2PPBE

Crystal structure of the t. thermophilus rnap polymerase elongation complex with the ntp substrate analog and antibiotic streptolydigin
Total Genus 17
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
17
sequence length
95
structure length
95
Chain Sequence
AEPGIDKLFGMVDSKYRLTVVVAKRAQQLLRHGFKNTVLEPEERPKMQTLEGLFDDPNAVTWAMKELLTGRLVFGENLVPEDRLQKEMERLYPVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis for substrate loading in bacterial RNA polymerase.
pubmed doi rcsb
molecule tags Transferase/dna/rna
molecule keywords DNA (5'-D(P*CP*CP*CP*TP*GP*TP*CP*TP*GP*GP*CP*GP*TP*TP*CP*GP*
total genus 17
structure length 95
sequence length 95
chains with identical sequence O
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2007-04-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 2ppbE00
1I6VE 5M5WF 4XSZE 2YU9F 4C3JF 5FJ8F 4A3EF 2R92F 1HQME 4MQ9E 4A3BF 2E2IF 4A3MF 4LJZE 4XSXE 4KN7E 3H3VG 3PO3F 5IP7F 5D4EE 1K83F 3S1NF 4MEYE 5E18E 4YFXE 4G7ZE 3EQLE 4BBRF 5IPLE 4Y7NF 5M5YF 3S1RF 4Q5SE 3GTLF 3H0GF 5C3EF 4C3HF 2JA5F 3S1MF 3GTQF 1TWCF 2A69E 2B63F 3HOWF 3HOYF 5C4JF 2R7ZF 5IYDF 1Y1WF 3CQZF 4BBSF 4Y52F 1TWFF 4YFKE 4LLGE 4A3FF 5D4DE 5C4XF 4LK1E 3S16F 3HOZF 5IYCF 3HKZK 4OIPE 1Y1VF 4A3GF 1SMYE 1SFOF 5FLMF 4A93F 1TWHF 3GTKF 4KN4E 4Q4ZE 2NVYF 1I50F 5M3FF 5IP9F 4A3LF 2O5JE 4XLPE 4OIOE 4OIRE 2A6EE 1TWAF 4ZH4E 5M5XF 1ZYRE 5C44F 4A3DF 3WODE 5IYBF 3I4NF 3S17F 4AYBK 2JA7F 3M3YF 2NVXF 2R93F 1YNNK 4YFNE 3S14F 1QKLA 4XLNE 3HOXF 3FKIF 3S15F 4LK0E 2A68E 4BY7F 2BE5E 5M3MF 4A3JF 3RZDF 2E2HF 4BXXF 4MEXE 5TMCE 3M4OF 4BY1F 3GTGF 1TWGF 2WB1I 2NVQF 3GTOF 2CW0E 4KMUE 3HOVF 5D4CE 1R9TF 1WCMF 1I6HF 3S2DF 2JA8F 2WAQK 4C2MF 4C3IF 4G7OE 3S1QF 3HOUF 4G7HE 3K7AF 4OIQE 2JA6F 4A3CF 3DXJE 4A3IF 2E2JF 3GTMF 4A3KF 1YNJK 3S2HF 1IW7E 2VUMF 5TMFE 3I4MF 3PO2F 4GZYE 2PMZK 2PPBE 4X6AF 2A6HE 2Y0SI 1I3QF 2NVTF 4YG2E 5E17E 3RZOF 3GTJF 4OINE 3GTPF 5BYHE 2O5IE 4JK1E
chains in the Genus database with same CATH superfamily
