2PTCI

The geometry of the reactive site and of the peptide groups in trypsin, trypsinogen and its complexes with inhibitors
Total Genus 11
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
11
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Geometry of the Reactive Site and of the Peptide Groups in Trypsin, Trypsinogen and its Complexes with Inhibitors
pubmed rcsb
molecule tags Complex (proteinase/inhibitor)
source organism Bos taurus
molecule keywords BETA-TRYPSIN
total genus 11
structure length 58
sequence length 58
ec nomenclature
pdb deposition date 1982-09-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2ptcI00
2PTCI 2W8XA 4U30W 1ZJDB 2ZJXA 3M7QB 1DENA 3AUGA 1KIGI 1P2KI 1F7ZI 3UOUB 1TFXC 1T8LB 5JB4A 4NTYB 2TPII 3FP7J 3OTJI 1ADZA 3AUEA 5JB7A 1T8OB 3BTQI 4Y10I 4ISOB 1BF0A 2KCRA 1JV9A 2J6DA 3BTKI 1BRBI 5JB5A 2M01A 2FI4I 3LDMA 4U32X 1PITA 3BTWI 1D0DB 1OA65 3LDJA 3BTFI 3U1JE 6PTIA 1TCPA 1CBWD 1BZ5A 3D65I 8PTIA 1ZR0B 3LDIA 1JV8A 3TPII 4BNRI 1T7CB 3AUCA 1B0CA 1BUNB 2ODYE 5PTIA 2FI5I 3T62D 1P2QB 1NAGA 1AALA 3FP8I 1Y62A 1K6UA 1BPIA 4Y11I 1EJMB 4PTIA 1D0DA 4NTXB 1JC6A 2R9PE 3AUIA 4Y0YI 3BTGI 3OFWA 3AUBA 3L33E 4NTWB 2ZVXA 3P95E 2DDIA 1P2JI 2M99A 3CI7A 1DEMA 1BTIA 1KUNA 4BQDA 1AAPA 1TAWB 1YLCB 2TGPI 2FTLI 1P2MB 2LFKA 1P2OB 1IRHA 1OA55 3FP6I 3WNYA 4BD9B 2KNTA 1BHCA 2FTMB 1CO7I 3P92E 3UIRC 2FI3I 1KNTA 3L3TE 2DDJA 1FANA 5JB6A 1QLQA 1BPTA 3BTDI 1LD6A 2LFLA 3BTHI 1F5RI 4Y0ZI 1T8NB 4ISNB 3TGJI 3AUHA 1BIKA 1YC0I 4DTGK 2IJOI 1BTHP 3TGII 1BRCI 1YKTB 1BZXI 2JOTA 4DG4C 1TAPA 2CA7A 4TPII 3GYMI 1P2NB 1UUAA 7PTIA 2UUYB 1G6XA 1MTND 3BTMI 1EAWB 1CA0D 1TOCR 2HEXA 3BTTI 1YLDB 3BYBA 1DTKA 9PTIA 1LD5A 4ISLB 1SHPA 1KTHA 3BTEI 1TPAI 1FAKI 3AUDA 1DTXA 5C67C 2UUXA 2RA3C 2KAII 1P2II 1FY8I 3TGKI 4WWYC 4WXVC 1UUBA 1T8MB
chains in the Genus database with same CATH superfamily
2PTCI 2W8XA 4U30W 1ZJDB 2ZJXA 3M7QB 1DENA 3AUGA 1KIGI 1P2KI 1F7ZI 3UOUB 1TFXC 1T8LB 5JB4A 4NTYB 2TPII 3FP7J 3OTJI 1ADZA 3AUEA 5JB7A 1T8OB 3BTQI 4Y10I 4ISOB 1BF0A 2KCRA 1JV9A 2J6DA 3BTKI 1BRBI 5JB5A 2M01A 2FI4I 3LDMA 4U32X 1PITA 3BTWI 1D0DB 1OA65 3LDJA 3BTFI 3U1JE 6PTIA 1TCPA 1CBWD 1BZ5A 3D65I 8PTIA 1ZR0B 3LDIA 1JV8A 3TPII 4BNRI 1T7CB 3AUCA 1B0CA 1BUNB 2ODYE 5PTIA 2FI5I 3T62D 1P2QB 1NAGA 1AALA 3FP8I 1Y62A 1K6UA 1BPIA 4Y11I 1EJMB 4PTIA 1D0DA 4NTXB 1JC6A 2R9PE 3AUIA 4Y0YI 3BTGI 3OFWA 3AUBA 3L33E 4NTWB 2ZVXA 3P95E 