3CQZE

Crystal structure of 10 subunit rna polymerase ii in complex with the inhibitor alpha-amanitin
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
sequence length
213
structure length
213
Chain Sequence
QENERNISRLWRAFRTVKEMVKDRGYFITQEEVELPLEDFKAKYCDSMGRPQRKMMSFQANPTEESISKFPDMGSLWVEFCDEPSVGVKTMKTFVIHIQEKNFQTGIFVYQNNITPSAMKLVPSIPPATIETFNEAALVVNITHHELVPKHIRLSSDEKRELLKRYRLKESQLPRIQRADPVALYLGLKRGEVVKIIRKSETSGRYASYRICM
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The RNA Polymerase II Trigger Loop Functions in Substrate Selection and is Directly Targeted by Alpha-Amanitin.
pubmed doi rcsb
molecule tags Transcription/toxin
molecule keywords DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1
total genus 59
structure length 213
sequence length 213
ec nomenclature
pdb deposition date 2008-04-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01191 RNA_pol_Rpb5_C RNA polymerase Rpb5, C-terminal domain
E PF03871 RNA_pol_Rpb5_N RNA polymerase Rpb5, N-terminal domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.1340.10 Alpha Beta 3-Layer(aba) Sandwich Dna-directed Rna Polymerases I, Ii, And Iii 27 Kd Polypeptide; Chain: A; domain 1 RNA polymerase, Rpb5, N-terminal domain 3cqzE01
3.90.940.20 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit RPB5-like RNA polymerase subunit 3cqzE02
4C2ME 2NVQE 3H3VF 5M5WE 3GTOE 5IYCE 3CQZE 3GTLE 3PO3E 2E2JE 4QIWH 5M3FE 2JA6E 4BY1E 3S14E 1EIKA 3GTQE 5IP7E 2Y0SH 4A3GE 2YU9E 3PO2E 4A3FE 1R9TE 2WB1H 5IP9E 5IYBE 4BXXE 2JA5E 2WAQH 2NVTE 3FKIE 3S1ME 3S1RE 4Y52E 3S2DE 1Y1WE 3I4NE 3HOUE 3HKZH 3S1QE 3RZDE 1SFOE 4A3CE 2VUME 1WCME 1I6HE 3GTME 4Y7NE 3HOVE 1I3QE 5C44E 2PMZH 5FLME 3S2HE 1Y1VE 4A3KE 2NVYE 3S15E 1TWFE 4BY7E 3GTPE 3S17E 3GTJE 1TWCE 5M3ME 4AYBH 4A3LE 4BBRE 2R92E 4A3IE 3HOYE 3I4ME 4A3BE 4A93E 3HOXE 1TWAE 3S16E 1TWGE 5M5XE 5IYDE 2JA7E 1DZFA 4A3ME 4C3JE 3GTKE 5C4JE 2JA8E 4A3JE 2NVXE 4C3HE 5C3EE 3HOWE 1TWHE 4X6AE 5FJ8E 4BBSE 2R7ZE 5C4XE 4C3IE 3K7AE 3RZOE 3GTGE 2E2HE 1K83E 4A3EE 3S1NE 5M5YE 4A3DE 3HOZE 2E2IE 2B63E 1I50E 3H0GE 2R93E 3M4OE 3M3YE
chains in the Genus database with same CATH superfamily
