2ZVXA

Structure of a bpti-[5,55] variant containing gly/val at the 14/38th positions
Total Genus 8
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
8
sequence length
58
structure length
58
Chain Sequence
RPDFCLEPPYTGPGKARIIRYFYNAKAGLAQTFVYGGVRAKRNNFKSAEDALRTCGGA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Thermodynamic and structural analysis of highly stabilized BPTIs by single and double mutations
pubmed doi rcsb
molecule tags Hydrolase inhibitor
source organism Bos taurus
molecule keywords Pancreatic trypsin inhibitor
total genus 8
structure length 58
sequence length 58
chains with identical sequence B
ec nomenclature
pdb deposition date 2008-11-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00014 Kunitz_BPTI Kunitz/Bovine pancreatic trypsin inhibitor domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.410.10 Few Secondary Structures Irregular Factor Xa Inhibitor Pancreatic trypsin inhibitor Kunitz domain 2zvxA00
3LDIA 3TGII 1AAPA 4BD9B 3BTEI 3T62D 2TPII 5JB4A 1BTHP 9PTIA 1SHPA 1EAWB 1BHCA 3M7QB 1AALA 1P2KI 2M99A 3TPII 4BQDA 1KNTA 3AUCA 1T8LB 5JB7A 3WNYA 3TGJI 3AUGA 2UUYB 1LD6A 1P2OB 1BPTA 1MTND 7PTIA 4Y10I 2JOTA 4U32X 3BTHI 1TPAI 2FI4I 3AUIA 1JC6A 1BZ5A 1ZR0B 1OA55 4DG4C 3UIRC 1YC0I 2ZVXA 1CBWD 2ODYE 2HEXA 3L3TE 1QLQA 5JB5A 4NTXB 3BTQI 4WXVC 1K6UA 3AUBA 2LFLA 1BIKA 3BTDI 1CA0D 1BPIA 3TGKI 3BTFI 1YLCB 1DTXA 1T8MB 3BTMI 1D0DB 4WWYC 4TPII 2M01A 1EJMB 1CO7I 2KNTA 1F7ZI 1T8NB 1TAPA 3BTWI 1YKTB 1DTKA 1KUNA 3GYMI 3BTKI 2FI5I 2KCRA 3AUDA 1JV8A 4DTGK 1T8OB 4U30W 2LFKA 1FANA 2UUXA 3AUHA 1FAKI 1KIGI 1LD5A 2ZJXA 4BNRI 4Y0ZI 1P2JI 3U1JE 1G6XA 2W8XA 2J6DA 3BTGI 1NAGA 1Y62A 4Y0YI 3P92E 3OFWA 4Y11I 3P95E 1KTHA 1UUAA 5PTIA 5JB6A 1B0CA 1UUBA 2DDJA 3FP8I 4NTYB 3BYBA 2FTLI 1T7CB 4NTWB 2DDIA 1BZXI 1OA65 2TGPI 2PTCI 3UOUB 2FI3I 4PTIA 1DENA 1P2QB 4ISNB 3AUEA 3FP6I 2R9PE 1D0DA 1BRBI 6PTIA 3CI7A 1F5RI 1P2NB 1ADZA 8PTIA 1PITA 1YLDB 1DEMA 1P2MB 1P2II 1TCPA 2CA7A 1BRCI 1JV9A 1IRHA 1ZJDB 1TOCR 2KAII 3OTJI 1TAWB 4ISOB 2RA3C 5C67C 1BTIA 1FY8I 3L33E 4ISLB 1BUNB 3LDJA 3FP7J 1TFXC 3D65I 3BTTI 3LDMA 1BF0A 2IJOI 2FTMB
chains in the Genus database with same CATH superfamily
