3EQLE

Crystal structure of the t. thermophilus rna polymerase holoenzyme in complex with antibiotic myxopyronin
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
95
structure length
95
Chain Sequence
AEPGIDKLFGMVDSKYRLTVVVAKRAQQLLRHGFKNTVLEPEERPKMQTLEGLFDDPNAVTWAMKELLTGRLVFGENLVPEDRLQKEMERLYPVE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase
publication title Transcription inactivation through local refolding of the RNA polymerase structure.
pubmed doi rcsb
molecule keywords DNA-directed RNA polymerase subunit alpha
total genus 14
structure length 95
sequence length 95
chains with identical sequence O
ec nomenclature ec 2.7.7.6: DNA-directed RNA polymerase.
pdb deposition date 2008-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF01192 RNA_pol_Rpb6 RNA polymerase Rpb6
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.940.10 Alpha Beta Alpha-Beta Complex Eukaryotic RPB6 RNA polymerase subunit Eukaryotic RPB6 RNA polymerase subunit 3eqlE00
4YFNE 3EQLE 4A3MF 1YNJK 4KMUE 2NVYF 3HOYF 1YNNK 2CW0E 4A93F 5C44F 4OIOE 2O5JE 4OINE 4X6AF 3RZOF 4Y7NF 4XLPE 4BY7F 4MQ9E 3H0GF 5M3MF 3S1RF 4A3EF 4LLGE 1WCMF 4A3FF 4OIPE 5IYBF 2A69E 5E17E 5IP7F 1SMYE 3HOXF 4A3DF 4MEYE 2A68E 4XSZE 4A3JF 2R93F 4G7HE 4Q4ZE 4BY1F 2PPBE 3GTOF 4MEXE 3S15F 4ZH4E 4A3BF 1I3QF 5IYDF 4Y52F 2E2HF 1ZYRE 4C3JF 2B63F 2NVTF 2A6EE 2R7ZF 1Y1VF 3HKZK 2A6HE 1TWFF 5TMFE 1I6VE 4A3KF 3S14F 1TWCF 3M4OF 5M5YF 2PMZK 3GTQF 3GTGF 3HOVF 4A3LF 4XLNE 5IPLE 3GTJF 5FJ8F 4Q5SE 2WB1I 1TWAF 5TMCE 2JA6F 3PO2F 4G7OE 5BYHE 3K7AF 4A3GF 4YFXE 3RZDF 4C3HF 2NVXF 4BBSF 4LK0E 2JA8F 3S1QF 2BE5E 2YU9F 5D4EE 4LJZE 1R9TF 1I50F 1TWGF 3GTLF 3PO3F 3GTPF 5IYCF 3GTKF 2WAQK 1IW7E 1HQME 5D4DE 3HOUF 4YG2E 3FKIF 1I6HF 2NVQF 2Y0SI 4JK1E 2JA5F 4G7ZE 5C4XF 2JA7F 4XSXE 4OIRE 5M3FF 5M5XF 2O5IE 5IP9F 2E2JF 3CQZF 4GZYE 3I4NF 3S16F 5C3EF 2VUMF 3WODE 4KN4E 4A3CF 5D4CE 2E2IF 1K83F 4AYBK 3S2HF 3S2DF 2R92F 5E18E 5FLMF 3I4MF 4BBRF 4C2MF 3M3YF 4A3IF 5M5WF 4BXXF 4YFKE 1Y1WF 1SFOF 3S1MF 3HOZF 4LK1E 3DXJE 4C3IF 3H3VG 4OIQE 3S1NF 5C4JF 3HOWF 1TWHF 3S17F 4KN7E 3GTMF 1QKLA
chains in the Genus database with same CATH superfamily
