PO2 F;  5M5W F;  4X6A F;  3K7A F;  1QKL A;  1TWF F;  4C2M F;  4A3L F;  4BXX F;  1TWH F;  2A69 E;  5FJ8 F;  4KN7 E;  3I4M F;  2NVT F;  5M5X F;  2E2I F;  3S2H F;  4YFN E;  4MEX E;  2BE5 E;  2Y0S I;  2O5J E;  3GTJ F;  3S2D F;  4BY1 F;  4MEY E;  2R93 F;  3S1R F;  4Y7N F;  2JA5 F;  3I4N F;  5IYD F;  3GTK F;  1YNJ K;  2VUM F;  5IP7 F;  3S14 F;  3H3V G;  2A68 E;  3DXJ E;  5E18 E;  1SMY E;  3HKZ K;  4LK0 E;  5FLM F;  5BYH E;  4QIW K;  1TWC F;  5IP9 F;  4OIO E;  4BY7 F;  5C4J F;  1YNN K;  4A3C F;  1TWA F;  2PPB E;  4YFX E;  4A3M F;  2PMZ K;  4C3I F;  5E17 E;  4XLP E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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