2LFLA

Nmr solution structure of the intermediate iiib of tdpi-short
Total Genus 8
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
8
sequence length
57
structure length
57
Chain Sequence
GDKEECTVPIGWSEPVKGLCKARFTRYYCMGNCCKVYEGCYTGGYSRMGECARNCPG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Oxidative folding and structural analyses of a kunitz-related inhibitor and its disulfide intermediates: functional implications.
pubmed doi rcsb
molecule tags Hydrolase inhibitor
source organism Rhipicephalus appendiculatus
molecule keywords Tryptase inhibitor
total genus 8
structure length 57
sequence length 57
ec nomenclature
pdb deposition date 2011-07-06
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2lflA01
1T8OB 2FTMB 1YKTB 3UOUB 2FTLI 4DTGK 4ISLB 3AUCA 1TCPA 2J6DA 5JB7A 3AUHA 3L3TE 3AUGA 1AALA 3BYBA 3T62D 1TAWB 1BHCA 2DDJA 2FI4I 3LDIA 4BD9B 1F7ZI 4U30W 3AUDA 3FP7J 1P2JI 3FP6I 2FI5I 4ISOB 1LD5A 2TPII 5JB5A 1IRHA 1CO7I 2M99A 1EJMB 3BTQI 1T8LB 1KTHA 1AAPA 1LD6A 1ZR0B 4Y10I 1CBWD 1OA55 1TPAI 1PITA 1T8NB 1EAWB 2KAII 1ADZA 1T7CB 1JV8A 2R9PE 4BNRI 4Y11I 3BTEI 2PTCI 3OFWA 1D0DB 9PTIA 1NAGA 5PTIA 1BTHP 4DG4C 4WXVC 2RA3C 1KNTA 1TAPA 1FAKI 1P2OB 4NTYB 2IJOI 2LFLA 1MTND 8PTIA 1BZXI 4U32X 1BZ5A 2CA7A 1UUAA 2UUXA 1OA65 1BTIA 1TFXC 4WWYC 4PTIA 2KCRA 5JB4A 1G6XA 1BPTA 1QLQA 3BTDI 4Y0ZI 4ISNB 1F5RI 2TGPI 2W8XA 3TPII 4Y0YI 4TPII 2ODYE 5JB6A 1P2KI 3CI7A 3M7QB 3P92E 3U1JE 1BIKA 3FP8I 1BUNB 1DTXA 2M01A 1TOCR 1BRBI 3BTTI 1FANA 1DENA 1JC6A 7PTIA 2LFKA 6PTIA 3BTGI 2ZJXA 1B0CA 1CA0D 1P2II 1YLCB 1ZJDB 3BTHI 3AUIA 2ZVXA 1D0DA 1FY8I 1K6UA 1YC0I 1BPIA 1JV9A 3TGJI 1BF0A 3AUBA 1Y62A 2HEXA 1T8MB 3UIRC 3TGKI 1UUBA 3LDMA 4BQDA 1P2NB 3BTKI 1SHPA 3AUEA 3BTFI 1KIGI 3BTWI 3D65I 3GYMI 5C67C 1DEMA 2FI3I 1YLDB 3OTJI 2UUYB 3WNYA 3LDJA 3L33E 3P95E 3TGII 2JOTA 1P2QB 4NTXB 4NTWB 1DTKA 1P2MB 3BTMI 1KUNA 1BRCI 2DDIA 2KNTA
chains in the Genus database with same CATH superfamily
1T8OB 2FTMB 1YKTB 3UOUB 2FTLI 4DTGK 4ISLB 3AUCA 1TCPA 2J6DA 5JB7A 3AUHA 3L3TE 3AUGA 1AALA 3BYBA 3T62D 1TAWB 1BHCA 2DDJA 2FI4I 3LDIA 4BD9B 1F7ZI 4U30W 3AUDA 3FP7J 1P2JI 3FP6I 2FI5I 4ISOB 1LD5A 2TPII 5JB5A 1IRHA 1CO7I 2M99A 1EJMB 3BTQI 1T8LB 1KTHA 1AAPA 1LD6A 1ZR0B 4Y10I 1CBWD 1OA55 1TPAI 1PITA 1T8NB 1EAWB 2KAII 1ADZA 1T7CB 1JV8A 2R9PE 4BNRI 4Y11I 3BTEI 2PTCI 3OFWA 1D0DB 9PTIA 1NAGA 5PTIA 1BTHP 4DG4C 4WXVC 2RA3C 1KNTA 1TAPA 1FAKI 1P2OB 4NTYB 2IJOI 