2VUMF

Alpha-amanitin inhibited complete rna polymerase ii elongation complex
Total Genus 22
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
22
sequence length
84
structure length
84
Chain Sequence
KAIPKDQRATTPYMTKYERARILGTRALQISMNAPVFVDLEGETDPLRIAMKELAEKKIPLVIRRYLPDGSFEDWSVEELIVDL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis of Transcription Inhibition by Alpha-Amanitin and Implications for RNA Polymerase II Translocation.
pubmed doi rcsb
molecule tags Transferase
molecule keywords DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1
total genus 22
structure length 84
sequence length 84
ec nomenclature
pdb deposition date 2008-05-27

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
F PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 2vumF00
4A3BF 3GTMF 3S1RF 5FLMF 1Y1WF 3GTLF 5IPLE 5D4CE 4ZH4E 4X6AF 4XLNE 5BYHE 3GTKF 1Y1VF 3I4NF 2VUMF 4BY7F 4C3IF 4Y7NF 1SMYE 4AYBK 4OIPE 1TWCF 4YG2E 4BY1F 3H0GF 4A3DF 1K83F 5IYCF 2B63F 3PO3F 4KMUE 4OIOE 5IP9F 4A3IF 3GTGF 5C3EF 3RZDF 5TMCE 2PPBE 5M3MF 3S16F 3FKIF 4Q4ZE 3M3YF 5TMFE 3EQLE 4BBRF 2BE5E 5C4JF 5M3FF 2JA8F 5M5WF 3RZOF 3GTPF 4GZYE 2NVTF 4C3JF 3GTOF 3S2DF 2JA6F 2R93F 4LK0E 4A3JF 3S1NF 5D4DE 2NVXF 3HOUF 2O5JE 5M5YF 3CQZF 4YFKE 4BXXF 2R7ZF 4KN7E 4KN4E 5IYBF 4A3CF 3HOYF 4C3HF 4A3MF 3HOXF 4MQ9E 4A3GF 2JA7F 3H3VG 1TWHF 4A3KF 4BBSF 5C4XF 4XLPE 4Y52F 4A3EF 4YFXE 2Y0SI 4A93F 4G7HE 3GTQF 1TWFF 2PMZK 4LLGE 5IYDF 5E17E 2YU9F 4Q5SE 3PO2F 4G7OE 5IP7F 3S15F 2NVYF 5M5XF 1TWAF 2A69E 3M4OF 1I6VE 3S1MF 4YFNE 1YNJK 4OINE 4G7ZE 4LJZE 1WCMF 4OIQE 4A3LF 1ZYRE 3S17F 4XSZE 2WB1I 3S2HF 3HOWF 5FJ8F 1I6HF 3S1QF 1YNNK 3DXJE 4XSXE 3K7AF 4LK1E 2A6HE 2A68E 2A6EE 1HQME 4MEXE 3S14F 1QKLA 5E18E 4MEYE 2CW0E 1I50F 1TWGF 5C44F 3GTJF 3HOVF 2E2IF 1IW7E 4A3FF 2R92F 2NVQF 1I3QF 5D4EE 3HKZK 3WODE 2WAQK 2O5IE 2E2HF 4JK1E 2E2JF 1R9TF 4OIRE 3I4MF 3HOZF 1SFOF 4C2MF 2JA5F
chains in the Genus database with same CATH superfamily
