2ODYE

Thrombin-bound boophilin displays a functional and accessible reactive-site loop
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
127
structure length
127
Chain Sequence
QRNGFCRLPADEGICKALIPRFYFNTETGKCTMFSYGGCGGNENNFETIEECQKACGAPERVNDFESADFKTGCEPAADSGSCAGQLERWFYNVQSGECETFVYGGCGGNDNNYESEEECELVCKNM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Isolation, cloning and structural characterisation of boophilin, a multifunctional kunitz-type proteinase inhibitor from the cattle tick.
pubmed doi rcsb
molecule tags Blood clotting/blood clotting inhibitor
source organism Rhipicephalus microplus
molecule keywords Prothrombin (EC 3.4.21.5)
total genus 28
structure length 127
sequence length 127
chains with identical sequence F
ec nomenclature
pdb deposition date 2006-12-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2odyE02
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2odyE01
3BTWI 4WXVC 2DDJA 2R9PE 1EJMB 3AUBA 1P2NB 3BTKI 1KNTA 1F7ZI 3AUDA 9PTIA 1F5RI 1P2QB 1TAWB 1TFXC 3P95E 1FY8I 1SHPA 1K6UA 5JB6A 1JV9A 3OFWA 1FAKI 4ISNB 3AUHA 1BRCI 1BRBI 1P2KI 2M99A 1DTKA 5PTIA 3BYBA 3L33E 3AUIA 1BPIA 3LDMA 2TPII 1JC6A 3UOUB 1TCPA 2JOTA 4U30W 1IRHA 2IJOI 4Y11I 1LD5A 1YC0I 3LDJA 3CI7A 1MTND 1LD6A 4TPII 1EAWB 1CBWD 6PTIA 1NAGA 2FTLI 1P2OB 3FP6I 5C67C 4Y0ZI 4NTXB 2HEXA 2PTCI 3AUCA 2KCRA 4U32X 3D65I 2ZJXA 1YKTB 3L3TE 4BNRI 2CA7A 1DTXA 1T8MB 1T8LB 1ZJDB 3TGJI 1YLDB 1CA0D 3AUGA 3BTMI 1P2MB 3LDIA 4ISLB 3T62D 2FTMB 1BHCA 1FANA 1B0CA 2UUYB 2KNTA 1T8NB 1PITA 3BTHI 4NTYB 3WNYA 1KIGI 1OA65 1BUNB 1Y62A 3TPII 1KUNA 1AAPA 1BIKA 5JB4A 1AALA 1T8OB 2FI5I 1D0DA 2LFLA 4NTWB 1OA55 3BTFI 1ADZA 3M7QB 4DTGK 1KTHA 3BTQI 1P2JI 1G6XA 4Y0YI 3BTEI 3BTGI 2UUXA 4ISOB 2LFKA 2KAII 1TPAI 3TGII 1T7CB 3OTJI 1JV8A 1ZR0B 2ZVXA 1UUAA 2FI4I 1BTIA 4WWYC 5JB7A 3UIRC 2DDIA 4BD9B 4BQDA 1QLQA 5JB5A 8PTIA 3P92E 3BTTI 3TGKI 7PTIA 1DEMA 1BF0A 2FI3I 3U1JE 1UUBA 3BTDI 1BZXI 2W8XA 1CO7I 1BZ5A 1BTHP 4PTIA 1DENA 4Y10I 2M01A 1BPTA 1P2II 1TAPA 3FP7J 1YLCB 3AUEA 3GYMI 1D0DB 3FP8I 2RA3C 2TGPI 1TOCR 4DG4C 2J6DA 2ODYE
chains in the Genus database with same CATH superfamily