2DDIA 1P2JI 2M99A 3CI7A 1DEMA 1BTIA 1KUNA 4BQDA 1AAPA 1TAWB 1YLCB 2TGPI 2FTLI 1P2MB 2LFKA 1P2OB 1IRHA 1OA55 3FP6I 3WNYA 4BD9B 2KNTA 1BHCA 2FTMB 1CO7I 3P92E 3UIRC 2FI3I 1KNTA 3L3TE 2DDJA 1FANA 5JB6A 1QLQA 1BPTA 3BTDI 1LD6A 2LFLA 3BTHI 1F5RI 4Y0ZI 1T8NB 4ISNB 3TGJI 3AUHA 1BIKA 1YC0I 4DTGK 2IJOI 1BTHP 3TGII 1BRCI 1YKTB 1BZXI 2JOTA 4DG4C 1TAPA 2CA7A 4TPII 3GYMI 1P2NB 1UUAA 7PTIA 2UUYB 1G6XA 1MTND 3BTMI 1EAWB 1CA0D 1TOCR 2HEXA 3BTTI 1YLDB 3BYBA 1DTKA 9PTIA 1LD5A 4ISLB 1SHPA 1KTHA 3BTEI 1TPAI 1FAKI 3AUDA 1DTXA 5C67C 2UUXA 2RA3C 2KAII 1P2II 1FY8I 3TGKI 4WWYC 4WXVC 1UUBA 1T8MB
chains in the Genus database with same CATH topology
2PTCI 2W8XA 4U30W 1ZJDB 2ZJXA 3M7QB 1DENA 3AUGA 1KIGI 1P2KI 1F7ZI 3UOUB 1TFXC 1T8LB 5JB4A 4NTYB 2TPII 3FP7J 3OTJI 1ADZA 3AUEA 5JB7A 1T8OB 3BTQI 4Y10I 4ISOB 1BF0A 2KCRA 1JV9A 2J6DA 3BTKI 1BRBI 5JB5A 2M01A 2FI4I 3LDMA 4U32X 1PITA 3BTWI 1D0DB 1OA65 3LDJA 3BTFI 3U1JE 6PTIA 1TCPA 1CBWD 1BZ5A 3D65I 8PTIA 1ZR0B 3LDIA 1JV8A 3TPII 4BNRI 1T7CB 3AUCA 1B0CA 1BUNB 2ODYE 5PTIA 2FI5I 3T62D 1P2QB 1NAGA 1AALA 3FP8I 1Y62A 1K6UA 1BPIA 4Y11I 1EJMB 4PTIA 1D0DA 4NTXB 1JC6A 2R9PE 3AUIA 4Y0YI 3BTGI 3OFWA 3AUBA 3L33E 4NTWB 2ZVXA 3P95E 2DDIA 1P2JI 2M99A 3CI7A 1DEMA 1BTIA 1KUNA 4BQDA 1AAPA 1TAWB 1YLCB 2TGPI 2FTLI 1P2MB 2LFKA 1P2OB 1IRHA 1OA55 3FP6I 3WNYA 4BD9B 2KNTA 1BHCA 2FTMB 1CO7I 3P92E 3UIRC 2FI3I 1KNTA 3L3TE 2DDJA 1FANA 5JB6A 1QLQA 1BPTA 3BTDI 1LD6A 2LFLA 3BTHI 1F5RI 4Y0ZI 1T8NB 4ISNB 3TGJI 3AUHA 1BIKA 1YC0I 4DTGK 2IJOI 1BTHP 3TGII 1BRCI 1YKTB 1BZXI 2JOTA 4DG4C 1TAPA 2CA7A 4TPII 3GYMI 1P2NB 1UUAA 7PTIA 2UUYB 1G6XA 1MTND 3BTMI 1EAWB 1CA0D 1TOCR 2HEXA 3BTTI 1YLDB 3BYBA 1DTKA 9PTIA 1LD5A 4ISLB 1SHPA 1KTHA 3BTEI 1TPAI 1FAKI 3AUDA 1DTXA 5C67C 2UUXA 2RA3C 2KAII 1P2II 1FY8I 3TGKI 4WWYC 4WXVC 1UUBA 1T8MB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2PTC I;  2W8X A;  4U30 W;  1ZJD B;  2ZJX A;  3M7Q B;  1DEN A;  3AUG A;  1KIG I;  1P2K I;  1F7Z I;  3UOU B;  1TFX C;  1T8L B;  5JB4 A;  4NTY B;  2TPI I;  3FP7 J;  3OTJ I;  1ADZ A;  3AUE A;  5JB7 A;  1T8O B;  3BTQ I;  4Y10 I;  4ISO B;  1BF0 A;  2KCR A;  1JV9 A;  2J6D A;  3BTK I;  1BRB I;  5JB5 A;  2M01 A;  2FI4 I;  3LDM A;  4U32 X;  1PIT A;  3BTW I;  1D0D B;  1OA6 5;  3LDJ A;  3BTF I;  3U1J E;  6PTI A;  1TCP A;  1CBW D;  1BZ5 A;  3D65 I;  8PTI A;  1ZR0 B;  3LDI A;  1JV8 A;  3TPI I;  4BNR I;  1T7C B;  3AUC A;  1B0C A;  1BUN