2FTLI

Crystal structure of trypsin complexed with bpti at 100k
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
57
structure length
57
Chain Sequence
PDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Rigidification of a Flexible Protease Inhibitor Variant upon Binding to Trypsin.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Bos taurus
molecule keywords Cationic trypsin
total genus 11
structure length 57
sequence length 57
ec nomenclature
pdb deposition date 2006-01-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2ftlI00
4DTGK 7PTIA 2HEXA 1OA65 3OTJI 1KIGI 4PTIA 1P2JI 3BTQI 1YLDB 3BTHI 1MTND 3L33E 2RA3C 1KUNA 2PTCI 1BTHP 3BTDI 1ADZA 1LD5A 2DDJA 1F5RI 1KTHA 2J6DA 3WNYA 3AUIA 1QLQA 1CA0D 2TPII 2KAII 2DDIA 3AUGA 2FI3I 1AALA 1NAGA 5JB5A 3LDMA 4NTWB 1F7ZI 4BNRI 3FP6I 2R9PE 3AUBA 2LFLA 1UUAA 1T8OB 2FTLI 1FY8I 1T8LB 2KCRA 2FI5I 2CA7A 4TPII 1FANA 1P2KI 3AUHA 1JC6A 4U30W 3P95E 3AUDA 8PTIA 3BYBA 3TGII 4DG4C 1FAKI 1JV9A 1YC0I 4NTYB 1IRHA 1D0DB 1ZR0B 1T8NB 1TPAI 2UUXA 3UOUB 3D65I 4BD9B 2ODYE 1BPTA 1YKTB 1BIKA 1PITA 4BQDA 3GYMI 3M7QB 4WWYC 3BTGI 1JV8A 5PTIA 2FI4I 3CI7A 4WXVC 1UUBA 1B0CA 1LD6A 1CO7I 2TGPI 2UUYB 1YLCB 2W8XA 1DENA 1BUNB 5C67C 3BTKI 1P2II 3FP8I 3LDJA 4ISOB 1KNTA 1T7CB 1P2NB 1TAPA 3FP7J 1DEMA 1DTXA 1AAPA 3BTWI 4ISNB 1G6XA 1EJMB 1BRCI 1TFXC 3BTTI 3AUEA 1Y62A 1SHPA 2FTMB 1BTIA 1CBWD 9PTIA 2M99A 2ZVXA 4Y10I 4Y11I 3TGJI 3UIRC 3U1JE 1P2OB 1TCPA 1BZXI 2M01A 1P2MB 1OA55 3P92E 3LDIA 1EAWB 2IJOI 3BTEI 3TPII 1T8MB 1BPIA 3AUCA 2LFKA 1K6UA 1BRBI 5JB4A 3OFWA 2ZJXA 1BF0A 3L3TE 1DTKA 2KNTA 5JB6A 1TAWB 3BTMI 1BHCA 3BTFI 2JOTA 4U32X 5JB7A 1TOCR 4ISLB 6PTIA 4NTXB 1D0DA 1ZJDB 4Y0ZI 3T62D 1P2QB 4Y0YI 1BZ5A 3TGKI
chains in the Genus database with same CATH superfamily
4DTGK 7PTIA 2HEXA 1OA65 3OTJI 1KIGI 4PTIA 1P2JI 3BTQI 1YLDB 3BTHI 1MTND 3L33E 2RA3C 1KUNA 2PTCI 1BTHP 3BTDI 1ADZA 1LD5A 2DDJA 1F5RI 1KTHA 2J6DA 3WNYA 3AUIA 1QLQA 1CA0D 2TPII 2KAII 2DDIA 3AUGA 2FI3I 1AALA 1NAGA 5JB5A 3LDMA 4NTWB 1F7ZI 4BNRI 3FP6I 2R9PE 3AUBA 2LFLA 1UUAA 1T8OB 2FTLI 1FY8I 1T8LB 2KCRA 2FI5I 2CA7A 4TPII 1FANA 1P2KI 3AUHA 1JC6A 4U30W 3P95E 3AUDA 8PTIA 3BYBA 3TGII 4DG4C 1FAKI 1JV9A 1YC0I 4NTYB 1IRHA 1D0DB 1ZR0B 1T8NB 1TPAI 2UUXA 3UOUB 3D65I 4BD9B 2ODYE 1BPTA 1YKTB 1BIKA 1PITA 4BQDA 3GYMI 3M7QB 4WWYC 3BTGI 1JV8A 5PTIA 2FI4I 3CI7A 4WXVC 1UUBA 1B0CA 1LD6A 1CO7I 2TGPI 