2W8XA

Structure of the tick ion-channel modulator ra-klp
Total Genus 21
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
72
structure length
72
Chain Sequence
FNCNKREGPCSQRSLCECDPNLQLGRHSDQLWHYNLRTNRCERGGYRDNCNSHSSSGACVMACERIHHHHHH
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title An Ion-Channel Modulator from the Saliva of the Brown Ear Tick Has a Highly Modified Kunitz/Bpti Structure.
pubmed doi rcsb
molecule tags Membrane protein
source organism Rhipicephalus appendiculatus
molecule keywords ION-CHANNEL MODULATOR RAKLP
total genus 21
structure length 72
sequence length 72
chains with identical sequence B
ec nomenclature
pdb deposition date 2009-01-20
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2w8xA00
1MTND 1UUBA 1DTKA 1AAPA 2IJOI 4NTWB 3AUBA 1BHCA 4ISOB 3BTGI 1TPAI 2W8XA 1DEMA 3U1JE 1BF0A 1JV8A 1T8NB 1P2OB 3P95E 1T8OB 1T7CB 4Y0YI 1YLCB 1Y62A 1BIKA 2FTLI 3AUGA 2M01A 1LD6A 4NTYB 1OA55 2J6DA 3P92E 2KNTA 1K6UA 1BRCI 3CI7A 1TAPA 2ZVXA 3LDMA 1P2QB 2KAII 3BTEI 2UUYB 2FI4I 2UUXA 1KUNA 1UUAA 5JB5A 4BQDA 3FP7J 1T8MB 3WNYA 1D0DA 2FI3I 3BTDI 1LD5A 1T8LB 4Y11I 1TAWB 3AUCA 2TPII 1PITA 2M99A 5C67C 1P2NB 3M7QB 1SHPA 1YLDB 2ODYE 1FAKI 3BTTI 1ZR0B 1BZXI 1KTHA 2RA3C 1BRBI 1P2II 1OA65 1B0CA 1QLQA 1TOCR 2TGPI 2HEXA 4Y0ZI 3TGII 2LFLA 4WXVC 6PTIA 3L3TE 3BTFI 4U32X 4WWYC 1TCPA 2JOTA 1CO7I 3UOUB 2PTCI 1F5RI 1AALA 4U30W 4BD9B 1BZ5A 1FANA 1BTHP 3OTJI 1JC6A 3D65I 3LDIA 3AUIA 4TPII 5JB4A 2DDJA 3AUEA 1FY8I 1KIGI 1P2JI 1JV9A 1YKTB 4DTGK 3BTKI 1BPTA 3LDJA 4NTXB 3AUHA 5PTIA 1EAWB 3FP8I 3OFWA 1P2MB 3BTWI 3TGJI 3GYMI 4ISNB 9PTIA 2ZJXA 3BTQI 2FI5I 3T62D 1TFXC 2CA7A 5JB6A 1CA0D 1ADZA 8PTIA 1CBWD 3UIRC 4ISLB 5JB7A 4BNRI 1DENA 3BTMI 1KNTA 1DTXA 1BPIA 2KCRA 1P2KI 3AUDA 3BTHI 1IRHA 1BUNB 3TGKI 4PTIA 1EJMB 3BYBA 7PTIA 2R9PE 3TPII 4Y10I 3FP6I 1NAGA 1BTIA 1YC0I 2FTMB 3L33E 1F7ZI 2LFKA 2DDIA 1ZJDB 4DG4C 1D0DB 1G6XA
chains in the Genus database with same CATH superfamily
1MTND 1UUBA 1DTKA 1AAPA 2IJOI 4NTWB 3AUBA 1BHCA 4ISOB 3BTGI 1TPAI 2W8XA 1DEMA 3U1JE 1BF0A 1JV8A 1T8NB 1P2OB 3P95E 1T8OB 1T7CB 4Y0YI 1YLCB 1Y62A 1BIKA 2FTLI 3AUGA 2M01A 1LD6A 4NTYB 1OA55 2J6DA 3P92E 2KNTA 1K6UA 1BRCI 3CI7A 1TAPA 2ZVXA 3LDMA 1P2QB 2KAII 3BTEI 2UUYB 2FI4I 2UUXA 1KUNA 1UUAA 5JB5A 4BQDA 3FP7J 1T8MB 3WNYA 1D0DA 2FI3I 3BTDI 1LD5A 1T8LB 4Y11I 1TAWB 3AUCA 2TPII 1PITA 2M99A 5C67C 1P2NB 3M7QB 1SHPA 1YLDB 2ODYE 1FAKI 