3BTWI 4WXVC 2DDJA 2R9PE 1EJMB 3AUBA 1P2NB 3BTKI 1KNTA 1F7ZI 3AUDA 9PTIA 1F5RI 1P2QB 1TAWB 1TFXC 3P95E 1FY8I 1SHPA 1K6UA 5JB6A 1JV9A 3OFWA 1FAKI 4ISNB 3AUHA 1BRCI 1BRBI 1P2KI 2M99A 1DTKA 5PTIA 3BYBA 3L33E 3AUIA 1BPIA 3LDMA 2TPII 1JC6A 3UOUB 1TCPA 2JOTA 4U30W 1IRHA 2IJOI 4Y11I 1LD5A 1YC0I 3LDJA 3CI7A 1MTND 1LD6A 4TPII 1EAWB 1CBWD 6PTIA 1NAGA 2FTLI 1P2OB 3FP6I 5C67C 4Y0ZI 4NTXB 2HEXA 2PTCI 3AUCA 2KCRA 4U32X 3D65I 2ZJXA 1YKTB 3L3TE 4BNRI 2CA7A 1DTXA 1T8MB 1T8LB 1ZJDB 3TGJI 1YLDB 1CA0D 3AUGA 3BTMI 1P2MB 3LDIA 4ISLB 3T62D 2FTMB 1BHCA 1FANA 1B0CA 2UUYB 2KNTA 1T8NB 1PITA 3BTHI 4NTYB 3WNYA 1KIGI 1OA65 1BUNB 1Y62A 3TPII 1KUNA 1AAPA 1BIKA 5JB4A 1AALA 1T8OB 2FI5I 1D0DA 2LFLA 4NTWB 1OA55 3BTFI 1ADZA 3M7QB 4DTGK 1KTHA 3BTQI 1P2JI 1G6XA 4Y0YI 3BTEI 3BTGI 2UUXA 4ISOB 2LFKA 2KAII 1TPAI 3TGII 1T7CB 3OTJI 1JV8A 1ZR0B 2ZVXA 1UUAA 2FI4I 1BTIA 4WWYC 5JB7A 3UIRC 2DDIA 4BD9B 4BQDA 1QLQA 5JB5A 8PTIA 3P92E 3BTTI 3TGKI 7PTIA 1DEMA 1BF0A 2FI3I 3U1JE 1UUBA 3BTDI 1BZXI 2W8XA 1CO7I 1BZ5A 1BTHP 4PTIA 1DENA 4Y10I 2M01A 1BPTA 1P2II 1TAPA 3FP7J 1YLCB 3AUEA 3GYMI 1D0DB 3FP8I 2RA3C 2TGPI 1TOCR 4DG4C 2J6DA 2ODYE
chains in the Genus database with same CATH topology
3BTWI 4WXVC 2DDJA 2R9PE 1EJMB 3AUBA 1P2NB 3BTKI 1KNTA 1F7ZI 3AUDA 9PTIA 1F5RI 1P2QB 1TAWB 1TFXC 3P95E 1FY8I 1SHPA 1K6UA 5JB6A 1JV9A 3OFWA 1FAKI 4ISNB 3AUHA 1BRCI 1BRBI 1P2KI 2M99A 1DTKA 5PTIA 3BYBA 3L33E 3AUIA 1BPIA 3LDMA 2TPII 1JC6A 3UOUB 1TCPA 2JOTA 4U30W 1IRHA 2IJOI 4Y11I 1LD5A 1YC0I 3LDJA 3CI7A 1MTND 1LD6A 4TPII 1EAWB 1CBWD 6PTIA 1NAGA 2FTLI 1P2OB 3FP6I 5C67C 4Y0ZI 4NTXB 2HEXA 2PTCI 3AUCA 2KCRA 4U32X 3D65I 2ZJXA 1YKTB 3L3TE 4BNRI 2CA7A 1DTXA 1T8MB 1T8LB 1ZJDB 3TGJI 1YLDB 1CA0D 3AUGA 3BTMI 1P2MB 3LDIA 4ISLB 3T62D 2FTMB 1BHCA 1FANA 1B0CA 2UUYB 2KNTA 1T8NB 1PITA 3BTHI 4NTYB 3WNYA 1KIGI 1OA65 1BUNB 1Y62A 3TPII 1KUNA 1AAPA 1BIKA 5JB4A 1AALA 1T8OB 2FI5I 1D0DA 2LFLA 4NTWB 1OA55 3BTFI 1ADZA 3M7QB 4DTGK 1KTHA 3BTQI 1P2JI 1G6XA 4Y0YI 3BTEI 3BTGI 2UUXA 4ISOB 2LFKA 2KAII 1TPAI 3TGII 1T7CB 3OTJI 1JV8A 1ZR0B 2ZVXA 1UUAA 2FI4I 1BTIA 4WWYC 5JB7A 3UIRC 2DDIA 4BD9B 4BQDA 1QLQA 5JB5A 8PTIA 3P92E 3BTTI 3TGKI 7PTIA 1DEMA 1BF0A 2FI3I 3U1JE 1UUBA 3BTDI 1BZXI 2W8XA 1CO7I 1BZ5A 1BTHP 4PTIA 1DENA 4Y10I 2M01A 1BPTA 1P2II 1TAPA 3FP7J 1YLCB 3AUEA 3GYMI 1D0DB 3FP8I 2RA3C 2TGPI 1TOCR 4DG4C 2J6DA 2ODYE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BTW I;  4WXV C;  2DDJ A;  2R9P E;  1EJM B;  3AUB A;  1P2N B;  3BTK I;  1KNT A;  1F7Z I;  3AUD A;  9PTI A;  1F5R I;  1P2Q B;  1TAW B;  1TFX C;  3P95 E;  1FY8 I;  1SHP A;  1K6U A;  5JB6 A;  1JV9 A;  3OFW A;  1FAK I;  4ISN B;  3AUH A;  1BRC I;  1BRB I;  1P2K I;  2M99 A;  1DTK A;  5PTI A;  3BYB A;  3L33 E;  3AUI A;  1BPI A;  3LDM A;  2TPI I;  1JC6 A;  3UOU B;  1TCP A;  2JOT A;  4U30 W;  1IRH