2RA3C

Human cationic trypsin complexed with bovine pancreatic trypsin inhibitor (bpti)
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
56
structure length
56
Chain Sequence
RPDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for Accelerated Cleavage of Bovine Pancreatic Trypsin Inhibitor (BPTI) by Human Mesotrypsin.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Trypsin-1
total genus 12
structure length 56
sequence length 56
chains with identical sequence I
ec nomenclature
pdb deposition date 2007-09-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2ra3C00
1AALA 3BYBA 5JB5A 1G6XA 1TOCR 2CA7A 8PTIA 1BZ5A 2ZVXA 1P2MB 2TGPI 4U30W 5JB4A 1Y62A 3BTGI 1JV8A 1LD5A 2HEXA 1TAWB 4DG4C 2UUXA 2KAII 2RA3C 4NTWB 1PITA 3AUIA 4ISLB 4ISNB 3TPII 3FP8I 1D0DA 3FP7J 3TGII 1TCPA 4BD9B 3OTJI 3WNYA 1KIGI 3BTFI 1T7CB 1LD6A 1P2QB 3BTKI 1BUNB 1DEMA 1B0CA 3TGKI 1ZR0B 1QLQA 1D0DB 2FTLI 1BIKA 4BQDA 7PTIA 3T62D 1P2JI 1YKTB 1FANA 1T8LB 3L3TE 3TGJI 3UOUB 1BPIA 1KUNA 1BRCI 1UUBA 1CO7I 1ZJDB 4NTXB 1JC6A 5PTIA 4Y10I 1AAPA 1P2NB 1P2OB 3BTHI 3BTWI 3LDJA 4BNRI 1F7ZI 6PTIA 2DDJA 1P2KI 2TPII 2DDIA 2LFKA 2R9PE 2KCRA 1KTHA 3AUHA 1BTHP 1CA0D 1CBWD 3CI7A 1BRBI 1IRHA 3LDIA 2FI4I 3P92E 1ADZA 5C67C 1FAKI 1F5RI 3LDMA 3BTDI 2W8XA 2KNTA 1K6UA 1OA55 4DTGK 2FI3I 3U1JE 1BF0A 2PTCI 3GYMI 1EAWB 2JOTA 1BZXI 3BTMI 1KNTA 1UUAA 1YC0I 4ISOB 3P95E 5JB7A 1YLDB 4Y11I 4WXVC 4NTYB 1TFXC 2ZJXA 2IJOI 1YLCB 1T8OB 2ODYE 3AUGA 3AUDA 4Y0ZI 4U32X 1P2II 3AUEA 3L33E 1DTXA 1DENA 5JB6A 1BTIA 2FI5I 4Y0YI 1TPAI 4TPII 2FTMB 3AUBA 1T8MB 1FY8I 1TAPA 1JV9A 1BHCA 3M7QB 3BTEI 2LFLA 1DTKA 3BTQI 2UUYB 1SHPA 3OFWA 1OA65 1T8NB 2M99A 3FP6I 2J6DA 3AUCA 3UIRC 4WWYC 9PTIA 1BPTA 1MTND 3D65I 4PTIA 1NAGA 3BTTI 1EJMB 2M01A
chains in the Genus database with same CATH superfamily
1AALA 3BYBA 5JB5A 1G6XA 1TOCR 2CA7A 8PTIA 1BZ5A 2ZVXA 1P2MB 2TGPI 4U30W 5JB4A 1Y62A 3BTGI 1JV8A 1LD5A 2HEXA 1TAWB 4DG4C 2UUXA 2KAII 2RA3C 4NTWB 1PITA 3AUIA 4ISLB 4ISNB 3TPII 3FP8I 1D0DA 3FP7J 3TGII 1TCPA 4BD9B 3OTJI 3WNYA 1KIGI 3BTFI 1T7CB 1LD6A 1P2QB 3BTKI 1BUNB 1DEMA 1B0CA 3TGKI 1ZR0B 1QLQA 1D0DB 2FTLI 1BIKA 4BQDA 7PTIA 3T62D 1P2JI 1YKTB 1FANA 1T8LB 3L3TE 3TGJI 3UOUB 1BPIA 1KUNA 1BRCI 1UUBA 1CO7I 1ZJDB 4NTXB 1JC6A 5PTIA 4Y10I 1AAPA 1P2NB 1P2OB 3BTHI 3BTWI 3LDJA 4BNRI 1F7ZI 6PTIA 2DDJA 1P2KI 2TPII 2DDIA 2LFKA 2R9PE 2KCRA 1KTHA 3AUHA 1BTHP 1CA0D 1CBWD 