2TPII

On the disordered activation domain in trypsinogen. chemical labelling and low-temperature crystallography
Total Genus 8
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
8
sequence length
56
structure length
56
Chain Sequence
PDFCLEPPYTGPCKARIIRYFYNAKAGLCQTFVYGGCRAKRNNFKSAEDCMRTCGG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title On the Disordered Activation Domain in Trypsinogen. Chemical Labelling and Low-Temperature Crystallography
pubmed rcsb
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords TRYPSINOGEN
total genus 8
structure length 56
sequence length 56
ec nomenclature
pdb deposition date 1981-10-26

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2tpiI00
1BIKA 2FI5I 2KCRA 3AUHA 1LD5A 4Y0ZI 3T62D 2LFLA 1K6UA 3LDIA 4BD9B 1D0DA 1TPAI 3GYMI 1CO7I 1P2MB 1TFXC 2FTMB 3AUDA 2J6DA 3TPII 5JB5A 9PTIA 3FP8I 3BTFI 1F5RI 3AUCA 2KAII 1ADZA 3AUIA 1BF0A 1YKTB 3LDJA 1B0CA 1T7CB 2M01A 5JB7A 1AALA 1G6XA 1P2NB 1BZXI 3BTMI 4TPII 3BYBA 8PTIA 1AAPA 2W8XA 5C67C 7PTIA 1DEMA 4BNRI 3BTTI 4Y10I 1YLCB 4U32X 3P92E 2DDIA 2HEXA 1CA0D 2DDJA 1PITA 1BPIA 2TPII 3AUGA 1SHPA 2R9PE 1OA55 1P2QB 1KTHA 1DTKA 2JOTA 1T8NB 2FI4I 4Y11I 3BTHI 1DTXA 1BHCA 1EJMB 3BTGI 4ISOB 2M99A 2UUYB 1BTHP 3UIRC 1P2OB 4BQDA 5PTIA 1CBWD 3P95E 3TGII 3BTQI 1TCPA 1BPTA 3L3TE 3L33E 1P2KI 2LFKA 2KNTA 2IJOI 3BTDI 3BTWI 1TOCR 4DG4C 1FAKI 1UUBA 3M7QB 3FP7J 1MTND 3UOUB 5JB4A 6PTIA 5JB6A 1D0DB 2CA7A 1YC0I 3U1JE 2FTLI 1BRBI 3FP6I 3TGJI 1OA65 4WWYC 4PTIA 3D65I 1FANA 1JV8A 1F7ZI 3BTKI 1KIGI 4U30W 1YLDB 3AUBA 1DENA 4ISNB 1BTIA 1KNTA 1Y62A 1BRCI 3TGKI 3LDMA 1IRHA 2ZJXA 2ODYE 1T8MB 3BTEI 1P2JI 1QLQA 2ZVXA 1JV9A 3WNYA 1NAGA 4DTGK 1TAWB 2FI3I 1BZ5A 2TGPI 3OFWA 4ISLB 1T8LB 1KUNA 1FY8I 3AUEA 1BUNB 1UUAA 1P2II 2RA3C 4Y0YI 2PTCI 4NTYB 4WXVC 3OTJI 1EAWB 2UUXA 4NTWB 1ZR0B 4NTXB 1JC6A 1TAPA 1ZJDB 1LD6A 1T8OB 3CI7A
chains in the Genus database with same CATH superfamily
1BIKA 2FI5I 2KCRA 3AUHA 1LD5A 4Y0ZI 3T62D 2LFLA 1K6UA 3LDIA 4BD9B 1D0DA 1TPAI 3GYMI 1CO7I 1P2MB 1TFXC 2FTMB 3AUDA 2J6DA 3TPII 5JB5A 9PTIA 3FP8I 3BTFI 1F5RI 3AUCA 2KAII 1ADZA 3AUIA 1BF0A 1YKTB 3LDJA 1B0CA 1T7CB 2M01A 5JB7A 1AALA 1G6XA 1P2NB 1BZXI 3BTMI 4TPII 3BYBA 8PTIA 1AAPA 2W8XA 5C67C 7PTIA 1DEMA 4BNRI 3BTTI 4Y10I 1YLCB 4U32X 3P92E 2DDIA 2HEXA 1CA0D 2DDJA 1PITA 1BPIA 2TPII 3AUGA 1SHPA 2R9PE 1OA55 1P2QB 1KTHA 1DTKA 2JOTA 1T8NB 2FI4I 4Y11I 3BTHI 1DTXA 1BHCA 