2FTMB

Crystal structure of trypsin complexed with the bpti variant (tyr35->gly)
Total Genus 11
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVGGGCRAKRNNFKSAEDCMRTCGGA
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Rigidification of a Flexible Protease Inhibitor Variant upon Binding to Trypsin.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Bos taurus
molecule keywords Cationic trypsin
total genus 11
structure length 58
sequence length 58
ec nomenclature
pdb deposition date 2006-01-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2ftmB00
1D0DB 3P95E 2TGPI 1BZ5A 1P2NB 1BF0A 3AUGA 3LDJA 2KAII 3TGII 1KUNA 1LD5A 2UUXA 3T62D 1YLDB 1P2JI 1UUAA 1B0CA 3BTFI 2UUYB 1SHPA 3GYMI 1JV9A 1BTHP 4ISOB 1F7ZI 1LD6A 1BHCA 1ZJDB 2FI5I 1BPIA 3D65I 3P92E 3U1JE 1OA65 1ADZA 1CA0D 3AUCA 1P2MB 1FANA 3FP7J 1FY8I 1P2KI 2W8XA 3L3TE 4WWYC 1TAPA 1T8LB 1TAWB 3AUEA 3FP6I 3M7QB 4U32X 3BTEI 1QLQA 4Y10I 1TCPA 3BTDI 3AUIA 4ISLB 4U30W 2KNTA 1K6UA 1P2QB 3AUBA 1G6XA 1BRBI 2LFKA 1KNTA 2ZVXA 1BPTA 2PTCI 1KTHA 8PTIA 1BTIA 1TOCR 4PTIA 2JOTA 1D0DA 2FTLI 1T8OB 2J6DA 1OA55 2LFLA 3OFWA 1FAKI 3BTTI 3BTMI 1DTKA 2FI3I 1CBWD 4Y0YI 4Y11I 5JB5A 3LDMA 1CO7I 3LDIA 4DG4C 1AAPA 1YKTB 4NTWB 2TPII 9PTIA 1P2II 3FP8I 1TPAI 3UOUB 2IJOI 3AUHA 1TFXC 5JB4A 4DTGK 1BRCI 1NAGA 2FI4I 2CA7A 2KCRA 1BUNB 4Y0ZI 4NTYB 1DTXA 6PTIA 2DDJA 1JV8A 1EJMB 2HEXA 1BZXI 1T8MB 1BIKA 3BTGI 4NTXB 1IRHA 1MTND 7PTIA 1EAWB 4BNRI 3TGJI 2M99A 5PTIA 1DENA 1AALA 1Y62A 1UUBA 3BTWI 1DEMA 3TPII 3BTKI 3OTJI 2M01A 3TGKI 2R9PE 4WXVC 3BYBA 1ZR0B 3BTHI 2RA3C 1JC6A 3BTQI 1PITA 1KIGI 2FTMB 3CI7A 5JB7A 5JB6A 4TPII 3UIRC 3WNYA 1YLCB 2DDIA 2ODYE 3AUDA 5C67C 4BQDA 4BD9B 1T7CB 4ISNB 1T8NB 1F5RI 1P2OB 2ZJXA 3L33E 1YC0I
chains in the Genus database with same CATH superfamily
1D0DB 3P95E 2TGPI 1BZ5A 1P2NB 1BF0A 3AUGA 3LDJA 2KAII 3TGII 1KUNA 1LD5A 2UUXA 3T62D 1YLDB 1P2JI 1UUAA 1B0CA 3BTFI 2UUYB 1SHPA 3GYMI 1JV9A 1BTHP 4ISOB 1F7ZI 1LD6A 1BHCA 1ZJDB 2FI5I 1BPIA 3D65I 3P92E 3U1JE 1OA65 1ADZA 1CA0D 3AUCA 1P2MB 1FANA 3FP7J 1FY8I 1P2KI 2W8XA 3L3TE 4WWYC 1TAPA 1T8LB 1TAWB 3AUEA 3FP6I 3M7QB 4U32X 3BTEI 1QLQA 4Y10I 1TCPA 3BTDI 3AUIA 4ISLB 4U30W 2KNTA 1K6UA 1P2QB 3AUBA 1G6XA 1BRBI 2LFKA 1KNTA 2ZVXA 1BPTA 2PTCI 1KTHA 8PTIA 1BTIA 1TOCR 4PTIA 2JOTA 1D0DA 2FTLI 1T8OB 2J6DA 1OA55 2LFLA 3OFWA 1FAKI 3BTTI 3BTMI 1DTKA 2FI3I 1CBWD 4Y0YI 4Y11I 