3CI7A 1BRBI 1IRHA 3LDIA 2FI4I 3P92E 1ADZA 5C67C 1FAKI 1F5RI 3LDMA 3BTDI 2W8XA 2KNTA 1K6UA 1OA55 4DTGK 2FI3I 3U1JE 1BF0A 2PTCI 3GYMI 1EAWB 2JOTA 1BZXI 3BTMI 1KNTA 1UUAA 1YC0I 4ISOB 3P95E 5JB7A 1YLDB 4Y11I 4WXVC 4NTYB 1TFXC 2ZJXA 2IJOI 1YLCB 1T8OB 2ODYE 3AUGA 3AUDA 4Y0ZI 4U32X 1P2II 3AUEA 3L33E 1DTXA 1DENA 5JB6A 1BTIA 2FI5I 4Y0YI 1TPAI 4TPII 2FTMB 3AUBA 1T8MB 1FY8I 1TAPA 1JV9A 1BHCA 3M7QB 3BTEI 2LFLA 1DTKA 3BTQI 2UUYB 1SHPA 3OFWA 1OA65 1T8NB 2M99A 3FP6I 2J6DA 3AUCA 3UIRC 4WWYC 9PTIA 1BPTA 1MTND 3D65I 4PTIA 1NAGA 3BTTI 1EJMB 2M01A
chains in the Genus database with same CATH topology
1AALA 3BYBA 5JB5A 1G6XA 1TOCR 2CA7A 8PTIA 1BZ5A 2ZVXA 1P2MB 2TGPI 4U30W 5JB4A 1Y62A 3BTGI 1JV8A 1LD5A 2HEXA 1TAWB 4DG4C 2UUXA 2KAII 2RA3C 4NTWB 1PITA 3AUIA 4ISLB 4ISNB 3TPII 3FP8I 1D0DA 3FP7J 3TGII 1TCPA 4BD9B 3OTJI 3WNYA 1KIGI 3BTFI 1T7CB 1LD6A 1P2QB 3BTKI 1BUNB 1DEMA 1B0CA 3TGKI 1ZR0B 1QLQA 1D0DB 2FTLI 1BIKA 4BQDA 7PTIA 3T62D 1P2JI 1YKTB 1FANA 1T8LB 3L3TE 3TGJI 3UOUB 1BPIA 1KUNA 1BRCI 1UUBA 1CO7I 1ZJDB 4NTXB 1JC6A 5PTIA 4Y10I 1AAPA 1P2NB 1P2OB 3BTHI 3BTWI 3LDJA 4BNRI 1F7ZI 6PTIA 2DDJA 1P2KI 2TPII 2DDIA 2LFKA 2R9PE 2KCRA 1KTHA 3AUHA 1BTHP 1CA0D 1CBWD 3CI7A 1BRBI 1IRHA 3LDIA 2FI4I 3P92E 1ADZA 5C67C 1FAKI 1F5RI 3LDMA 3BTDI 2W8XA 2KNTA 1K6UA 1OA55 4DTGK 2FI3I 3U1JE 1BF0A 2PTCI 3GYMI 1EAWB 2JOTA 1BZXI 3BTMI 1KNTA 1UUAA 1YC0I 4ISOB 3P95E 5JB7A 1YLDB 4Y11I 4WXVC 4NTYB 1TFXC 2ZJXA 2IJOI 1YLCB 1T8OB 2ODYE 3AUGA 3AUDA 4Y0ZI 4U32X 1P2II 3AUEA 3L33E 1DTXA 1DENA 5JB6A 1BTIA 2FI5I 4Y0YI 1TPAI 4TPII 2FTMB 3AUBA 1T8MB 1FY8I 1TAPA 1JV9A 1BHCA 3M7QB 3BTEI 2LFLA 1DTKA 3BTQI 2UUYB 1SHPA 3OFWA 1OA65 1T8NB 2M99A 3FP6I 2J6DA 3AUCA 3UIRC 4WWYC 9PTIA 1BPTA 1MTND 3D65I 4PTIA 1NAGA 3BTTI 1EJMB 2M01A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AAL A;  3BYB A;  5JB5 A;  1G6X A;  1TOC R;  2CA7 A;  8PTI A;  1BZ5 A;  2ZVX A;  1P2M B;  2TGP I;  4U30 W;  5JB4 A;  1Y62 A;  3BTG I;  1JV8 A;  1LD5 A;  2HEX A;  1TAW B;  4DG4 C;  2UUX A;  2KAI I;  2RA3 C;  4NTW B;  1PIT A;  3AUI A;  4ISL B;  4ISN B;  3TPI I;  3FP8 I;  1D0D A;  3FP7 J;  3TGI I;  1TCP A;  4BD9 B;  3OTJ I;  3WNY A;  1KIG I;  3BTF I;  1T7C B;  1LD6 A;  1P2Q B;  3BTK I;  1BUN B;  1DEM A;  1B0C A;  3TGK I;  1ZR0 B;  1QLQ A;  1D0D B;  2FTL I;  1BIK A;  4BQD A;  7PTI A;  3T62 D;  1P2J I;  1YKT B;  1FAN A;  1T8L B;  3L3T E;  3TGJ I;  3UOU