2E2JE

Rna polymerase ii elongation complex in 5 mm mg+2 with gmpcpp
Total Genus 46
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
46
sequence length
214
structure length
214
Chain Sequence
DQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSAMKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis
pubmed doi rcsb
molecule tags Transcription,transferase/dna-rna hybrid
molecule keywords 5'-R(P*AP*UP*CP*GP*AP*GP*AP*GP*G)-3'
total genus 46
structure length 214
sequence length 214
ec nomenclature
pdb deposition date 2006-11-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01191 RNA_pol_Rpb5_C RNA polymerase Rpb5, C-terminal domain
E PF03871 RNA_pol_Rpb5_N RNA polymerase Rpb5, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1340.10 Alpha Beta 3-Layer(aba) Sandwich Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1 RNA polymerase, Rpb5, N-terminal domain 2e2jE01
3.90.940.20 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit RPB5-like RNA polymerase subunit 2e2jE02
2R92E 2JA8E 3S1NE 1TWAE 1Y1WE 5IYBE 3S15E 2JA6E 2NVTE 4A3KE 5C3EE 3S2HE 5M3ME 3GTPE 5FJ8E 3RZDE 1DZFA 4C3JE 4X6AE 3S17E 4A3ME 5M5YE 2VUME 1TWHE 4Y7NE 4Y52E 4A3JE 4BXXE 3S1RE 3S1ME 1WCME 5C4JE 5IP9E 3HKZH 4A3FE 1R9TE 3HOUE 4BBRE 3HOYE 3HOVE 5M3FE 4BBSE 2Y0SH 4A3BE 2NVXE 1TWGE 1I6HE 4C3HE 4A3EE 4AYBH 1EIKA 4A3IE 5FLME 3GTME 3GTGE 1K83E 2YU9E 3S16E 2JA5E 3RZOE 5IYCE 2PMZH 5M5WE 2JA7E 4BY7E 3GTLE 3CQZE 3S14E 4A3LE 3S2DE 4BY1E 4A3CE 4C3IE 5M5XE 1SFOE 4A3DE 2E2HE 3I4NE 5C44E 3PO3E 5IYDE 1I50E 4A93E 3HOWE 3GTJE 1Y1VE 3FKIE 3I4ME 1I3QE 4C2ME 3GTKE 3H3VF 2R7ZE 5IP7E 2NVYE 2WB1H 1TWCE 3H0GE 3GTOE 3HOXE 3GTQE 4A3GE 4QIWH 3HOZE 2WAQH 2NVQE 2E2JE 3M3YE 3PO2E 5C4XE 2E2IE 2B63E 3S1QE 3M4OE 1TWFE 3K7AE 2R93E
chains in the Genus database with same CATH superfamily
2R92E 2JA8E 3FKIF 3M4OF 3S1NE 1TWFF 1ZYRE 1TWAE 1Y1WE 3K7AF 4G7ZE 2R93F 5BYHE 5IYBE 3S15E 2R92F 2JA8F 4G7OE 5E18E 2JA6E 2NVTE 1TWAF 4A3KE 5C3EE 3S2HE 4QIWK 4YG2E 5IYBF 2A68E 5M3ME 3GTPE 5FJ8E 2WAQK 2JA6F 2NVTF 4A3KF 3RZDE 1DZFA 4C3JE 4X6AE 3S17E 4A3ME 5M3MF 3GTPF 5M5YE 5FJ8F 4LK0E 3RZDF 2VUME 4C3JF 4X6AF 3S17F 4A3MF 1TWHE 4Y7NE 4Y52E 2BE5E 5M5YF 4A3JE 4BXXE 3S1RE 2VUMF 1SMYE 3S1ME 4MEXE 1TWHF 4Y52F 4Y7NF 5IPLE 4A3JF 4YFXE 3S1RF 4YFNE 1WCME 2A6HE 5C4JE 3S1MF 4XLNE 5C4XF 5IP9E 3HKZH 4A3FE 1WCMF 1R9TE 3HOUE 5C4JF 2Y0SI 4BBRE 5IP9F 3HOYE 3HOVE 5M3FE 4KN7E 4A3FF 