4C2ME 4BBRF 2R92F 2NVQE 3H3VF 4YG2E 4A3IF 4A3EF 5M5YF 3I4MF 5M5WE 3GTOE 3HOXF 4A3BF 2E2IF 4A93F 5IYCE 3CQZE 3H0GF 1TWAF 2Y0SI 3EQLE 3GTLE 3PO3E 2WAQK 2E2JE 4OIQE 3S16F 4QIWH 4AYBK 2R93F 2O5JE 5M3FE 1TWGF 2JA6E 4BY1E 5M5XF 3S14E 1EIKA 3GTQE 2JA7F 5IP7E 2Y0SH 5D4EE 1ZYRE 4Q4ZE 5TMFE 4A3GE 4A3MF 2YU9E 4C3JF 4LJZE 4YFKE 3GTKF 3PO2E 5C4JF 2JA8F 4A3JF 4OIOE 3HKZK 2NVXF 2WB1I 3DXJE 5TMCE 4C3HF 4OIRE 5C3EF 4A3FE 2JA6F 1TWHF 3HOWF 3WODE 4X6AF 1R9TE 4BBSF 4A3GF 2WB1H 2R7ZF 4C3IF 3K7AF 3RZOF 5IP9E 2PMZK 2E2HF 5IYBE 2CW0E 1K83F 4BXXE 2A6EE 3S1NF 2JA5E 5E18E 4A3DF 1YNNK 3HOZF 2B63F 1I50F 2WAQH 2NVTE 4YFNE 2O5IE 3FKIE 3S1ME 3M4OF 3M3YF 3S1RE 4Y52E 4C2MF 3S2DE 5IPLE 2NVQF 1Y1WE 5M5WF 3GTOF 3I4NE 3HOUE 5IYCF 2A68E 3CQZF 3HKZH 4XLPE 3S1QE 3GTLF 3PO3F 3RZDE 2E2JF 3FKIF 3S1MF 5M3FF 1SFOE 4BY1F 4A3CE 3S14F 3GTQF 2VUME 1WCME 1I6HE 5IP7F 3GTME 4G7HE 4XSZE 1Y1WF 4Y7NE 4GZYE 3H3VG 3HOVE 2YU9F 1I3QE 5C44E 2PMZH 3PO2F 3S1QF 5FLME 3S2HE 1Y1VE 4A3KE 2NVYE 3S15E 2PPBE 3HOYF 4LLGE 4G7ZE 1TWFE 4BY7E 1SMYE 4A3FF 3GTPE 3S17E 4KMUE 4QIWK 1I6HF 3GTJE 1R9TF 4XLNE 4Y7NF 5D4DE 1TWCE 5M3ME 3HOVF 1I3QF 2A6HE 5IP9F 4AYBH 4A3LE 5IYBF 2NVYF 4Q5SE 3S15F 5D4CE 4BXXF 4BBRE 4XSXE 2JA5F 3GTPF 5E17E 2R92E 4A3IE 3HOYE 3I4ME 4A3BE 2BE5E 4A93E 3HOXE 4ZH4E 2NVTF 1TWAE 4MEXE 3S1RF 3S16E 4Y52F 3GTGF 3S2DF 1TWGE 5M5XE 4MQ9E 4YFXE 5IYDE 2JA7E 5BYHE 2KRXA 3I4NF 3HOUF 1DZFA 4OIPE 1QKLA 4KN7E 4A3ME 4C3JE 3RZDF 1IW7E 3GTKE 5C4JE 2JA8E 4LK1E 4A3JE 2NVXE 2A69E 4LK0E 4C3HE 1SFOF 4OINE 4A3CF 5C3EE 3HOWE 1WCMF 1TWHE 2VUMF 3GTMF 5IYDF 4X6AE 5FJ8E 4BBSE 2R7ZE 5C44F 5C4XE 4C3IE 3K7AE 3RZOE 5FLMF 4JK1E 3S2HF 1Y1VF 4A3KF 3GTGE 2E2HE 1TWFF 4BY7F 1K83E 4A3EE 3S17F 4G7OE 3S1NE 1I6VE 5M5YE 4A3DE 1YNJK 3GTJF 3HOZE 2E2IE 2B63E 4MEYE 1I50E 1TWCF 5M3MF 5FJ8F 3H0GE 5C4XF 4A3LF 4KN4E 2R93E 3M4OE 3M3YE 1HQME
chains in the Genus database with same CATH topology
4C2ME 2NVQE 3H3VF 5M5WE 3GTOE 5IYCE 3CQZE 3GTLE 3PO3E 2E2JE 4QIWH 5M3FE 2JA6E 4BY1E 3S14E 1EIKA 3GTQE 5IP7E 2Y0SH 4A3GE 2YU9E 3PO2E 4A3FE 1R9TE 2WB1H 5IP9E 5IYBE 4BXXE 2JA5E 2WAQH 2NVTE 3FKIE 3S1ME 3S1RE 4Y52E 3S2DE 1Y1WE 3I4NE 3HOUE 3HKZH 3S1QE 3RZDE 1SFOE 4A3CE 2VUME 1WCME 1I6HE 3GTME 4Y7NE 3HOVE 1I3QE 5C44E 2PMZH 5FLME 3S2HE 1Y1VE 4A3KE 2NVYE 3S15E 1TWFE 4BY7E 3GTPE 3S17E 3GTJE 1TWCE 5M3ME 4AYBH 4A3LE 4BBRE 2R92E 4A3IE 3HOYE 3I4ME 4A3BE 4A93E 3HOXE 1TWAE 3S16E 1TWGE 5M5XE 5IYDE 2JA7E 1DZFA 4A3ME 4C3JE 3GTKE 5C4JE 2JA8E 4A3JE 2NVXE 4C3HE 5C3EE 3HOWE 1TWHE 4X6AE 5FJ8E 4BBSE 2R7ZE 5C4XE 4C3IE 3K7AE 3RZOE 3GTGE 2E2HE 1K83E 4A3EE 3S1NE 5M5YE 4A3DE 3HOZE 2E2IE 2B63E 1I50E 3H0GE 2R93E 3M4OE 3M3YE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4C2M E;  2NVQ E;  3H3V F;  5M5W E;  3GTO E;  5IYC E;  3CQZ E;  3GTL E;  3PO3 E;  2E2J E;  4QIW H;  5M3F E;  2JA6 E;  4BY1 E;  3S14 E;  1EIK A;  3GTQ E;  