5JB5A 3LDMA 1CO7I 3LDIA 4DG4C 1AAPA 1YKTB 4NTWB 2TPII 9PTIA 1P2II 3FP8I 1TPAI 3UOUB 2IJOI 3AUHA 1TFXC 5JB4A 4DTGK 1BRCI 1NAGA 2FI4I 2CA7A 2KCRA 1BUNB 4Y0ZI 4NTYB 1DTXA 6PTIA 2DDJA 1JV8A 1EJMB 2HEXA 1BZXI 1T8MB 1BIKA 3BTGI 4NTXB 1IRHA 1MTND 7PTIA 1EAWB 4BNRI 3TGJI 2M99A 5PTIA 1DENA 1AALA 1Y62A 1UUBA 3BTWI 1DEMA 3TPII 3BTKI 3OTJI 2M01A 3TGKI 2R9PE 4WXVC 3BYBA 1ZR0B 3BTHI 2RA3C 1JC6A 3BTQI 1PITA 1KIGI 2FTMB 3CI7A 5JB7A 5JB6A 4TPII 3UIRC 3WNYA 1YLCB 2DDIA 2ODYE 3AUDA 5C67C 4BQDA 4BD9B 1T7CB 4ISNB 1T8NB 1F5RI 1P2OB 2ZJXA 3L33E 1YC0I
chains in the Genus database with same CATH topology
1D0DB 3P95E 2TGPI 1BZ5A 1P2NB 1BF0A 3AUGA 3LDJA 2KAII 3TGII 1KUNA 1LD5A 2UUXA 3T62D 1YLDB 1P2JI 1UUAA 1B0CA 3BTFI 2UUYB 1SHPA 3GYMI 1JV9A 1BTHP 4ISOB 1F7ZI 1LD6A 1BHCA 1ZJDB 2FI5I 1BPIA 3D65I 3P92E 3U1JE 1OA65 1ADZA 1CA0D 3AUCA 1P2MB 1FANA 3FP7J 1FY8I 1P2KI 2W8XA 3L3TE 4WWYC 1TAPA 1T8LB 1TAWB 3AUEA 3FP6I 3M7QB 4U32X 3BTEI 1QLQA 4Y10I 1TCPA 3BTDI 3AUIA 4ISLB 4U30W 2KNTA 1K6UA 1P2QB 3AUBA 1G6XA 1BRBI 2LFKA 1KNTA 2ZVXA 1BPTA 2PTCI 1KTHA 8PTIA 1BTIA 1TOCR 4PTIA 2JOTA 1D0DA 2FTLI 1T8OB 2J6DA 1OA55 2LFLA 3OFWA 1FAKI 3BTTI 3BTMI 1DTKA 2FI3I 1CBWD 4Y0YI 4Y11I 5JB5A 3LDMA 1CO7I 3LDIA 4DG4C 1AAPA 1YKTB 4NTWB 2TPII 9PTIA 1P2II 3FP8I 1TPAI 3UOUB 2IJOI 3AUHA 1TFXC 5JB4A 4DTGK 1BRCI 1NAGA 2FI4I 2CA7A 2KCRA 1BUNB 4Y0ZI 4NTYB 1DTXA 6PTIA 2DDJA 1JV8A 1EJMB 2HEXA 1BZXI 1T8MB 1BIKA 3BTGI 4NTXB 1IRHA 1MTND 7PTIA 1EAWB 4BNRI 3TGJI 2M99A 5PTIA 1DENA 1AALA 1Y62A 1UUBA 3BTWI 1DEMA 3TPII 3BTKI 3OTJI 2M01A 3TGKI 2R9PE 4WXVC 3BYBA 1ZR0B 3BTHI 2RA3C 1JC6A 3BTQI 1PITA 1KIGI 2FTMB 3CI7A 5JB7A 5JB6A 4TPII 3UIRC 3WNYA 1YLCB 2DDIA 2ODYE 3AUDA 5C67C 4BQDA 4BD9B 1T7CB 4ISNB 1T8NB 1F5RI 1P2OB 2ZJXA 3L33E 1YC0I
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1D0D B;  3P95 E;  2TGP I;  1BZ5 A;  1P2N B;  1BF0 A;  3AUG A;  3LDJ A;  2KAI I;  3TGI I;  1KUN A;  1LD5 A;  2UUX A;  3T62 D;  1YLD B;  1P2J I;  1UUA A;  1B0C A;  3BTF I;  2UUY B;  1SHP A;  3GYM I;  1JV9 A;  1BTH P;  4ISO B;  1F7Z I;  1LD6 A;  1BHC A;  1ZJD B;  2FI5 I;  1BPI A;  3D65 I;  3P92 E;  3U1J E;  1OA6 5;  1ADZ A;  1CA0 D;  3AUC A;  1P2M B;  1FAN A;  3FP7 J;  1FY8 I;  1P2K I;  2W8X A;  3L3T E;  4WWY C;  1TAP A;  1T8L B;  1TAW B;  3AUE A;  3FP6 I;  3M7Q B;  4U32 X;  3BTE I;  1QLQ A;  4Y10 I;  1TCP A;  3BTD I;  3AUI A;  4ISL