4A3BF 3GTMF 3S1RF 5FLMF 1Y1WF 4A93E 3GTLF 5IPLE 1TWFE 4ZH4E 5D4CE 4X6AF 4XLNE 1I50E 5BYHE 3GTKF 1Y1VF 3I4NF 3GTJE 5C44E 2NVYE 3HOVE 2VUMF 3PO2E 5M5XE 2E2IE 4BY7F 2R92E 4A3FE 4C3IF 4Y7NF 1SMYE 2WB1H 4AYBK 4OIPE 1TWCF 4YG2E 4BY1F 3H0GF 4A3DF 1K83F 5IYCF 2B63F 2E2HE 4A3LE 5C4XE 3PO3F 4KMUE 2E2JE 4OIOE 1R9TE 3I4ME 3HOZE 1SFOE 5IP9F 4C2ME 4A3IF 3GTGF 5C3EF 3RZDF 2JA5E 5TMCE 2PPBE 4A3BE 3GTME 5M3MF 3S16F 3S1RE 3FKIF 4Q4ZE 1Y1WE 3M3YF 5TMFE 3EQLE 4BBRF 3S14E 3GTLE 2JA7E 2BE5E 4X6AE 5C4JF 5M3FF 2PMZH 2JA8F 5M5WF 3RZOF 3GTPF 4GZYE 2NVTF 1Y1VE 3GTKE 3I4NE 4C3JF 2VUME 3GTOF 3S2DF 2JA6F 1TWGE 4LK0E 2KRXA 4A3JF 4BY7E 2R93F 3S1NF 5D4DE 2NVXF 3HOUF 2O5JE 5M5YF 2NVQE 1TWCE 3CQZF 1I3QE 4A3DE 3H0GE 4YFKE 1K83E 5IYCE 2B63E 2R7ZF 2WAQH 4KN7E 4KN4E 4BXXF 5IYBF 3PO3E 4A3CF 3HOYF 4C3HF 4A3MF 5IP9E 3HOXF 4MQ9E 4A3GF 5C3EE 2JA7F 1TWHF 3RZDE 3H3VG 4A3KF 4BBSF 5C4XF 4XLPE 5M3ME 3S16E 3M3YE 4Y52F 4BBRE 1DZFA 4YFXE 2Y0SI 5FLME 4A3EF 4G7HE 4A93F 3GTQF 1TWFF 2PMZK 4LLGE 5C4JE 5IYDF 2JA8E 5M5WE 3RZOE 2NVTE 2YU9F 4Q5SE 3PO2F 4G7OE 4C3JE 5IP7F 2NVYF 3S15F 5E17E 5M5XF 1TWAF 2A69E 2JA6E 3M4OF 4A3JE 1I6VE 3S2DE 2R93E 3S1MF 4YFNE 1YNJK 4C3IE 5M5YE 4G7ZE 4LJZE 3CQZE 4Y7NE 4OINE 4AYBH 1WCMF 4OIQE 2R7ZE 4BY1E 3HKZH 4A3LF 1ZYRE 4A3CE 3S17F 4XSZE 2WB1I 4C3HE 3HOYE 4A3ME 3S2HF 3HOXE 3HOWF 4A3GE 3H3VF 5FJ8F 1I6HF 3S1QF 1YNNK 3DXJE 4XSXE 4A3KE 4A3IE 3GTGE 3K7AF 4BBSE 4LK1E 2A6HE 4Y52E 2A68E 2A6EE 4A3EE 1HQME 3FKIE 4QIWH 4MEXE 3S14F 1QKLA 5E18E 3GTQE 4MEYE 5IYDE 5M3FE 2CW0E 2YU9E 5IP7E 1I50F 3GTPE 3S15E 1TWAE 1TWGF 5C44F 3GTJF 3HOVF 3M4OE 3GTOE 2E2IF 3S1ME 1IW7E 4A3FF 2R92F 2NVQF 3S1NE 1EIKA 2NVXE 3HOUE 1I3QF 5D4EE 1WCME 3HKZK 3WODE 2WAQK 2O5IE 4BXXE 2E2HF 3S17E 5IYBE 4JK1E 2E2JF 3S2HE 1R9TF 4OIRE 3I4MF 3HOWE 3HOZF 5FJ8E 1SFOF 3S1QE 1I6HE 2Y0SH 4C2MF 3K7AE 1TWHE 2JA5F 4QIWK
chains in the Genus database with same CATH topology
4A3BF 3GTMF 3S1RF 5FLMF 1Y1WF 3GTLF 5IPLE 5D4CE 4ZH4E 4X6AF 4XLNE 5BYHE 3GTKF 1Y1VF 3I4NF 2VUMF 4BY7F 4C3IF 4Y7NF 1SMYE 4AYBK 4OIPE 1TWCF 4YG2E 4BY1F 3H0GF 4A3DF 1K83F 5IYCF 2B63F 3PO3F 4KMUE 4OIOE 5IP9F 4A3IF 3GTGF 5C3EF 3RZDF 5TMCE 2PPBE 5M3MF 3S16F 3FKIF 4Q4ZE 3M3YF 5TMFE 3EQLE 4BBRF 2BE5E 5C4JF 5M3FF 2JA8F 5M5WF 3RZOF 3GTPF 4GZYE 2NVTF 4C3JF 3GTOF 3S2DF 2JA6F 2R93F 4LK0E 2KRXA 4A3JF 3S1NF 5D4DE 2NVXF 3HOUF 2O5JE 5M5YF 3CQZF 4YFKE 4BXXF 2R7ZF 4KN7E 4KN4E 5IYBF 4A3CF 3HOYF 4C3HF 4A3MF 3HOXF 4MQ9E 4A3GF 2JA7F 3H3VG 1TWHF 4A3KF 4BBSF 5C4XF 4XLPE 4Y52F 4A3EF 4YFXE 2Y0SI 4A93F 4G7HE 3GTQF 1TWFF 2PMZK 4LLGE 5IYDF 5E17E 2YU9F 