3LDIA 3TGII 1AAPA 4BD9B 3BTEI 3T62D 2TPII 5JB4A 1BTHP 9PTIA 1SHPA 1EAWB 1BHCA 3M7QB 1AALA 1P2KI 2M99A 3TPII 4BQDA 1KNTA 3AUCA 1T8LB 5JB7A 3WNYA 3TGJI 3AUGA 2UUYB 1LD6A 1P2OB 1BPTA 1MTND 7PTIA 4Y10I 2JOTA 4U32X 3BTHI 1TPAI 2FI4I 3AUIA 1JC6A 1BZ5A 1ZR0B 1OA55 4DG4C 3UIRC 1YC0I 2ZVXA 1CBWD 2ODYE 2HEXA 3L3TE 1QLQA 5JB5A 4NTXB 3BTQI 4WXVC 1K6UA 3AUBA 2LFLA 1BIKA 3BTDI 1CA0D 1BPIA 3TGKI 3BTFI 1YLCB 1DTXA 1T8MB 3BTMI 1D0DB 4WWYC 4TPII 2M01A 1EJMB 1CO7I 2KNTA 1F7ZI 1T8NB 1TAPA 3BTWI 1YKTB 1DTKA 1KUNA 3GYMI 3BTKI 2FI5I 2KCRA 3AUDA 1JV8A 4DTGK 1T8OB 4U30W 2LFKA 1FANA 2UUXA 3AUHA 1FAKI 1KIGI 1LD5A 2ZJXA 4BNRI 4Y0ZI 1P2JI 3U1JE 1G6XA 2W8XA 2J6DA 3BTGI 1NAGA 1Y62A 4Y0YI 3P92E 3OFWA 4Y11I 3P95E 1KTHA 1UUAA 5PTIA 5JB6A 1B0CA 1UUBA 2DDJA 3FP8I 4NTYB 3BYBA 2FTLI 1T7CB 4NTWB 2DDIA 1BZXI 1OA65 2TGPI 2PTCI 3UOUB 2FI3I 4PTIA 1DENA 1P2QB 4ISNB 3AUEA 3FP6I 2R9PE 1D0DA 1BRBI 6PTIA 3CI7A 1F5RI 1P2NB 1ADZA 8PTIA 1PITA 1YLDB 1DEMA 1P2MB 1P2II 1TCPA 2CA7A 1BRCI 1JV9A 1IRHA 1ZJDB 1TOCR 2KAII 3OTJI 1TAWB 4ISOB 2RA3C 5C67C 1BTIA 1FY8I 3L33E 4ISLB 1BUNB 3LDJA 3FP7J 1TFXC 3D65I 3BTTI 3LDMA 1BF0A 2IJOI 2FTMB
chains in the Genus database with same CATH topology
3LDIA 3TGII 1AAPA 4BD9B 3BTEI 3T62D 2TPII 5JB4A 1BTHP 9PTIA 1SHPA 1EAWB 1BHCA 3M7QB 1AALA 1P2KI 2M99A 3TPII 4BQDA 1KNTA 3AUCA 1T8LB 5JB7A 3WNYA 3TGJI 3AUGA 2UUYB 1LD6A 1P2OB 1BPTA 1MTND 7PTIA 4Y10I 2JOTA 4U32X 3BTHI 1TPAI 2FI4I 3AUIA 1JC6A 1BZ5A 1ZR0B 1OA55 4DG4C 3UIRC 1YC0I 2ZVXA 1CBWD 2ODYE 2HEXA 3L3TE 1QLQA 5JB5A 4NTXB 3BTQI 4WXVC 1K6UA 3AUBA 2LFLA 1BIKA 3BTDI 1CA0D 1BPIA 3TGKI 3BTFI 1YLCB 1DTXA 1T8MB 3BTMI 1D0DB 4WWYC 4TPII 2M01A 1EJMB 1CO7I 2KNTA 1F7ZI 1T8NB 1TAPA 3BTWI 1YKTB 1DTKA 1KUNA 3GYMI 3BTKI 2FI5I 2KCRA 3AUDA 1JV8A 4DTGK 1T8OB 4U30W 2LFKA 1FANA 2UUXA 3AUHA 1FAKI 1KIGI 1LD5A 2ZJXA 4BNRI 4Y0ZI 1P2JI 3U1JE 1G6XA 2W8XA 2J6DA 3BTGI 1NAGA 1Y62A 4Y0YI 3P92E 3OFWA 4Y11I 3P95E 1KTHA 1UUAA 5PTIA 5JB6A 1B0CA 1UUBA 2DDJA 3FP8I 4NTYB 3BYBA 2FTLI 1T7CB 4NTWB 2DDIA 1BZXI 1OA65 2TGPI 2PTCI 3UOUB 2FI3I 4PTIA 1DENA 1P2QB 4ISNB 3AUEA 3FP6I 2R9PE 1D0DA 1BRBI 6PTIA 3CI7A 1F5RI 1P2NB 1ADZA 8PTIA 1PITA 1YLDB 1DEMA 1P2MB 1P2II 1TCPA 2CA7A 1BRCI 1JV9A 1IRHA 1ZJDB 1TOCR 2KAII 3OTJI 1TAWB 4ISOB 2RA3C 5C67C 1BTIA 1FY8I 3L33E 4ISLB 1BUNB 3LDJA 3FP7J 1TFXC 3D65I 3BTTI 3LDMA 1BF0A 2IJOI 2FTMB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LDI A;  3TGI I;  1AAP A;  4BD9 B;  3BTE I;  3T62 D;  2TPI I;  5JB4 A;  1BTH P;  9PTI A;  1SHP A;  1EAW B;  1BHC A;  3M7Q B;  1AAL A;  1P2K I;  2M99 A;  3TPI I;  4BQD A;  1KNT A;  3AUC A;  1T8L B;  5JB7 A;  3WNY A;  3TGJ I;  3AUG A;  2UUY B;  1LD6 A;  1P2O B;  1BPT A;  1MTN D;  7PTI A;  4Y10 I;  2JOT A;  4U32 X;  3BTH I;  1TPA I;  2FI4 I;  3AUI A;  1JC6 A;  1BZ5 A;  