B;  2ODY E;  5PTI A;  2FI5 I;  3T62 D;  1P2Q B;  1NAG A;  1AAL A;  3FP8 I;  1Y62 A;  1K6U A;  1BPI A;  4Y11 I;  1EJM B;  4PTI A;  1D0D A;  4NTX B;  1JC6 A;  2R9P E;  3AUI A;  4Y0Y I;  3BTG I;  3OFW A;  3AUB A;  3L33 E;  4NTW B;  2ZVX A;  3P95 E;  2DDI A;  1P2J I;  2M99 A;  3CI7 A;  1DEM A;  1BTI A;  1KUN A;  4BQD A;  1AAP A;  1TAW B;  1YLC B;  2TGP I;  2FTL I;  1P2M B;  2LFK A;  1P2O B;  1IRH A;  1OA5 5;  3FP6 I;  3WNY A;  4BD9 B;  2KNT A;  1BHC A;  2FTM B;  1CO7 I;  3P92 E;  3UIR C;  2FI3 I;  1KNT A;  3L3T E;  2DDJ A;  1FAN A;  5JB6 A;  1QLQ A;  1BPT A;  3BTD I;  1LD6 A;  2LFL A;  3BTH I;  1F5R I;  4Y0Z I;  1T8N B;  4ISN B;  3TGJ I;  3AUH A;  1BIK A;  1YC0 I;  4DTG K;  2IJO I;  1BTH P;  3TGI I;  1BRC I;  1YKT B;  1BZX I;  2JOT A;  4DG4 C;  1TAP A;  2CA7 A;  4TPI I;  3GYM I;  1P2N B;  1UUA A;  7PTI A;  2UUY B;  1G6X A;  1MTN D;  3BTM I;  1EAW B;  1CA0 D;  1TOC R;  2HEX A;  3BTT I;  1YLD B;  3BYB A;  1DTK A;  9PTI A;  1LD5 A;  4ISL B;  1SHP A;  1KTH A;  3BTE I;  1TPA I;  1FAK I;  3AUD A;  1DTX A;  5C67 C;  2UUX A;  2RA3 C;  2KAI I;  1P2I I;  1FY8 I;  3TGK I;  4WWY C;  4WXV C;  1UUB A;  1T8M B; 
#chains in the Genus database with same CATH topology
 2PTC I;  2W8X A;  4U30 W;  1ZJD B;  2ZJX A;  3M7Q B;  1DEN A;  3AUG A;  1KIG I;  1P2K I;  1F7Z I;  3UOU B;  1TFX C;  1T8L B;  5JB4 A;  4NTY B;  2TPI I;  3FP7 J;  3OTJ I;  1ADZ A;  3AUE A;  5JB7 A;  1T8O B;  3BTQ I;  4Y10 I;  4ISO B;  1BF0 A;  2KCR A;  1JV9 A;  2J6D A;  3BTK I;  1BRB I;  5JB5 A;  2M01 A;  2FI4 I;  3LDM A;  4U32 X;  1PIT A;  3BTW I;  1D0D B;  1OA6 5;  3LDJ A;  3BTF I;  3U1J E;  6PTI A;  1TCP A;  1CBW D;  1BZ5 A;  3D65 I;  8PTI A;  1ZR0 B;  3LDI A;  1JV8 A;  3TPI I;  4BNR I;  1T7C B;  3AUC A;  1B0C A;  1BUN B;  2ODY E;  5PTI A;  2FI5 I;  3T62 D;  1P2Q B;  1NAG A;  1AAL A;  3FP8 I;  1Y62 A;  1K6U A;  1BPI A;  4Y11 I;  1EJM B;  4PTI A;  1D0D A;  4NTX B;  1JC6 A;  2R9P E;  3AUI A;  4Y0Y I;  3BTG I;  3OFW A;  3AUB A;  3L33 E;  4NTW B;  2ZVX A;  3P95 E;  2DDI A;  1P2J I;  2M99 A;  3CI7 A;  1DEM A;  1BTI A;  1KUN A;  4BQD A;  1AAP A;  1TAW B;  1YLC B;  2TGP I;  2FTL I;  1P2M B;  2LFK A;  1P2O B;  1IRH A;  1OA5 5;  3FP6 I;  3WNY A;  4BD9 B;  2KNT A;  1BHC A;  2FTM B;  1CO7 I;  3P92 E;  3UIR C;  2FI3 I;  1KNT A;  3L3T E;  2DDJ A;  1FAN A;  5JB6 A;  1QLQ A;  1BPT A;  3BTD I;  1LD6 A;  2LFL A;  3BTH I;  1F5R I;  