4Q5SE 3PO2F 4G7OE 5IP7F 3S15F 2NVYF 5M5XF 1TWAF 2A69E 3M4OF 1I6VE 3S1MF 4YFNE 1YNJK 4OINE 4G7ZE 4LJZE 1WCMF 4OIQE 4A3LF 1ZYRE 3S17F 4XSZE 2WB1I 3S2HF 3HOWF 5FJ8F 1I6HF 3S1QF 1YNNK 3DXJE 4XSXE 3K7AF 4LK1E 2A6HE 2A68E 2A6EE 1HQME 4MEXE 3S14F 1QKLA 5E18E 4MEYE 2CW0E 1I50F 1TWGF 5C44F 3GTJF 3HOVF 2E2IF 1IW7E 4A3FF 2R92F 2NVQF 1I3QF 5D4EE 3HKZK 3WODE 2WAQK 2O5IE 2E2HF 4JK1E 2E2JF 1R9TF 4OIRE 3I4MF 3HOZF 1SFOF 4C2MF 2JA5F 4QIWK
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4A3B F;  3GTM F;  3S1R F;  5FLM F;  1Y1W F;  3GTL F;  5IPL E;  5D4C E;  4ZH4 E;  4X6A F;  4XLN E;  5BYH E;  3GTK F;  1Y1V F;  3I4N F;  2VUM F;  4BY7 F;  4C3I F;  4Y7N F;  1SMY E;  4AYB K;  4OIP E;  1TWC F;  4YG2 E;  4BY1 F;  3H0G F;  4A3D F;  1K83 F;  5IYC F;  2B63 F;  3PO3 F;  4KMU E;  4OIO E;  5IP9 F;  4A3I F;  3GTG F;  5C3E F;  3RZD F;  5TMC E;  2PPB E;  5M3M F;  3S16 F;  3FKI F;  4Q4Z E;  3M3Y F;  5TMF E;  3EQL E;  4BBR F;  2BE5 E;  5C4J F;  5M3F F;  2JA8 F;  5M5W F;  3RZO F;  3GTP F;  4GZY E;  2NVT F;  4C3J F;  3GTO F;  3S2D F;  2JA6 F;  2R93 F;  4LK0 E;  4A3J F;  3S1N F;  5D4D E;  2NVX F;  3HOU F;  2O5J E;  5M5Y F;  3CQZ F;  4YFK E;  4BXX F;  2R7Z F;  4KN7 E;  4KN4 E;  5IYB F;  4A3C F;  3HOY F;  4C3H F;  4A3M F;  3HOX F;  4MQ9 E;  4A3G F;  2JA7 F;  3H3V G;  1TWH F;  4A3K F;  4BBS F;  5C4X F;  4XLP E;  4Y52 F;  4A3E F;  4YFX E;  2Y0S I;  4A93 F;  4G7H E;  3GTQ F;  1TWF F;  2PMZ K;  4LLG E;  5IYD F;  5E17 E;  2YU9 F;  4Q5S E;  3PO2 F;  4G7O E;  5IP7 F;  3S15 F;  2NVY F;  5M5X F;  1TWA F;  2A69 E;  3M4O F;  1I6V E;  3S1M F;  4YFN E;  1YNJ K;  4OIN E;  4G7Z E;  4LJZ E;  1WCM F;  4OIQ E;  4A3L F;  1ZYR E;  3S17 F;  4XSZ E;  2WB1 I;  3S2H F;  3HOW F;  5FJ8 F;  1I6H F;  3S1Q F;  1YNN K;  3DXJ E;  4XSX E;  3K7A F;  4LK1 E;  2A6H E;  2A68 E;  2A6E E;  1HQM E;  4MEX E;  3S14 F;  1QKL A;  5E18 E;  4MEY E;  2CW0 E;  1I50 F;  1TWG F;  5C44 F;  3GTJ F;  3HOV F;  2E2I F;  1IW7 E;  4A3F F;  2R92 F;  2NVQ F;  1I3Q F;  5D4E E;  3HKZ K;  3WOD E;  2WAQ K;  2O5I E;  2E2H F;  4JK1 E;  2E2J F;  1R9T F;  4OIR E;  3I4M F;  3HOZ F;  1SFO F;  4C2M F;  2JA5 F; 
#chains in the Genus database with same CATH topology