2UUYB 1YLCB 2W8XA 1DENA 1BUNB 5C67C 3BTKI 1P2II 3FP8I 3LDJA 4ISOB 1KNTA 1T7CB 1P2NB 1TAPA 3FP7J 1DEMA 1DTXA 1AAPA 3BTWI 4ISNB 1G6XA 1EJMB 1BRCI 1TFXC 3BTTI 3AUEA 1Y62A 1SHPA 2FTMB 1BTIA 1CBWD 9PTIA 2M99A 2ZVXA 4Y10I 4Y11I 3TGJI 3UIRC 3U1JE 1P2OB 1TCPA 1BZXI 2M01A 1P2MB 1OA55 3P92E 3LDIA 1EAWB 2IJOI 3BTEI 3TPII 1T8MB 1BPIA 3AUCA 2LFKA 1K6UA 1BRBI 5JB4A 3OFWA 2ZJXA 1BF0A 3L3TE 1DTKA 2KNTA 5JB6A 1TAWB 3BTMI 1BHCA 3BTFI 2JOTA 4U32X 5JB7A 1TOCR 4ISLB 6PTIA 4NTXB 1D0DA 1ZJDB 4Y0ZI 3T62D 1P2QB 4Y0YI 1BZ5A 3TGKI
chains in the Genus database with same CATH topology
4DTGK 7PTIA 2HEXA 1OA65 3OTJI 1KIGI 4PTIA 1P2JI 3BTQI 1YLDB 3BTHI 1MTND 3L33E 2RA3C 1KUNA 2PTCI 1BTHP 3BTDI 1ADZA 1LD5A 2DDJA 1F5RI 1KTHA 2J6DA 3WNYA 3AUIA 1QLQA 1CA0D 2TPII 2KAII 2DDIA 3AUGA 2FI3I 1AALA 1NAGA 5JB5A 3LDMA 4NTWB 1F7ZI 4BNRI 3FP6I 2R9PE 3AUBA 2LFLA 1UUAA 1T8OB 2FTLI 1FY8I 1T8LB 2KCRA 2FI5I 2CA7A 4TPII 1FANA 1P2KI 3AUHA 1JC6A 4U30W 3P95E 3AUDA 8PTIA 3BYBA 3TGII 4DG4C 1FAKI 1JV9A 1YC0I 4NTYB 1IRHA 1D0DB 1ZR0B 1T8NB 1TPAI 2UUXA 3UOUB 3D65I 4BD9B 2ODYE 1BPTA 1YKTB 1BIKA 1PITA 4BQDA 3GYMI 3M7QB 4WWYC 3BTGI 1JV8A 5PTIA 2FI4I 3CI7A 4WXVC 1UUBA 1B0CA 1LD6A 1CO7I 2TGPI 2UUYB 1YLCB 2W8XA 1DENA 1BUNB 5C67C 3BTKI 1P2II 3FP8I 3LDJA 4ISOB 1KNTA 1T7CB 1P2NB 1TAPA 3FP7J 1DEMA 1DTXA 1AAPA 3BTWI 4ISNB 1G6XA 1EJMB 1BRCI 1TFXC 3BTTI 3AUEA 1Y62A 1SHPA 2FTMB 1BTIA 1CBWD 9PTIA 2M99A 2ZVXA 4Y10I 4Y11I 3TGJI 3UIRC 3U1JE 1P2OB 1TCPA 1BZXI 2M01A 1P2MB 1OA55 3P92E 3LDIA 1EAWB 2IJOI 3BTEI 3TPII 1T8MB 1BPIA 3AUCA 2LFKA 1K6UA 1BRBI 5JB4A 3OFWA 2ZJXA 1BF0A 3L3TE 1DTKA 2KNTA 5JB6A 1TAWB 3BTMI 1BHCA 3BTFI 2JOTA 4U32X 5JB7A 1TOCR 4ISLB 6PTIA 4NTXB 1D0DA 1ZJDB 4Y0ZI 3T62D 1P2QB 4Y0YI 1BZ5A 3TGKI
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4DTG K;  7PTI A;  2HEX A;  1OA6 5;  3OTJ I;  1KIG I;  4PTI A;  1P2J I;  3BTQ I;  1YLD B;  3BTH I;  1MTN D;  3L33 E;  2RA3 C;  1KUN A;  2PTC I;  1BTH P;  3BTD I;  1ADZ A;  1LD5 A;  2DDJ A;  1F5R I;  1KTH A;  2J6D A;  3WNY A;  3AUI A;  1QLQ A;  1CA0 D;  2TPI I;  2KAI I;  2DDI A;  3AUG A;  2FI3 I;  1AAL A;  1NAG A;  5JB5 A;  3LDM A;  4NTW B;  1F7Z I;  4BNR I;  3FP6 I;  2R9P E;  3AUB A;  2LFL A;  1UUA A;  1T8O B;  2FTL I;  1FY8 I;  1T8L B;  2KCR A;  2FI5 I;  2CA7 A;  4TPI I;  1FAN A;  1P2K I;  3AUH A;  1JC6 A;  4U30 W;  3P95 E;  3AUD A;  8PTI A;  3BYB A;  3TGI I;  4DG4 