2LFKA

Nmr solution structure of native tdpi-short
Total Genus 3
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
3
sequence length
57
structure length
57
Chain Sequence
GDKEECTVPIGWSEPVKGLCKARFTRYYCMGNCCKVYEGCYTGGYSRMGECARNCPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Oxidative folding and structural analyses of a kunitz-related inhibitor and its disulfide intermediates: functional implications.
pubmed doi rcsb
molecule tags Hydrolase inhibitor
source organism Rhipicephalus appendiculatus
molecule keywords Tryptase inhibitor
total genus 3
structure length 57
sequence length 57
ec nomenclature
pdb deposition date 2011-07-06
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2lfkA01
1KIGI 2DDJA 1P2QB 2FTLI 2DDIA 6PTIA 1AAPA 1OA55 1YC0I 3BYBA 3BTGI 1OA65 2JOTA 3AUIA 1P2II 2ZJXA 2IJOI 3BTHI 3UOUB 1YKTB 1BZXI 4Y11I 3OFWA 1ADZA 2LFKA 5JB7A 1Y62A 1BIKA 1ZR0B 2KCRA 1P2MB 1SHPA 3AUHA 1JV8A 1T8LB 3FP8I 2CA7A 2ODYE 3TGKI 4DG4C 1P2OB 3AUDA 4ISNB 3LDMA 1UUBA 3TGII 1D0DB 1T7CB 5C67C 3AUGA 1TCPA 3M7QB 1FY8I 1K6UA 1KNTA 1BPTA 1F7ZI 3TGJI 1P2NB 3FP7J 4Y10I 1BHCA 1F5RI 3FP6I 1TAPA 2M99A 3BTTI 1CA0D 1B0CA 3LDIA 1LD5A 4WXVC 3BTEI 8PTIA 4TPII 1CBWD 2ZVXA 1YLDB 4NTXB 1IRHA 1ZJDB 3CI7A 3TPII 2FI3I 3L3TE 4U32X 4PTIA 1DTXA 3L33E 4BQDA 2UUYB 1TAWB 4DTGK 4ISOB 1DENA 2KNTA 4NTYB 1TPAI 2LFLA 1FANA 1DEMA 1AALA 1T8MB 3U1JE 5JB4A 2TPII 1BF0A 2RA3C 1T8OB 3P95E 1PITA 3BTWI 4Y0ZI 4BD9B 2KAII 3UIRC 1NAGA 2FI5I 3BTDI 1D0DA 1CO7I 2PTCI 2M01A 1DTKA 1QLQA 1BTIA 1KUNA 3BTMI 4Y0YI 1T8NB 1JV9A 1BZ5A 4ISLB 2R9PE 1FAKI 2J6DA 3AUEA 3AUBA 1P2KI 3GYMI 5JB6A 4BNRI 3BTFI 1TOCR 3T62D 2FTMB 2HEXA 1BPIA 9PTIA 2UUXA 4U30W 4NTWB 3WNYA 1TFXC 5JB5A 3BTQI 1LD6A 1YLCB 1BTHP 3LDJA 1EAWB 1KTHA 3BTKI 3P92E 1P2JI 4WWYC 1MTND 2W8XA 1G6XA 1UUAA 3AUCA 1BRBI 2TGPI 3D65I 1BUNB 1BRCI 5PTIA 7PTIA 1JC6A 2FI4I 3OTJI 1EJMB
chains in the Genus database with same CATH superfamily
1KIGI 2DDJA 1P2QB 2FTLI 2DDIA 6PTIA 1AAPA 1OA55 1YC0I 3BYBA 3BTGI 1OA65 2JOTA 3AUIA 1P2II 2ZJXA 2IJOI 3BTHI 3UOUB 1YKTB 1BZXI 4Y11I 3OFWA 1ADZA 2LFKA 5JB7A 1Y62A 1BIKA 1ZR0B 2KCRA 1P2MB 1SHPA 3AUHA 1JV8A 1T8LB 3FP8I 2CA7A 2ODYE 3TGKI 4DG4C 1P2OB 3AUDA 4ISNB 3LDMA 1UUBA 3TGII 1D0DB 1T7CB 5C67C 3AUGA 1TCPA 3M7QB 1FY8I 1K6UA 1KNTA 1BPTA 1F7ZI 3TGJI 1P2NB 3FP7J 4Y10I 1BHCA 1F5RI 3FP6I 1TAPA 2M99A 3BTTI 1CA0D 1B0CA 3LDIA 1LD5A 4WXVC 3BTEI 8PTIA 4TPII 1CBWD 2ZVXA 