A;  2IJO I;  4Y11 I;  1LD5 A;  1YC0 I;  3LDJ A;  3CI7 A;  1MTN D;  1LD6 A;  4TPI I;  1EAW B;  1CBW D;  6PTI A;  1NAG A;  2FTL I;  1P2O B;  3FP6 I;  5C67 C;  4Y0Z I;  4NTX B;  2HEX A;  2PTC I;  3AUC A;  2KCR A;  4U32 X;  3D65 I;  2ZJX A;  1YKT B;  3L3T E;  4BNR I;  2CA7 A;  1DTX A;  1T8M B;  1T8L B;  1ZJD B;  3TGJ I;  1YLD B;  1CA0 D;  3AUG A;  3BTM I;  1P2M B;  3LDI A;  4ISL B;  3T62 D;  2FTM B;  1BHC A;  1FAN A;  1B0C A;  2UUY B;  2KNT A;  1T8N B;  1PIT A;  3BTH I;  4NTY B;  3WNY A;  1KIG I;  1OA6 5;  1BUN B;  1Y62 A;  3TPI I;  1KUN A;  1AAP A;  1BIK A;  5JB4 A;  1AAL A;  1T8O B;  2FI5 I;  1D0D A;  2LFL A;  4NTW B;  1OA5 5;  3BTF I;  1ADZ A;  3M7Q B;  4DTG K;  1KTH A;  3BTQ I;  1P2J I;  1G6X A;  4Y0Y I;  3BTE I;  3BTG I;  2UUX A;  4ISO B;  2LFK A;  2KAI I;  1TPA I;  3TGI I;  1T7C B;  3OTJ I;  1JV8 A;  1ZR0 B;  2ZVX A;  1UUA A;  2FI4 I;  1BTI A;  4WWY C;  5JB7 A;  3UIR C;  2DDI A;  4BD9 B;  4BQD A;  1QLQ A;  5JB5 A;  8PTI A;  3P92 E;  3BTT I;  3TGK I;  7PTI A;  1DEM A;  1BF0 A;  2FI3 I;  3U1J E;  1UUB A;  3BTD I;  1BZX I;  2W8X A;  1CO7 I;  1BZ5 A;  1BTH P;  4PTI A;  1DEN A;  4Y10 I;  2M01 A;  1BPT A;  1P2I I;  1TAP A;  3FP7 J;  1YLC B;  3AUE A;  3GYM I;  1D0D B;  3FP8 I;  2RA3 C;  2TGP I;  1TOC R;  4DG4 C;  2J6D A;  2ODY E; 
#chains in the Genus database with same CATH topology
 3BTW I;  4WXV C;  2DDJ A;  2R9P E;  1EJM B;  3AUB A;  1P2N B;  3BTK I;  1KNT A;  1F7Z I;  3AUD A;  9PTI A;  1F5R I;  1P2Q B;  1TAW B;  1TFX C;  3P95 E;  1FY8 I;  1SHP A;  1K6U A;  5JB6 A;  1JV9 A;  3OFW A;  1FAK I;  4ISN B;  3AUH A;  1BRC I;  1BRB I;  1P2K I;  2M99 A;  1DTK A;  5PTI A;  3BYB A;  3L33 E;  3AUI A;  1BPI A;  3LDM A;  2TPI I;  1JC6 A;  3UOU B;  1TCP A;  2JOT A;  4U30 W;  1IRH A;  2IJO I;  4Y11 I;  1LD5 A;  1YC0 I;  3LDJ A;  3CI7 A;  1MTN D;  1LD6 A;  4TPI I;  1EAW B;  1CBW D;  6PTI A;  1NAG A;  2FTL I;  1P2O B;  3FP6 I;  5C67 C;  4Y0Z I;  4NTX B;  2HEX A;  2PTC I;  3AUC A;  2KCR A;  4U32 X;  3D65 I;  2ZJX A;  1YKT B;  3L3T E;  4BNR I;  2CA7 A;  1DTX A;  1T8M B;  1T8L B;  1ZJD B;  3TGJ I;  1YLD B;  1CA0 D;  3AUG A;  3BTM I;  1P2M B;  3LDI A;  4ISL B;  3T62 D;  2FTM B;  1BHC A;  1FAN A;  1B0C A;  2UUY B;  2KNT A;  1T8N B;  1PIT A;  3BTH I;  4NTY B;  3WNY A;  1KIG I;  1OA6 5;  1BUN B;  1Y62 A;  3TPI I;  1KUN A;  1AAP A;  1BIK A;  5JB4 A;  1AAL A;  1T8O B;  2FI5 I;  1D0D A;  2LFL A;  4NTW B;  1OA5 5;  3BTF I;  1ADZ A;  3M7Q B;  4DTG K;  1KTH