1YNJK 1R9TF 3HOUF 4BBRF 4BBSE 2Y0SH 3HOVF 4KMUE 3HOYF 4A3BE 3S1NF 2NVXE 1Y1WF 1TWGE 3S15F 4LK1E 1I6HE 4A3BF 4C3HE 4A3EE 1I6VE 4AYBH 2NVXF 1TWGF 5C3EF 3S2HF 4OIQE 1I6HF 1IW7E 4C3HF 4A3IE 4YFKE 1EIKA 5D4EE 5FLME 5D4CE 4A3IF 3H3VG 3GTME 3HKZK 1QKLA 5FLMF 3GTGE 1K83E 2YU9E 4KN4E 3S16E 2JA5E 3RZOE 5IYCE 4OIPE 4G7HE 2PMZH 5M5WE 3GTMF 4BXXF 4Q4ZE 4OIRE 1K83F 2YU9F 2JA7E 2WB1I 4BY7E 3RZOF 5IYCF 3GTLE 4MEYE 4GZYE 5M5WF 2JA7F 3CQZE 3S14E 2O5IE 4BY7F 3GTLF 4OINE 4AYBK 4A3LE 3CQZF 2KRXA 3S2DE 5M3FF 4BY1E 3WODE 4Q5SE 4A3CE 4A3LF 4C3IE 5M5XE 4XSXE 3S2DF 4BBSF 4BY1F 1SFOE 4XSZE 4A3DE 4A3CF 2E2HE 1YNNK 4C3IF 5M5XF 3I4NE 4OIOE 1SFOF 5C44E 4LLGE 4A3EF 3PO3E 2E2HF 3EQLE 2PMZK 3I4NF 5IYDE 2A6EE 5C44F 1I50E 4A93E 3PO3F 1HQME 5IYDF 3HOWE 4XLPE 5D4DE 3GTJE 1Y1VE 4A93F 3FKIE 3DXJE 3I4ME 3GTGF 3HOWF 3S1QF 3GTJF 1Y1VF 1I3QE 4C2ME 3S16F 2JA5F 5E17E 3GTKE 3H3VF 2PPBE 2R7ZE 3I4MF 5IP7E 5TMFE 2NVYE 2O5JE 1I3QF 5TMCE 4C2MF 3GTKF 2WB1H 2R7ZF 5IP7F 2NVYF 1TWCE 3S14F 3H0GE 2A69E 3GTOE 4LJZE 1TWCF 3HOXE 3GTQE 3H0GF 4A3GE 3GTOF 4QIWH 3HOZE 3HOXF 2CW0E 3GTQF 4A3GF 2WAQH 4A3DF 2NVQE 3HOZF 2E2JE 3M3YE 3PO2E 5C4XE 4MQ9E 4ZH4E 2NVQF 2E2JF 2E2IE 3M3YF 3PO2F 2B63E 3S1QE 1I50F 3M4OE 1TWFE 2E2IF 4JK1E 2B63F 3K7AE 2R93E
chains in the Genus database with same CATH topology
2R92E 2JA8E 3S1NE 1TWAE 1Y1WE 5IYBE 3S15E 2JA6E 2NVTE 4A3KE 5C3EE 3S2HE 5M3ME 3GTPE 5FJ8E 3RZDE 1DZFA 4C3JE 4X6AE 3S17E 4A3ME 5M5YE 2VUME 1TWHE 4Y7NE 4Y52E 4A3JE 4BXXE 3S1RE 3S1ME 1WCME 5C4JE 5IP9E 3HKZH 4A3FE 1R9TE 3HOUE 4BBRE 3HOYE 3HOVE 5M3FE 4BBSE 2Y0SH 4A3BE 2NVXE 1TWGE 1I6HE 4C3HE 4A3EE 4AYBH 1EIKA 4A3IE 5FLME 3GTME 3GTGE 1K83E 2YU9E 3S16E 2JA5E 3RZOE 5IYCE 2PMZH 5M5WE 2JA7E 4BY7E 3GTLE 3CQZE 3S14E 4A3LE 3S2DE 4BY1E 4A3CE 4C3IE 5M5XE 1SFOE 4A3DE 2E2HE 3I4NE 5C44E 3PO3E 5IYDE 1I50E 4A93E 3HOWE 3GTJE 1Y1VE 3FKIE 3I4ME 1I3QE 4C2ME 3GTKE 3H3VF 2R7ZE 5IP7E 2NVYE 2WB1H 1TWCE 3H0GE 3GTOE 3HOXE 3GTQE 4A3GE 4QIWH 3HOZE 2WAQH 2NVQE 2E2JE 3M3YE 3PO2E 5C4XE 2E2IE 2B63E 3S1QE 3M4OE 1TWFE 3K7AE 2R93E
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2R92 E;  2JA8 E;  3S1N E;  1TWA E;  1Y1W E;  5IYB E;  3S15 E;  2JA6 E;  2NVT E;  4A3K E;  5C3E E;  3S2H E;  5M3M E;  3GTP E;  5FJ8 E;  3RZD E;  1DZF A;  4C3J E;  4X6A E;  3S17 E;  4A3M E;  5M5Y E;  2VUM E;  1TWH E;  4Y7N E;  4Y52 E;  4A3J E;  4BXX E;  3S1R E;  3S1M E;  1WCM E;  5C4J E;  5IP9 E;  3HKZ H;  4A3F E;  