2R7ZE

Cisplatin lesion containing rna polymerase ii elongation complex
Total Genus 53
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
53
sequence length
214
structure length
214
Chain Sequence
DQENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSAMKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Mechanism of transcriptional stalling at cisplatin-damaged DNA.
pubmed doi rcsb
molecule tags Transcription/dna-rna hybrid
molecule keywords 5'-D(*TP*AP*CP*TP*TP*GUP*CP*CP*CP*TP*CP*CP*TP*CP*AP*T)-3'
total genus 53
structure length 214
sequence length 214
ec nomenclature
pdb deposition date 2007-09-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01191 RNA_pol_Rpb5_C RNA polymerase Rpb5, C-terminal domain
E PF03871 RNA_pol_Rpb5_N RNA polymerase Rpb5, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1340.10 Alpha Beta 3-Layer(aba) Sandwich Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1 RNA polymerase, Rpb5, N-terminal domain 2r7zE01
3.90.940.20 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit RPB5-like RNA polymerase subunit 2r7zE02
4A3JE 4Y52E 2B63E 1WCME 4A3LE 5C4XE 3HOUE 1SFOE 1TWGE 4A3CE 4A3BE 3GTGE 3M3YE 4A3FE 3GTKE 1I3QE 1TWAE 5M3ME 2NVXE 3I4ME 5C44E 1Y1VE 4Y7NE 4A3IE 4A3KE 3HKZH 4C3JE 3S1QE 2JA8E 3HOWE 4BXXE 4BBRE 2E2JE 3K7AE 1TWHE 2PMZH 3H0GE 5C4JE 4BY1E 3S15E 4A3ME 5M3FE 3RZOE 2JA5E 3GTLE 3I4NE 4A93E 2VUME 3HOXE 3HOVE 2YU9E 2JA6E 1TWFE 3M4OE 3CQZE 4C2ME 4AYBH 2WB1H 2R93E 2JA7E 4A3DE 2Y0SH 1K83E 3S1RE 1TWCE 1R9TE 1DZFA 3S1ME 5IYCE 3H3VF 2E2IE 2R92E 3RZDE 5C3EE 2NVQE 3S17E 4X6AE 4A3EE 1I50E 2E2HE 3S2HE 5FLME 3FKIE 5M5YE 4QIWH 3PO2E 3S2DE 5IYDE 5IP9E 5M5WE 3GTQE 4C3IE 5M5XE 4BBSE 2WAQH 5FJ8E 1EIKA 3GTPE 3GTJE 4A3GE 5IYBE 5IP7E 1Y1WE 2R7ZE 3PO3E 2NVTE 3S16E 3GTME 3S14E 3S1NE 3HOZE 4C3HE 1I6HE 4BY7E 3GTOE 3HOYE 2NVYE
chains in the Genus database with same CATH superfamily
4A3JE 4Y52E 2WAQK 3S1QF 2B63E 1WCME 2NVYF 4A3LE 5C4XE 1I6VE 4A3JF 3HOUE 1WCMF 5C4XF 1SFOE 2A68E 1TWGE 3HOUF 3K7AF 5E18E 1QKLA 4A3CE 2A6EE 1HQME 3H0GF 4A3BE 4OINE 3GTGE 3M3YE 5C4JF 3S15F 4A3FE 3GTKE 4A3BF 3M3YF 1I3QE 1TWAE 5M3ME 2NVXE 3I4ME 1ZYRE 2WB1I 5C44E 3EQLE 4OIQE 4A93F 2Y0SI 4JK1E 1TWAF 5M3MF 1Y1VE 4G7ZE 3I4MF 4Y7NE 5C44F 2A6HE 2JA6F 4A3IE 5TMCE 4A3KE 1TWFF 1Y1VF 4C3JE 3HKZH 4LK1E 3M4OF 4A3IF 3S1QE 4A3KF 4GZYE 4A3DF 2JA8E 3HOWE 1K83F 3S1RF 4BXXE 4BBRE 2JA8F 2E2JE 3HOWF 5D4CE 3K7AE 1TWHE 4BXXF 