B;  4U30 W;  2KNT A;  1K6U A;  1P2Q B;  3AUB A;  1G6X A;  1BRB I;  2LFK A;  1KNT A;  2ZVX A;  1BPT A;  2PTC I;  1KTH A;  8PTI A;  1BTI A;  1TOC R;  4PTI A;  2JOT A;  1D0D A;  2FTL I;  1T8O B;  2J6D A;  1OA5 5;  2LFL A;  3OFW A;  1FAK I;  3BTT I;  3BTM I;  1DTK A;  2FI3 I;  1CBW D;  4Y0Y I;  4Y11 I;  5JB5 A;  3LDM A;  1CO7 I;  3LDI A;  4DG4 C;  1AAP A;  1YKT B;  4NTW B;  2TPI I;  9PTI A;  1P2I I;  3FP8 I;  1TPA I;  3UOU B;  2IJO I;  3AUH A;  1TFX C;  5JB4 A;  4DTG K;  1BRC I;  1NAG A;  2FI4 I;  2CA7 A;  2KCR A;  1BUN B;  4Y0Z I;  4NTY B;  1DTX A;  6PTI A;  2DDJ A;  1JV8 A;  1EJM B;  2HEX A;  1BZX I;  1T8M B;  1BIK A;  3BTG I;  4NTX B;  1IRH A;  1MTN D;  7PTI A;  1EAW B;  4BNR I;  3TGJ I;  2M99 A;  5PTI A;  1DEN A;  1AAL A;  1Y62 A;  1UUB A;  3BTW I;  1DEM A;  3TPI I;  3BTK I;  3OTJ I;  2M01 A;  3TGK I;  2R9P E;  4WXV C;  3BYB A;  1ZR0 B;  3BTH I;  2RA3 C;  1JC6 A;  3BTQ I;  1PIT A;  1KIG I;  2FTM B;  3CI7 A;  5JB7 A;  5JB6 A;  4TPI I;  3UIR C;  3WNY A;  1YLC B;  2DDI A;  2ODY E;  3AUD A;  5C67 C;  4BQD A;  4BD9 B;  1T7C B;  4ISN B;  1T8N B;  1F5R I;  1P2O B;  2ZJX A;  3L33 E;  1YC0 I; 
#chains in the Genus database with same CATH topology
 1D0D B;  3P95 E;  2TGP I;  1BZ5 A;  1P2N B;  1BF0 A;  3AUG A;  3LDJ A;  2KAI I;  3TGI I;  1KUN A;  1LD5 A;  2UUX A;  3T62 D;  1YLD B;  1P2J I;  1UUA A;  1B0C A;  3BTF I;  2UUY B;  1SHP A;  3GYM I;  1JV9 A;  1BTH P;  4ISO B;  1F7Z I;  1LD6 A;  1BHC A;  1ZJD B;  2FI5 I;  1BPI A;  3D65 I;  3P92 E;  3U1J E;  1OA6 5;  1ADZ A;  1CA0 D;  3AUC A;  1P2M B;  1FAN A;  3FP7 J;  1FY8 I;  1P2K I;  2W8X A;  3L3T E;  4WWY C;  1TAP A;  1T8L B;  1TAW B;  3AUE A;  3FP6 I;  3M7Q B;  4U32 X;  3BTE I;  1QLQ A;  4Y10 I;  1TCP A;  3BTD I;  3AUI A;  4ISL B;  4U30 W;  2KNT A;  1K6U A;  1P2Q B;  3AUB A;  1G6X A;  1BRB I;  2LFK A;  1KNT A;  2ZVX A;  1BPT A;  2PTC I;  1KTH A;  8PTI A;  1BTI A;  1TOC R;  4PTI A;  2JOT A;  1D0D A;  2FTL I;  1T8O B;  2J6D A;  1OA5 5;  2LFL A;  3OFW A;  1FAK I;  3BTT I;  3BTM I;  1DTK A;  2FI3 I;  1CBW D;  4Y0Y I;  4Y11 I;  5JB5 A;  3LDM A;  1CO7 I;  3LDI A;  4DG4 C;  1AAP A;  1YKT B;  4NTW B;  2TPI I;  9PTI A;  1P2I I;  3FP8 I;  1TPA I;  3UOU B;  2IJO I;  3AUH A;  1TFX C;  5JB4 A;  4DTG K;  1BRC I;  1NAG A;  2FI4 I;  2CA7 A;  2KCR A;  1BUN B;  4Y0Z I;  4NTY B;  1DTX A;  6PTI A;  2DDJ A;  1JV8 A;  