C;  1FAK I;  1JV9 A;  1YC0 I;  4NTY B;  1IRH A;  1D0D B;  1ZR0 B;  1T8N B;  1TPA I;  2UUX A;  3UOU B;  3D65 I;  4BD9 B;  2ODY E;  1BPT A;  1YKT B;  1BIK A;  1PIT A;  4BQD A;  3GYM I;  3M7Q B;  4WWY C;  3BTG I;  1JV8 A;  5PTI A;  2FI4 I;  3CI7 A;  4WXV C;  1UUB A;  1B0C A;  1LD6 A;  1CO7 I;  2TGP I;  2UUY B;  1YLC B;  2W8X A;  1DEN A;  1BUN B;  5C67 C;  3BTK I;  1P2I I;  3FP8 I;  3LDJ A;  4ISO B;  1KNT A;  1T7C B;  1P2N B;  1TAP A;  3FP7 J;  1DEM A;  1DTX A;  1AAP A;  3BTW I;  4ISN B;  1G6X A;  1EJM B;  1BRC I;  1TFX C;  3BTT I;  3AUE A;  1Y62 A;  1SHP A;  2FTM B;  1BTI A;  1CBW D;  9PTI A;  2M99 A;  2ZVX A;  4Y10 I;  4Y11 I;  3TGJ I;  3UIR C;  3U1J E;  1P2O B;  1TCP A;  1BZX I;  2M01 A;  1P2M B;  1OA5 5;  3P92 E;  3LDI A;  1EAW B;  2IJO I;  3BTE I;  3TPI I;  1T8M B;  1BPI A;  3AUC A;  2LFK A;  1K6U A;  1BRB I;  5JB4 A;  3OFW A;  2ZJX A;  1BF0 A;  3L3T E;  1DTK A;  2KNT A;  5JB6 A;  1TAW B;  3BTM I;  1BHC A;  3BTF I;  2JOT A;  4U32 X;  5JB7 A;  1TOC R;  4ISL B;  6PTI A;  4NTX B;  1D0D A;  1ZJD B;  4Y0Z I;  3T62 D;  1P2Q B;  4Y0Y I;  1BZ5 A;  3TGK I; 
#chains in the Genus database with same CATH topology
 4DTG K;  7PTI A;  2HEX A;  1OA6 5;  3OTJ I;  1KIG I;  4PTI A;  1P2J I;  3BTQ I;  1YLD B;  3BTH I;  1MTN D;  3L33 E;  2RA3 C;  1KUN A;  2PTC I;  1BTH P;  3BTD I;  1ADZ A;  1LD5 A;  2DDJ A;  1F5R I;  1KTH A;  2J6D A;  3WNY A;  3AUI A;  1QLQ A;  1CA0 D;  2TPI I;  2KAI I;  2DDI A;  3AUG A;  2FI3 I;  1AAL A;  1NAG A;  5JB5 A;  3LDM A;  4NTW B;  1F7Z I;  4BNR I;  3FP6 I;  2R9P E;  3AUB A;  2LFL A;  1UUA A;  1T8O B;  2FTL I;  1FY8 I;  1T8L B;  2KCR A;  2FI5 I;  2CA7 A;  4TPI I;  1FAN A;  1P2K I;  3AUH A;  1JC6 A;  4U30 W;  3P95 E;  3AUD A;  8PTI A;  3BYB A;  3TGI I;  4DG4 C;  1FAK I;  1JV9 A;  1YC0 I;  4NTY B;  1IRH A;  1D0D B;  1ZR0 B;  1T8N B;  1TPA I;  2UUX A;  3UOU B;  3D65 I;  4BD9 B;  2ODY E;  1BPT A;  1YKT B;  1BIK A;  1PIT A;  4BQD A;  3GYM I;  3M7Q B;  4WWY C;  3BTG I;  1JV8 A;  5PTI A;  2FI4 I;  3CI7 A;  4WXV C;  1UUB A;  1B0C A;  1LD6 A;  1CO7 I;  2TGP I;  2UUY B;  1YLC B;  2W8X A;  1DEN A;  1BUN B;  5C67 C;  3BTK I;  1P2I I;  3FP8 I;  3LDJ A;  4ISO B;  1KNT A;  1T7C B;  1P2N B;  1TAP A;  3FP7 J;  1DEM A;  1DTX A;  1AAP A;  3BTW I;  4ISN B;  1G6X A;  1EJM B;  1BRC I;  1TFX C;  3BTT I;  3AUE A;  1Y62 A;  1SHP A;  2FTM B;  1BTI A;  1CBW