5M5YE 3GTQE 4YFNE 3GTGE 3HOVE 4A3LE 3EQLE 4A3MF 1YNJK 1TWAE 4KMUE 2NVYF 3H3VF 3HOYF 2JA6E 5IYBE 1YNNK 2CW0E 4A93F 5C44F 3HKZH 4OIOE 2O5JE 5IP7E 4OINE 4A3GE 4X6AF 3RZOF 4A3DE 4A3KE 4Y7NF 4C3HE 4XLPE 4A3JE 2PMZH 4BY7F 3RZDE 2JA8E 4MQ9E 3S1QE 4BBSE 3H0GF 3S14E 5M3MF 3S1RF 2YU9E 4A3EF 4LLGE 1R9TE 1WCMF 4A3FF 1I50E 1TWGE 4OIPE 3GTLE 5IYBF 3PO3E 2A69E 3GTPE 5IYCE 5E17E 5IP7F 1SMYE 3GTKE 3HOXF 4A3DF 3HOUE 4MEYE 2A68E 4XSZE 4A3JF 3M4OE 2R93F 4G7HE 3FKIE 4Q4ZE 1I6HE 4BY1F 2NVQE 3GTJE 2JA5E 4MEXE 2PPBE 3GTOF 5C4XE 3S15F 4ZH4E 4A3BF 1I3QF 5IYDF 4Y52F 2E2HF 1ZYRE 4C3JF 5M5XE 5M3FE 2A6EE 5IP9E 2B63F 2NVTF 2E2JE 3CQZE 1Y1VF 2R7ZF 3PO2E 3HKZK 2WAQH 2A6HE 3I4NE 1TWFF 3K7AE 3S16E 5TMFE 1I6VE 5C3EE 4A3KF 1TWCF 2VUME 2NVXE 5M5YF 2PMZK 3M4OF 3GTQF 3S14F 3GTGF 3HOVF 4A3LF 4XLNE 4A3CE 2E2IE 5IPLE 1K83E 3GTJF 5FJ8F 4Q5SE 2WB1I 1TWAF 5TMCE 3S2DE 2R92E 2JA6F 3I4ME 4BBRE 4C2ME 3M3YE 4A3IE 1DZFA 3PO2F 5M5WE 4G7OE 5BYHE 1SFOE 3K7AF 4A3GF 4YFXE 3S1ME 3HOZE 3RZDF 4C3HF 2NVXF 4BBSF 4LK0E 4C3IE 2JA8F 3S1QF 2Y0SH 2BE5E 3S1NE 2WB1H 2YU9F 4AYBH 5D4EE 1TWHE 4LJZE 3S17E 1EIKA 1R9TF 1I50F 2JA7E 1TWGF 3GTLF 3PO3F 3GTME 5FJ8E 3GTPF 5IYCF 3GTKF 2WAQK 1IW7E 1HQME 4QIWH 5D4DE 3HOUF 4YG2E 4A3ME 3FKIF 1I6HF 2NVYE 2NVQF 3HOYE 2Y0SI 4JK1E 2JA5F 4A93E 4G7ZE 5C44E 3S2HE 5C4XF 2JA7F 4XSXE 4OIRE 5FLME 5M3FF 5M5XF 2O5IE 3RZOE 5IP9F 4X6AE 4Y7NE 2E2JF 3CQZF 4BY7E 4BXXE 4GZYE 1Y1WE 3I4NF 3H0GE 3S16F 5M3ME 5C3EF 3S1RE 2VUMF 4A3EE 3WODE 4KN4E 1WCME 4A3FE 4A3CF 5D4CE 2E2IF 1K83F 5C4JE 4AYBK 3HOWE 3S2HF 3S2DF 2R92F 5E18E 5FLMF 3HOXE 4BBRF 3I4MF 4C2MF 3M3YF 4A3IF 5M5WF 4BXXF 2R93E 4YFKE 1Y1WF 1SFOF 4QIWK 4BY1E 3S1MF 2KRXA 3HOZF 4LK1E 3DXJE 3GTOE 4C3IF 3H3VG 3S15E 4A3BE 1I3QE 5IYDE 2E2HE 4OIQE 2B63E 4C3JE 3S1NF 2NVTE 5C4JF 3HOWF 4Y52E 2R7ZE 1TWHF 1Y1VE 3S17F 1TWFE 4KN7E 3GTMF 1TWCE 1QKLA
chains in the Genus database with same CATH topology
4YFNE 3EQLE 4A3MF 1YNJK 4KMUE 2NVYF 3HOYF 1YNNK 2CW0E 4A93F 5C44F 4OIOE 2O5JE 4OINE 4X6AF 3RZOF 4Y7NF 4XLPE 4BY7F 4MQ9E 3H0GF 5M3MF 3S1RF 4A3EF 4LLGE 1WCMF 4A3FF 4OIPE 5IYBF 2A69E 5E17E 5IP7F 1SMYE 3HOXF 4A3DF 4MEYE 2A68E 4XSZE 4A3JF 2R93F 4G7HE 4Q4ZE 4BY1F 2PPBE 3GTOF 4MEXE 3S15F 4ZH4E 4A3BF 1I3QF 5IYDF 4Y52F 2E2HF 1ZYRE 4C3JF 2B63F 2NVTF 2A6EE 2R7ZF 1Y1VF 3HKZK 2A6HE 1TWFF 5TMFE 1I6VE 4A3KF 3S14F 1TWCF 3M4OF 5M5YF 2PMZK 3GTQF 3GTGF 3HOVF 4A3LF 4XLNE 5IPLE 3GTJF 5FJ8F 4Q5SE 2WB1I 1TWAF 5TMCE 2JA6F 3PO2F 