5IP7 E;  2Y0S H;  4A3G E;  2YU9 E;  3PO2 E;  4A3F E;  1R9T E;  2WB1 H;  5IP9 E;  5IYB E;  4BXX E;  2JA5 E;  2WAQ H;  2NVT E;  3FKI E;  3S1M E;  3S1R E;  4Y52 E;  3S2D E;  1Y1W E;  3I4N E;  3HOU E;  3HKZ H;  3S1Q E;  3RZD E;  1SFO E;  4A3C E;  2VUM E;  1WCM E;  1I6H E;  3GTM E;  4Y7N E;  3HOV E;  1I3Q E;  5C44 E;  2PMZ H;  5FLM E;  3S2H E;  1Y1V E;  4A3K E;  2NVY E;  3S15 E;  1TWF E;  4BY7 E;  3GTP E;  3S17 E;  3GTJ E;  1TWC E;  5M3M E;  4AYB H;  4A3L E;  4BBR E;  2R92 E;  4A3I E;  3HOY E;  3I4M E;  4A3B E;  4A93 E;  3HOX E;  1TWA E;  3S16 E;  1TWG E;  5M5X E;  5IYD E;  2JA7 E;  1DZF A;  4A3M E;  4C3J E;  3GTK E;  5C4J E;  2JA8 E;  4A3J E;  2NVX E;  4C3H E;  5C3E E;  3HOW E;  1TWH E;  4X6A E;  5FJ8 E;  4BBS E;  2R7Z E;  5C4X E;  4C3I E;  3K7A E;  3RZO E;  3GTG E;  2E2H E;  1K83 E;  4A3E E;  3S1N E;  5M5Y E;  4A3D E;  3HOZ E;  2E2I E;  2B63 E;  1I50 E;  3H0G E;  2R93 E;  3M4O E;  3M3Y E; 
#chains in the Genus database with same CATH topology
 4C2M E;  4BBR F;  2R92 F;  2NVQ E;  3H3V F;  4YG2 E;  4A3I F;  4A3E F;  5M5Y F;  3I4M F;  5M5W E;  3GTO E;  3HOX F;  4A3B F;  2E2I F;  4A93 F;  5IYC E;  3CQZ E;  3H0G F;  1TWA F;  2Y0S I;  3EQL E;  3GTL E;  3PO3 E;  2WAQ K;  2E2J E;  4OIQ E;  3S16 F;  4QIW H;  4AYB K;  2R93 F;  2O5J E;  5M3F E;  1TWG F;  2JA6 E;  4BY1 E;  5M5X F;  3S14 E;  1EIK A;  3GTQ E;  2JA7 F;  5IP7 E;  2Y0S H;  5D4E E;  1ZYR E;  4Q4Z E;  5TMF E;  4A3G E;  4A3M F;  2YU9 E;  4C3J F;  4LJZ E;  4YFK E;  3GTK F;  3PO2 E;  5C4J F;  2JA8 F;  4A3J F;  4OIO E;  3HKZ K;  2NVX F;  2WB1 I;  3DXJ E;  5TMC E;  4C3H F;  4OIR E;  5C3E F;  4A3F E;  2JA6 F;  1TWH F;  3HOW F;  3WOD E;  4X6A F;  1R9T E;  4BBS F;  4A3G F;  2WB1 H;  2R7Z F;  4C3I F;  3K7A F;  3RZO F;  5IP9 E;  2PMZ K;  2E2H F;  5IYB E;  2CW0 E;  1K83 F;  4BXX E;  2A6E E;  3S1N F;  2JA5 E;  5E18 E;  4A3D F;  1YNN K;  3HOZ F;  2B63 F;  1I50 F;  2WAQ H;  2NVT E;  4YFN E;  2O5I E;  3FKI E;  3S1M E;  3M4O F;  3M3Y F;  3S1R E;  4Y52 E;  4C2M F;  3S2D E;  5IPL E;  2NVQ F;  1Y1W E;  5M5W F;  3GTO F;  3I4N E;  3HOU E;  5IYC F;  2A68 E;  3CQZ F;  3HKZ H;  4XLP E;  3S1Q E;  3GTL F;  3PO3 F;  3RZD E;  2E2J F;  3FKI F;  3S1M F;  5M3F F;  1SFO E;  4BY1 F;  4A3C E;  3S14 F;  3GTQ F;  2VUM E;  1WCM E;  1I6H E;  5IP7 F;  3GTM E;  4G7H E;  4XSZ E;  1Y1W F;  4Y7N E;  4GZY E;  3H3V G;  3HOV E;  2YU9 F;  1I3Q E;  5C44 E;  2PMZ H;  3PO2 F;  3S1Q F;  5FLM E;  3S2H E;  1Y1V E;  4A3K E;  2NVY E;  3S15 E;  2PPB E;  3HOY F;  4LLG E;  