1ZR0 B;  1OA5 5;  4DG4 C;  3UIR C;  1YC0 I;  2ZVX A;  1CBW D;  2ODY E;  2HEX A;  3L3T E;  1QLQ A;  5JB5 A;  4NTX B;  3BTQ I;  4WXV C;  1K6U A;  3AUB A;  2LFL A;  1BIK A;  3BTD I;  1CA0 D;  1BPI A;  3TGK I;  3BTF I;  1YLC B;  1DTX A;  1T8M B;  3BTM I;  1D0D B;  4WWY C;  4TPI I;  2M01 A;  1EJM B;  1CO7 I;  2KNT A;  1F7Z I;  1T8N B;  1TAP A;  3BTW I;  1YKT B;  1DTK A;  1KUN A;  3GYM I;  3BTK I;  2FI5 I;  2KCR A;  3AUD A;  1JV8 A;  4DTG K;  1T8O B;  4U30 W;  2LFK A;  1FAN A;  2UUX A;  3AUH A;  1FAK I;  1KIG I;  1LD5 A;  2ZJX A;  4BNR I;  4Y0Z I;  1P2J I;  3U1J E;  1G6X A;  2W8X A;  2J6D A;  3BTG I;  1NAG A;  1Y62 A;  4Y0Y I;  3P92 E;  3OFW A;  4Y11 I;  3P95 E;  1KTH A;  1UUA A;  5PTI A;  5JB6 A;  1B0C A;  1UUB A;  2DDJ A;  3FP8 I;  4NTY B;  3BYB A;  2FTL I;  1T7C B;  4NTW B;  2DDI A;  1BZX I;  1OA6 5;  2TGP I;  2PTC I;  3UOU B;  2FI3 I;  4PTI A;  1DEN A;  1P2Q B;  4ISN B;  3AUE A;  3FP6 I;  2R9P E;  1D0D A;  1BRB I;  6PTI A;  3CI7 A;  1F5R I;  1P2N B;  1ADZ A;  8PTI A;  1PIT A;  1YLD B;  1DEM A;  1P2M B;  1P2I I;  1TCP A;  2CA7 A;  1BRC I;  1JV9 A;  1IRH A;  1ZJD B;  1TOC R;  2KAI I;  3OTJ I;  1TAW B;  4ISO B;  2RA3 C;  5C67 C;  1BTI A;  1FY8 I;  3L33 E;  4ISL B;  1BUN B;  3LDJ A;  3FP7 J;  1TFX C;  3D65 I;  3BTT I;  3LDM A;  1BF0 A;  2IJO I;  2FTM B; 
#chains in the Genus database with same CATH topology
 3LDI A;  3TGI I;  1AAP A;  4BD9 B;  3BTE I;  3T62 D;  2TPI I;  5JB4 A;  1BTH P;  9PTI A;  1SHP A;  1EAW B;  1BHC A;  3M7Q B;  1AAL A;  1P2K I;  2M99 A;  3TPI I;  4BQD A;  1KNT A;  3AUC A;  1T8L B;  5JB7 A;  3WNY A;  3TGJ I;  3AUG A;  2UUY B;  1LD6 A;  1P2O B;  1BPT A;  1MTN D;  7PTI A;  4Y10 I;  2JOT A;  4U32 X;  3BTH I;  1TPA I;  2FI4 I;  3AUI A;  1JC6 A;  1BZ5 A;  1ZR0 B;  1OA5 5;  4DG4 C;  3UIR C;  1YC0 I;  2ZVX A;  1CBW D;  2ODY E;  2HEX A;  3L3T E;  1QLQ A;  5JB5 A;  4NTX B;  3BTQ I;  4WXV C;  1K6U A;  3AUB A;  2LFL A;  1BIK A;  3BTD I;  1CA0 D;  1BPI A;  3TGK I;  3BTF I;  1YLC B;  1DTX A;  1T8M B;  3BTM I;  1D0D B;  4WWY C;  4TPI I;  2M01 A;  1EJM B;  1CO7 I;  2KNT A;  1F7Z I;  1T8N B;  1TAP A;  3BTW I;  1YKT B;  1DTK A;  1KUN A;  3GYM I;  3BTK I;  2FI5 I;  2KCR A;  3AUD A;  1JV8 A;  4DTG K;  1T8O B;  4U30 W;  2LFK A;  1FAN A;  2UUX A;  3AUH A;  1FAK I;  1KIG I;  1LD5 A;  2ZJX A;  4BNR I;  4Y0Z I;  1P2J I;  3U1J E;  1G6X A;  2W8X A;  2J6D A;  3BTG I;  1NAG A;  1Y62 A;  4Y0Y I;  3P92 E;  3OFW A;  4Y11 I;  3P95 E;  1KTH A;  1UUA A;  