1EJMB 3BTGI 4ISOB 2M99A 2UUYB 1BTHP 3UIRC 1P2OB 4BQDA 5PTIA 1CBWD 3P95E 3TGII 3BTQI 1TCPA 1BPTA 3L3TE 3L33E 1P2KI 2LFKA 2KNTA 2IJOI 3BTDI 3BTWI 1TOCR 4DG4C 1FAKI 1UUBA 3M7QB 3FP7J 1MTND 3UOUB 5JB4A 6PTIA 5JB6A 1D0DB 2CA7A 1YC0I 3U1JE 2FTLI 1BRBI 3FP6I 3TGJI 1OA65 4WWYC 4PTIA 3D65I 1FANA 1JV8A 1F7ZI 3BTKI 1KIGI 4U30W 1YLDB 3AUBA 1DENA 4ISNB 1BTIA 1KNTA 1Y62A 1BRCI 3TGKI 3LDMA 1IRHA 2ZJXA 2ODYE 1T8MB 3BTEI 1P2JI 1QLQA 2ZVXA 1JV9A 3WNYA 1NAGA 4DTGK 1TAWB 2FI3I 1BZ5A 2TGPI 3OFWA 4ISLB 1T8LB 1KUNA 1FY8I 3AUEA 1BUNB 1UUAA 1P2II 2RA3C 4Y0YI 2PTCI 4NTYB 4WXVC 3OTJI 1EAWB 2UUXA 4NTWB 1ZR0B 4NTXB 1JC6A 1TAPA 1ZJDB 1LD6A 1T8OB 3CI7A
chains in the Genus database with same CATH topology
1BIKA 2FI5I 2KCRA 3AUHA 1LD5A 4Y0ZI 3T62D 2LFLA 1K6UA 3LDIA 4BD9B 1D0DA 1TPAI 3GYMI 1CO7I 1P2MB 1TFXC 2FTMB 3AUDA 2J6DA 3TPII 5JB5A 9PTIA 3FP8I 3BTFI 1F5RI 3AUCA 2KAII 1ADZA 3AUIA 1BF0A 1YKTB 3LDJA 1B0CA 1T7CB 2M01A 5JB7A 1AALA 1G6XA 1P2NB 1BZXI 3BTMI 4TPII 3BYBA 8PTIA 1AAPA 2W8XA 5C67C 7PTIA 1DEMA 4BNRI 3BTTI 4Y10I 1YLCB 4U32X 3P92E 2DDIA 2HEXA 1CA0D 2DDJA 1PITA 1BPIA 2TPII 3AUGA 1SHPA 2R9PE 1OA55 1P2QB 1KTHA 1DTKA 2JOTA 1T8NB 2FI4I 4Y11I 3BTHI 1DTXA 1BHCA 1EJMB 3BTGI 4ISOB 2M99A 2UUYB 1BTHP 3UIRC 1P2OB 4BQDA 5PTIA 1CBWD 3P95E 3TGII 3BTQI 1TCPA 1BPTA 3L3TE 3L33E 1P2KI 2LFKA 2KNTA 2IJOI 3BTDI 3BTWI 1TOCR 4DG4C 1FAKI 1UUBA 3M7QB 3FP7J 1MTND 3UOUB 5JB4A 6PTIA 5JB6A 1D0DB 2CA7A 1YC0I 3U1JE 2FTLI 1BRBI 3FP6I 3TGJI 1OA65 4WWYC 4PTIA 3D65I 1FANA 1JV8A 1F7ZI 3BTKI 1KIGI 4U30W 1YLDB 3AUBA 1DENA 4ISNB 1BTIA 1KNTA 1Y62A 1BRCI 3TGKI 3LDMA 1IRHA 2ZJXA 2ODYE 1T8MB 3BTEI 1P2JI 1QLQA 2ZVXA 1JV9A 3WNYA 1NAGA 4DTGK 1TAWB 2FI3I 1BZ5A 2TGPI 3OFWA 4ISLB 1T8LB 1KUNA 1FY8I 3AUEA 1BUNB 1UUAA 1P2II 2RA3C 4Y0YI 2PTCI 4NTYB 4WXVC 3OTJI 1EAWB 2UUXA 4NTWB 1ZR0B 4NTXB 1JC6A 1TAPA 1ZJDB 1LD6A 1T8OB 3CI7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1BIK A;  2FI5 I;  2KCR A;  3AUH A;  1LD5 A;  4Y0Z I;  3T62 D;  2LFL A;  1K6U A;  3LDI A;  4BD9 B;  1D0D A;  1TPA I;  3GYM I;  1CO7 I;  1P2M B;  1TFX C;  2FTM B;  3AUD A;  2J6D A;  3TPI I;  5JB5 A;  9PTI A;  3FP8 I;  3BTF I;  1F5R I;  3AUC A;  2KAI I;  1ADZ A;  3AUI A;  1BF0 A;  1YKT B;  3LDJ A;  1B0C A;  1T7C B;  2M01 A;  5JB7 A;  1AAL A;  1G6X A;  1P2N B;  1BZX I;  3BTM I;  4TPI I;  3BYB A;  8PTI A;  1AAP A;  2W8X A;  5C67 C;  7PTI A;  1DEM A;  4BNR I;  3BTT I;  4Y10 I;  1YLC B;  4U32 