1YLDB 4NTXB 1IRHA 1ZJDB 3CI7A 3TPII 2FI3I 3L3TE 4U32X 4PTIA 1DTXA 3L33E 4BQDA 2UUYB 1TAWB 4DTGK 4ISOB 1DENA 2KNTA 4NTYB 1TPAI 2LFLA 1FANA 1DEMA 1AALA 1T8MB 3U1JE 5JB4A 2TPII 1BF0A 2RA3C 1T8OB 3P95E 1PITA 3BTWI 4Y0ZI 4BD9B 2KAII 3UIRC 1NAGA 2FI5I 3BTDI 1D0DA 1CO7I 2PTCI 2M01A 1DTKA 1QLQA 1BTIA 1KUNA 3BTMI 4Y0YI 1T8NB 1JV9A 1BZ5A 4ISLB 2R9PE 1FAKI 2J6DA 3AUEA 3AUBA 1P2KI 3GYMI 5JB6A 4BNRI 3BTFI 1TOCR 3T62D 2FTMB 2HEXA 1BPIA 9PTIA 2UUXA 4U30W 4NTWB 3WNYA 1TFXC 5JB5A 3BTQI 1LD6A 1YLCB 1BTHP 3LDJA 1EAWB 1KTHA 3BTKI 3P92E 1P2JI 4WWYC 1MTND 2W8XA 1G6XA 1UUAA 3AUCA 1BRBI 2TGPI 3D65I 1BUNB 1BRCI 5PTIA 7PTIA 1JC6A 2FI4I 3OTJI 1EJMB
chains in the Genus database with same CATH topology
1KIGI 2DDJA 1P2QB 2FTLI 2DDIA 6PTIA 1AAPA 1OA55 1YC0I 3BYBA 3BTGI 1OA65 2JOTA 3AUIA 1P2II 2ZJXA 2IJOI 3BTHI 3UOUB 1YKTB 1BZXI 4Y11I 3OFWA 1ADZA 2LFKA 5JB7A 1Y62A 1BIKA 1ZR0B 2KCRA 1P2MB 1SHPA 3AUHA 1JV8A 1T8LB 3FP8I 2CA7A 2ODYE 3TGKI 4DG4C 1P2OB 3AUDA 4ISNB 3LDMA 1UUBA 3TGII 1D0DB 1T7CB 5C67C 3AUGA 1TCPA 3M7QB 1FY8I 1K6UA 1KNTA 1BPTA 1F7ZI 3TGJI 1P2NB 3FP7J 4Y10I 1BHCA 1F5RI 3FP6I 1TAPA 2M99A 3BTTI 1CA0D 1B0CA 3LDIA 1LD5A 4WXVC 3BTEI 8PTIA 4TPII 1CBWD 2ZVXA 1YLDB 4NTXB 1IRHA 1ZJDB 3CI7A 3TPII 2FI3I 3L3TE 4U32X 4PTIA 1DTXA 3L33E 4BQDA 2UUYB 1TAWB 4DTGK 4ISOB 1DENA 2KNTA 4NTYB 1TPAI 2LFLA 1FANA 1DEMA 1AALA 1T8MB 3U1JE 5JB4A 2TPII 1BF0A 2RA3C 1T8OB 3P95E 1PITA 3BTWI 4Y0ZI 4BD9B 2KAII 3UIRC 1NAGA 2FI5I 3BTDI 1D0DA 1CO7I 2PTCI 2M01A 1DTKA 1QLQA 1BTIA 1KUNA 3BTMI 4Y0YI 1T8NB 1JV9A 1BZ5A 4ISLB 2R9PE 1FAKI 2J6DA 3AUEA 3AUBA 1P2KI 3GYMI 5JB6A 4BNRI 3BTFI 1TOCR 3T62D 2FTMB 2HEXA 1BPIA 9PTIA 2UUXA 4U30W 4NTWB 3WNYA 1TFXC 5JB5A 3BTQI 1LD6A 1YLCB 1BTHP 3LDJA 1EAWB 1KTHA 3BTKI 3P92E 1P2JI 4WWYC 1MTND 2W8XA 1G6XA 1UUAA 3AUCA 1BRBI 2TGPI 3D65I 1BUNB 1BRCI 5PTIA 7PTIA 1JC6A 2FI4I 3OTJI 1EJMB
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1KIG I;  2DDJ A;  1P2Q B;  2FTL I;  2DDI A;  6PTI A;  1AAP A;  1OA5 5;  1YC0 I;  3BYB A;  3BTG I;  1OA6 5;  2JOT A;  3AUI A;  1P2I I;  2ZJX A;  2IJO I;  3BTH I;  3UOU B;  1YKT B;  1BZX I;  4Y11 I;  3OFW A;  1ADZ A;  2LFK A;  5JB7 A;  1Y62 A;  1BIK A;  1ZR0 B;  2KCR A;  1P2M B;  1SHP A;  3AUH A;  1JV8 A;  1T8L B;  3FP8 I;  2CA7 A;  2ODY E;  3TGK I;  4DG4 C;  1P2O B;  3AUD A;  4ISN B;  3LDM A;  1UUB A;  3TGI I;  1D0D B;  1T7C B;  5C67 C;  3AUG A;  1TCP A;  3M7Q B;  1FY8 I;  1K6U A;  1KNT