A;  3BTQ I;  1P2J I;  1G6X A;  4Y0Y I;  3BTE I;  3BTG I;  2UUX A;  4ISO B;  2LFK A;  2KAI I;  1TPA I;  3TGI I;  1T7C B;  3OTJ I;  1JV8 A;  1ZR0 B;  2ZVX A;  1UUA A;  2FI4 I;  1BTI A;  4WWY C;  5JB7 A;  3UIR C;  2DDI A;  4BD9 B;  4BQD A;  1QLQ A;  5JB5 A;  8PTI A;  3P92 E;  3BTT I;  3TGK I;  7PTI A;  1DEM A;  1BF0 A;  2FI3 I;  3U1J E;  1UUB A;  3BTD I;  1BZX I;  2W8X A;  1CO7 I;  1BZ5 A;  1BTH P;  4PTI A;  1DEN A;  4Y10 I;  2M01 A;  1BPT A;  1P2I I;  1TAP A;  3FP7 J;  1YLC B;  3AUE A;  3GYM I;  1D0D B;  3FP8 I;  2RA3 C;  2TGP I;  1TOC R;  4DG4 C;  2J6D A;  2ODY E; 
#chains in the Genus database with same CATH homology
 3BTW I;  4WXV C;  2DDJ A;  2R9P E;  1EJM B;  3AUB A;  1P2N B;  3BTK I;  1KNT A;  1F7Z I;  3AUD A;  9PTI A;  1F5R I;  1P2Q B;  1TAW B;  1TFX C;  3P95 E;  1FY8 I;  1SHP A;  1K6U A;  5JB6 A;  1JV9 A;  3OFW A;  1FAK I;  4ISN B;  3AUH A;  1BRC I;  1BRB I;  1P2K I;  2M99 A;  1DTK A;  5PTI A;  3BYB A;  3L33 E;  3AUI A;  1BPI A;  3LDM A;  2TPI I;  1JC6 A;  3UOU B;  1TCP A;  2JOT A;  4U30 W;  1IRH A;  2IJO I;  4Y11 I;  1LD5 A;  1YC0 I;  3LDJ A;  3CI7 A;  1MTN D;  1LD6 A;  4TPI I;  1EAW B;  1CBW D;  6PTI A;  1NAG A;  2FTL I;  1P2O B;  3FP6 I;  5C67 C;  4Y0Z I;  4NTX B;  2HEX A;  2PTC I;  3AUC A;  2KCR A;  4U32 X;  3D65 I;  2ZJX A;  1YKT B;  3L3T E;  4BNR I;  2CA7 A;  1DTX A;  1T8M B;  1T8L B;  1ZJD B;  3TGJ I;  1YLD B;  1CA0 D;  3AUG A;  3BTM I;  1P2M B;  3LDI A;  4ISL B;  3T62 D;  2FTM B;  1BHC A;  1FAN A;  1B0C A;  2UUY B;  2KNT A;  1T8N B;  1PIT A;  3BTH I;  4NTY B;  3WNY A;  1KIG I;  1OA6 5;  1BUN B;  1Y62 A;  3TPI I;  1KUN A;  1AAP A;  1BIK A;  5JB4 A;  1AAL A;  1T8O B;  2FI5 I;  1D0D A;  2LFL A;  4NTW B;  1OA5 5;  3BTF I;  1ADZ A;  3M7Q B;  4DTG K;  1KTH A;  3BTQ I;  1P2J I;  1G6X A;  4Y0Y I;  3BTE I;  3BTG I;  2UUX A;  4ISO B;  2LFK A;  2KAI I;  1TPA I;  3TGI I;  1T7C B;  3OTJ I;  1JV8 A;  1ZR0 B;  2ZVX A;  1UUA A;  2FI4 I;  1BTI A;  4WWY C;  5JB7 A;  3UIR C;  2DDI A;  4BD9 B;  4BQD A;  1QLQ A;  5JB5 A;  8PTI A;  3P92 E;  3BTT I;  3TGK I;  7PTI A;  1DEM A;  1BF0 A;  2FI3 I;  3U1J E;  1UUB A;  3BTD I;  1BZX I;  2W8X A;  1CO7 I;  1BZ5 A;  1BTH P;  4PTI A;  1DEN A;  4Y10 I;  2M01 A;  1BPT A;  1P2I I;  1TAP A;  3FP7 J;  1YLC B;  3AUE A;  3GYM I;  1D0D B;  3FP8 I;  2RA3 C;  2TGP I;  1TOC R;  4DG4 C;  2J6D A;  2ODY E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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