3BTTI 1ZR0B 1BZXI 1KTHA 2RA3C 1BRBI 1P2II 1OA65 1B0CA 1QLQA 1TOCR 2TGPI 2HEXA 4Y0ZI 3TGII 2LFLA 4WXVC 6PTIA 3L3TE 3BTFI 4U32X 4WWYC 1TCPA 2JOTA 1CO7I 3UOUB 2PTCI 1F5RI 1AALA 4U30W 4BD9B 1BZ5A 1FANA 1BTHP 3OTJI 1JC6A 3D65I 3LDIA 3AUIA 4TPII 5JB4A 2DDJA 3AUEA 1FY8I 1KIGI 1P2JI 1JV9A 1YKTB 4DTGK 3BTKI 1BPTA 3LDJA 4NTXB 3AUHA 5PTIA 1EAWB 3FP8I 3OFWA 1P2MB 3BTWI 3TGJI 3GYMI 4ISNB 9PTIA 2ZJXA 3BTQI 2FI5I 3T62D 1TFXC 2CA7A 5JB6A 1CA0D 1ADZA 8PTIA 1CBWD 3UIRC 4ISLB 5JB7A 4BNRI 1DENA 3BTMI 1KNTA 1DTXA 1BPIA 2KCRA 1P2KI 3AUDA 3BTHI 1IRHA 1BUNB 3TGKI 4PTIA 1EJMB 3BYBA 7PTIA 2R9PE 3TPII 4Y10I 3FP6I 1NAGA 1BTIA 1YC0I 2FTMB 3L33E 1F7ZI 2LFKA 2DDIA 1ZJDB 4DG4C 1D0DB 1G6XA
chains in the Genus database with same CATH topology
1MTND 1UUBA 1DTKA 1AAPA 2IJOI 4NTWB 3AUBA 1BHCA 4ISOB 3BTGI 1TPAI 2W8XA 1DEMA 3U1JE 1BF0A 1JV8A 1T8NB 1P2OB 3P95E 1T8OB 1T7CB 4Y0YI 1YLCB 1Y62A 1BIKA 2FTLI 3AUGA 2M01A 1LD6A 4NTYB 1OA55 2J6DA 3P92E 2KNTA 1K6UA 1BRCI 3CI7A 1TAPA 2ZVXA 3LDMA 1P2QB 2KAII 3BTEI 2UUYB 2FI4I 2UUXA 1KUNA 1UUAA 5JB5A 4BQDA 3FP7J 1T8MB 3WNYA 1D0DA 2FI3I 3BTDI 1LD5A 1T8LB 4Y11I 1TAWB 3AUCA 2TPII 1PITA 2M99A 5C67C 1P2NB 3M7QB 1SHPA 1YLDB 2ODYE 1FAKI 3BTTI 1ZR0B 1BZXI 1KTHA 2RA3C 1BRBI 1P2II 1OA65 1B0CA 1QLQA 1TOCR 2TGPI 2HEXA 4Y0ZI 3TGII 2LFLA 4WXVC 6PTIA 3L3TE 3BTFI 4U32X 4WWYC 1TCPA 2JOTA 1CO7I 3UOUB 2PTCI 1F5RI 1AALA 4U30W 4BD9B 1BZ5A 1FANA 1BTHP 3OTJI 1JC6A 3D65I 3LDIA 3AUIA 4TPII 5JB4A 2DDJA 3AUEA 1FY8I 1KIGI 1P2JI 1JV9A 1YKTB 4DTGK 3BTKI 1BPTA 3LDJA 4NTXB 3AUHA 5PTIA 1EAWB 3FP8I 3OFWA 1P2MB 3BTWI 3TGJI 3GYMI 4ISNB 9PTIA 2ZJXA 3BTQI 2FI5I 3T62D 1TFXC 2CA7A 5JB6A 1CA0D 1ADZA 8PTIA 1CBWD 3UIRC 4ISLB 5JB7A 4BNRI 1DENA 3BTMI 1KNTA 1DTXA 1BPIA 2KCRA 1P2KI 3AUDA 3BTHI 1IRHA 1BUNB 3TGKI 4PTIA 1EJMB 3BYBA 7PTIA 2R9PE 3TPII 4Y10I 3FP6I 1NAGA 1BTIA 1YC0I 2FTMB 3L33E 1F7ZI 2LFKA 2DDIA 1ZJDB 4DG4C 1D0DB 1G6XA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1MTN D;  1UUB A;  1DTK A;  1AAP A;  2IJO I;  4NTW B;  3AUB A;  1BHC A;  4ISO B;  3BTG I;  1TPA I;  2W8X A;  1DEM A;  3U1J E;  1BF0 A;  1JV8 A;  1T8N B;  1P2O B;  3P95 E;  1T8O B;  1T7C B;  4Y0Y I;  1YLC B;  1Y62 A;  1BIK A;  2FTL I;  3AUG A;  2M01 A;  1LD6 A;  4NTY B;  1OA5 5;  2J6D A;  3P92 E;  2KNT A;  1K6U A;  1BRC I;  3CI7 A;  1TAP A;  2ZVX A;  3LDM A;  1P2Q B;  2KAI I;  3BTE I;  2UUY B;  2FI4 I;  2UUX A;  1KUN A;  1UUA A;  5JB5 A;  4BQD A;  