4Y0Z I;  1T8N B;  4ISN B;  3TGJ I;  3AUH A;  1BIK A;  1YC0 I;  4DTG K;  2IJO I;  1BTH P;  3TGI I;  1BRC I;  1YKT B;  1BZX I;  2JOT A;  4DG4 C;  1TAP A;  2CA7 A;  4TPI I;  3GYM I;  1P2N B;  1UUA A;  7PTI A;  2UUY B;  1G6X A;  1MTN D;  3BTM I;  1EAW B;  1CA0 D;  1TOC R;  2HEX A;  3BTT I;  1YLD B;  3BYB A;  1DTK A;  9PTI A;  1LD5 A;  4ISL B;  1SHP A;  1KTH A;  3BTE I;  1TPA I;  1FAK I;  3AUD A;  1DTX A;  5C67 C;  2UUX A;  2RA3 C;  2KAI I;  1P2I I;  1FY8 I;  3TGK I;  4WWY C;  4WXV C;  1UUB A;  1T8M B; 
#chains in the Genus database with same CATH homology
 2PTC I;  2W8X A;  4U30 W;  1ZJD B;  2ZJX A;  3M7Q B;  1DEN A;  3AUG A;  1KIG I;  1P2K I;  1F7Z I;  3UOU B;  1TFX C;  1T8L B;  5JB4 A;  4NTY B;  2TPI I;  3FP7 J;  3OTJ I;  1ADZ A;  3AUE A;  5JB7 A;  1T8O B;  3BTQ I;  4Y10 I;  4ISO B;  1BF0 A;  2KCR A;  1JV9 A;  2J6D A;  3BTK I;  1BRB I;  5JB5 A;  2M01 A;  2FI4 I;  3LDM A;  4U32 X;  1PIT A;  3BTW I;  1D0D B;  1OA6 5;  3LDJ A;  3BTF I;  3U1J E;  6PTI A;  1TCP A;  1CBW D;  1BZ5 A;  3D65 I;  8PTI A;  1ZR0 B;  3LDI A;  1JV8 A;  3TPI I;  4BNR I;  1T7C B;  3AUC A;  1B0C A;  1BUN B;  2ODY E;  5PTI A;  2FI5 I;  3T62 D;  1P2Q B;  1NAG A;  1AAL A;  3FP8 I;  1Y62 A;  1K6U A;  1BPI A;  4Y11 I;  1EJM B;  4PTI A;  1D0D A;  4NTX B;  1JC6 A;  2R9P E;  3AUI A;  4Y0Y I;  3BTG I;  3OFW A;  3AUB A;  3L33 E;  4NTW B;  2ZVX A;  3P95 E;  2DDI A;  1P2J I;  2M99 A;  3CI7 A;  1DEM A;  1BTI A;  1KUN A;  4BQD A;  1AAP A;  1TAW B;  1YLC B;  2TGP I;  2FTL I;  1P2M B;  2LFK A;  1P2O B;  1IRH A;  1OA5 5;  3FP6 I;  3WNY A;  4BD9 B;  2KNT A;  1BHC A;  2FTM B;  1CO7 I;  3P92 E;  3UIR C;  2FI3 I;  1KNT A;  3L3T E;  2DDJ A;  1FAN A;  5JB6 A;  1QLQ A;  1BPT A;  3BTD I;  1LD6 A;  2LFL A;  3BTH I;  1F5R I;  4Y0Z I;  1T8N B;  4ISN B;  3TGJ I;  3AUH A;  1BIK A;  1YC0 I;  4DTG K;  2IJO I;  1BTH P;  3TGI I;  1BRC I;  1YKT B;  1BZX I;  2JOT A;  4DG4 C;  1TAP A;  2CA7 A;  4TPI I;  3GYM I;  1P2N B;  1UUA A;  7PTI A;  2UUY B;  1G6X A;  1MTN D;  3BTM I;  1EAW B;  1CA0 D;  1TOC R;  2HEX A;  3BTT I;  1YLD B;  3BYB A;  1DTK A;  9PTI A;  1LD5 A;  4ISL B;  1SHP A;  1KTH A;  3BTE I;  1TPA I;  1FAK I;  3AUD A;  1DTX A;  5C67 C;  2UUX A;  2RA3 C;  2KAI I;  1P2I I;  1FY8 I;  3TGK I;  4WWY C;  4WXV C;  1UUB A;  1T8M B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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