5IYCF 4BBRF 2PMZH 2E2JF 3WODE 3H0GE 1TWHF 5BYHE 5C4JE 4BY1E 2R92F 3S15E 4A3ME 5M3FE 3RZOE 3RZDF 2JA5E 1SMYE 3GTLE 4XSZE 4BY1F 4A3MF 3I4NE 3S17F 5M3FF 3HKZK 4MQ9E 4A93E 2JA5F 3RZOF 4X6AF 2VUME 2BE5E 3GTLF 3HOXE 3I4NF 3HOVE 4A3EF 1I50F 5E17E 2YU9E 2JA6E 4G7HE 2VUMF 1TWFE 3HOXF 5TMFE 3HOVF 3M4OE 5FLMF 5D4DE 3CQZE 2YU9F 4C2ME 4AYBH 2WB1H 2R93E 2JA7E 3DXJE 4Q4ZE 4A3DE 3CQZF 4C3JF 4YG2E 2Y0SH 4C2MF 1K83E 3S1RE 3PO2F 2JA7F 4KMUE 1TWCE 2R93F 4XLPE 1R9TE 5IYDF 4OIOE 1DZFA 3H3VG 3S1ME 4C3IF 5IYCE 3H3VF 1TWCF 4LK0E 4OIRE 2E2IE 1R9TF 3S1MF 2R92E 4ZH4E 4XLNE 2E2IF 3GTPF 4A3GF 3RZDE 4YFXE 5C3EE 2NVQE 3S17E 4XSXE 4X6AE 4KN7E 5C3EF 2R7ZF 4A3EE 2A69E 4AYBK 1I50E 2NVQF 3S14F 3S16F 5D4EE 2E2HE 3S1NF 3S2HE 5FLME 4C3HF 1I6HF 4BY7F 3FKIE 5M5YE 2E2HF 3GTOF 3S2HF 3HOYF 3FKIF 5M5YF 1YNJK 4QIWH 3PO2E 3S2DE 4G7OE 2KRXA 5IYDE 5IP9E 4Y52F 5M5WE 2PMZK 3GTQE 4C3IE 4LLGE 4YFKE 2B63F 3S2DF 5M5XE 4A3LF 5IPLE 4Q5SE 5IP9F 4BBSE 5M5WF 3GTQF 2WAQH 5FJ8E 5M5XF 1EIKA 3GTPE 3GTJE 4A3GE 1SFOF 2PPBE 4BBSF 1TWGF 5IYBE 5FJ8F 5IP7E 3GTJF 4MEYE 4A3CF 1Y1WE 5IYBF 3GTGF 2R7ZE 3PO3E 2NVTE 3S16E 4KN4E 4LJZE 3GTME 3S14E 5IP7F 4A3FF 1Y1WF 3GTKF 3S1NE 1I3QF 3HOZE 2NVXF 2NVTF 3PO3F 4QIWK 4C3HE 3GTMF 1I6HE 4BY7E 4YFNE 2O5IE 3HOZF 3GTOE 4Y7NF 1IW7E 2O5JE 3HOYE 4OIPE 1YNNK 4MEXE 2CW0E 2NVYE
chains in the Genus database with same CATH topology
4A3JE 4Y52E 2B63E 1WCME 4A3LE 5C4XE 3HOUE 1SFOE 1TWGE 4A3CE 4A3BE 3GTGE 3M3YE 4A3FE 3GTKE 1I3QE 1TWAE 5M3ME 2NVXE 3I4ME 5C44E 1Y1VE 4Y7NE 4A3IE 4A3KE 3HKZH 4C3JE 3S1QE 2JA8E 3HOWE 4BXXE 4BBRE 2E2JE 3K7AE 1TWHE 2PMZH 3H0GE 5C4JE 4BY1E 3S15E 4A3ME 5M3FE 3RZOE 2JA5E 3GTLE 3I4NE 4A93E 2VUME 3HOXE 3HOVE 2YU9E 2JA6E 1TWFE 3M4OE 3CQZE 4C2ME 4AYBH 2WB1H 2R93E 2JA7E 4A3DE 2Y0SH 1K83E 3S1RE 1TWCE 1R9TE 1DZFA 3S1ME 5IYCE 3H3VF 2E2IE 2R92E 3RZDE 5C3EE 2NVQE 3S17E 4X6AE 4A3EE 1I50E 2E2HE 3S2HE 5FLME 3FKIE 5M5YE 4QIWH 3PO2E 3S2DE 5IYDE 5IP9E 5M5WE 3GTQE 4C3IE 5M5XE 4BBSE 2WAQH 5FJ8E 1EIKA 3GTPE 3GTJE 4A3GE 5IYBE 5IP7E 1Y1WE 2R7ZE 3PO3E 2NVTE 3S16E 3GTME 3S14E 3S1NE 3HOZE 4C3HE 1I6HE 4BY7E 3GTOE 3HOYE 2NVYE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4A3J E;  4Y52 E;  2B63 E;  1WCM E;  4A3L E;  5C4X E;  3HOU E;  1SFO E;  1TWG E;  4A3C E;  4A3B E;  3GTG E;  3M3Y E;  4A3F E;  3GTK E;  1I3Q E;  1TWA E;  5M3M E;  2NVX E;  3I4M E;  5C44 E;  1Y1V E;  4Y7N E;  4A3I E;  4A3K E;  3HKZ H;  4C3J E;  3S1Q E;  2JA8 E;  3HOW E;  4BXX E;  