4G7Z E;  1TWF E;  4BY7 E;  1SMY E;  4A3F F;  3GTP E;  3S17 E;  4KMU E;  4QIW K;  1I6H F;  3GTJ E;  1R9T F;  4XLN E;  4Y7N F;  5D4D E;  1TWC E;  5M3M E;  3HOV F;  1I3Q F;  2A6H E;  5IP9 F;  4AYB H;  4A3L E;  5IYB F;  2NVY F;  4Q5S E;  3S15 F;  5D4C E;  4BXX F;  4BBR E;  4XSX E;  2JA5 F;  3GTP F;  5E17 E;  2R92 E;  4A3I E;  3HOY E;  3I4M E;  4A3B E;  2BE5 E;  4A93 E;  3HOX E;  4ZH4 E;  2NVT F;  1TWA E;  4MEX E;  3S1R F;  3S16 E;  4Y52 F;  3GTG F;  3S2D F;  1TWG E;  5M5X E;  4MQ9 E;  4YFX E;  5IYD E;  2JA7 E;  5BYH E;  2KRX A;  3I4N F;  3HOU F;  1DZF A;  4OIP E;  1QKL A;  4KN7 E;  4A3M E;  4C3J E;  3RZD F;  1IW7 E;  3GTK E;  5C4J E;  2JA8 E;  4LK1 E;  4A3J E;  2NVX E;  2A69 E;  4LK0 E;  4C3H E;  1SFO F;  4OIN E;  4A3C F;  5C3E E;  3HOW E;  1WCM F;  1TWH E;  2VUM F;  3GTM F;  5IYD F;  4X6A E;  5FJ8 E;  4BBS E;  2R7Z E;  5C44 F;  5C4X E;  4C3I E;  3K7A E;  3RZO E;  5FLM F;  4JK1 E;  3S2H F;  1Y1V F;  4A3K F;  3GTG E;  2E2H E;  1TWF F;  4BY7 F;  1K83 E;  4A3E E;  3S17 F;  4G7O E;  3S1N E;  1I6V E;  5M5Y E;  4A3D E;  1YNJ K;  3GTJ F;  3HOZ E;  2E2I E;  2B63 E;  4MEY E;  1I50 E;  1TWC F;  5M3M F;  5FJ8 F;  3H0G E;  5C4X F;  4A3L F;  4KN4 E;  2R93 E;  3M4O E;  3M3Y E;  1HQM E; 
#chains in the Genus database with same CATH homology
 4C2M E;  2NVQ E;  3H3V F;  5M5W E;  3GTO E;  5IYC E;  3CQZ E;  3GTL E;  3PO3 E;  2E2J E;  4QIW H;  5M3F E;  2JA6 E;  4BY1 E;  3S14 E;  1EIK A;  3GTQ E;  5IP7 E;  2Y0S H;  4A3G E;  2YU9 E;  3PO2 E;  4A3F E;  1R9T E;  2WB1 H;  5IP9 E;  5IYB E;  4BXX E;  2JA5 E;  2WAQ H;  2NVT E;  3FKI E;  3S1M E;  3S1R E;  4Y52 E;  3S2D E;  1Y1W E;  3I4N E;  3HOU E;  3HKZ H;  3S1Q E;  3RZD E;  1SFO E;  4A3C E;  2VUM E;  1WCM E;  1I6H E;  3GTM E;  4Y7N E;  3HOV E;  1I3Q E;  5C44 E;  2PMZ H;  5FLM E;  3S2H E;  1Y1V E;  4A3K E;  2NVY E;  3S15 E;  1TWF E;  4BY7 E;  3GTP E;  3S17 E;  3GTJ E;  1TWC E;  5M3M E;  4AYB H;  4A3L E;  4BBR E;  2R92 E;  4A3I E;  3HOY E;  3I4M E;  4A3B E;  4A93 E;  3HOX E;  1TWA E;  3S16 E;  1TWG E;  5M5X E;  5IYD E;  2JA7 E;  1DZF A;  4A3M E;  4C3J E;  3GTK E;  5C4J E;  2JA8 E;  4A3J E;  2NVX E;  4C3H E;  5C3E E;  3HOW E;  1TWH E;  4X6A E;  5FJ8 E;  4BBS E;  2R7Z E;  5C4X E;  4C3I E;  3K7A E;  3RZO E;  3GTG E;  2E2H E;  1K83 E;  4A3E E;  3S1N E;  5M5Y E;  4A3D E;  3HOZ E;  2E2I E;  2B63 E;  1I50 E;  3H0G E;  2R93 E;  3M4O E;  3M3Y E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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