1I6VE 4QIWK 3M4OE 5M5WF 1EIKA 1TWGE 4XSZE 3RZOE 2YU9F 4C3JF 1R9TE 3GTPE 1I6HE 5FJ8F 4A3EF 2R92F 1HQME 4MQ9E 3S1QE 2E2IF 4A3BF 3HOUE 4A3MF 3K7AE 2WB1H 4LJZE 4XSXE 2PMZH 4KN7E 4C3JE 2YU9E 3H3VG 3GTME 3PO3F 5IP7F 5D4EE 5FJ8E 1K83F 2E2IE 3S1NF 4MEYE 5E18E 4A3ME 2VUME 4YFXE 4G7ZE 3EQLE 4BBRF 3I4ME 4Y7NF 5IPLE 5M5YF 1K83E 3S1RF 3S1NE 4Q5SE 3GTLF 1I3QE 3H0GF 4C3HF 5C3EF 2JA5F 3S1MF 3GTQF 1TWCF 2A69E 4BBRE 4QIWH 2B63F 3HOWF 3HOYF 5C4JF 2R7ZF 5IYDF 1Y1WF 2Y0SH 3GTLE 3H0GE 3GTJE 4C3HE 2KRXA 3CQZF 4BBSF 4Y52F 1TWCE 1TWFF 2B63E 3HOWE 4YFKE 4LLGE 4A3FF 5D4DE 5C4JE 2R7ZE 5M5WE 5C4XF 4LK1E 3S16F 3HOZF 5IYCF 4Y52E 3HKZK 1TWFE 4OIPE 1Y1VF 4A3EE 4A3GF 2R92E 4A3BE 1SMYE 1SFOF 5FLMF 5C4XE 4A93F 3H3VF 1TWHF 3GTKF 3HOZE 4KN4E 4Q4ZE 3PO3E 2NVYF 1I50F 5IP7E 1DZFA 4A3GE 5M3FF 1SFOE 5IP9F 4A3LF 2O5JE 1TWHE 4XLPE 4OIOE 4OIRE 3GTKE 4Y7NE 2NVYE 2A6EE 1TWAF 4ZH4E 5M5YE 5M5XF 1ZYRE 5C44F 4A3DF 3WODE 5M3FE 3S1RE 5IYBF 5IP9E 3I4NF 4A3LE 5C3EE 3S17F 2JA5E 3S1ME 3GTQE 4AYBK 2JA7F 3HOYE 3M3YF 2NVXF 2R93F 1YNNK 4YFNE 5M5XE 1QKLA 3S14F 5C44E 5IYDE 4XLNE 1Y1WE 4A3DE 3HKZH 3FKIF 5IYBE 3HOXF 3I4NE 4LK0E 3S17E 3CQZE 3S15F 4BBSE 2A68E 4BY7F 2BE5E 5M3MF 4A3JF 3RZDF 2E2HF 2NVXE 4MEXE 3M3YE 4BXXF 4A3FE 5TMCE 3M4OF 4BY1F 3GTGF 1TWGF 2WB1I 3FKIE 3HOXE 2CW0E 4KMUE 2NVQF 5D4CE 3GTOF 5IYCE 1R9TF 3HOVF 1WCMF 3S16E 1I6HF 3S2DF 5M3ME 4A3JE 2JA8F 1Y1VE 2WAQK 4C2MF 4C3IF 4G7OE 3S1QF 5FLME 3HOUF 4BY1E 4G7HE 3GTGE 2NVQE 3K7AF 4OIQE 2JA6F 3HOVE 3GTOE 4A93E 4A3CF 1WCME 3DXJE 4A3IF 1I50E 4A3KF 2E2JF 2JA8E 3GTMF 3S2DE 4C3IE 4C2ME 1YNJK 3S2HF 1IW7E 2VUMF 4AYBH 5TMFE 4A3CE 2JA6E 3I4MF 4A3IE 2E2JE 3PO2F 4A3KE 1TWAE 4GZYE 2PMZK 2PPBE 3S2HE 4X6AF 2A6HE 2Y0SI 1I3QF 2NVTF 2JA7E 3PO2E 4YG2E 2R93E 3S14E 5E17E 4X6AE 3S15E 3RZOF 3GTJF 2WAQH 4OINE 3GTPF 5BYHE 2NVTE 3RZDE 4BY7E 2E2HE 2O5IE 4BXXE 4JK1E
chains in the Genus database with same CATH topology
1I6VE 4QIWK 5M5WF 4XSZE 2YU9F 4C3JF 5FJ8F 4A3EF 2R92F 1HQME 4MQ9E 4A3BF 2E2IF 4A3MF 4LJZE 4XSXE 4KN7E 3H3VG 3PO3F 5IP7F 5D4EE 1K83F 3S1NF 4MEYE 5E18E 4YFXE 4G7ZE 3EQLE 4BBRF 5IPLE 4Y7NF 5M5YF 3S1RF 4Q5SE 3GTLF 3H0GF 5C3EF 4C3HF 2JA5F 3S1MF 3GTQF 1TWCF 2A69E 2B63F 3HOWF 3HOYF 5C4JF 2R7ZF 5IYDF 1Y1WF 2KRXA 3CQZF 4BBSF 4Y52F 1TWFF 4YFKE 4LLGE 4A3FF 5D4DE 5C4XF 4LK1E 3S16F 3HOZF 5IYCF 3HKZK 4OIPE 1Y1VF 4A3GF 1SMYE 1SFOF 5FLMF 4A93F 1TWHF 3GTKF 4KN4E 4Q4ZE 2NVYF 1I50F 5M3FF 5IP9F 4A3LF 2O5JE 4XLPE 4OIOE 4OIRE 2A6EE 1TWAF 4ZH4E 5M5XF 1ZYRE 5C44F 4A3DF 3WODE 5IYBF 3I4NF 3S17F 4AYBK 2JA7F 3M3YF 2NVXF 2R93F 1YNNK 