D;  9PTI A;  2M99 A;  2ZVX A;  4Y10 I;  4Y11 I;  3TGJ I;  3UIR C;  3U1J E;  1P2O B;  1TCP A;  1BZX I;  2M01 A;  1P2M B;  1OA5 5;  3P92 E;  3LDI A;  1EAW B;  2IJO I;  3BTE I;  3TPI I;  1T8M B;  1BPI A;  3AUC A;  2LFK A;  1K6U A;  1BRB I;  5JB4 A;  3OFW A;  2ZJX A;  1BF0 A;  3L3T E;  1DTK A;  2KNT A;  5JB6 A;  1TAW B;  3BTM I;  1BHC A;  3BTF I;  2JOT A;  4U32 X;  5JB7 A;  1TOC R;  4ISL B;  6PTI A;  4NTX B;  1D0D A;  1ZJD B;  4Y0Z I;  3T62 D;  1P2Q B;  4Y0Y I;  1BZ5 A;  3TGK I; 
#chains in the Genus database with same CATH homology
 4DTG K;  7PTI A;  2HEX A;  1OA6 5;  3OTJ I;  1KIG I;  4PTI A;  1P2J I;  3BTQ I;  1YLD B;  3BTH I;  1MTN D;  3L33 E;  2RA3 C;  1KUN A;  2PTC I;  1BTH P;  3BTD I;  1ADZ A;  1LD5 A;  2DDJ A;  1F5R I;  1KTH A;  2J6D A;  3WNY A;  3AUI A;  1QLQ A;  1CA0 D;  2TPI I;  2KAI I;  2DDI A;  3AUG A;  2FI3 I;  1AAL A;  1NAG A;  5JB5 A;  3LDM A;  4NTW B;  1F7Z I;  4BNR I;  3FP6 I;  2R9P E;  3AUB A;  2LFL A;  1UUA A;  1T8O B;  2FTL I;  1FY8 I;  1T8L B;  2KCR A;  2FI5 I;  2CA7 A;  4TPI I;  1FAN A;  1P2K I;  3AUH A;  1JC6 A;  4U30 W;  3P95 E;  3AUD A;  8PTI A;  3BYB A;  3TGI I;  4DG4 C;  1FAK I;  1JV9 A;  1YC0 I;  4NTY B;  1IRH A;  1D0D B;  1ZR0 B;  1T8N B;  1TPA I;  2UUX A;  3UOU B;  3D65 I;  4BD9 B;  2ODY E;  1BPT A;  1YKT B;  1BIK A;  1PIT A;  4BQD A;  3GYM I;  3M7Q B;  4WWY C;  3BTG I;  1JV8 A;  5PTI A;  2FI4 I;  3CI7 A;  4WXV C;  1UUB A;  1B0C A;  1LD6 A;  1CO7 I;  2TGP I;  2UUY B;  1YLC B;  2W8X A;  1DEN A;  1BUN B;  5C67 C;  3BTK I;  1P2I I;  3FP8 I;  3LDJ A;  4ISO B;  1KNT A;  1T7C B;  1P2N B;  1TAP A;  3FP7 J;  1DEM A;  1DTX A;  1AAP A;  3BTW I;  4ISN B;  1G6X A;  1EJM B;  1BRC I;  1TFX C;  3BTT I;  3AUE A;  1Y62 A;  1SHP A;  2FTM B;  1BTI A;  1CBW D;  9PTI A;  2M99 A;  2ZVX A;  4Y10 I;  4Y11 I;  3TGJ I;  3UIR C;  3U1J E;  1P2O B;  1TCP A;  1BZX I;  2M01 A;  1P2M B;  1OA5 5;  3P92 E;  3LDI A;  1EAW B;  2IJO I;  3BTE I;  3TPI I;  1T8M B;  1BPI A;  3AUC A;  2LFK A;  1K6U A;  1BRB I;  5JB4 A;  3OFW A;  2ZJX A;  1BF0 A;  3L3T E;  1DTK A;  2KNT A;  5JB6 A;  1TAW B;  3BTM I;  1BHC A;  3BTF I;  2JOT A;  4U32 X;  5JB7 A;  1TOC R;  4ISL B;  6PTI A;  4NTX B;  1D0D A;  1ZJD B;  4Y0Z I;  3T62 D;  1P2Q B;  4Y0Y I;  1BZ5 A;  3TGK I; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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