A;  1BPT A;  1F7Z I;  3TGJ I;  1P2N B;  3FP7 J;  4Y10 I;  1BHC A;  1F5R I;  3FP6 I;  1TAP A;  2M99 A;  3BTT I;  1CA0 D;  1B0C A;  3LDI A;  1LD5 A;  4WXV C;  3BTE I;  8PTI A;  4TPI I;  1CBW D;  2ZVX A;  1YLD B;  4NTX B;  1IRH A;  1ZJD B;  3CI7 A;  3TPI I;  2FI3 I;  3L3T E;  4U32 X;  4PTI A;  1DTX A;  3L33 E;  4BQD A;  2UUY B;  1TAW B;  4DTG K;  4ISO B;  1DEN A;  2KNT A;  4NTY B;  1TPA I;  2LFL A;  1FAN A;  1DEM A;  1AAL A;  1T8M B;  3U1J E;  5JB4 A;  2TPI I;  1BF0 A;  2RA3 C;  1T8O B;  3P95 E;  1PIT A;  3BTW I;  4Y0Z I;  4BD9 B;  2KAI I;  3UIR C;  1NAG A;  2FI5 I;  3BTD I;  1D0D A;  1CO7 I;  2PTC I;  2M01 A;  1DTK A;  1QLQ A;  1BTI A;  1KUN A;  3BTM I;  4Y0Y I;  1T8N B;  1JV9 A;  1BZ5 A;  4ISL B;  2R9P E;  1FAK I;  2J6D A;  3AUE A;  3AUB A;  1P2K I;  3GYM I;  5JB6 A;  4BNR I;  3BTF I;  1TOC R;  3T62 D;  2FTM B;  2HEX A;  1BPI A;  9PTI A;  2UUX A;  4U30 W;  4NTW B;  3WNY A;  1TFX C;  5JB5 A;  3BTQ I;  1LD6 A;  1YLC B;  1BTH P;  3LDJ A;  1EAW B;  1KTH A;  3BTK I;  3P92 E;  1P2J I;  4WWY C;  1MTN D;  2W8X A;  1G6X A;  1UUA A;  3AUC A;  1BRB I;  2TGP I;  3D65 I;  1BUN B;  1BRC I;  5PTI A;  7PTI A;  1JC6 A;  2FI4 I;  3OTJ I;  1EJM B; 
#chains in the Genus database with same CATH topology
 1KIG I;  2DDJ A;  1P2Q B;  2FTL I;  2DDI A;  6PTI A;  1AAP A;  1OA5 5;  1YC0 I;  3BYB A;  3BTG I;  1OA6 5;  2JOT A;  3AUI A;  1P2I I;  2ZJX A;  2IJO I;  3BTH I;  3UOU B;  1YKT B;  1BZX I;  4Y11 I;  3OFW A;  1ADZ A;  2LFK A;  5JB7 A;  1Y62 A;  1BIK A;  1ZR0 B;  2KCR A;  1P2M B;  1SHP A;  3AUH A;  1JV8 A;  1T8L B;  3FP8 I;  2CA7 A;  2ODY E;  3TGK I;  4DG4 C;  1P2O B;  3AUD A;  4ISN B;  3LDM A;  1UUB A;  3TGI I;  1D0D B;  1T7C B;  5C67 C;  3AUG A;  1TCP A;  3M7Q B;  1FY8 I;  1K6U A;  1KNT A;  1BPT A;  1F7Z I;  3TGJ I;  1P2N B;  3FP7 J;  4Y10 I;  1BHC A;  1F5R I;  3FP6 I;  1TAP A;  2M99 A;  3BTT I;  1CA0 D;  1B0C A;  3LDI A;  1LD5 A;  4WXV C;  3BTE I;  8PTI A;  4TPI I;  1CBW D;  2ZVX A;  1YLD B;  4NTX B;  1IRH A;  1ZJD B;  3CI7 A;  3TPI I;  2FI3 I;  3L3T E;  4U32 X;  4PTI A;  1DTX A;  3L33 E;  4BQD A;  2UUY B;  1TAW B;  4DTG K;  4ISO B;  1DEN A;  2KNT A;  4NTY B;  1TPA I;  2LFL A;  1FAN A;  1DEM A;  1AAL A;  1T8M B;  3U1J E;  5JB4 A;  2TPI I;  1BF0 A;  2RA3 C;  1T8O B;  3P95 E;  1PIT A;  3BTW I;  4Y0Z I;  4BD9 B;  2KAI I;  3UIR C;  1NAG A;  2FI5 I;  3BTD I;  1D0D A;  1CO7 I;  2PTC I;  2M01 A;  1DTK A;  