4YFNE 3S14F 1QKLA 4XLNE 3HOXF 3FKIF 3S15F 4LK0E 2A68E 4BY7F 2BE5E 5M3MF 4A3JF 3RZDF 2E2HF 4BXXF 4MEXE 5TMCE 3M4OF 4BY1F 3GTGF 1TWGF 2WB1I 2NVQF 3GTOF 2CW0E 4KMUE 3HOVF 5D4CE 1R9TF 1WCMF 1I6HF 3S2DF 2JA8F 2WAQK 4C2MF 4C3IF 4G7OE 3S1QF 3HOUF 4G7HE 3K7AF 4OIQE 2JA6F 4A3CF 3DXJE 4A3IF 2E2JF 3GTMF 4A3KF 1YNJK 3S2HF 1IW7E 2VUMF 5TMFE 3I4MF 3PO2F 4GZYE 2PMZK 2PPBE 4X6AF 2A6HE 2Y0SI 1I3QF 2NVTF 4YG2E 5E17E 3RZOF 3GTJF 4OINE 3GTPF 5BYHE 2O5IE 4JK1E
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1I6V E;  5M5W F;  4XSZ E;  2YU9 F;  4C3J F;  5FJ8 F;  4A3E F;  2R92 F;  1HQM E;  4MQ9 E;  4A3B F;  2E2I F;  4A3M F;  4LJZ E;  4XSX E;  4KN7 E;  3H3V G;  3PO3 F;  5IP7 F;  5D4E E;  1K83 F;  3S1N F;  4MEY E;  5E18 E;  4YFX E;  4G7Z E;  3EQL E;  4BBR F;  5IPL E;  4Y7N F;  5M5Y F;  3S1R F;  4Q5S E;  3GTL F;  3H0G F;  5C3E F;  4C3H F;  2JA5 F;  3S1M F;  3GTQ F;  1TWC F;  2A69 E;  2B63 F;  3HOW F;  3HOY F;  5C4J F;  2R7Z F;  5IYD F;  1Y1W F;  3CQZ F;  4BBS F;  4Y52 F;  1TWF F;  4YFK E;  4LLG E;  4A3F F;  5D4D E;  5C4X F;  4LK1 E;  3S16 F;  3HOZ F;  5IYC F;  3HKZ K;  4OIP E;  1Y1V F;  4A3G F;  1SMY E;  1SFO F;  5FLM F;  4A93 F;  1TWH F;  3GTK F;  4KN4 E;  4Q4Z E;  2NVY F;  1I50 F;  5M3F F;  5IP9 F;  4A3L F;  2O5J E;  4XLP E;  4OIO E;  4OIR E;  2A6E E;  1TWA F;  4ZH4 E;  5M5X F;  1ZYR E;  5C44 F;  4A3D F;  3WOD E;  5IYB F;  3I4N F;  3S17 F;  4AYB K;  2JA7 F;  3M3Y F;  2NVX F;  2R93 F;  1YNN K;  4YFN E;  3S14 F;  1QKL A;  4XLN E;  3HOX F;  3FKI F;  3S15 F;  4LK0 E;  2A68 E;  4BY7 F;  2BE5 E;  5M3M F;  4A3J F;  3RZD F;  2E2H F;  4BXX F;  4MEX E;  5TMC E;  3M4O F;  4BY1 F;  3GTG F;  1TWG F;  2WB1 I;  2NVQ F;  3GTO F;  2CW0 E;  4KMU E;  3HOV F;  5D4C E;  1R9T F;  1WCM F;  1I6H F;  3S2D F;  2JA8 F;  2WAQ K;  4C2M F;  4C3I F;  4G7O E;  3S1Q F;  3HOU F;  4G7H E;  3K7A F;  4OIQ E;  2JA6 F;  4A3C F;  3DXJ E;  4A3I F;  2E2J F;  3GTM F;  4A3K F;  1YNJ K;  3S2H F;  1IW7 E;  2VUM F;  5TMF E;  3I4M F;  3PO2 F;  4GZY E;  2PMZ K;  2PPB E;  4X6A F;  2A6H E;  2Y0S I;  1I3Q F;  2NVT F;  4YG2 E;  5E17 E;  3RZO F;  3GTJ F;  4OIN E;  3GTP F;  5BYH E;  2O5I E;  4JK1 E; 
#chains in the Genus database with same CATH topology