2LFLA 1MTND 8PTIA 1BZXI 4U32X 1BZ5A 2CA7A 1UUAA 2UUXA 1OA65 1BTIA 1TFXC 4WWYC 4PTIA 2KCRA 5JB4A 1G6XA 1BPTA 1QLQA 3BTDI 4Y0ZI 4ISNB 1F5RI 2TGPI 2W8XA 3TPII 4Y0YI 4TPII 2ODYE 5JB6A 1P2KI 3CI7A 3M7QB 3P92E 3U1JE 1BIKA 3FP8I 1BUNB 1DTXA 2M01A 1TOCR 1BRBI 3BTTI 1FANA 1DENA 1JC6A 7PTIA 2LFKA 6PTIA 3BTGI 2ZJXA 1B0CA 1CA0D 1P2II 1YLCB 1ZJDB 3BTHI 3AUIA 2ZVXA 1D0DA 1FY8I 1K6UA 1YC0I 1BPIA 1JV9A 3TGJI 1BF0A 3AUBA 1Y62A 2HEXA 1T8MB 3UIRC 3TGKI 1UUBA 3LDMA 4BQDA 1P2NB 3BTKI 1SHPA 3AUEA 3BTFI 1KIGI 3BTWI 3D65I 3GYMI 5C67C 1DEMA 2FI3I 1YLDB 3OTJI 2UUYB 3WNYA 3LDJA 3L33E 3P95E 3TGII 2JOTA 1P2QB 4NTXB 4NTWB 1DTKA 1P2MB 3BTMI 1KUNA 1BRCI 2DDIA 2KNTA
chains in the Genus database with same CATH topology
1T8OB 2FTMB 1YKTB 3UOUB 2FTLI 4DTGK 4ISLB 3AUCA 1TCPA 2J6DA 5JB7A 3AUHA 3L3TE 3AUGA 1AALA 3BYBA 3T62D 1TAWB 1BHCA 2DDJA 2FI4I 3LDIA 4BD9B 1F7ZI 4U30W 3AUDA 3FP7J 1P2JI 3FP6I 2FI5I 4ISOB 1LD5A 2TPII 5JB5A 1IRHA 1CO7I 2M99A 1EJMB 3BTQI 1T8LB 1KTHA 1AAPA 1LD6A 1ZR0B 4Y10I 1CBWD 1OA55 1TPAI 1PITA 1T8NB 1EAWB 2KAII 1ADZA 1T7CB 1JV8A 2R9PE 4BNRI 4Y11I 3BTEI 2PTCI 3OFWA 1D0DB 9PTIA 1NAGA 5PTIA 1BTHP 4DG4C 4WXVC 2RA3C 1KNTA 1TAPA 1FAKI 1P2OB 4NTYB 2IJOI 2LFLA 1MTND 8PTIA 1BZXI 4U32X 1BZ5A 2CA7A 1UUAA 2UUXA 1OA65 1BTIA 1TFXC 4WWYC 4PTIA 2KCRA 5JB4A 1G6XA 1BPTA 1QLQA 3BTDI 4Y0ZI 4ISNB 1F5RI 2TGPI 2W8XA 3TPII 4Y0YI 4TPII 2ODYE 5JB6A 1P2KI 3CI7A 3M7QB 3P92E 3U1JE 1BIKA 3FP8I 1BUNB 1DTXA 2M01A 1TOCR 1BRBI 3BTTI 1FANA 1DENA 1JC6A 7PTIA 2LFKA 6PTIA 3BTGI 2ZJXA 1B0CA 1CA0D 1P2II 1YLCB 1ZJDB 3BTHI 3AUIA 2ZVXA 1D0DA 1FY8I 1K6UA 1YC0I 1BPIA 1JV9A 3TGJI 1BF0A 3AUBA 1Y62A 2HEXA 1T8MB 3UIRC 3TGKI 1UUBA 3LDMA 4BQDA 1P2NB 3BTKI 1SHPA 3AUEA 3BTFI 1KIGI 3BTWI 3D65I 3GYMI 5C67C 1DEMA 2FI3I 1YLDB 3OTJI 2UUYB 3WNYA 3LDJA 3L33E 3P95E 3TGII 2JOTA 1P2QB 4NTXB 4NTWB 1DTKA 1P2MB 3BTMI 1KUNA 1BRCI 2DDIA 2KNTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1T8O B;  2FTM B;  1YKT B;  3UOU B;  2FTL I;  4DTG K;  4ISL B;  3AUC A;  1TCP A;  2J6D A;  5JB7 A;  3AUH A;  3L3T E;  3AUG A;  1AAL A;  3BYB A;  3T62 D;  1TAW B;  1BHC A;  2DDJ A;  2FI4 I;  3LDI A;  4BD9 B;  1F7Z I;  4U30 W;  3AUD A;  3FP7 J;  1P2J I;  3FP6 I;  2FI5 I;  4ISO B;  1LD5 A;  2TPI I;  5JB5 A;  1IRH A;  1CO7 I;  2M99 A;  1EJM B;  3BTQ I;  1T8L B;  1KTH A;  1AAP A;  1LD6 A;  1ZR0 B;  4Y10 I;  1CBW D;  1OA5 5;  1TPA I;  1PIT A;  1T8N B;  1EAW B;  2KAI I;  1ADZ A;  1T7C