5PTI A;  5JB6 A;  1B0C A;  1UUB A;  2DDJ A;  3FP8 I;  4NTY B;  3BYB A;  2FTL I;  1T7C B;  4NTW B;  2DDI A;  1BZX I;  1OA6 5;  2TGP I;  2PTC I;  3UOU B;  2FI3 I;  4PTI A;  1DEN A;  1P2Q B;  4ISN B;  3AUE A;  3FP6 I;  2R9P E;  1D0D A;  1BRB I;  6PTI A;  3CI7 A;  1F5R I;  1P2N B;  1ADZ A;  8PTI A;  1PIT A;  1YLD B;  1DEM A;  1P2M B;  1P2I I;  1TCP A;  2CA7 A;  1BRC I;  1JV9 A;  1IRH A;  1ZJD B;  1TOC R;  2KAI I;  3OTJ I;  1TAW B;  4ISO B;  2RA3 C;  5C67 C;  1BTI A;  1FY8 I;  3L33 E;  4ISL B;  1BUN B;  3LDJ A;  3FP7 J;  1TFX C;  3D65 I;  3BTT I;  3LDM A;  1BF0 A;  2IJO I;  2FTM B; 
#chains in the Genus database with same CATH homology
 3LDI A;  3TGI I;  1AAP A;  4BD9 B;  3BTE I;  3T62 D;  2TPI I;  5JB4 A;  1BTH P;  9PTI A;  1SHP A;  1EAW B;  1BHC A;  3M7Q B;  1AAL A;  1P2K I;  2M99 A;  3TPI I;  4BQD A;  1KNT A;  3AUC A;  1T8L B;  5JB7 A;  3WNY A;  3TGJ I;  3AUG A;  2UUY B;  1LD6 A;  1P2O B;  1BPT A;  1MTN D;  7PTI A;  4Y10 I;  2JOT A;  4U32 X;  3BTH I;  1TPA I;  2FI4 I;  3AUI A;  1JC6 A;  1BZ5 A;  1ZR0 B;  1OA5 5;  4DG4 C;  3UIR C;  1YC0 I;  2ZVX A;  1CBW D;  2ODY E;  2HEX A;  3L3T E;  1QLQ A;  5JB5 A;  4NTX B;  3BTQ I;  4WXV C;  1K6U A;  3AUB A;  2LFL A;  1BIK A;  3BTD I;  1CA0 D;  1BPI A;  3TGK I;  3BTF I;  1YLC B;  1DTX A;  1T8M B;  3BTM I;  1D0D B;  4WWY C;  4TPI I;  2M01 A;  1EJM B;  1CO7 I;  2KNT A;  1F7Z I;  1T8N B;  1TAP A;  3BTW I;  1YKT B;  1DTK A;  1KUN A;  3GYM I;  3BTK I;  2FI5 I;  2KCR A;  3AUD A;  1JV8 A;  4DTG K;  1T8O B;  4U30 W;  2LFK A;  1FAN A;  2UUX A;  3AUH A;  1FAK I;  1KIG I;  1LD5 A;  2ZJX A;  4BNR I;  4Y0Z I;  1P2J I;  3U1J E;  1G6X A;  2W8X A;  2J6D A;  3BTG I;  1NAG A;  1Y62 A;  4Y0Y I;  3P92 E;  3OFW A;  4Y11 I;  3P95 E;  1KTH A;  1UUA A;  5PTI A;  5JB6 A;  1B0C A;  1UUB A;  2DDJ A;  3FP8 I;  4NTY B;  3BYB A;  2FTL I;  1T7C B;  4NTW B;  2DDI A;  1BZX I;  1OA6 5;  2TGP I;  2PTC I;  3UOU B;  2FI3 I;  4PTI A;  1DEN A;  1P2Q B;  4ISN B;  3AUE A;  3FP6 I;  2R9P E;  1D0D A;  1BRB I;  6PTI A;  3CI7 A;  1F5R I;  1P2N B;  1ADZ A;  8PTI A;  1PIT A;  1YLD B;  1DEM A;  1P2M B;  1P2I I;  1TCP A;  2CA7 A;  1BRC I;  1JV9 A;  1IRH A;  1ZJD B;  1TOC R;  2KAI I;  3OTJ I;  1TAW B;  4ISO B;  2RA3 C;  5C67 C;  1BTI A;  1FY8 I;  3L33 E;  4ISL B;  1BUN B;  3LDJ A;  3FP7 J;  1TFX C;  3D65 I;  3BTT I;  3LDM A;  1BF0 A;  2IJO I;  2FTM B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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