 1I6V E;  4QIW K;  3M4O E;  5M5W F;  1EIK A;  1TWG E;  4XSZ E;  3RZO E;  2YU9 F;  4C3J F;  1R9T E;  3GTP E;  1I6H E;  5FJ8 F;  4A3E F;  2R92 F;  1HQM E;  4MQ9 E;  3S1Q E;  2E2I F;  4A3B F;  3HOU E;  4A3M F;  3K7A E;  2WB1 H;  4LJZ E;  4XSX E;  2PMZ H;  4KN7 E;  4C3J E;  2YU9 E;  3H3V G;  3GTM E;  3PO3 F;  5IP7 F;  5D4E E;  5FJ8 E;  1K83 F;  2E2I E;  3S1N F;  4MEY E;  5E18 E;  4A3M E;  2VUM E;  4YFX E;  4G7Z E;  3EQL E;  4BBR F;  3I4M E;  4Y7N F;  5IPL E;  5M5Y F;  1K83 E;  3S1R F;  3S1N E;  4Q5S E;  3GTL F;  1I3Q E;  3H0G F;  4C3H F;  5C3E F;  2JA5 F;  3S1M F;  3GTQ F;  1TWC F;  2A69 E;  4BBR E;  4QIW H;  2B63 F;  3HOW F;  3HOY F;  5C4J F;  2R7Z F;  5IYD F;  1Y1W F;  2Y0S H;  3GTL E;  3H0G E;  3GTJ E;  4C3H E;  2KRX A;  3CQZ F;  4BBS F;  4Y52 F;  1TWC E;  1TWF F;  2B63 E;  3HOW E;  4YFK E;  4LLG E;  4A3F F;  5D4D E;  5C4J E;  2R7Z E;  5M5W E;  5C4X F;  4LK1 E;  3S16 F;  3HOZ F;  5IYC F;  4Y52 E;  3HKZ K;  1TWF E;  4OIP E;  1Y1V F;  4A3E E;  4A3G F;  2R92 E;  4A3B E;  1SMY E;  1SFO F;  5FLM F;  5C4X E;  4A93 F;  3H3V F;  1TWH F;  3GTK F;  3HOZ E;  4KN4 E;  4Q4Z E;  3PO3 E;  2NVY F;  1I50 F;  5IP7 E;  1DZF A;  4A3G E;  5M3F F;  1SFO E;  5IP9 F;  4A3L F;  2O5J E;  1TWH E;  4XLP E;  4OIO E;  4OIR E;  3GTK E;  4Y7N E;  2NVY E;  2A6E E;  1TWA F;  4ZH4 E;  5M5Y E;  5M5X F;  1ZYR E;  5C44 F;  4A3D F;  3WOD E;  5M3F E;  3S1R E;  5IYB F;  5IP9 E;  3I4N F;  4A3L E;  5C3E E;  3S17 F;  2JA5 E;  3S1M E;  3GTQ E;  4AYB K;  2JA7 F;  3HOY E;  3M3Y F;  2NVX F;  2R93 F;  1YNN K;  4YFN E;  5M5X E;  1QKL A;  3S14 F;  5C44 E;  5IYD E;  4XLN E;  1Y1W E;  4A3D E;  3HKZ H;  3FKI F;  5IYB E;  3HOX F;  3I4N E;  4LK0 E;  3S17 E;  3CQZ E;  3S15 F;  4BBS E;  2A68 E;  4BY7 F;  2BE5 E;  5M3M F;  4A3J F;  3RZD F;  2E2H F;  2NVX E;  4MEX E;  3M3Y E;  4BXX F;  4A3F E;  5TMC E;  3M4O F;  4BY1 F;  3GTG F;  1TWG F;  2WB1 I;  3FKI E;  3HOX E;  2CW0 E;  4KMU E;  2NVQ F;  5D4C E;  3GTO F;  5IYC E;  1R9T F;  3HOV F;  1WCM F;  3S16 E;  1I6H F;  3S2D F;  5M3M E;  4A3J E;  2JA8 F;  1Y1V E;  2WAQ K;  4C2M F;  4C3I F;  4G7O E;  3S1Q F;  5FLM E;  3HOU F;  4BY1 E;  4G7H E;  3GTG E;  2NVQ E;  3K7A F;  4OIQ E;  2JA6 F;  3HOV E;  3GTO E;  4A93 E;  4A3C F;  1WCM E;  3DXJ E;  4A3I F;  1I50 E;  4A3K F;  2E2J F;  2JA8 E;  3GTM F;  