3FP7 J;  1T8M B;  3WNY A;  1D0D A;  2FI3 I;  3BTD I;  1LD5 A;  1T8L B;  4Y11 I;  1TAW B;  3AUC A;  2TPI I;  1PIT A;  2M99 A;  5C67 C;  1P2N B;  3M7Q B;  1SHP A;  1YLD B;  2ODY E;  1FAK I;  3BTT I;  1ZR0 B;  1BZX I;  1KTH A;  2RA3 C;  1BRB I;  1P2I I;  1OA6 5;  1B0C A;  1QLQ A;  1TOC R;  2TGP I;  2HEX A;  4Y0Z I;  3TGI I;  2LFL A;  4WXV C;  6PTI A;  3L3T E;  3BTF I;  4U32 X;  4WWY C;  1TCP A;  2JOT A;  1CO7 I;  3UOU B;  2PTC I;  1F5R I;  1AAL A;  4U30 W;  4BD9 B;  1BZ5 A;  1FAN A;  1BTH P;  3OTJ I;  1JC6 A;  3D65 I;  3LDI A;  3AUI A;  4TPI I;  5JB4 A;  2DDJ A;  3AUE A;  1FY8 I;  1KIG I;  1P2J I;  1JV9 A;  1YKT B;  4DTG K;  3BTK I;  1BPT A;  3LDJ A;  4NTX B;  3AUH A;  5PTI A;  1EAW B;  3FP8 I;  3OFW A;  1P2M B;  3BTW I;  3TGJ I;  3GYM I;  4ISN B;  9PTI A;  2ZJX A;  3BTQ I;  2FI5 I;  3T62 D;  1TFX C;  2CA7 A;  5JB6 A;  1CA0 D;  1ADZ A;  8PTI A;  1CBW D;  3UIR C;  4ISL B;  5JB7 A;  4BNR I;  1DEN A;  3BTM I;  1KNT A;  1DTX A;  1BPI A;  2KCR A;  1P2K I;  3AUD A;  3BTH I;  1IRH A;  1BUN B;  3TGK I;  4PTI A;  1EJM B;  3BYB A;  7PTI A;  2R9P E;  3TPI I;  4Y10 I;  3FP6 I;  1NAG A;  1BTI A;  1YC0 I;  2FTM B;  3L33 E;  1F7Z I;  2LFK A;  2DDI A;  1ZJD B;  4DG4 C;  1D0D B;  1G6X A; 
#chains in the Genus database with same CATH topology
 1MTN D;  1UUB A;  1DTK A;  1AAP A;  2IJO I;  4NTW B;  3AUB A;  1BHC A;  4ISO B;  3BTG I;  1TPA I;  2W8X A;  1DEM A;  3U1J E;  1BF0 A;  1JV8 A;  1T8N B;  1P2O B;  3P95 E;  1T8O B;  1T7C B;  4Y0Y I;  1YLC B;  1Y62 A;  1BIK A;  2FTL I;  3AUG A;  2M01 A;  1LD6 A;  4NTY B;  1OA5 5;  2J6D A;  3P92 E;  2KNT A;  1K6U A;  1BRC I;  3CI7 A;  1TAP A;  2ZVX A;  3LDM A;  1P2Q B;  2KAI I;  3BTE I;  2UUY B;  2FI4 I;  2UUX A;  1KUN A;  1UUA A;  5JB5 A;  4BQD A;  3FP7 J;  1T8M B;  3WNY A;  1D0D A;  2FI3 I;  3BTD I;  1LD5 A;  1T8L B;  4Y11 I;  1TAW B;  3AUC A;  2TPI I;  1PIT A;  2M99 A;  5C67 C;  1P2N B;  3M7Q B;  1SHP A;  1YLD B;  2ODY E;  1FAK I;  3BTT I;  1ZR0 B;  1BZX I;  1KTH A;  2RA3 C;  1BRB I;  1P2I I;  1OA6 5;  1B0C A;  1QLQ A;  1TOC R;  2TGP I;  2HEX A;  4Y0Z I;  3TGI I;  2LFL A;  4WXV C;  6PTI A;  3L3T E;  3BTF I;  4U32 X;  4WWY C;  1TCP A;  2JOT A;  1CO7 I;  3UOU B;  2PTC I;  1F5R I;  1AAL A;  4U30 W;  4BD9 B;  1BZ5 A;  1FAN A;  1BTH P;  3OTJ I;  1JC6 A;  3D65 I;  3LDI A;  3AUI A;  4TPI I;  5JB4 A;  2DDJ A;  3AUE A;  1FY8 I;  1KIG I;  1P2J I;  1JV9 A;  1YKT B;  