4G7OE 5BYHE 3K7AF 4A3GF 4YFXE 3RZDF 4C3HF 2NVXF 4BBSF 4LK0E 2JA8F 3S1QF 2BE5E 2YU9F 5D4EE 4LJZE 1R9TF 1I50F 1TWGF 3GTLF 3PO3F 3GTPF 5IYCF 3GTKF 2WAQK 1IW7E 1HQME 5D4DE 3HOUF 4YG2E 3FKIF 1I6HF 2NVQF 2Y0SI 4JK1E 2JA5F 4G7ZE 5C4XF 2JA7F 4XSXE 4OIRE 5M3FF 5M5XF 2O5IE 5IP9F 2E2JF 3CQZF 4GZYE 3I4NF 3S16F 5C3EF 2VUMF 3WODE 4KN4E 4A3CF 5D4CE 2E2IF 1K83F 4AYBK 3S2HF 3S2DF 2R92F 5E18E 5FLMF 3I4MF 4BBRF 4C2MF 3M3YF 4A3IF 5M5WF 4BXXF 4YFKE 1Y1WF 1SFOF 4QIWK 3S1MF 2KRXA 3HOZF 4LK1E 3DXJE 4C3IF 3H3VG 4OIQE 3S1NF 5C4JF 3HOWF 1TWHF 3S17F 4KN7E 3GTMF 1QKLA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4YFN E;  3EQL E;  4A3M F;  1YNJ K;  4KMU E;  2NVY F;  3HOY F;  1YNN K;  2CW0 E;  4A93 F;  5C44 F;  4OIO E;  2O5J E;  4OIN E;  4X6A F;  3RZO F;  4Y7N F;  4XLP E;  4BY7 F;  4MQ9 E;  3H0G F;  5M3M F;  3S1R F;  4A3E F;  4LLG E;  1WCM F;  4A3F F;  4OIP E;  5IYB F;  2A69 E;  5E17 E;  5IP7 F;  1SMY E;  3HOX F;  4A3D F;  4MEY E;  2A68 E;  4XSZ E;  4A3J F;  2R93 F;  4G7H E;  4Q4Z E;  4BY1 F;  2PPB E;  3GTO F;  4MEX E;  3S15 F;  4ZH4 E;  4A3B F;  1I3Q F;  5IYD F;  4Y52 F;  2E2H F;  1ZYR E;  4C3J F;  2B63 F;  2NVT F;  2A6E E;  2R7Z F;  1Y1V F;  3HKZ K;  2A6H E;  1TWF F;  5TMF E;  1I6V E;  4A3K F;  3S14 F;  1TWC F;  3M4O F;  5M5Y F;  2PMZ K;  3GTQ F;  3GTG F;  3HOV F;  4A3L F;  4XLN E;  5IPL E;  3GTJ F;  5FJ8 F;  4Q5S E;  2WB1 I;  1TWA F;  5TMC E;  2JA6 F;  3PO2 F;  4G7O E;  5BYH E;  3K7A F;  4A3G F;  4YFX E;  3RZD F;  4C3H F;  2NVX F;  4BBS F;  4LK0 E;  2JA8 F;  3S1Q F;  2BE5 E;  2YU9 F;  5D4E E;  4LJZ E;  1R9T F;  1I50 F;  1TWG F;  3GTL F;  3PO3 F;  3GTP F;  5IYC F;  3GTK F;  2WAQ K;  1IW7 E;  1HQM E;  5D4D E;  3HOU F;  4YG2 E;  3FKI F;  1I6H F;  2NVQ F;  2Y0S I;  4JK1 E;  2JA5 F;  4G7Z E;  5C4X F;  2JA7 F;  4XSX E;  4OIR E;  5M3F F;  5M5X F;  2O5I E;  5IP9 F;  2E2J F;  3CQZ F;  4GZY E;  3I4N F;  3S16 F;  5C3E F;  2VUM F;  3WOD E;  4KN4 E;  4A3C F;  5D4C E;  2E2I F;  1K83 F;  4AYB K;  3S2H F;  3S2D F;  2R92 F;  5E18 E;  5FLM F;  3I4M F;  4BBR F;  4C2M F;  3M3Y F;  4A3I F;  5M5W F;  4BXX F;  4YFK E;  1Y1W F;  1SFO F;  3S1M F;  3HOZ F;  4LK1 E;  3DXJ E;  4C3I F;  3H3V G;  4OIQ E;  3S1N F;  5C4J F;  3HOW F;  1TWH F;  3S17 F;  4KN7 E;  3GTM F;  1QKL A; 
#chains in the Genus database with same CATH topology