B;  1BPI A;  1KUN A;  1BRC I;  1UUB A;  1CO7 I;  1ZJD B;  4NTX B;  1JC6 A;  5PTI A;  4Y10 I;  1AAP A;  1P2N B;  1P2O B;  3BTH I;  3BTW I;  3LDJ A;  4BNR I;  1F7Z I;  6PTI A;  2DDJ A;  1P2K I;  2TPI I;  2DDI A;  2LFK A;  2R9P E;  2KCR A;  1KTH A;  3AUH A;  1BTH P;  1CA0 D;  1CBW D;  3CI7 A;  1BRB I;  1IRH A;  3LDI A;  2FI4 I;  3P92 E;  1ADZ A;  5C67 C;  1FAK I;  1F5R I;  3LDM A;  3BTD I;  2W8X A;  2KNT A;  1K6U A;  1OA5 5;  4DTG K;  2FI3 I;  3U1J E;  1BF0 A;  2PTC I;  3GYM I;  1EAW B;  2JOT A;  1BZX I;  3BTM I;  1KNT A;  1UUA A;  1YC0 I;  4ISO B;  3P95 E;  5JB7 A;  1YLD B;  4Y11 I;  4WXV C;  4NTY B;  1TFX C;  2ZJX A;  2IJO I;  1YLC B;  1T8O B;  2ODY E;  3AUG A;  3AUD A;  4Y0Z I;  4U32 X;  1P2I I;  3AUE A;  3L33 E;  1DTX A;  1DEN A;  5JB6 A;  1BTI A;  2FI5 I;  4Y0Y I;  1TPA I;  4TPI I;  2FTM B;  3AUB A;  1T8M B;  1FY8 I;  1TAP A;  1JV9 A;  1BHC A;  3M7Q B;  3BTE I;  2LFL A;  1DTK A;  3BTQ I;  2UUY B;  1SHP A;  3OFW A;  1OA6 5;  1T8N B;  2M99 A;  3FP6 I;  2J6D A;  3AUC A;  3UIR C;  4WWY C;  9PTI A;  1BPT A;  1MTN D;  3D65 I;  4PTI A;  1NAG A;  3BTT I;  1EJM B;  2M01 A; 
#chains in the Genus database with same CATH topology
 1AAL A;  3BYB A;  5JB5 A;  1G6X A;  1TOC R;  2CA7 A;  8PTI A;  1BZ5 A;  2ZVX A;  1P2M B;  2TGP I;  4U30 W;  5JB4 A;  1Y62 A;  3BTG I;  1JV8 A;  1LD5 A;  2HEX A;  1TAW B;  4DG4 C;  2UUX A;  2KAI I;  2RA3 C;  4NTW B;  1PIT A;  3AUI A;  4ISL B;  4ISN B;  3TPI I;  3FP8 I;  1D0D A;  3FP7 J;  3TGI I;  1TCP A;  4BD9 B;  3OTJ I;  3WNY A;  1KIG I;  3BTF I;  1T7C B;  1LD6 A;  1P2Q B;  3BTK I;  1BUN B;  1DEM A;  1B0C A;  3TGK I;  1ZR0 B;  1QLQ A;  1D0D B;  2FTL I;  1BIK A;  4BQD A;  7PTI A;  3T62 D;  1P2J I;  1YKT B;  1FAN A;  1T8L B;  3L3T E;  3TGJ I;  3UOU B;  1BPI A;  1KUN A;  1BRC I;  1UUB A;  1CO7 I;  1ZJD B;  4NTX B;  1JC6 A;  5PTI A;  4Y10 I;  1AAP A;  1P2N B;  1P2O B;  3BTH I;  3BTW I;  3LDJ A;  4BNR I;  1F7Z I;  6PTI A;  2DDJ A;  1P2K I;  2TPI I;  2DDI A;  2LFK A;  2R9P E;  2KCR A;  1KTH A;  3AUH A;  1BTH P;  1CA0 D;  1CBW D;  3CI7 A;  1BRB I;  1IRH A;  3LDI A;  2FI4 I;  3P92 E;  1ADZ A;  5C67 C;  1FAK I;  1F5R I;  3LDM A;  3BTD I;  2W8X A;  2KNT A;  1K6U A;  1OA5 5;  4DTG K;  2FI3 I;  3U1J E;  1BF0 A;  2PTC I;  3GYM I;  1EAW B;  2JOT A;  1BZX I;  3BTM I;  1KNT A;  1UUA A;  1YC0 I;  4ISO B;  3P95 E;  5JB7 A;  1YLD B;  4Y11 I;  4WXV