4BBR E;  2E2J E;  3K7A E;  1TWH E;  2PMZ H;  3H0G E;  5C4J E;  4BY1 E;  3S15 E;  4A3M E;  5M3F E;  3RZO E;  2JA5 E;  3GTL E;  3I4N E;  4A93 E;  2VUM E;  3HOX E;  3HOV E;  2YU9 E;  2JA6 E;  1TWF E;  3M4O E;  3CQZ E;  4C2M E;  4AYB H;  2WB1 H;  2R93 E;  2JA7 E;  4A3D E;  2Y0S H;  1K83 E;  3S1R E;  1TWC E;  1R9T E;  1DZF A;  3S1M E;  5IYC E;  3H3V F;  2E2I E;  2R92 E;  3RZD E;  5C3E E;  2NVQ E;  3S17 E;  4X6A E;  4A3E E;  1I50 E;  2E2H E;  3S2H E;  5FLM E;  3FKI E;  5M5Y E;  4QIW H;  3PO2 E;  3S2D E;  5IYD E;  5IP9 E;  5M5W E;  3GTQ E;  4C3I E;  5M5X E;  4BBS E;  2WAQ H;  5FJ8 E;  1EIK A;  3GTP E;  3GTJ E;  4A3G E;  5IYB E;  5IP7 E;  1Y1W E;  2R7Z E;  3PO3 E;  2NVT E;  3S16 E;  3GTM E;  3S14 E;  3S1N E;  3HOZ E;  4C3H E;  1I6H E;  4BY7 E;  3GTO E;  3HOY E;  2NVY E; 
#chains in the Genus database with same CATH topology
 4A3J E;  4Y52 E;  2WAQ K;  3S1Q F;  2B63 E;  1WCM E;  2NVY F;  4A3L E;  5C4X E;  1I6V E;  4A3J F;  3HOU E;  1WCM F;  5C4X F;  1SFO E;  2A68 E;  1TWG E;  3HOU F;  3K7A F;  5E18 E;  1QKL A;  4A3C E;  2A6E E;  1HQM E;  3H0G F;  4A3B E;  4OIN E;  3GTG E;  3M3Y E;  5C4J F;  3S15 F;  4A3F E;  3GTK E;  4A3B F;  3M3Y F;  1I3Q E;  1TWA E;  5M3M E;  2NVX E;  3I4M E;  1ZYR E;  2WB1 I;  5C44 E;  3EQL E;  4OIQ E;  4A93 F;  2Y0S I;  4JK1 E;  1TWA F;  5M3M F;  1Y1V E;  4G7Z E;  3I4M F;  4Y7N E;  5C44 F;  2A6H E;  2JA6 F;  4A3I E;  5TMC E;  4A3K E;  1TWF F;  1Y1V F;  4C3J E;  3HKZ H;  4LK1 E;  3M4O F;  4A3I F;  3S1Q E;  4A3K F;  4GZY E;  4A3D F;  2JA8 E;  3HOW E;  1K83 F;  3S1R F;  4BXX E;  4BBR E;  2JA8 F;  2E2J E;  3HOW F;  5D4C E;  3K7A E;  1TWH E;  4BXX F;  5IYC F;  4BBR F;  2PMZ H;  2E2J F;  3WOD E;  3H0G E;  1TWH F;  5BYH E;  5C4J E;  4BY1 E;  2R92 F;  3S15 E;  4A3M E;  5M3F E;  3RZO E;  3RZD F;  2JA5 E;  1SMY E;  3GTL E;  4XSZ E;  4BY1 F;  4A3M F;  3I4N E;  3S17 F;  5M3F F;  3HKZ K;  4MQ9 E;  4A93 E;  2JA5 F;  3RZO F;  4X6A F;  2VUM E;  2BE5 E;  3GTL F;  3HOX E;  3I4N F;  3HOV E;  4A3E F;  1I50 F;  5E17 E;  2YU9 E;  2JA6 E;  4G7H E;  2VUM F;  1TWF E;  3HOX F;  5TMF E;  3HOV F;  3M4O E;  5FLM F;  5D4D E;  3CQZ E;  2YU9 F;  4C2M E;  4AYB H;  2WB1 H;  2R93 E;  2JA7 E;  3DXJ E;  4Q4Z E;  4A3D E;  3CQZ F;  4C3J F;  4YG2 E;  2Y0S H;  4C2M F;  1K83 E;  3S1R E;  3PO2 F;  2JA7 F;  4KMU E;  1TWC E;  2R93 F;  4XLP E;  1R9T E;  5IYD F;  4OIO E;  1DZF A;  3H3V G;  3S1M E;  4C3I F;  5IYC E;  3H3V F;  1TWC