B;  1JV8 A;  2R9P E;  4BNR I;  4Y11 I;  3BTE I;  2PTC I;  3OFW A;  1D0D B;  9PTI A;  1NAG A;  5PTI A;  1BTH P;  4DG4 C;  4WXV C;  2RA3 C;  1KNT A;  1TAP A;  1FAK I;  1P2O B;  4NTY B;  2IJO I;  2LFL A;  1MTN D;  8PTI A;  1BZX I;  4U32 X;  1BZ5 A;  2CA7 A;  1UUA A;  2UUX A;  1OA6 5;  1BTI A;  1TFX C;  4WWY C;  4PTI A;  2KCR A;  5JB4 A;  1G6X A;  1BPT A;  1QLQ A;  3BTD I;  4Y0Z I;  4ISN B;  1F5R I;  2TGP I;  2W8X A;  3TPI I;  4Y0Y I;  4TPI I;  2ODY E;  5JB6 A;  1P2K I;  3CI7 A;  3M7Q B;  3P92 E;  3U1J E;  1BIK A;  3FP8 I;  1BUN B;  1DTX A;  2M01 A;  1TOC R;  1BRB I;  3BTT I;  1FAN A;  1DEN A;  1JC6 A;  7PTI A;  2LFK A;  6PTI A;  3BTG I;  2ZJX A;  1B0C A;  1CA0 D;  1P2I I;  1YLC B;  1ZJD B;  3BTH I;  3AUI A;  2ZVX A;  1D0D A;  1FY8 I;  1K6U A;  1YC0 I;  1BPI A;  1JV9 A;  3TGJ I;  1BF0 A;  3AUB A;  1Y62 A;  2HEX A;  1T8M B;  3UIR C;  3TGK I;  1UUB A;  3LDM A;  4BQD A;  1P2N B;  3BTK I;  1SHP A;  3AUE A;  3BTF I;  1KIG I;  3BTW I;  3D65 I;  3GYM I;  5C67 C;  1DEM A;  2FI3 I;  1YLD B;  3OTJ I;  2UUY B;  3WNY A;  3LDJ A;  3L33 E;  3P95 E;  3TGI I;  2JOT A;  1P2Q B;  4NTX B;  4NTW B;  1DTK A;  1P2M B;  3BTM I;  1KUN A;  1BRC I;  2DDI A;  2KNT A; 
#chains in the Genus database with same CATH topology
 1T8O B;  2FTM B;  1YKT B;  3UOU B;  2FTL I;  4DTG K;  4ISL B;  3AUC A;  1TCP A;  2J6D A;  5JB7 A;  3AUH A;  3L3T E;  3AUG A;  1AAL A;  3BYB A;  3T62 D;  1TAW B;  1BHC A;  2DDJ A;  2FI4 I;  3LDI A;  4BD9 B;  1F7Z I;  4U30 W;  3AUD A;  3FP7 J;  1P2J I;  3FP6 I;  2FI5 I;  4ISO B;  1LD5 A;  2TPI I;  5JB5 A;  1IRH A;  1CO7 I;  2M99 A;  1EJM B;  3BTQ I;  1T8L B;  1KTH A;  1AAP A;  1LD6 A;  1ZR0 B;  4Y10 I;  1CBW D;  1OA5 5;  1TPA I;  1PIT A;  1T8N B;  1EAW B;  2KAI I;  1ADZ A;  1T7C B;  1JV8 A;  2R9P E;  4BNR I;  4Y11 I;  3BTE I;  2PTC I;  3OFW A;  1D0D B;  9PTI A;  1NAG A;  5PTI A;  1BTH P;  4DG4 C;  4WXV C;  2RA3 C;  1KNT A;  1TAP A;  1FAK I;  1P2O B;  4NTY B;  2IJO I;  2LFL A;  1MTN D;  8PTI A;  1BZX I;  4U32 X;  1BZ5 A;  2CA7 A;  1UUA A;  2UUX A;  1OA6 5;  1BTI A;  1TFX C;  4WWY C;  4PTI A;  2KCR A;  5JB4 A;  1G6X A;  1BPT A;  1QLQ A;  3BTD I;  4Y0Z I;  4ISN B;  1F5R I;  2TGP I;  2W8X A;  3TPI I;  4Y0Y I;  4TPI I;  2ODY E;  5JB6 A;  1P2K I;  3CI7 A;  3M7Q B;  3P92 E;  3U1J E;  1BIK A;  3FP8 I;  1BUN B;  1DTX A;  2M01 A;  1TOC R;  1BRB I;  3BTT I;  1FAN A;  1DEN A;  1JC6 A;  7PTI A;  2LFK A;  6PTI