1R9T E;  3HOU E;  4BBR E;  3HOY E;  3HOV E;  5M3F E;  4BBS E;  2Y0S H;  4A3B E;  2NVX E;  1TWG E;  1I6H E;  4C3H E;  4A3E E;  4AYB H;  1EIK A;  4A3I E;  5FLM E;  3GTM E;  3GTG E;  1K83 E;  2YU9 E;  3S16 E;  2JA5 E;  3RZO E;  5IYC E;  2PMZ H;  5M5W E;  2JA7 E;  4BY7 E;  3GTL E;  3CQZ E;  3S14 E;  4A3L E;  3S2D E;  4BY1 E;  4A3C E;  4C3I E;  5M5X E;  1SFO E;  4A3D E;  2E2H E;  3I4N E;  5C44 E;  3PO3 E;  5IYD E;  1I50 E;  4A93 E;  3HOW E;  3GTJ E;  1Y1V E;  3FKI E;  3I4M E;  1I3Q E;  4C2M E;  3GTK E;  3H3V F;  2R7Z E;  5IP7 E;  2NVY E;  2WB1 H;  1TWC E;  3H0G E;  3GTO E;  3HOX E;  3GTQ E;  4A3G E;  4QIW H;  3HOZ E;  2WAQ H;  2NVQ E;  2E2J E;  3M3Y E;  3PO2 E;  5C4X E;  2E2I E;  2B63 E;  3S1Q E;  3M4O E;  1TWF E;  3K7A E;  2R93 E; 
#chains in the Genus database with same CATH topology
 2R92 E;  2JA8 E;  3FKI F;  3M4O F;  3S1N E;  1TWF F;  1ZYR E;  1TWA E;  1Y1W E;  3K7A F;  4G7Z E;  2R93 F;  5BYH E;  5IYB E;  3S15 E;  2R92 F;  2JA8 F;  4G7O E;  5E18 E;  2JA6 E;  2NVT E;  1TWA F;  4A3K E;  5C3E E;  3S2H E;  4QIW K;  4YG2 E;  5IYB F;  2A68 E;  5M3M E;  3GTP E;  5FJ8 E;  2WAQ K;  2JA6 F;  2NVT F;  4A3K F;  3RZD E;  1DZF A;  4C3J E;  4X6A E;  3S17 E;  4A3M E;  5M3M F;  3GTP F;  5M5Y E;  5FJ8 F;  4LK0 E;  3RZD F;  2VUM E;  4C3J F;  4X6A F;  3S17 F;  4A3M F;  1TWH E;  4Y7N E;  4Y52 E;  2BE5 E;  5M5Y F;  4A3J E;  4BXX E;  3S1R E;  2VUM F;  1SMY E;  3S1M E;  4MEX E;  1TWH F;  4Y52 F;  4Y7N F;  5IPL E;  4A3J F;  4YFX E;  3S1R F;  4YFN E;  1WCM E;  2A6H E;  5C4J E;  3S1M F;  4XLN E;  5C4X F;  5IP9 E;  3HKZ H;  4A3F E;  1WCM F;  1R9T E;  3HOU E;  5C4J F;  2Y0S I;  4BBR E;  5IP9 F;  3HOY E;  3HOV E;  5M3F E;  4KN7 E;  4A3F F;  1YNJ K;  1R9T F;  3HOU F;  4BBR F;  4BBS E;  2Y0S H;  3HOV F;  4KMU E;  3HOY F;  4A3B E;  3S1N F;  2NVX E;  1Y1W F;  1TWG E;  3S15 F;  4LK1 E;  1I6H E;  4A3B F;  4C3H E;  4A3E E;  1I6V E;  4AYB H;  2NVX F;  1TWG F;  5C3E F;  3S2H F;  4OIQ E;  1I6H F;  1IW7 E;  4C3H F;  4A3I E;  4YFK E;  1EIK A;  5D4E E;  5FLM E;  5D4C E;  4A3I F;  3H3V G;  3GTM E;  3HKZ K;  1QKL A;  5FLM F;  3GTG E;  1K83 E;  2YU9 E;  4KN4 E;  3S16 E;  2JA5 E;  3RZO E;  5IYC E;  4OIP E;  4G7H E;  2PMZ H;  5M5W E;  3GTM F;  4BXX F;  4Q4Z E;  4OIR E;  1K83 F;  2YU9 F;  2JA7 E;  2WB1 I;  4BY7 E;  3RZO F;  5IYC F;  3GTL E;  4MEY E;  4GZY E;  5M5W F;  2JA7 F;  3CQZ E;  3S14 E;  2O5I E;  4BY7 F;  3GTL F;  4OIN