 4A3B F;  3GTM F;  3S1R F;  5FLM F;  1Y1W F;  4A93 E;  3GTL F;  5IPL E;  1TWF E;  4ZH4 E;  5D4C E;  4X6A F;  4XLN E;  1I50 E;  5BYH E;  3GTK F;  1Y1V F;  3I4N F;  3GTJ E;  5C44 E;  2NVY E;  3HOV E;  2VUM F;  3PO2 E;  5M5X E;  2E2I E;  4BY7 F;  2R92 E;  4A3F E;  4C3I F;  4Y7N F;  1SMY E;  2WB1 H;  4AYB K;  4OIP E;  1TWC F;  4YG2 E;  4BY1 F;  3H0G F;  4A3D F;  1K83 F;  5IYC F;  2B63 F;  2E2H E;  4A3L E;  5C4X E;  3PO3 F;  4KMU E;  2E2J E;  4OIO E;  1R9T E;  3I4M E;  3HOZ E;  1SFO E;  5IP9 F;  4C2M E;  4A3I F;  3GTG F;  5C3E F;  3RZD F;  2JA5 E;  5TMC E;  2PPB E;  4A3B E;  3GTM E;  5M3M F;  3S16 F;  3S1R E;  3FKI F;  4Q4Z E;  1Y1W E;  3M3Y F;  5TMF E;  3EQL E;  4BBR F;  3S14 E;  3GTL E;  2JA7 E;  2BE5 E;  4X6A E;  5C4J F;  5M3F F;  2PMZ H;  2JA8 F;  5M5W F;  3RZO F;  3GTP F;  4GZY E;  2NVT F;  1Y1V E;  3GTK E;  3I4N E;  4C3J F;  2VUM E;  3GTO F;  3S2D F;  2JA6 F;  1TWG E;  4LK0 E;  2KRX A;  4A3J F;  4BY7 E;  2R93 F;  3S1N F;  5D4D E;  2NVX F;  3HOU F;  2O5J E;  5M5Y F;  2NVQ E;  1TWC E;  3CQZ F;  1I3Q E;  4A3D E;  3H0G E;  4YFK E;  1K83 E;  5IYC E;  2B63 E;  2R7Z F;  2WAQ H;  4KN7 E;  4KN4 E;  4BXX F;  5IYB F;  3PO3 E;  4A3C F;  3HOY F;  4C3H F;  4A3M F;  5IP9 E;  3HOX F;  4MQ9 E;  4A3G F;  5C3E E;  2JA7 F;  1TWH F;  3RZD E;  3H3V G;  4A3K F;  4BBS F;  5C4X F;  4XLP E;  5M3M E;  3S16 E;  3M3Y E;  4Y52 F;  4BBR E;  1DZF A;  4YFX E;  2Y0S I;  5FLM E;  4A3E F;  4G7H E;  4A93 F;  3GTQ F;  1TWF F;  2PMZ K;  4LLG E;  5C4J E;  5IYD F;  2JA8 E;  5M5W E;  3RZO E;  2NVT E;  2YU9 F;  4Q5S E;  3PO2 F;  4G7O E;  4C3J E;  5IP7 F;  2NVY F;  3S15 F;  5E17 E;  5M5X F;  1TWA F;  2A69 E;  2JA6 E;  3M4O F;  4A3J E;  1I6V E;  3S2D E;  2R93 E;  3S1M F;  4YFN E;  1YNJ K;  4C3I E;  5M5Y E;  4G7Z E;  4LJZ E;  3CQZ E;  4Y7N E;  4OIN E;  4AYB H;  1WCM F;  4OIQ E;  2R7Z E;  4BY1 E;  3HKZ H;  4A3L F;  1ZYR E;  4A3C E;  3S17 F;  4XSZ E;  2WB1 I;  4C3H E;  3HOY E;  4A3M E;  3S2H F;  3HOX E;  3HOW F;  4A3G E;  3H3V F;  5FJ8 F;  1I6H F;  3S1Q F;  1YNN K;  3DXJ E;  4XSX E;  4A3K E;  4A3I E;  3GTG E;  3K7A F;  4BBS E;  4LK1 E;  2A6H E;  4Y52 E;  2A68 E;  2A6E E;  4A3E E;  1HQM E;  3FKI E;  4QIW H;  4MEX E;  3S14 F;  1QKL A;  5E18 E;  3GTQ E;  4MEY E;  5IYD E;  5M3F E;  2CW0 E;  2YU9 E;  5IP7 E;  1I50 F;  3GTP E;  3S15 