 5M5Y E;  3GTQ E;  4YFN E;  3GTG E;  3HOV E;  4A3L E;  3EQL E;  4A3M F;  1YNJ K;  1TWA E;  4KMU E;  2NVY F;  3H3V F;  3HOY F;  2JA6 E;  5IYB E;  1YNN K;  2CW0 E;  4A93 F;  5C44 F;  3HKZ H;  4OIO E;  2O5J E;  5IP7 E;  4OIN E;  4A3G E;  4X6A F;  3RZO F;  4A3D E;  4A3K E;  4Y7N F;  4C3H E;  4XLP E;  4A3J E;  2PMZ H;  4BY7 F;  3RZD E;  2JA8 E;  4MQ9 E;  3S1Q E;  4BBS E;  3H0G F;  3S14 E;  5M3M F;  3S1R F;  2YU9 E;  4A3E F;  4LLG E;  1R9T E;  1WCM F;  4A3F F;  1I50 E;  1TWG E;  4OIP E;  3GTL E;  5IYB F;  3PO3 E;  2A69 E;  3GTP E;  5IYC E;  5E17 E;  5IP7 F;  1SMY E;  3GTK E;  3HOX F;  4A3D F;  3HOU E;  4MEY E;  2A68 E;  4XSZ E;  4A3J F;  3M4O E;  2R93 F;  4G7H E;  3FKI E;  4Q4Z E;  1I6H E;  4BY1 F;  2NVQ E;  3GTJ E;  2JA5 E;  4MEX E;  2PPB E;  3GTO F;  5C4X E;  3S15 F;  4ZH4 E;  4A3B F;  1I3Q F;  5IYD F;  4Y52 F;  2E2H F;  1ZYR E;  4C3J F;  5M5X E;  5M3F E;  2A6E E;  5IP9 E;  2B63 F;  2NVT F;  2E2J E;  3CQZ E;  1Y1V F;  2R7Z F;  3PO2 E;  3HKZ K;  2WAQ H;  2A6H E;  3I4N E;  1TWF F;  3K7A E;  3S16 E;  5TMF E;  1I6V E;  5C3E E;  4A3K F;  1TWC F;  2VUM E;  2NVX E;  5M5Y F;  2PMZ K;  3M4O F;  3GTQ F;  3S14 F;  3GTG F;  3HOV F;  4A3L F;  4XLN E;  4A3C E;  2E2I E;  5IPL E;  1K83 E;  3GTJ F;  5FJ8 F;  4Q5S E;  2WB1 I;  1TWA F;  5TMC E;  3S2D E;  2R92 E;  2JA6 F;  3I4M E;  4BBR E;  4C2M E;  3M3Y E;  4A3I E;  1DZF A;  3PO2 F;  5M5W E;  4G7O E;  5BYH E;  1SFO E;  3K7A F;  4A3G F;  4YFX E;  3S1M E;  3HOZ E;  3RZD F;  4C3H F;  2NVX F;  4BBS F;  4LK0 E;  4C3I E;  2JA8 F;  3S1Q F;  2Y0S H;  2BE5 E;  3S1N E;  2WB1 H;  2YU9 F;  4AYB H;  5D4E E;  1TWH E;  4LJZ E;  3S17 E;  1EIK A;  1R9T F;  1I50 F;  2JA7 E;  1TWG F;  3GTL F;  3PO3 F;  3GTM E;  5FJ8 E;  3GTP F;  5IYC F;  3GTK F;  2WAQ K;  1IW7 E;  1HQM E;  4QIW H;  5D4D E;  3HOU F;  4YG2 E;  4A3M E;  3FKI F;  1I6H F;  2NVY E;  2NVQ F;  3HOY E;  2Y0S I;  4JK1 E;  2JA5 F;  4A93 E;  4G7Z E;  5C44 E;  3S2H E;  5C4X F;  2JA7 F;  4XSX E;  4OIR E;  5FLM E;  5M3F F;  5M5X F;  2O5I E;  3RZO E;  5IP9 F;  4X6A E;  4Y7N E;  2E2J F;  3CQZ F;  4BY7 E;  4BXX E;  4GZY E;  1Y1W E;  3I4N F;  3H0G E;  3S16 F;  5M3M E;  5C3E F;  3S1R E;  2VUM F;  4A3E E;  3WOD E;  4KN4 E;  1WCM E;  4A3F E;  4A3C F;  5D4C E;  2E2I F;  1K83 F;  5C4J E;  