F;  4LK0 E;  4OIR E;  2E2I E;  1R9T F;  3S1M F;  2R92 E;  4ZH4 E;  4XLN E;  2E2I F;  3GTP F;  4A3G F;  3RZD E;  4YFX E;  5C3E E;  2NVQ E;  3S17 E;  4XSX E;  4X6A E;  4KN7 E;  5C3E F;  2R7Z F;  4A3E E;  2A69 E;  4AYB K;  1I50 E;  2NVQ F;  3S14 F;  3S16 F;  5D4E E;  2E2H E;  3S1N F;  3S2H E;  5FLM E;  4C3H F;  1I6H F;  4BY7 F;  3FKI E;  5M5Y E;  2E2H F;  3GTO F;  3S2H F;  3HOY F;  3FKI F;  5M5Y F;  1YNJ K;  4QIW H;  3PO2 E;  3S2D E;  4G7O E;  2KRX A;  5IYD E;  5IP9 E;  4Y52 F;  5M5W E;  2PMZ K;  3GTQ E;  4C3I E;  4LLG E;  4YFK E;  2B63 F;  3S2D F;  5M5X E;  4A3L F;  5IPL E;  4Q5S E;  5IP9 F;  4BBS E;  5M5W F;  3GTQ F;  2WAQ H;  5FJ8 E;  5M5X F;  1EIK A;  3GTP E;  3GTJ E;  4A3G E;  1SFO F;  2PPB E;  4BBS F;  1TWG F;  5IYB E;  5FJ8 F;  5IP7 E;  3GTJ F;  4MEY E;  4A3C F;  1Y1W E;  5IYB F;  3GTG F;  2R7Z E;  3PO3 E;  2NVT E;  3S16 E;  4KN4 E;  4LJZ E;  3GTM E;  3S14 E;  5IP7 F;  4A3F F;  1Y1W F;  3GTK F;  3S1N E;  1I3Q F;  3HOZ E;  2NVX F;  2NVT F;  3PO3 F;  4QIW K;  4C3H E;  3GTM F;  1I6H E;  4BY7 E;  4YFN E;  2O5I E;  3HOZ F;  3GTO E;  4Y7N F;  1IW7 E;  2O5J E;  3HOY E;  4OIP E;  1YNN K;  4MEX E;  2CW0 E;  2NVY E; 
#chains in the Genus database with same CATH homology
 4A3J E;  4Y52 E;  2B63 E;  1WCM E;  4A3L E;  5C4X E;  3HOU E;  1SFO E;  1TWG E;  4A3C E;  4A3B E;  3GTG E;  3M3Y E;  4A3F E;  3GTK E;  1I3Q E;  1TWA E;  5M3M E;  2NVX E;  3I4M E;  5C44 E;  1Y1V E;  4Y7N E;  4A3I E;  4A3K E;  3HKZ H;  4C3J E;  3S1Q E;  2JA8 E;  3HOW E;  4BXX E;  4BBR E;  2E2J E;  3K7A E;  1TWH E;  2PMZ H;  3H0G E;  5C4J E;  4BY1 E;  3S15 E;  4A3M E;  5M3F E;  3RZO E;  2JA5 E;  3GTL E;  3I4N E;  4A93 E;  2VUM E;  3HOX E;  3HOV E;  2YU9 E;  2JA6 E;  1TWF E;  3M4O E;  3CQZ E;  4C2M E;  4AYB H;  2WB1 H;  2R93 E;  2JA7 E;  4A3D E;  2Y0S H;  1K83 E;  3S1R E;  1TWC E;  1R9T E;  1DZF A;  3S1M E;  5IYC E;  3H3V F;  2E2I E;  2R92 E;  3RZD E;  5C3E E;  2NVQ E;  3S17 E;  4X6A E;  4A3E E;  1I50 E;  2E2H E;  3S2H E;  5FLM E;  3FKI E;  5M5Y E;  4QIW H;  3PO2 E;  3S2D E;  5IYD E;  5IP9 E;  5M5W E;  3GTQ E;  4C3I E;  5M5X E;  4BBS E;  2WAQ H;  5FJ8 E;  1EIK A;  3GTP E;  3GTJ E;  4A3G E;  5IYB E;  5IP7 E;  1Y1W E;  2R7Z E;  3PO3 E;  2NVT E;  3S16 E;  3GTM E;  3S14 E;  3S1N E;  3HOZ E;  4C3H E;  1I6H E;  4BY7 E;  3GTO E;  3HOY E;  2NVY E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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