E;  1TWA E;  1TWG F;  5C44 F;  3GTJ F;  3HOV F;  3M4O E;  3GTO E;  2E2I F;  3S1M E;  1IW7 E;  4A3F F;  2R92 F;  2NVQ F;  3S1N E;  1EIK A;  2NVX E;  3HOU E;  1I3Q F;  5D4E E;  1WCM E;  3HKZ K;  3WOD E;  2WAQ K;  2O5I E;  4BXX E;  2E2H F;  3S17 E;  5IYB E;  4JK1 E;  2E2J F;  3S2H E;  1R9T F;  4OIR E;  3I4M F;  3HOW E;  3HOZ F;  5FJ8 E;  1SFO F;  3S1Q E;  1I6H E;  2Y0S H;  4C2M F;  3K7A E;  1TWH E;  2JA5 F;  4QIW K; 
#chains in the Genus database with same CATH homology
 4A3B F;  3GTM F;  3S1R F;  5FLM F;  1Y1W F;  3GTL F;  5IPL E;  5D4C E;  4ZH4 E;  4X6A F;  4XLN E;  5BYH E;  3GTK F;  1Y1V F;  3I4N F;  2VUM F;  4BY7 F;  4C3I F;  4Y7N F;  1SMY E;  4AYB K;  4OIP E;  1TWC F;  4YG2 E;  4BY1 F;  3H0G F;  4A3D F;  1K83 F;  5IYC F;  2B63 F;  3PO3 F;  4KMU E;  4OIO E;  5IP9 F;  4A3I F;  3GTG F;  5C3E F;  3RZD F;  5TMC E;  2PPB E;  5M3M F;  3S16 F;  3FKI F;  4Q4Z E;  3M3Y F;  5TMF E;  3EQL E;  4BBR F;  2BE5 E;  5C4J F;  5M3F F;  2JA8 F;  5M5W F;  3RZO F;  3GTP F;  4GZY E;  2NVT F;  4C3J F;  3GTO F;  3S2D F;  2JA6 F;  2R93 F;  4LK0 E;  2KRX A;  4A3J F;  3S1N F;  5D4D E;  2NVX F;  3HOU F;  2O5J E;  5M5Y F;  3CQZ F;  4YFK E;  4BXX F;  2R7Z F;  4KN7 E;  4KN4 E;  5IYB F;  4A3C F;  3HOY F;  4C3H F;  4A3M F;  3HOX F;  4MQ9 E;  4A3G F;  2JA7 F;  3H3V G;  1TWH F;  4A3K F;  4BBS F;  5C4X F;  4XLP E;  4Y52 F;  4A3E F;  4YFX E;  2Y0S I;  4A93 F;  4G7H E;  3GTQ F;  1TWF F;  2PMZ K;  4LLG E;  5IYD F;  5E17 E;  2YU9 F;  4Q5S E;  3PO2 F;  4G7O E;  5IP7 F;  3S15 F;  2NVY F;  5M5X F;  1TWA F;  2A69 E;  3M4O F;  1I6V E;  3S1M F;  4YFN E;  1YNJ K;  4OIN E;  4G7Z E;  4LJZ E;  1WCM F;  4OIQ E;  4A3L F;  1ZYR E;  3S17 F;  4XSZ E;  2WB1 I;  3S2H F;  3HOW F;  5FJ8 F;  1I6H F;  3S1Q F;  1YNN K;  3DXJ E;  4XSX E;  3K7A F;  4LK1 E;  2A6H E;  2A68 E;  2A6E E;  1HQM E;  4MEX E;  3S14 F;  1QKL A;  5E18 E;  4MEY E;  2CW0 E;  1I50 F;  1TWG F;  5C44 F;  3GTJ F;  3HOV F;  2E2I F;  1IW7 E;  4A3F F;  2R92 F;  2NVQ F;  1I3Q F;  5D4E E;  3HKZ K;  3WOD E;  2WAQ K;  2O5I E;  2E2H F;  4JK1 E;  2E2J F;  1R9T F;  4OIR E;  3I4M F;  3HOZ F;  1SFO F;  4C2M F;  2JA5 F;  4QIW K; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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