4AYB K;  3HOW E;  3S2H F;  3S2D F;  2R92 F;  5E18 E;  5FLM F;  3HOX E;  4BBR F;  3I4M F;  4C2M F;  3M3Y F;  4A3I F;  5M5W F;  4BXX F;  2R93 E;  4YFK E;  1Y1W F;  1SFO F;  4QIW K;  4BY1 E;  3S1M F;  2KRX A;  3HOZ F;  4LK1 E;  3DXJ E;  3GTO E;  4C3I F;  3H3V G;  3S15 E;  4A3B E;  1I3Q E;  5IYD E;  2E2H E;  4OIQ E;  2B63 E;  4C3J E;  3S1N F;  2NVT E;  5C4J F;  3HOW F;  4Y52 E;  2R7Z E;  1TWH F;  1Y1V E;  3S17 F;  1TWF E;  4KN7 E;  3GTM F;  1TWC E;  1QKL A; 
#chains in the Genus database with same CATH homology
 4YFN E;  3EQL E;  4A3M F;  1YNJ K;  4KMU E;  2NVY F;  3HOY F;  1YNN K;  2CW0 E;  4A93 F;  5C44 F;  4OIO E;  2O5J E;  4OIN E;  4X6A F;  3RZO F;  4Y7N F;  4XLP E;  4BY7 F;  4MQ9 E;  3H0G F;  5M3M F;  3S1R F;  4A3E F;  4LLG E;  1WCM F;  4A3F F;  4OIP E;  5IYB F;  2A69 E;  5E17 E;  5IP7 F;  1SMY E;  3HOX F;  4A3D F;  4MEY E;  2A68 E;  4XSZ E;  4A3J F;  2R93 F;  4G7H E;  4Q4Z E;  4BY1 F;  2PPB E;  3GTO F;  4MEX E;  3S15 F;  4ZH4 E;  4A3B F;  1I3Q F;  5IYD F;  4Y52 F;  2E2H F;  1ZYR E;  4C3J F;  2B63 F;  2NVT F;  2A6E E;  2R7Z F;  1Y1V F;  3HKZ K;  2A6H E;  1TWF F;  5TMF E;  1I6V E;  4A3K F;  3S14 F;  1TWC F;  3M4O F;  5M5Y F;  2PMZ K;  3GTQ F;  3GTG F;  3HOV F;  4A3L F;  4XLN E;  5IPL E;  3GTJ F;  5FJ8 F;  4Q5S E;  2WB1 I;  1TWA F;  5TMC E;  2JA6 F;  3PO2 F;  4G7O E;  5BYH E;  3K7A F;  4A3G F;  4YFX E;  3RZD F;  4C3H F;  2NVX F;  4BBS F;  4LK0 E;  2JA8 F;  3S1Q F;  2BE5 E;  2YU9 F;  5D4E E;  4LJZ E;  1R9T F;  1I50 F;  1TWG F;  3GTL F;  3PO3 F;  3GTP F;  5IYC F;  3GTK F;  2WAQ K;  1IW7 E;  1HQM E;  5D4D E;  3HOU F;  4YG2 E;  3FKI F;  1I6H F;  2NVQ F;  2Y0S I;  4JK1 E;  2JA5 F;  4G7Z E;  5C4X F;  2JA7 F;  4XSX E;  4OIR E;  5M3F F;  5M5X F;  2O5I E;  5IP9 F;  2E2J F;  3CQZ F;  4GZY E;  3I4N F;  3S16 F;  5C3E F;  2VUM F;  3WOD E;  4KN4 E;  4A3C F;  5D4C E;  2E2I F;  1K83 F;  4AYB K;  3S2H F;  3S2D F;  2R92 F;  5E18 E;  5FLM F;  3I4M F;  4BBR F;  4C2M F;  3M3Y F;  4A3I F;  5M5W F;  4BXX F;  4YFK E;  1Y1W F;  1SFO F;  4QIW K;  3S1M F;  2KRX A;  3HOZ F;  4LK1 E;  3DXJ E;  4C3I F;  3H3V G;  4OIQ E;  3S1N F;  5C4J F;  3HOW F;  1TWH F;  3S17 F;  4KN7 E;  3GTM F;  1QKL A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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