X;  3P92 E;  2DDI A;  2HEX A;  1CA0 D;  2DDJ A;  1PIT A;  1BPI A;  2TPI I;  3AUG A;  1SHP A;  2R9P E;  1OA5 5;  1P2Q B;  1KTH A;  1DTK A;  2JOT A;  1T8N B;  2FI4 I;  4Y11 I;  3BTH I;  1DTX A;  1BHC A;  1EJM B;  3BTG I;  4ISO B;  2M99 A;  2UUY B;  1BTH P;  3UIR C;  1P2O B;  4BQD A;  5PTI A;  1CBW D;  3P95 E;  3TGI I;  3BTQ I;  1TCP A;  1BPT A;  3L3T E;  3L33 E;  1P2K I;  2LFK A;  2KNT A;  2IJO I;  3BTD I;  3BTW I;  1TOC R;  4DG4 C;  1FAK I;  1UUB A;  3M7Q B;  3FP7 J;  1MTN D;  3UOU B;  5JB4 A;  6PTI A;  5JB6 A;  1D0D B;  2CA7 A;  1YC0 I;  3U1J E;  2FTL I;  1BRB I;  3FP6 I;  3TGJ I;  1OA6 5;  4WWY C;  4PTI A;  3D65 I;  1FAN A;  1JV8 A;  1F7Z I;  3BTK I;  1KIG I;  4U30 W;  1YLD B;  3AUB A;  1DEN A;  4ISN B;  1BTI A;  1KNT A;  1Y62 A;  1BRC I;  3TGK I;  3LDM A;  1IRH A;  2ZJX A;  2ODY E;  1T8M B;  3BTE I;  1P2J I;  1QLQ A;  2ZVX A;  1JV9 A;  3WNY A;  1NAG A;  4DTG K;  1TAW B;  2FI3 I;  1BZ5 A;  2TGP I;  3OFW A;  4ISL B;  1T8L B;  1KUN A;  1FY8 I;  3AUE A;  1BUN B;  1UUA A;  1P2I I;  2RA3 C;  4Y0Y I;  2PTC I;  4NTY B;  4WXV C;  3OTJ I;  1EAW B;  2UUX A;  4NTW B;  1ZR0 B;  4NTX B;  1JC6 A;  1TAP A;  1ZJD B;  1LD6 A;  1T8O B;  3CI7 A; 
#chains in the Genus database with same CATH topology
 1BIK A;  2FI5 I;  2KCR A;  3AUH A;  1LD5 A;  4Y0Z I;  3T62 D;  2LFL A;  1K6U A;  3LDI A;  4BD9 B;  1D0D A;  1TPA I;  3GYM I;  1CO7 I;  1P2M B;  1TFX C;  2FTM B;  3AUD A;  2J6D A;  3TPI I;  5JB5 A;  9PTI A;  3FP8 I;  3BTF I;  1F5R I;  3AUC A;  2KAI I;  1ADZ A;  3AUI A;  1BF0 A;  1YKT B;  3LDJ A;  1B0C A;  1T7C B;  2M01 A;  5JB7 A;  1AAL A;  1G6X A;  1P2N B;  1BZX I;  3BTM I;  4TPI I;  3BYB A;  8PTI A;  1AAP A;  2W8X A;  5C67 C;  7PTI A;  1DEM A;  4BNR I;  3BTT I;  4Y10 I;  1YLC B;  4U32 X;  3P92 E;  2DDI A;  2HEX A;  1CA0 D;  2DDJ A;  1PIT A;  1BPI A;  2TPI I;  3AUG A;  1SHP A;  2R9P E;  1OA5 5;  1P2Q B;  1KTH A;  1DTK A;  2JOT A;  1T8N B;  2FI4 I;  4Y11 I;  3BTH I;  1DTX A;  1BHC A;  1EJM B;  3BTG I;  4ISO B;  2M99 A;  2UUY B;  1BTH P;  3UIR C;  1P2O B;  4BQD A;  5PTI A;  1CBW D;  3P95 E;  3TGI I;  3BTQ I;  1TCP A;  1BPT A;  3L3T E;  3L33 E;  1P2K I;  2LFK A;  2KNT A;  2IJO I;  3BTD I;  3BTW I;  1TOC R;  4DG4 C;  1FAK I;  1UUB A;  3M7Q B;  3FP7 J;  1MTN D;  3UOU B;  5JB4 A;  6PTI A;  5JB6 A;  1D0D B;  2CA7 A;  1YC0 I;  3U1J E;  2FTL I;  1BRB I;  3FP6 I;  3TGJ I;  1OA6 5;  4WWY C;  4PTI A;  3D65 I;  