C;  4NTY B;  1TFX C;  2ZJX A;  2IJO I;  1YLC B;  1T8O B;  2ODY E;  3AUG A;  3AUD A;  4Y0Z I;  4U32 X;  1P2I I;  3AUE A;  3L33 E;  1DTX A;  1DEN A;  5JB6 A;  1BTI A;  2FI5 I;  4Y0Y I;  1TPA I;  4TPI I;  2FTM B;  3AUB A;  1T8M B;  1FY8 I;  1TAP A;  1JV9 A;  1BHC A;  3M7Q B;  3BTE I;  2LFL A;  1DTK A;  3BTQ I;  2UUY B;  1SHP A;  3OFW A;  1OA6 5;  1T8N B;  2M99 A;  3FP6 I;  2J6D A;  3AUC A;  3UIR C;  4WWY C;  9PTI A;  1BPT A;  1MTN D;  3D65 I;  4PTI A;  1NAG A;  3BTT I;  1EJM B;  2M01 A; 
#chains in the Genus database with same CATH homology
 1AAL A;  3BYB A;  5JB5 A;  1G6X A;  1TOC R;  2CA7 A;  8PTI A;  1BZ5 A;  2ZVX A;  1P2M B;  2TGP I;  4U30 W;  5JB4 A;  1Y62 A;  3BTG I;  1JV8 A;  1LD5 A;  2HEX A;  1TAW B;  4DG4 C;  2UUX A;  2KAI I;  2RA3 C;  4NTW B;  1PIT A;  3AUI A;  4ISL B;  4ISN B;  3TPI I;  3FP8 I;  1D0D A;  3FP7 J;  3TGI I;  1TCP A;  4BD9 B;  3OTJ I;  3WNY A;  1KIG I;  3BTF I;  1T7C B;  1LD6 A;  1P2Q B;  3BTK I;  1BUN B;  1DEM A;  1B0C A;  3TGK I;  1ZR0 B;  1QLQ A;  1D0D B;  2FTL I;  1BIK A;  4BQD A;  7PTI A;  3T62 D;  1P2J I;  1YKT B;  1FAN A;  1T8L B;  3L3T E;  3TGJ I;  3UOU B;  1BPI A;  1KUN A;  1BRC I;  1UUB A;  1CO7 I;  1ZJD B;  4NTX B;  1JC6 A;  5PTI A;  4Y10 I;  1AAP A;  1P2N B;  1P2O B;  3BTH I;  3BTW I;  3LDJ A;  4BNR I;  1F7Z I;  6PTI A;  2DDJ A;  1P2K I;  2TPI I;  2DDI A;  2LFK A;  2R9P E;  2KCR A;  1KTH A;  3AUH A;  1BTH P;  1CA0 D;  1CBW D;  3CI7 A;  1BRB I;  1IRH A;  3LDI A;  2FI4 I;  3P92 E;  1ADZ A;  5C67 C;  1FAK I;  1F5R I;  3LDM A;  3BTD I;  2W8X A;  2KNT A;  1K6U A;  1OA5 5;  4DTG K;  2FI3 I;  3U1J E;  1BF0 A;  2PTC I;  3GYM I;  1EAW B;  2JOT A;  1BZX I;  3BTM I;  1KNT A;  1UUA A;  1YC0 I;  4ISO B;  3P95 E;  5JB7 A;  1YLD B;  4Y11 I;  4WXV C;  4NTY B;  1TFX C;  2ZJX A;  2IJO I;  1YLC B;  1T8O B;  2ODY E;  3AUG A;  3AUD A;  4Y0Z I;  4U32 X;  1P2I I;  3AUE A;  3L33 E;  1DTX A;  1DEN A;  5JB6 A;  1BTI A;  2FI5 I;  4Y0Y I;  1TPA I;  4TPI I;  2FTM B;  3AUB A;  1T8M B;  1FY8 I;  1TAP A;  1JV9 A;  1BHC A;  3M7Q B;  3BTE I;  2LFL A;  1DTK A;  3BTQ I;  2UUY B;  1SHP A;  3OFW A;  1OA6 5;  1T8N B;  2M99 A;  3FP6 I;  2J6D A;  3AUC A;  3UIR C;  4WWY C;  9PTI A;  1BPT A;  1MTN D;  3D65 I;  4PTI A;  1NAG A;  3BTT I;  1EJM B;  2M01 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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