A;  3BTG I;  2ZJX A;  1B0C A;  1CA0 D;  1P2I I;  1YLC B;  1ZJD B;  3BTH I;  3AUI A;  2ZVX A;  1D0D A;  1FY8 I;  1K6U A;  1YC0 I;  1BPI A;  1JV9 A;  3TGJ I;  1BF0 A;  3AUB A;  1Y62 A;  2HEX A;  1T8M B;  3UIR C;  3TGK I;  1UUB A;  3LDM A;  4BQD A;  1P2N B;  3BTK I;  1SHP A;  3AUE A;  3BTF I;  1KIG I;  3BTW I;  3D65 I;  3GYM I;  5C67 C;  1DEM A;  2FI3 I;  1YLD B;  3OTJ I;  2UUY B;  3WNY A;  3LDJ A;  3L33 E;  3P95 E;  3TGI I;  2JOT A;  1P2Q B;  4NTX B;  4NTW B;  1DTK A;  1P2M B;  3BTM I;  1KUN A;  1BRC I;  2DDI A;  2KNT A; 
#chains in the Genus database with same CATH homology
 1T8O B;  2FTM B;  1YKT B;  3UOU B;  2FTL I;  4DTG K;  4ISL B;  3AUC A;  1TCP A;  2J6D A;  5JB7 A;  3AUH A;  3L3T E;  3AUG A;  1AAL A;  3BYB A;  3T62 D;  1TAW B;  1BHC A;  2DDJ A;  2FI4 I;  3LDI A;  4BD9 B;  1F7Z I;  4U30 W;  3AUD A;  3FP7 J;  1P2J I;  3FP6 I;  2FI5 I;  4ISO B;  1LD5 A;  2TPI I;  5JB5 A;  1IRH A;  1CO7 I;  2M99 A;  1EJM B;  3BTQ I;  1T8L B;  1KTH A;  1AAP A;  1LD6 A;  1ZR0 B;  4Y10 I;  1CBW D;  1OA5 5;  1TPA I;  1PIT A;  1T8N B;  1EAW B;  2KAI I;  1ADZ A;  1T7C B;  1JV8 A;  2R9P E;  4BNR I;  4Y11 I;  3BTE I;  2PTC I;  3OFW A;  1D0D B;  9PTI A;  1NAG A;  5PTI A;  1BTH P;  4DG4 C;  4WXV C;  2RA3 C;  1KNT A;  1TAP A;  1FAK I;  1P2O B;  4NTY B;  2IJO I;  2LFL A;  1MTN D;  8PTI A;  1BZX I;  4U32 X;  1BZ5 A;  2CA7 A;  1UUA A;  2UUX A;  1OA6 5;  1BTI A;  1TFX C;  4WWY C;  4PTI A;  2KCR A;  5JB4 A;  1G6X A;  1BPT A;  1QLQ A;  3BTD I;  4Y0Z I;  4ISN B;  1F5R I;  2TGP I;  2W8X A;  3TPI I;  4Y0Y I;  4TPI I;  2ODY E;  5JB6 A;  1P2K I;  3CI7 A;  3M7Q B;  3P92 E;  3U1J E;  1BIK A;  3FP8 I;  1BUN B;  1DTX A;  2M01 A;  1TOC R;  1BRB I;  3BTT I;  1FAN A;  1DEN A;  1JC6 A;  7PTI A;  2LFK A;  6PTI A;  3BTG I;  2ZJX A;  1B0C A;  1CA0 D;  1P2I I;  1YLC B;  1ZJD B;  3BTH I;  3AUI A;  2ZVX A;  1D0D A;  1FY8 I;  1K6U A;  1YC0 I;  1BPI A;  1JV9 A;  3TGJ I;  1BF0 A;  3AUB A;  1Y62 A;  2HEX A;  1T8M B;  3UIR C;  3TGK I;  1UUB A;  3LDM A;  4BQD A;  1P2N B;  3BTK I;  1SHP A;  3AUE A;  3BTF I;  1KIG I;  3BTW I;  3D65 I;  3GYM I;  5C67 C;  1DEM A;  2FI3 I;  1YLD B;  3OTJ I;  2UUY B;  3WNY A;  3LDJ A;  3L33 E;  3P95 E;  3TGI I;  2JOT A;  1P2Q B;  4NTX B;  4NTW B;  1DTK A;  1P2M B;  3BTM I;  1KUN A;  1BRC I;  2DDI A;  2KNT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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