1EJM B;  2HEX A;  1BZX I;  1T8M B;  1BIK A;  3BTG I;  4NTX B;  1IRH A;  1MTN D;  7PTI A;  1EAW B;  4BNR I;  3TGJ I;  2M99 A;  5PTI A;  1DEN A;  1AAL A;  1Y62 A;  1UUB A;  3BTW I;  1DEM A;  3TPI I;  3BTK I;  3OTJ I;  2M01 A;  3TGK I;  2R9P E;  4WXV C;  3BYB A;  1ZR0 B;  3BTH I;  2RA3 C;  1JC6 A;  3BTQ I;  1PIT A;  1KIG I;  2FTM B;  3CI7 A;  5JB7 A;  5JB6 A;  4TPI I;  3UIR C;  3WNY A;  1YLC B;  2DDI A;  2ODY E;  3AUD A;  5C67 C;  4BQD A;  4BD9 B;  1T7C B;  4ISN B;  1T8N B;  1F5R I;  1P2O B;  2ZJX A;  3L33 E;  1YC0 I; 
#chains in the Genus database with same CATH homology
 1D0D B;  3P95 E;  2TGP I;  1BZ5 A;  1P2N B;  1BF0 A;  3AUG A;  3LDJ A;  2KAI I;  3TGI I;  1KUN A;  1LD5 A;  2UUX A;  3T62 D;  1YLD B;  1P2J I;  1UUA A;  1B0C A;  3BTF I;  2UUY B;  1SHP A;  3GYM I;  1JV9 A;  1BTH P;  4ISO B;  1F7Z I;  1LD6 A;  1BHC A;  1ZJD B;  2FI5 I;  1BPI A;  3D65 I;  3P92 E;  3U1J E;  1OA6 5;  1ADZ A;  1CA0 D;  3AUC A;  1P2M B;  1FAN A;  3FP7 J;  1FY8 I;  1P2K I;  2W8X A;  3L3T E;  4WWY C;  1TAP A;  1T8L B;  1TAW B;  3AUE A;  3FP6 I;  3M7Q B;  4U32 X;  3BTE I;  1QLQ A;  4Y10 I;  1TCP A;  3BTD I;  3AUI A;  4ISL B;  4U30 W;  2KNT A;  1K6U A;  1P2Q B;  3AUB A;  1G6X A;  1BRB I;  2LFK A;  1KNT A;  2ZVX A;  1BPT A;  2PTC I;  1KTH A;  8PTI A;  1BTI A;  1TOC R;  4PTI A;  2JOT A;  1D0D A;  2FTL I;  1T8O B;  2J6D A;  1OA5 5;  2LFL A;  3OFW A;  1FAK I;  3BTT I;  3BTM I;  1DTK A;  2FI3 I;  1CBW D;  4Y0Y I;  4Y11 I;  5JB5 A;  3LDM A;  1CO7 I;  3LDI A;  4DG4 C;  1AAP A;  1YKT B;  4NTW B;  2TPI I;  9PTI A;  1P2I I;  3FP8 I;  1TPA I;  3UOU B;  2IJO I;  3AUH A;  1TFX C;  5JB4 A;  4DTG K;  1BRC I;  1NAG A;  2FI4 I;  2CA7 A;  2KCR A;  1BUN B;  4Y0Z I;  4NTY B;  1DTX A;  6PTI A;  2DDJ A;  1JV8 A;  1EJM B;  2HEX A;  1BZX I;  1T8M B;  1BIK A;  3BTG I;  4NTX B;  1IRH A;  1MTN D;  7PTI A;  1EAW B;  4BNR I;  3TGJ I;  2M99 A;  5PTI A;  1DEN A;  1AAL A;  1Y62 A;  1UUB A;  3BTW I;  1DEM A;  3TPI I;  3BTK I;  3OTJ I;  2M01 A;  3TGK I;  2R9P E;  4WXV C;  3BYB A;  1ZR0 B;  3BTH I;  2RA3 C;  1JC6 A;  3BTQ I;  1PIT A;  1KIG I;  2FTM B;  3CI7 A;  5JB7 A;  5JB6 A;  4TPI I;  3UIR C;  3WNY A;  1YLC B;  2DDI A;  2ODY E;  3AUD A;  5C67 C;  4BQD A;  4BD9 B;  1T7C B;  4ISN B;  1T8N B;  1F5R I;  1P2O B;  2ZJX A;  3L33 E;  1YC0 I; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...