E;  4AYB K;  4A3L E;  3CQZ F;  2KRX A;  3S2D E;  5M3F F;  4BY1 E;  3WOD E;  4Q5S E;  4A3C E;  4A3L F;  4C3I E;  5M5X E;  4XSX E;  3S2D F;  4BBS F;  4BY1 F;  1SFO E;  4XSZ E;  4A3D E;  4A3C F;  2E2H E;  1YNN K;  4C3I F;  5M5X F;  3I4N E;  4OIO E;  1SFO F;  5C44 E;  4LLG E;  4A3E F;  3PO3 E;  2E2H F;  3EQL E;  2PMZ K;  3I4N F;  5IYD E;  2A6E E;  5C44 F;  1I50 E;  4A93 E;  3PO3 F;  1HQM E;  5IYD F;  3HOW E;  4XLP E;  5D4D E;  3GTJ E;  1Y1V E;  4A93 F;  3FKI E;  3DXJ E;  3I4M E;  3GTG F;  3HOW F;  3S1Q F;  3GTJ F;  1Y1V F;  1I3Q E;  4C2M E;  3S16 F;  2JA5 F;  5E17 E;  3GTK E;  3H3V F;  2PPB E;  2R7Z E;  3I4M F;  5IP7 E;  5TMF E;  2NVY E;  2O5J E;  1I3Q F;  5TMC E;  4C2M F;  3GTK F;  2WB1 H;  2R7Z F;  5IP7 F;  2NVY F;  1TWC E;  3S14 F;  3H0G E;  2A69 E;  3GTO E;  4LJZ E;  1TWC F;  3HOX E;  3GTQ E;  3H0G F;  4A3G E;  3GTO F;  4QIW H;  3HOZ E;  3HOX F;  2CW0 E;  3GTQ F;  4A3G F;  2WAQ H;  4A3D F;  2NVQ E;  3HOZ F;  2E2J E;  3M3Y E;  3PO2 E;  5C4X E;  4MQ9 E;  4ZH4 E;  2NVQ F;  2E2J F;  2E2I E;  3M3Y F;  3PO2 F;  2B63 E;  3S1Q E;  1I50 F;  3M4O E;  1TWF E;  2E2I F;  4JK1 E;  2B63 F;  3K7A E;  2R93 E; 
#chains in the Genus database with same CATH homology
 2R92 E;  2JA8 E;  3S1N E;  1TWA E;  1Y1W E;  5IYB E;  3S15 E;  2JA6 E;  2NVT E;  4A3K E;  5C3E E;  3S2H E;  5M3M E;  3GTP E;  5FJ8 E;  3RZD E;  1DZF A;  4C3J E;  4X6A E;  3S17 E;  4A3M E;  5M5Y E;  2VUM E;  1TWH E;  4Y7N E;  4Y52 E;  4A3J E;  4BXX E;  3S1R E;  3S1M E;  1WCM E;  5C4J E;  5IP9 E;  3HKZ H;  4A3F E;  1R9T E;  3HOU E;  4BBR E;  3HOY E;  3HOV E;  5M3F E;  4BBS E;  2Y0S H;  4A3B E;  2NVX E;  1TWG E;  1I6H E;  4C3H E;  4A3E E;  4AYB H;  1EIK A;  4A3I E;  5FLM E;  3GTM E;  3GTG E;  1K83 E;  2YU9 E;  3S16 E;  2JA5 E;  3RZO E;  5IYC E;  2PMZ H;  5M5W E;  2JA7 E;  4BY7 E;  3GTL E;  3CQZ E;  3S14 E;  4A3L E;  3S2D E;  4BY1 E;  4A3C E;  4C3I E;  5M5X E;  1SFO E;  4A3D E;  2E2H E;  3I4N E;  5C44 E;  3PO3 E;  5IYD E;  1I50 E;  4A93 E;  3HOW E;  3GTJ E;  1Y1V E;  3FKI E;  3I4M E;  1I3Q E;  4C2M E;  3GTK E;  3H3V F;  2R7Z E;  5IP7 E;  2NVY E;  2WB1 H;  1TWC E;  3H0G E;  3GTO E;  3HOX E;  3GTQ E;  4A3G E;  4QIW H;  3HOZ E;  2WAQ H;  2NVQ E;  2E2J E;  3M3Y E;  3PO2 E;  5C4X E;  2E2I E;  2B63 E;  3S1Q E;  3M4O E;  1TWF E;  3K7A E;  2R93 E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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