3S2D E;  4C3I E;  4C2M E;  1YNJ K;  3S2H F;  1IW7 E;  2VUM F;  4AYB H;  5TMF E;  4A3C E;  2JA6 E;  3I4M F;  4A3I E;  2E2J E;  3PO2 F;  4A3K E;  1TWA E;  4GZY E;  2PMZ K;  2PPB E;  3S2H E;  4X6A F;  2A6H E;  2Y0S I;  1I3Q F;  2NVT F;  2JA7 E;  3PO2 E;  4YG2 E;  2R93 E;  3S14 E;  5E17 E;  4X6A E;  3S15 E;  3RZO F;  3GTJ F;  2WAQ H;  4OIN E;  3GTP F;  5BYH E;  2NVT E;  3RZD E;  4BY7 E;  2E2H E;  2O5I E;  4BXX E;  4JK1 E; 
#chains in the Genus database with same CATH homology
 1I6V E;  4QIW K;  5M5W F;  4XSZ E;  2YU9 F;  4C3J F;  5FJ8 F;  4A3E F;  2R92 F;  1HQM E;  4MQ9 E;  4A3B F;  2E2I F;  4A3M F;  4LJZ E;  4XSX E;  4KN7 E;  3H3V G;  3PO3 F;  5IP7 F;  5D4E E;  1K83 F;  3S1N F;  4MEY E;  5E18 E;  4YFX E;  4G7Z E;  3EQL E;  4BBR F;  5IPL E;  4Y7N F;  5M5Y F;  3S1R F;  4Q5S E;  3GTL F;  3H0G F;  5C3E F;  4C3H F;  2JA5 F;  3S1M F;  3GTQ F;  1TWC F;  2A69 E;  2B63 F;  3HOW F;  3HOY F;  5C4J F;  2R7Z F;  5IYD F;  1Y1W F;  2KRX A;  3CQZ F;  4BBS F;  4Y52 F;  1TWF F;  4YFK E;  4LLG E;  4A3F F;  5D4D E;  5C4X F;  4LK1 E;  3S16 F;  3HOZ F;  5IYC F;  3HKZ K;  4OIP E;  1Y1V F;  4A3G F;  1SMY E;  1SFO F;  5FLM F;  4A93 F;  1TWH F;  3GTK F;  4KN4 E;  4Q4Z E;  2NVY F;  1I50 F;  5M3F F;  5IP9 F;  4A3L F;  2O5J E;  4XLP E;  4OIO E;  4OIR E;  2A6E E;  1TWA F;  4ZH4 E;  5M5X F;  1ZYR E;  5C44 F;  4A3D F;  3WOD E;  5IYB F;  3I4N F;  3S17 F;  4AYB K;  2JA7 F;  3M3Y F;  2NVX F;  2R93 F;  1YNN K;  4YFN E;  3S14 F;  1QKL A;  4XLN E;  3HOX F;  3FKI F;  3S15 F;  4LK0 E;  2A68 E;  4BY7 F;  2BE5 E;  5M3M F;  4A3J F;  3RZD F;  2E2H F;  4BXX F;  4MEX E;  5TMC E;  3M4O F;  4BY1 F;  3GTG F;  1TWG F;  2WB1 I;  2NVQ F;  3GTO F;  2CW0 E;  4KMU E;  3HOV F;  5D4C E;  1R9T F;  1WCM F;  1I6H F;  3S2D F;  2JA8 F;  2WAQ K;  4C2M F;  4C3I F;  4G7O E;  3S1Q F;  3HOU F;  4G7H E;  3K7A F;  4OIQ E;  2JA6 F;  4A3C F;  3DXJ E;  4A3I F;  2E2J F;  3GTM F;  4A3K F;  1YNJ K;  3S2H F;  1IW7 E;  2VUM F;  5TMF E;  3I4M F;  3PO2 F;  4GZY E;  2PMZ K;  2PPB E;  4X6A F;  2A6H E;  2Y0S I;  1I3Q F;  2NVT F;  4YG2 E;  5E17 E;  3RZO F;  3GTJ F;  4OIN E;  3GTP F;  5BYH E;  2O5I E;  4JK1 E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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