1QLQ A;  1BTI A;  1KUN A;  3BTM I;  4Y0Y I;  1T8N B;  1JV9 A;  1BZ5 A;  4ISL B;  2R9P E;  1FAK I;  2J6D A;  3AUE A;  3AUB A;  1P2K I;  3GYM I;  5JB6 A;  4BNR I;  3BTF I;  1TOC R;  3T62 D;  2FTM B;  2HEX A;  1BPI A;  9PTI A;  2UUX A;  4U30 W;  4NTW B;  3WNY A;  1TFX C;  5JB5 A;  3BTQ I;  1LD6 A;  1YLC B;  1BTH P;  3LDJ A;  1EAW B;  1KTH A;  3BTK I;  3P92 E;  1P2J I;  4WWY C;  1MTN D;  2W8X A;  1G6X A;  1UUA A;  3AUC A;  1BRB I;  2TGP I;  3D65 I;  1BUN B;  1BRC I;  5PTI A;  7PTI A;  1JC6 A;  2FI4 I;  3OTJ I;  1EJM B; 
#chains in the Genus database with same CATH homology
 1KIG I;  2DDJ A;  1P2Q B;  2FTL I;  2DDI A;  6PTI A;  1AAP A;  1OA5 5;  1YC0 I;  3BYB A;  3BTG I;  1OA6 5;  2JOT A;  3AUI A;  1P2I I;  2ZJX A;  2IJO I;  3BTH I;  3UOU B;  1YKT B;  1BZX I;  4Y11 I;  3OFW A;  1ADZ A;  2LFK A;  5JB7 A;  1Y62 A;  1BIK A;  1ZR0 B;  2KCR A;  1P2M B;  1SHP A;  3AUH A;  1JV8 A;  1T8L B;  3FP8 I;  2CA7 A;  2ODY E;  3TGK I;  4DG4 C;  1P2O B;  3AUD A;  4ISN B;  3LDM A;  1UUB A;  3TGI I;  1D0D B;  1T7C B;  5C67 C;  3AUG A;  1TCP A;  3M7Q B;  1FY8 I;  1K6U A;  1KNT A;  1BPT A;  1F7Z I;  3TGJ I;  1P2N B;  3FP7 J;  4Y10 I;  1BHC A;  1F5R I;  3FP6 I;  1TAP A;  2M99 A;  3BTT I;  1CA0 D;  1B0C A;  3LDI A;  1LD5 A;  4WXV C;  3BTE I;  8PTI A;  4TPI I;  1CBW D;  2ZVX A;  1YLD B;  4NTX B;  1IRH A;  1ZJD B;  3CI7 A;  3TPI I;  2FI3 I;  3L3T E;  4U32 X;  4PTI A;  1DTX A;  3L33 E;  4BQD A;  2UUY B;  1TAW B;  4DTG K;  4ISO B;  1DEN A;  2KNT A;  4NTY B;  1TPA I;  2LFL A;  1FAN A;  1DEM A;  1AAL A;  1T8M B;  3U1J E;  5JB4 A;  2TPI I;  1BF0 A;  2RA3 C;  1T8O B;  3P95 E;  1PIT A;  3BTW I;  4Y0Z I;  4BD9 B;  2KAI I;  3UIR C;  1NAG A;  2FI5 I;  3BTD I;  1D0D A;  1CO7 I;  2PTC I;  2M01 A;  1DTK A;  1QLQ A;  1BTI A;  1KUN A;  3BTM I;  4Y0Y I;  1T8N B;  1JV9 A;  1BZ5 A;  4ISL B;  2R9P E;  1FAK I;  2J6D A;  3AUE A;  3AUB A;  1P2K I;  3GYM I;  5JB6 A;  4BNR I;  3BTF I;  1TOC R;  3T62 D;  2FTM B;  2HEX A;  1BPI A;  9PTI A;  2UUX A;  4U30 W;  4NTW B;  3WNY A;  1TFX C;  5JB5 A;  3BTQ I;  1LD6 A;  1YLC B;  1BTH P;  3LDJ A;  1EAW B;  1KTH A;  3BTK I;  3P92 E;  1P2J I;  4WWY C;  1MTN D;  2W8X A;  1G6X A;  1UUA A;  3AUC A;  1BRB I;  2TGP I;  3D65 I;  1BUN B;  1BRC I;  5PTI A;  7PTI A;  1JC6 A;  2FI4 I;  3OTJ I;  1EJM B;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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