4DTG K;  3BTK I;  1BPT A;  3LDJ A;  4NTX B;  3AUH A;  5PTI A;  1EAW B;  3FP8 I;  3OFW A;  1P2M B;  3BTW I;  3TGJ I;  3GYM I;  4ISN B;  9PTI A;  2ZJX A;  3BTQ I;  2FI5 I;  3T62 D;  1TFX C;  2CA7 A;  5JB6 A;  1CA0 D;  1ADZ A;  8PTI A;  1CBW D;  3UIR C;  4ISL B;  5JB7 A;  4BNR I;  1DEN A;  3BTM I;  1KNT A;  1DTX A;  1BPI A;  2KCR A;  1P2K I;  3AUD A;  3BTH I;  1IRH A;  1BUN B;  3TGK I;  4PTI A;  1EJM B;  3BYB A;  7PTI A;  2R9P E;  3TPI I;  4Y10 I;  3FP6 I;  1NAG A;  1BTI A;  1YC0 I;  2FTM B;  3L33 E;  1F7Z I;  2LFK A;  2DDI A;  1ZJD B;  4DG4 C;  1D0D B;  1G6X A; 
#chains in the Genus database with same CATH homology
 1MTN D;  1UUB A;  1DTK A;  1AAP A;  2IJO I;  4NTW B;  3AUB A;  1BHC A;  4ISO B;  3BTG I;  1TPA I;  2W8X A;  1DEM A;  3U1J E;  1BF0 A;  1JV8 A;  1T8N B;  1P2O B;  3P95 E;  1T8O B;  1T7C B;  4Y0Y I;  1YLC B;  1Y62 A;  1BIK A;  2FTL I;  3AUG A;  2M01 A;  1LD6 A;  4NTY B;  1OA5 5;  2J6D A;  3P92 E;  2KNT A;  1K6U A;  1BRC I;  3CI7 A;  1TAP A;  2ZVX A;  3LDM A;  1P2Q B;  2KAI I;  3BTE I;  2UUY B;  2FI4 I;  2UUX A;  1KUN A;  1UUA A;  5JB5 A;  4BQD A;  3FP7 J;  1T8M B;  3WNY A;  1D0D A;  2FI3 I;  3BTD I;  1LD5 A;  1T8L B;  4Y11 I;  1TAW B;  3AUC A;  2TPI I;  1PIT A;  2M99 A;  5C67 C;  1P2N B;  3M7Q B;  1SHP A;  1YLD B;  2ODY E;  1FAK I;  3BTT I;  1ZR0 B;  1BZX I;  1KTH A;  2RA3 C;  1BRB I;  1P2I I;  1OA6 5;  1B0C A;  1QLQ A;  1TOC R;  2TGP I;  2HEX A;  4Y0Z I;  3TGI I;  2LFL A;  4WXV C;  6PTI A;  3L3T E;  3BTF I;  4U32 X;  4WWY C;  1TCP A;  2JOT A;  1CO7 I;  3UOU B;  2PTC I;  1F5R I;  1AAL A;  4U30 W;  4BD9 B;  1BZ5 A;  1FAN A;  1BTH P;  3OTJ I;  1JC6 A;  3D65 I;  3LDI A;  3AUI A;  4TPI I;  5JB4 A;  2DDJ A;  3AUE A;  1FY8 I;  1KIG I;  1P2J I;  1JV9 A;  1YKT B;  4DTG K;  3BTK I;  1BPT A;  3LDJ A;  4NTX B;  3AUH A;  5PTI A;  1EAW B;  3FP8 I;  3OFW A;  1P2M B;  3BTW I;  3TGJ I;  3GYM I;  4ISN B;  9PTI A;  2ZJX A;  3BTQ I;  2FI5 I;  3T62 D;  1TFX C;  2CA7 A;  5JB6 A;  1CA0 D;  1ADZ A;  8PTI A;  1CBW D;  3UIR C;  4ISL B;  5JB7 A;  4BNR I;  1DEN A;  3BTM I;  1KNT A;  1DTX A;  1BPI A;  2KCR A;  1P2K I;  3AUD A;  3BTH I;  1IRH A;  1BUN B;  3TGK I;  4PTI A;  1EJM B;  3BYB A;  7PTI A;  2R9P E;  3TPI I;  4Y10 I;  3FP6 I;  1NAG A;  1BTI A;  1YC0 I;  2FTM B;  3L33 E;  1F7Z I;  2LFK A;  2DDI A;  1ZJD B;  4DG4 C;  1D0D B;  1G6X A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...