1FAN A;  1JV8 A;  1F7Z I;  3BTK I;  1KIG I;  4U30 W;  1YLD B;  3AUB A;  1DEN A;  4ISN B;  1BTI A;  1KNT A;  1Y62 A;  1BRC I;  3TGK I;  3LDM A;  1IRH A;  2ZJX A;  2ODY E;  1T8M B;  3BTE I;  1P2J I;  1QLQ A;  2ZVX A;  1JV9 A;  3WNY A;  1NAG A;  4DTG K;  1TAW B;  2FI3 I;  1BZ5 A;  2TGP I;  3OFW A;  4ISL B;  1T8L B;  1KUN A;  1FY8 I;  3AUE A;  1BUN B;  1UUA A;  1P2I I;  2RA3 C;  4Y0Y I;  2PTC I;  4NTY B;  4WXV C;  3OTJ I;  1EAW B;  2UUX A;  4NTW B;  1ZR0 B;  4NTX B;  1JC6 A;  1TAP A;  1ZJD B;  1LD6 A;  1T8O B;  3CI7 A; 
#chains in the Genus database with same CATH homology
 1BIK A;  2FI5 I;  2KCR A;  3AUH A;  1LD5 A;  4Y0Z I;  3T62 D;  2LFL A;  1K6U A;  3LDI A;  4BD9 B;  1D0D A;  1TPA I;  3GYM I;  1CO7 I;  1P2M B;  1TFX C;  2FTM B;  3AUD A;  2J6D A;  3TPI I;  5JB5 A;  9PTI A;  3FP8 I;  3BTF I;  1F5R I;  3AUC A;  2KAI I;  1ADZ A;  3AUI A;  1BF0 A;  1YKT B;  3LDJ A;  1B0C A;  1T7C B;  2M01 A;  5JB7 A;  1AAL A;  1G6X A;  1P2N B;  1BZX I;  3BTM I;  4TPI I;  3BYB A;  8PTI A;  1AAP A;  2W8X A;  5C67 C;  7PTI A;  1DEM A;  4BNR I;  3BTT I;  4Y10 I;  1YLC B;  4U32 X;  3P92 E;  2DDI A;  2HEX A;  1CA0 D;  2DDJ A;  1PIT A;  1BPI A;  2TPI I;  3AUG A;  1SHP A;  2R9P E;  1OA5 5;  1P2Q B;  1KTH A;  1DTK A;  2JOT A;  1T8N B;  2FI4 I;  4Y11 I;  3BTH I;  1DTX A;  1BHC A;  1EJM B;  3BTG I;  4ISO B;  2M99 A;  2UUY B;  1BTH P;  3UIR C;  1P2O B;  4BQD A;  5PTI A;  1CBW D;  3P95 E;  3TGI I;  3BTQ I;  1TCP A;  1BPT A;  3L3T E;  3L33 E;  1P2K I;  2LFK A;  2KNT A;  2IJO I;  3BTD I;  3BTW I;  1TOC R;  4DG4 C;  1FAK I;  1UUB A;  3M7Q B;  3FP7 J;  1MTN D;  3UOU B;  5JB4 A;  6PTI A;  5JB6 A;  1D0D B;  2CA7 A;  1YC0 I;  3U1J E;  2FTL I;  1BRB I;  3FP6 I;  3TGJ I;  1OA6 5;  4WWY C;  4PTI A;  3D65 I;  1FAN A;  1JV8 A;  1F7Z I;  3BTK I;  1KIG I;  4U30 W;  1YLD B;  3AUB A;  1DEN A;  4ISN B;  1BTI A;  1KNT A;  1Y62 A;  1BRC I;  3TGK I;  3LDM A;  1IRH A;  2ZJX A;  2ODY E;  1T8M B;  3BTE I;  1P2J I;  1QLQ A;  2ZVX A;  1JV9 A;  3WNY A;  1NAG A;  4DTG K;  1TAW B;  2FI3 I;  1BZ5 A;  2TGP I;  3OFW A;  4ISL B;  1T8L B;  1KUN A;  1FY8 I;  3AUE A;  1BUN B;  1UUA A;  1P2I I;  2RA3 C;  4Y0Y I;  2PTC I;  4NTY B;  4WXV C;  3OTJ I;  1EAW B;  2UUX A;  4NTW B;  1ZR0 B;  4NTX B;  1JC6 A;  1TAP A;  1ZJD B;  1LD6 A;  1T8O B;  3CI7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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